The buds of Syzygium aromaticum (Myrtaceae) is used in traditional medicine in the treatment of gastric ulcer. This pathology affects approximately 10% of the world's population. The current study aims to verify the antiulcer effect of an aqueous extract of the buds of Syzygium aromaticum (EASA) in wistar rats. For this, the 1000 mg/kg B.W. dose of EASA was tested on gastric ulcer induced with (Eth/HCl/H2O) in rats compared to the effect of 20 mg/kg B.W. of Omeprazole for 14 days. Also, a phytochemical screening was carried out on this extract. After 3 days of ulcer induction, the ulceration index was 3 and the ulceration percentage was 100% in the stomachs of the rats. The results after 14 days of treatment with EASA show that the ulceration index and the percentage of ulceration are 0.5 and 8.83% against 0 for Omeprazole. The aqueous extract of Syzygium aromaticum therefore treats the induced ulcer at 91.17% against 100% for Omeprazole. These results are confirmed by observations of scars on histological sections on the fourteenth day. Phytochemical screening indicates that EASA contains sterols, polyterpenes and polyphenols, quinone compounds, alkaloids and gallic tannins. These results would justify the use of Syzygium aromaticum buds in traditional medicine in the treatment of gastric ulcer.
| Published in | Advances in Applied Physiology (Volume 8, Issue 1) |
| DOI | 10.11648/j.aap.20230801.14 |
| Page(s) | 20-28 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Phytochemical Screening, Syzygium aromaticum, Ulcer, Induction, Omeprazole
| [1] | Gimenez F., Brazier M., Calop J., Dine T., Tchiakpé L. & Claerbout J. F., 2000. Traitement de l’ulcère gastroduodénal dans Pharmacie Clinique et Thérapeutique, Paris: Edition Masson, 165 p. |
| [2] | Pateron D. & Pourriat J. L., 2008. Hémorragies digestives non traumatiques de l’adulte. Acute gastrointestinal bleeding in adults EMC Gastro-entérologie. 36-726-D-10. |
| [3] | Ndjitoyap, N. E. C., Tzeuton, C., Njoya, O., Tagni, S. M., Kamdoum, M. (1998). Tolérance et acceptabilité de l’endoscopie digestive haute: analyse prospective de 530 examens. Acta endoscopia. 3 (28), 226p. |
| [4] | Hoogerwerf W. & Pasricha P., 2001. Agents used for control of gastric acidity and treatment of peptic ulcers and gastroesophageal reflux disease. Goodman & Gilman’s The Pharmacological Basis of Therapeutics, 10th ed Mc Graw-Hill, New York: pp 1005-1019. |
| [5] | W.H.O. 2002. Stratégie de l’OMS pour la médecine traditionnelle pour 2002-2005. WHO/EDM/TRM/2002, Genève, 65p. |
| [6] | Ghedira K. & Goetz P., 2010. Syzygium aromaticum (L.) Merr & Poiré (Myrtacees) Girofier. Phytothérapie, 8: 37-43. |
| [7] | Anonymous. (1986). Council Directive of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes. Official Journal of the European Communities, 358, 1-28. |
| [8] | Abo K. J. C., 2013. De la plante à la molécule: toxicité, effets pharmacologiques et mécanisme d'action de Justicia Secunda (Acanthaceae), plante antihypertensive, sur le système cardio-vasculaire de mammifères. Thèse de doctorat d'état ès Sciences Naturelles, Université Félix Houphouët-Boigny (Abidjan, Côte d'Ivoire); n° 752/2013, 351 p. |
| [9] | Kamguia Guifo HF, Fokunang C, Ngameni B, Njinkio Nono B, Tembe-Fokunang E. (2011). Effet cytoprotecteur de l’extrait aqueux des racines de Dorstenia psilurussur l’ullcère gastrique chez les rats mâles de souche Wistar. Health Sci. Dis: Vol 12 (4), 11p. |
| [10] | Nyilimana C., 2007. Contribution à l’étude l’activité antiulcéreuse de Leptadenia Hasta (pers) DECNE (Asclepiadaceae), Thèse de Médecine vétérinaire, Université Cheikh Anta Diop de Dakar, Senegal, 79 p. |
| [11] | Lwoff J. M., 1971. Activité ulcérogène chez le rat. Fiche technique n°12, Tome II (n°1) Joum Pharmacologique, 2 (1) 81-83. |
| [12] | Meba M. A., 2005. Contribution à l’étude de l’activité anti-ulcéreuse de Euphorbia hirta (L.) (Euphorbiacées). Thèse Médecine Vétérinaire, Université Cheikh Anta Diop de Dakar, 132 p. |
| [13] | Lambert R., 1958. Les aspects récents de l’ulcère expérimental. Thèse de Médecine, Lyon, 47 (5): 582-587. |
| [14] | Cederberg C. & Ekenved G., 1985. Acid inhibitory characteristics of omeprazole in man, Scandinavian Journal of Gastroenterology, 20 (108): 105-112. |
| [15] | Mignon M., 1983. Gastro-entérologie; Paris: Editions ellipses/AUPELF, 703p. |
| [16] | Bouvenot G., Devulder & Guillevin L., 1995. Pathologie médicale, Gastro-entérologie, hépatologie, hématologie; Paris: Masson: pp 27-42. |
| [17] | Bacchi F. M. & Sertie J. A., 1994. Anti-ulcer action of styrax campocum and Caesalpinia ferrea. PLanta media, 60 (2): 118-120. |
| [18] | Neyres Z. T. J., Heloina S. F., Isis F. G., Thiago J. A. L., Gedson R. M. L., Jose M. B., Josean F. T., Marcelo S. S., Petronio F. A. F. & Leonia M. B., 2012. Tannins, peptic Ulcers and Related Mechanisms. International Journal of Molecular Sciences, 13 (3): 3203 – 322. |
| [19] | Lenoir L., 2011. Effet protecteur des polyphénols de la verveine odorante dans un modèle d’inflammation colique chez le rat. Mémoire de doctorat, Ecole doctorale des Sciences de la vie et de la Santé Université d’Auvergne: pp 69-73. |
| [20] | Tossou R., Gbenou J. & Dansou P., 2008. Etude des propriétés anti-anémiques de Justiscia secunda vahl (Acanthaceae) chez des rats de souche wistar, Revue CAMES Série A, 6: 26 29. |
| [21] | Bruneton J., 1999. Pharmacognosie phytochimie plante médicinales 3ème Edition, Techniques et Documentation, Lavoisier, Paris, 215p. |
APA Style
Irié Bi Jean Sévérin, Kahou Bi Gohi Parfait, N’Doua Akouah Leatitia Rosemonde, Lehou Monnhéssea Flore Danielle, Zahoui Ouga Stanistlas, et al. (2023). Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats. Advances in Applied Physiology, 8(1), 20-28. https://doi.org/10.11648/j.aap.20230801.14
ACS Style
Irié Bi Jean Sévérin; Kahou Bi Gohi Parfait; N’Doua Akouah Leatitia Rosemonde; Lehou Monnhéssea Flore Danielle; Zahoui Ouga Stanistlas, et al. Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats. Adv. Appl. Physiol. 2023, 8(1), 20-28. doi: 10.11648/j.aap.20230801.14
AMA Style
Irié Bi Jean Sévérin, Kahou Bi Gohi Parfait, N’Doua Akouah Leatitia Rosemonde, Lehou Monnhéssea Flore Danielle, Zahoui Ouga Stanistlas, et al. Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats. Adv Appl Physiol. 2023;8(1):20-28. doi: 10.11648/j.aap.20230801.14
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Download@article{10.11648/j.aap.20230801.14,
author = {Irié Bi Jean Sévérin and Kahou Bi Gohi Parfait and N’Doua Akouah Leatitia Rosemonde and Lehou Monnhéssea Flore Danielle and Zahoui Ouga Stanistlas and Abo Kouakou Jean-Claude},
title = {Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats},
journal = {Advances in Applied Physiology},
volume = {8},
number = {1},
pages = {20-28},
doi = {10.11648/j.aap.20230801.14},
url = {https://doi.org/10.11648/j.aap.20230801.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.aap.20230801.14},
abstract = {The buds of Syzygium aromaticum (Myrtaceae) is used in traditional medicine in the treatment of gastric ulcer. This pathology affects approximately 10% of the world's population. The current study aims to verify the antiulcer effect of an aqueous extract of the buds of Syzygium aromaticum (EASA) in wistar rats. For this, the 1000 mg/kg B.W. dose of EASA was tested on gastric ulcer induced with (Eth/HCl/H2O) in rats compared to the effect of 20 mg/kg B.W. of Omeprazole for 14 days. Also, a phytochemical screening was carried out on this extract. After 3 days of ulcer induction, the ulceration index was 3 and the ulceration percentage was 100% in the stomachs of the rats. The results after 14 days of treatment with EASA show that the ulceration index and the percentage of ulceration are 0.5 and 8.83% against 0 for Omeprazole. The aqueous extract of Syzygium aromaticum therefore treats the induced ulcer at 91.17% against 100% for Omeprazole. These results are confirmed by observations of scars on histological sections on the fourteenth day. Phytochemical screening indicates that EASA contains sterols, polyterpenes and polyphenols, quinone compounds, alkaloids and gallic tannins. These results would justify the use of Syzygium aromaticum buds in traditional medicine in the treatment of gastric ulcer.},
year = {2023}
}
TY - JOUR T1 - Antiulcer Effect of an Aqueous Extract of Syzygium aromaticum (Myrtaceae) Buds in Wistar Rats AU - Irié Bi Jean Sévérin AU - Kahou Bi Gohi Parfait AU - N’Doua Akouah Leatitia Rosemonde AU - Lehou Monnhéssea Flore Danielle AU - Zahoui Ouga Stanistlas AU - Abo Kouakou Jean-Claude Y1 - 2023/05/17 PY - 2023 N1 - https://doi.org/10.11648/j.aap.20230801.14 DO - 10.11648/j.aap.20230801.14 T2 - Advances in Applied Physiology JF - Advances in Applied Physiology JO - Advances in Applied Physiology SP - 20 EP - 28 PB - Science Publishing Group SN - 2471-9714 UR - https://doi.org/10.11648/j.aap.20230801.14 AB - The buds of Syzygium aromaticum (Myrtaceae) is used in traditional medicine in the treatment of gastric ulcer. This pathology affects approximately 10% of the world's population. The current study aims to verify the antiulcer effect of an aqueous extract of the buds of Syzygium aromaticum (EASA) in wistar rats. For this, the 1000 mg/kg B.W. dose of EASA was tested on gastric ulcer induced with (Eth/HCl/H2O) in rats compared to the effect of 20 mg/kg B.W. of Omeprazole for 14 days. Also, a phytochemical screening was carried out on this extract. After 3 days of ulcer induction, the ulceration index was 3 and the ulceration percentage was 100% in the stomachs of the rats. The results after 14 days of treatment with EASA show that the ulceration index and the percentage of ulceration are 0.5 and 8.83% against 0 for Omeprazole. The aqueous extract of Syzygium aromaticum therefore treats the induced ulcer at 91.17% against 100% for Omeprazole. These results are confirmed by observations of scars on histological sections on the fourteenth day. Phytochemical screening indicates that EASA contains sterols, polyterpenes and polyphenols, quinone compounds, alkaloids and gallic tannins. These results would justify the use of Syzygium aromaticum buds in traditional medicine in the treatment of gastric ulcer. VL - 8 IS - 1 ER -
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