Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets

Doaa Assar; Zizy Elbialy; Rasha Al Wakeel; Naglaa Gomaa; Mahmoud Metwaly El-Maghraby; Wael Mohamed Nagy; Adel Abd El Aziz El-badawy; Abdel-Khalek El-Sayed Abdel-Khalek

doi:doi:10.11648/j.aap.20230801.12

Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets

Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, Wael Mohamed Nagy, Adel Abd El Aziz El-badawy, Abdel-Khalek El-Sayed Abdel-Khalek

Published in Advances in Applied Physiology (Volume 8, Issue 1)

Received: 4 February 2023 Accepted: 22 February 2023 Published: 3 March 2023

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Abstract

Recently, chitosan gained a great attention due to its unique biological activities as a natural biodegradable polymer derived from chitin with non-antigenic, non-toxic. It has several positive impacts on animal health including potent antioxidant, antimicrobial activities, and anti-immunogenicity. Therefore, it is a natural, bioactive, mucoadhesive, and biocompatible compound used commonly as a safe additive in animal production. This study was conducted to detect the effects of dietary inclusion of chitosan in high-fat diet (HFD) on growth, hematology, lipid profile, rumen function, oxidative stress, and antioxidant status of Zaraibi goat bucks. Total of 18 sexually mature bucks (38.69±0.57 kg BW) were allocated into 3 groups (n= 6); the control group fed the control diet and treatment groups received HFD (the control diet with 3% fat) and the HFD plus 2.5% chitosan for 8 weeks, respectively. Results showed that HFD increase (P<0.05) final body weight, total weight gain, white blood cells (WBCs), and serum total cholesterol (TC), triglycerides (TG), VLDL, LDL, and malondialdehyde (MDA) with declined free T4 hormone, and HDL with the exhaustion of GSH, CAT and GPx activities beside reducing ruminal total proteins, glucose, ammonia-N, TVFA, total and L-lactate concentrations. Chitosan dietary inclusion to HFD reversed the aforementioned parameters with a notable enhancement of the antioxidant enzyme activities, suppressed the elevated MDA levels, and restored the depleted T4 level. Therefore, chitosan could be safely utilized as a dietary supplement in buck's diets to improve organ functions, lipid profile, antioxidant defense system, scavenge free radicals, and potentiate Buck's reproductive activities.

Published in	Advances in Applied Physiology (Volume 8, Issue 1)
DOI	10.11648/j.aap.20230801.12
Page(s)	8-16
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Chitosan, High Fat Diet, Lipid Metabolism, Antioxidant, Leukocytes, Zaraibi Goat Bucks

References

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Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, et al. (2023). Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Advances in Applied Physiology, 8(1), 8-16. https://doi.org/10.11648/j.aap.20230801.12

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Doaa Assar; Zizy Elbialy; Rasha Al Wakeel; Naglaa Gomaa; Mahmoud Metwaly El-Maghraby, et al. Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Adv. Appl. Physiol. 2023, 8(1), 8-16. doi: 10.11648/j.aap.20230801.12

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Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, et al. Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Adv Appl Physiol. 2023;8(1):8-16. doi: 10.11648/j.aap.20230801.12

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@article{10.11648/j.aap.20230801.12,
  author = {Doaa Assar and Zizy Elbialy and Rasha Al Wakeel and Naglaa Gomaa and Mahmoud Metwaly El-Maghraby and Wael Mohamed Nagy and Adel Abd El Aziz El-badawy and Abdel-Khalek El-Sayed Abdel-Khalek},
  title = {Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets},
  journal = {Advances in Applied Physiology},
  volume = {8},
  number = {1},
  pages = {8-16},
  doi = {10.11648/j.aap.20230801.12},
  url = {https://doi.org/10.11648/j.aap.20230801.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20230801.12},
  abstract = {Recently, chitosan gained a great attention due to its unique biological activities as a natural biodegradable polymer derived from chitin with non-antigenic, non-toxic. It has several positive impacts on animal health including potent antioxidant, antimicrobial activities, and anti-immunogenicity. Therefore, it is a natural, bioactive, mucoadhesive, and biocompatible compound used commonly as a safe additive in animal production. This study was conducted to detect the effects of dietary inclusion of chitosan in high-fat diet (HFD) on growth, hematology, lipid profile, rumen function, oxidative stress, and antioxidant status of Zaraibi goat bucks. Total of 18 sexually mature bucks (38.69±0.57 kg BW) were allocated into 3 groups (n= 6); the control group fed the control diet and treatment groups received HFD (the control diet with 3% fat) and the HFD plus 2.5% chitosan for 8 weeks, respectively. Results showed that HFD increase (P<0.05) final body weight, total weight gain, white blood cells (WBCs), and serum total cholesterol (TC), triglycerides (TG), VLDL, LDL, and malondialdehyde (MDA) with declined free T4 hormone, and HDL with the exhaustion of GSH, CAT and GPx activities beside reducing ruminal total proteins, glucose, ammonia-N, TVFA, total and L-lactate concentrations. Chitosan dietary inclusion to HFD reversed the aforementioned parameters with a notable enhancement of the antioxidant enzyme activities, suppressed the elevated MDA levels, and restored the depleted T4 level. Therefore, chitosan could be safely utilized as a dietary supplement in buck's diets to improve organ functions, lipid profile, antioxidant defense system, scavenge free radicals, and potentiate Buck's reproductive activities.},
 year = {2023}
}

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TY  - JOUR
T1  - Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets
AU  - Doaa Assar
AU  - Zizy Elbialy
AU  - Rasha Al Wakeel
AU  - Naglaa Gomaa
AU  - Mahmoud Metwaly El-Maghraby
AU  - Wael Mohamed Nagy
AU  - Adel Abd El Aziz El-badawy
AU  - Abdel-Khalek El-Sayed Abdel-Khalek
Y1  - 2023/03/03
PY  - 2023
N1  - https://doi.org/10.11648/j.aap.20230801.12
DO  - 10.11648/j.aap.20230801.12
T2  - Advances in Applied Physiology
JF  - Advances in Applied Physiology
JO  - Advances in Applied Physiology
SP  - 8
EP  - 16
PB  - Science Publishing Group
SN  - 2471-9714
UR  - https://doi.org/10.11648/j.aap.20230801.12
AB  - Recently, chitosan gained a great attention due to its unique biological activities as a natural biodegradable polymer derived from chitin with non-antigenic, non-toxic. It has several positive impacts on animal health including potent antioxidant, antimicrobial activities, and anti-immunogenicity. Therefore, it is a natural, bioactive, mucoadhesive, and biocompatible compound used commonly as a safe additive in animal production. This study was conducted to detect the effects of dietary inclusion of chitosan in high-fat diet (HFD) on growth, hematology, lipid profile, rumen function, oxidative stress, and antioxidant status of Zaraibi goat bucks. Total of 18 sexually mature bucks (38.69±0.57 kg BW) were allocated into 3 groups (n= 6); the control group fed the control diet and treatment groups received HFD (the control diet with 3% fat) and the HFD plus 2.5% chitosan for 8 weeks, respectively. Results showed that HFD increase (P<0.05) final body weight, total weight gain, white blood cells (WBCs), and serum total cholesterol (TC), triglycerides (TG), VLDL, LDL, and malondialdehyde (MDA) with declined free T4 hormone, and HDL with the exhaustion of GSH, CAT and GPx activities beside reducing ruminal total proteins, glucose, ammonia-N, TVFA, total and L-lactate concentrations. Chitosan dietary inclusion to HFD reversed the aforementioned parameters with a notable enhancement of the antioxidant enzyme activities, suppressed the elevated MDA levels, and restored the depleted T4 level. Therefore, chitosan could be safely utilized as a dietary supplement in buck's diets to improve organ functions, lipid profile, antioxidant defense system, scavenge free radicals, and potentiate Buck's reproductive activities.
VL  - 8
IS  - 1
ER  -

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Author Information

Doaa Assar

Department of Clinical Pathology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt
Zizy Elbialy

Department of Fish Processing and Biotechnology, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafrelsheikh, Egypt
Rasha Al Wakeel

Department of Physiology, Faculty of Veterinary Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt
Naglaa Gomaa

Department of Animal Medicine, Faculty of Veterinary Medicine, Kafrelshiekh University, Kafrelsheikh, Egypt
Mahmoud Metwaly El-Maghraby

Animal Production Research Institute, Agricultural Research Center, Giza, Egypt
Wael Mohamed Nagy

Animal Production Research Institute, Agricultural Research Center, Giza, Egypt
Adel Abd El Aziz El-badawy

Animal Production Research Institute, Agricultural Research Center, Giza, Egypt
Abdel-Khalek El-Sayed Abdel-Khalek

Animal Production Department, Faculty of Agriculture, Mansoura University, Mansoura, Egypt

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APA Style

Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, et al. (2023). Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Advances in Applied Physiology, 8(1), 8-16. https://doi.org/10.11648/j.aap.20230801.12

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ACS Style

Doaa Assar; Zizy Elbialy; Rasha Al Wakeel; Naglaa Gomaa; Mahmoud Metwaly El-Maghraby, et al. Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Adv. Appl. Physiol. 2023, 8(1), 8-16. doi: 10.11648/j.aap.20230801.12

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AMA Style

Doaa Assar, Zizy Elbialy, Rasha Al Wakeel, Naglaa Gomaa, Mahmoud Metwaly El-Maghraby, et al. Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets. Adv Appl Physiol. 2023;8(1):8-16. doi: 10.11648/j.aap.20230801.12

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@article{10.11648/j.aap.20230801.12,
  author = {Doaa Assar and Zizy Elbialy and Rasha Al Wakeel and Naglaa Gomaa and Mahmoud Metwaly El-Maghraby and Wael Mohamed Nagy and Adel Abd El Aziz El-badawy and Abdel-Khalek El-Sayed Abdel-Khalek},
  title = {Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets},
  journal = {Advances in Applied Physiology},
  volume = {8},
  number = {1},
  pages = {8-16},
  doi = {10.11648/j.aap.20230801.12},
  url = {https://doi.org/10.11648/j.aap.20230801.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20230801.12},
  abstract = {Recently, chitosan gained a great attention due to its unique biological activities as a natural biodegradable polymer derived from chitin with non-antigenic, non-toxic. It has several positive impacts on animal health including potent antioxidant, antimicrobial activities, and anti-immunogenicity. Therefore, it is a natural, bioactive, mucoadhesive, and biocompatible compound used commonly as a safe additive in animal production. This study was conducted to detect the effects of dietary inclusion of chitosan in high-fat diet (HFD) on growth, hematology, lipid profile, rumen function, oxidative stress, and antioxidant status of Zaraibi goat bucks. Total of 18 sexually mature bucks (38.69±0.57 kg BW) were allocated into 3 groups (n= 6); the control group fed the control diet and treatment groups received HFD (the control diet with 3% fat) and the HFD plus 2.5% chitosan for 8 weeks, respectively. Results showed that HFD increase (P<0.05) final body weight, total weight gain, white blood cells (WBCs), and serum total cholesterol (TC), triglycerides (TG), VLDL, LDL, and malondialdehyde (MDA) with declined free T4 hormone, and HDL with the exhaustion of GSH, CAT and GPx activities beside reducing ruminal total proteins, glucose, ammonia-N, TVFA, total and L-lactate concentrations. Chitosan dietary inclusion to HFD reversed the aforementioned parameters with a notable enhancement of the antioxidant enzyme activities, suppressed the elevated MDA levels, and restored the depleted T4 level. Therefore, chitosan could be safely utilized as a dietary supplement in buck's diets to improve organ functions, lipid profile, antioxidant defense system, scavenge free radicals, and potentiate Buck's reproductive activities.},
 year = {2023}
}

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TY  - JOUR
T1  - Dietary Chitosan Supplementation Modulates Hematology, Lipid Profile, Rumen Function, Antioxidant Status, and Thyroxin in Zaraibi Goat Bucks Fed on High-Fat Diets
AU  - Doaa Assar
AU  - Zizy Elbialy
AU  - Rasha Al Wakeel
AU  - Naglaa Gomaa
AU  - Mahmoud Metwaly El-Maghraby
AU  - Wael Mohamed Nagy
AU  - Adel Abd El Aziz El-badawy
AU  - Abdel-Khalek El-Sayed Abdel-Khalek
Y1  - 2023/03/03
PY  - 2023
N1  - https://doi.org/10.11648/j.aap.20230801.12
DO  - 10.11648/j.aap.20230801.12
T2  - Advances in Applied Physiology
JF  - Advances in Applied Physiology
JO  - Advances in Applied Physiology
SP  - 8
EP  - 16
PB  - Science Publishing Group
SN  - 2471-9714
UR  - https://doi.org/10.11648/j.aap.20230801.12
AB  - Recently, chitosan gained a great attention due to its unique biological activities as a natural biodegradable polymer derived from chitin with non-antigenic, non-toxic. It has several positive impacts on animal health including potent antioxidant, antimicrobial activities, and anti-immunogenicity. Therefore, it is a natural, bioactive, mucoadhesive, and biocompatible compound used commonly as a safe additive in animal production. This study was conducted to detect the effects of dietary inclusion of chitosan in high-fat diet (HFD) on growth, hematology, lipid profile, rumen function, oxidative stress, and antioxidant status of Zaraibi goat bucks. Total of 18 sexually mature bucks (38.69±0.57 kg BW) were allocated into 3 groups (n= 6); the control group fed the control diet and treatment groups received HFD (the control diet with 3% fat) and the HFD plus 2.5% chitosan for 8 weeks, respectively. Results showed that HFD increase (P<0.05) final body weight, total weight gain, white blood cells (WBCs), and serum total cholesterol (TC), triglycerides (TG), VLDL, LDL, and malondialdehyde (MDA) with declined free T4 hormone, and HDL with the exhaustion of GSH, CAT and GPx activities beside reducing ruminal total proteins, glucose, ammonia-N, TVFA, total and L-lactate concentrations. Chitosan dietary inclusion to HFD reversed the aforementioned parameters with a notable enhancement of the antioxidant enzyme activities, suppressed the elevated MDA levels, and restored the depleted T4 level. Therefore, chitosan could be safely utilized as a dietary supplement in buck's diets to improve organ functions, lipid profile, antioxidant defense system, scavenge free radicals, and potentiate Buck's reproductive activities.
VL  - 8
IS  - 1
ER  -

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