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Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases

Received: 4 December 2023    Accepted: 18 January 2024    Published: 1 February 2024
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Abstract

The primary mucinous adenocarcinoma of the bladder is an extremely rare urologic entity, which is found in less than 2% of all urinary bladder tumors and is often presented as metastatic. The authors report two cases of bladder adenocarcinoma with epispadias bladder exstrophy complex in two adults. The first case was about a 40-year-old patient referred for management of an EEC evolving since birth. The examination on admission revealed a deterioration in general condition and a bladder plate seat of an ulcero-necrotic tumefaction 3 x 2,5 cm with complete epispadias. The ureteral meatus were visible on each side at the lower part of the plate. Biopsy of the ulcero-necrotic mass revealed a well-differentiated bladder adenocarcinoma. Radical cystectomy and urinary diversion with an ileal conduit, and an expanded local lymphadenectomy was Indicated but the patient died before performing surgery. The second case is about a 28-year-old patient referred for management of an EEC evolving since birth associated with bilateral groin hernia. He had a good general condition, a bladder plate with complete epispadias. Treatment was cystectomy with Bricker urinary. Histo-pathological examination of the specimen reveled mucinous adenocarcinoma of the bladder. After review of the literature, it is a histological type with a poor prognosis and the role of surgery and adjuvant treatment remains to be defined.

Published in International Journal of Clinical Urology (Volume 8, Issue 1)
DOI 10.11648/ijcu.20240801.11
Page(s) 1-3
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Exstrophy-Epispadias Complex, Adenocarcinoma, Cystectomy

References
[1] Grossfeld GD and Carroll PR: Evaluation of asymptomatic microscopic hematuria. Urol Clin North Am 1998, 25: 661-676.
[2] Smeulders N and Woodhouse CR: Neoplasia in adult exstrophy patients. BJU Int 87: 623-628, 2001.
[3] Xiong, W, Peng R, Zhu L, Zhong Z. Bladder exstrophy-epispadias complex with adenocarcinoma in an adult patient: A case report. Experimental and Therapeutic Medicine 2015, 10(6), 2194-2196.
[4] Hamid, A. R. A., Mochtar, C. A., Saraswati, M., Matondang, S., & Affan, M. I. F. (2021). Adenocarcinoma mucinosum of extrophy bladder: A rare case report. International Journal of Surgery Case Reports, 88, 106493.
[5] Sharma PK, Pandey PK, Vijay M. K, Bera MK, Singh JP, Saha, K. Squamous cell carcinoma in exstrophy of the bladder. Korean journal of urology 2013, 54(8), 555-557.
[6] Ze Ondo C, Fall B, Sow Y, Diallo Y, Sarr A, Thiam A et al. Journal Africain de Chirurgie 2016; 4(2): 67-70.
[7] Ziouziou I, Karmouni T, El Khader K, Koutani A, Iben Attya Andaloussi A. L’exstrophie vésicale chez l’adulte: A propos de 5 cas. Afr J Urol 2014; 20(1): 53-58.
[8] Castagnetti M, Tocco A, Capizzi A, Rigamonti W, Artibani W. Sexual function in men born with classic bladder exstro- phy: a norm related study. J Urol 2010; 183: 1118-1122.
[9] Mohammed B, Paul OJ, Mustapha A, Soufiane M, Fadl TM, Hassan, FM. Adénocarcinome sur une exstrophie de vessie chez un patient adulte: à propos d’un cas. Pan African Medical Journal 2018, 29(1), 1-6.
[10] Roux, S., Poli-Merol, M. L., Merzeau, N., Larré, S., & Leon, P. Rare neuroendocrine tumor decades after bladder exstrophy repair with enterocystoplasty. Journal of pediatric surgery case reports 2018; 31: 10-12.
[11] Touil A, Loughlimi H, El-Abbassi S, Elouazzani H, Mahassini N. Squamous cell carcinoma in bladder extrophy: a case report and literature review. J Clin Case Rep, 2017: 7(982), 2.
[12] Kadouri Y, Hachem F, Lakssir J, Sayegh H, Benslimane L, Nouini Y. Adénocarcinome primitif de la vessie: à propos de 6 cas. Pan Afr Med J. 2020 Jun 3; 36: 61.
[13] Filmer RB, Spencer JR. Malignancies in bladder augmentations and intestinal conduits. J Urol. 1990 Avr; 143(4): 671–678.
[14] Culp DA. The histology of the exstrophied bladder. J Urol. 1964 Mai; 91: 538–548.
[15] Ebert AK, Reutter H, Ludwig M, Rösch WH. The exstrophy-epispadias complex. Orphanet Journal of Rare Diseases 2009; 4(1), 1-17.
Cite This Article
  • APA Style

    Sine, B., Feki, M., Bagayogo, N. A., Sarr, A., Ndiath, A., et al. (2024). Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases. International Journal of Clinical Urology, 8(1), 1-3. https://doi.org/10.11648/ijcu.20240801.11

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    ACS Style

    Sine, B.; Feki, M.; Bagayogo, N. A.; Sarr, A.; Ndiath, A., et al. Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases. Int. J. Clin. Urol. 2024, 8(1), 1-3. doi: 10.11648/ijcu.20240801.11

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    AMA Style

    Sine B, Feki M, Bagayogo NA, Sarr A, Ndiath A, et al. Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases. Int J Clin Urol. 2024;8(1):1-3. doi: 10.11648/ijcu.20240801.11

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  • @article{10.11648/ijcu.20240801.11,
      author = {Babacar Sine and Mouhamed Feki and Ndéye Aissatou Bagayogo and Alioune Sarr and Abdoulaye Ndiath and Amath Thiam and Ndiaga Seck Ndour and Ousmane Sow and El Hadji Malick Diaw and Cyrille Ze Ondo and Yaya Sow and Alain Khassim Ndoye},
      title = {Adenocarcinoma of the Bladder in Exstrophy-Epispadias Complex in Adult Patients: About Two Cases},
      journal = {International Journal of Clinical Urology},
      volume = {8},
      number = {1},
      pages = {1-3},
      doi = {10.11648/ijcu.20240801.11},
      url = {https://doi.org/10.11648/ijcu.20240801.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.ijcu.20240801.11},
      abstract = {The primary mucinous adenocarcinoma of the bladder is an extremely rare urologic entity, which is found in less than 2% of all urinary bladder tumors and is often presented as metastatic. The authors report two cases of bladder adenocarcinoma with epispadias bladder exstrophy complex in two adults. The first case was about a 40-year-old patient referred for management of an EEC evolving since birth. The examination on admission revealed a deterioration in general condition and a bladder plate seat of an ulcero-necrotic tumefaction 3 x 2,5 cm with complete epispadias. The ureteral meatus were visible on each side at the lower part of the plate. Biopsy of the ulcero-necrotic mass revealed a well-differentiated bladder adenocarcinoma. Radical cystectomy and urinary diversion with an ileal conduit, and an expanded local lymphadenectomy was Indicated but the patient died before performing surgery. The second case is about a 28-year-old patient referred for management of an EEC evolving since birth associated with bilateral groin hernia. He had a good general condition, a bladder plate with complete epispadias. Treatment was cystectomy with Bricker urinary. Histo-pathological examination of the specimen reveled mucinous adenocarcinoma of the bladder. After review of the literature, it is a histological type with a poor prognosis and the role of surgery and adjuvant treatment remains to be defined.
    },
     year = {2024}
    }
    

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    AU  - Amath Thiam
    AU  - Ndiaga Seck Ndour
    AU  - Ousmane Sow
    AU  - El Hadji Malick Diaw
    AU  - Cyrille Ze Ondo
    AU  - Yaya Sow
    AU  - Alain Khassim Ndoye
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    JF  - International Journal of Clinical Urology
    JO  - International Journal of Clinical Urology
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    AB  - The primary mucinous adenocarcinoma of the bladder is an extremely rare urologic entity, which is found in less than 2% of all urinary bladder tumors and is often presented as metastatic. The authors report two cases of bladder adenocarcinoma with epispadias bladder exstrophy complex in two adults. The first case was about a 40-year-old patient referred for management of an EEC evolving since birth. The examination on admission revealed a deterioration in general condition and a bladder plate seat of an ulcero-necrotic tumefaction 3 x 2,5 cm with complete epispadias. The ureteral meatus were visible on each side at the lower part of the plate. Biopsy of the ulcero-necrotic mass revealed a well-differentiated bladder adenocarcinoma. Radical cystectomy and urinary diversion with an ileal conduit, and an expanded local lymphadenectomy was Indicated but the patient died before performing surgery. The second case is about a 28-year-old patient referred for management of an EEC evolving since birth associated with bilateral groin hernia. He had a good general condition, a bladder plate with complete epispadias. Treatment was cystectomy with Bricker urinary. Histo-pathological examination of the specimen reveled mucinous adenocarcinoma of the bladder. After review of the literature, it is a histological type with a poor prognosis and the role of surgery and adjuvant treatment remains to be defined.
    
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Author Information
  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal; Urology Andrology Department, Ouakam Military Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Ouakam Military Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Ouakam Military Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

  • Urology Andrology Department, Aristide Le Dantec Hospital, Dakar, Senegal

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