Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola

Alli Smith Y. R.; Adanlawo I. G.

doi:doi:10.11648/j.ab.20130101.11

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Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola

Alli Smith Y. R., Adanlawo I. G.

Published in Advances in Biochemistry (Volume 1, Issue 1)

Published: 2 April 2013

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Abstract

The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.

Published in	Advances in Biochemistry (Volume 1, Issue 1)
DOI	10.11648/j.ab.20130101.11
Page(s)	1-4
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2013. Published by Science Publishing Group

Keywords

Garcinia kola, Saponin, lipid profile, tissue, dose dependent, Hyperlipidemia

References

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Alli Smith Y. R., Adanlawo I. G. (2013). Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Advances in Biochemistry, 1(1), 1-4. https://doi.org/10.11648/j.ab.20130101.11

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Alli Smith Y. R.; Adanlawo I. G. Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Adv. Biochem. 2013, 1(1), 1-4. doi: 10.11648/j.ab.20130101.11

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AMA Style

Alli Smith Y. R., Adanlawo I. G. Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Adv Biochem. 2013;1(1):1-4. doi: 10.11648/j.ab.20130101.11

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@article{10.11648/j.ab.20130101.11,
  author = {Alli Smith Y. R. and Adanlawo I. G.},
  title = {Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola},
  journal = {Advances in Biochemistry},
  volume = {1},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ab.20130101.11},
  url = {https://doi.org/10.11648/j.ab.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130101.11},
  abstract = {The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.},
 year = {2013}
}

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TY - JOUR
T1 - Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola
AU - Alli Smith Y. R.
AU - Adanlawo I. G.
Y1 - 2013/04/02
PY - 2013
N1 - https://doi.org/10.11648/j.ab.20130101.11
DO - 10.11648/j.ab.20130101.11
T2 - Advances in Biochemistry
JF - Advances in Biochemistry
JO - Advances in Biochemistry
SP - 1
EP - 4
PB - Science Publishing Group
SN - 2329-0862
UR - https://doi.org/10.11648/j.ab.20130101.11
AB - The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.
VL - 1
IS - 1
ER -

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Author Information

Alli Smith Y. R.

Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria
Adanlawo I. G.

Department of Biochemistry, Faculty of Science, Ekiti State University, Ado Ekiti, Nigeria

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APA Style

Alli Smith Y. R., Adanlawo I. G. (2013). Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Advances in Biochemistry, 1(1), 1-4. https://doi.org/10.11648/j.ab.20130101.11

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ACS Style

Alli Smith Y. R.; Adanlawo I. G. Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Adv. Biochem. 2013, 1(1), 1-4. doi: 10.11648/j.ab.20130101.11

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AMA Style

Alli Smith Y. R., Adanlawo I. G. Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola. Adv Biochem. 2013;1(1):1-4. doi: 10.11648/j.ab.20130101.11

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@article{10.11648/j.ab.20130101.11,
  author = {Alli Smith Y. R. and Adanlawo I. G.},
  title = {Tissue Lipid Profile of Rats Administered Saponin Extract From The Root of Bitter kola},
  journal = {Advances in Biochemistry},
  volume = {1},
  number = {1},
  pages = {1-4},
  doi = {10.11648/j.ab.20130101.11},
  url = {https://doi.org/10.11648/j.ab.20130101.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20130101.11},
  abstract = {The present study was undertaken to investigate the effect of saponin extract from the root of Bitter kola (Garcinia kola) on the lipid profile of albino rats tissues (Liver, Kidney and Heart). Twenty albino rats were divided into 4 groups of 5 rats each. They were given rats mash and water ad libitum for 2 weeks to acclimatize them; they were then subjected to different doses of saponin extract from the root of Garcinia kola. Group I (control) received an equivalent volume of water, group II received 100mg/Kg body weight of extract, and group III was given 200mg/Kg body weight, while group IV received 400mg/Kg body weight of saponin extract orally everyday for 21days. The serum, heart, liver and kidney were then analysed for Total cholesterol(TC), High density lipoprotein cholesterol (HDL-C), Low density lipoprotein cholesterol (LDL-C) and Triglycerides(TG). Administration of 100, 200 and 400 mg/kg doses of saponin extract from the root of Garcinia kola led to a significant reduction (P <05) in total cholesterol, LDL cholesterol and Triglyceride levels in the serum, Liver, kidney and heart when compared with the control and a significant increase (P <05) in HDL cholesterol concentration when compared with control. Hyperlipidemia, being an important risk factor for cardiovascular disease, is a serious public health problem in the world. This result suggests a dose dependent hypolipidemic potential of saponin extract from the root of Garcinia kola and could play a cardio protective role.},
 year = {2013}
}

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