State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
State Key Laboratory of Esophageal Cancer Prevention & Treatment and Henan Key Laboratory for Esophageal Cancer Research of the First Affiliated Hospital, Zhengzhou University, Zhengzhou, China
Objective To compare the genomic variants of primary esophageal squamous cell carcinoma (ESCC) and primary esophageal adenocarcinoma (EAC) using a special model of concurrent ESCC and EAC in the same individual. Methods Six samples of ESCC, EAC and normal esophageal tissues from two patients with concurrent ESCC and EAC in the same individual were subjected to whole-exome sequencing by using whole-exome sequencing. Results ESCC and EAC have different mutational features, and 19 mutated genes shared in esophageal squamous carcinoma and esophageal adenocarcinoma were found (OBSCN, TMEM261, ZNF462, STYXL1, EDEM3, SCN2A, WDR87, MACROD2, PAGE1, ANKRD18B, OR4Q3, GOLGA3, A2ML1, CACNA1A, PSMD3, CD1E, EPRS, PCDH11X and CHN1), three genes (DST, PCM1 and KIAA1328) were found to be mutated both in the two ESCC, and no co-occurring genes were found in the two EAC. Conclusion ESCC and EAC have obvious characteristics of tumor heterogeneity and gene mutation, and may have the same molecular mechanism.
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