Coronary heart disease (CHD) has become the most important cause of premature morbidity and mortality. The chief risk factors for CHD includes Smoking, Hypertension, Diabetes mellitus, Hypercholesterolemia, Low high density lipoprotein, Obesity, Mental stress, Type A personality and Genetic factors. Lipoprotein (a) has been established as a strong independent risk factor for premature CHD, which is highly thrombogenic and antifibrinolytic which begins to block the arteries much earlier than other risk factors. This study is planned to determine the antioxidant status and to estimate Serum lipoprotein (a) levels in patients of CHD and in patients with risk factors for CHD. Among all the patients, majority of patients belongs to upper and middle class. In routine investigations an increase in serum cholesterol, serum LDL, TC/HDL and LDL/HDL ratio were seen in all five groups including MI, HT, DM, Smokers and obesity cases, which were statistically significant. Serum Triglycerides were increased in MI, DM, Smokers and obesity cases, which were statistically significant, where as significant increase was not seen in HT cases. Serum VLDL showed a statistically significant increase in MI, Smokers and obesity cases, where as significant increases was not seen in HT and DM cases. Blood glucose showed a significant increase in DM cases, where as no significant increase were seen in MI, HT, smokers and obesity cases. A statistically significant decrease in serum HDL were seen in all five groups including MI, HT, DM, Smokers and obesity cases. In special investigations, there is significant increase in MDA, Lipoprotein (a) levels and significant decrease of antioxidants such as blood glutathione, Serum vitamin E, vitamin C and vitamin A in cases of coronary heart diseases and also in cases with risk factors for Coronary heart diseases including hypertension, diabetes mellitus, smoking and obesity. Hence, it is therefore concluded that MDA, Lipoprotein (a) and antioxidants like glutathione, vitamin E, Vitamin C and Vitamin A, be evaluated as biochemical parameters for preclinical assessment of “at risk group” for Coronary heart diseases and for assessing and monitoring cases of Coronary heart diseases.
| Published in | Advances in Biochemistry (Volume 2, Issue 1) |
| DOI | 10.11648/j.ab.20140201.11 |
| Page(s) | 1-8 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Coronary Heart Diseases, Lipoprotein (A), MDA, Antioxidants
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APA Style
Sudeep. R. Lokapure, Jano Zore, Kavitha. Y. Ullikashi, Chitra Dhume. (2014). Evaluation of Antioxidant Status and Serum Lipoprotein(a) in Coronary Heart Diseases. Advances in Biochemistry, 2(1), 1-8. https://doi.org/10.11648/j.ab.20140201.11
ACS Style
Sudeep. R. Lokapure; Jano Zore; Kavitha. Y. Ullikashi; Chitra Dhume. Evaluation of Antioxidant Status and Serum Lipoprotein(a) in Coronary Heart Diseases. Adv. Biochem. 2014, 2(1), 1-8. doi: 10.11648/j.ab.20140201.11
AMA Style
Sudeep. R. Lokapure, Jano Zore, Kavitha. Y. Ullikashi, Chitra Dhume. Evaluation of Antioxidant Status and Serum Lipoprotein(a) in Coronary Heart Diseases. Adv Biochem. 2014;2(1):1-8. doi: 10.11648/j.ab.20140201.11
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Download@article{10.11648/j.ab.20140201.11,
author = {Sudeep. R. Lokapure and Jano Zore and Kavitha. Y. Ullikashi and Chitra Dhume},
title = {Evaluation of Antioxidant Status and Serum Lipoprotein(a) in Coronary Heart Diseases},
journal = {Advances in Biochemistry},
volume = {2},
number = {1},
pages = {1-8},
doi = {10.11648/j.ab.20140201.11},
url = {https://doi.org/10.11648/j.ab.20140201.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20140201.11},
abstract = {Coronary heart disease (CHD) has become the most important cause of premature morbidity and mortality. The chief risk factors for CHD includes Smoking, Hypertension, Diabetes mellitus, Hypercholesterolemia, Low high density lipoprotein, Obesity, Mental stress, Type A personality and Genetic factors. Lipoprotein (a) has been established as a strong independent risk factor for premature CHD, which is highly thrombogenic and antifibrinolytic which begins to block the arteries much earlier than other risk factors. This study is planned to determine the antioxidant status and to estimate Serum lipoprotein (a) levels in patients of CHD and in patients with risk factors for CHD. Among all the patients, majority of patients belongs to upper and middle class. In routine investigations an increase in serum cholesterol, serum LDL, TC/HDL and LDL/HDL ratio were seen in all five groups including MI, HT, DM, Smokers and obesity cases, which were statistically significant. Serum Triglycerides were increased in MI, DM, Smokers and obesity cases, which were statistically significant, where as significant increase was not seen in HT cases. Serum VLDL showed a statistically significant increase in MI, Smokers and obesity cases, where as significant increases was not seen in HT and DM cases. Blood glucose showed a significant increase in DM cases, where as no significant increase were seen in MI, HT, smokers and obesity cases. A statistically significant decrease in serum HDL were seen in all five groups including MI, HT, DM, Smokers and obesity cases. In special investigations, there is significant increase in MDA, Lipoprotein (a) levels and significant decrease of antioxidants such as blood glutathione, Serum vitamin E, vitamin C and vitamin A in cases of coronary heart diseases and also in cases with risk factors for Coronary heart diseases including hypertension, diabetes mellitus, smoking and obesity. Hence, it is therefore concluded that MDA, Lipoprotein (a) and antioxidants like glutathione, vitamin E, Vitamin C and Vitamin A, be evaluated as biochemical parameters for preclinical assessment of “at risk group” for Coronary heart diseases and for assessing and monitoring cases of Coronary heart diseases.},
year = {2014}
}
TY - JOUR T1 - Evaluation of Antioxidant Status and Serum Lipoprotein(a) in Coronary Heart Diseases AU - Sudeep. R. Lokapure AU - Jano Zore AU - Kavitha. Y. Ullikashi AU - Chitra Dhume Y1 - 2014/01/20 PY - 2014 N1 - https://doi.org/10.11648/j.ab.20140201.11 DO - 10.11648/j.ab.20140201.11 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 1 EP - 8 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20140201.11 AB - Coronary heart disease (CHD) has become the most important cause of premature morbidity and mortality. The chief risk factors for CHD includes Smoking, Hypertension, Diabetes mellitus, Hypercholesterolemia, Low high density lipoprotein, Obesity, Mental stress, Type A personality and Genetic factors. Lipoprotein (a) has been established as a strong independent risk factor for premature CHD, which is highly thrombogenic and antifibrinolytic which begins to block the arteries much earlier than other risk factors. This study is planned to determine the antioxidant status and to estimate Serum lipoprotein (a) levels in patients of CHD and in patients with risk factors for CHD. Among all the patients, majority of patients belongs to upper and middle class. In routine investigations an increase in serum cholesterol, serum LDL, TC/HDL and LDL/HDL ratio were seen in all five groups including MI, HT, DM, Smokers and obesity cases, which were statistically significant. Serum Triglycerides were increased in MI, DM, Smokers and obesity cases, which were statistically significant, where as significant increase was not seen in HT cases. Serum VLDL showed a statistically significant increase in MI, Smokers and obesity cases, where as significant increases was not seen in HT and DM cases. Blood glucose showed a significant increase in DM cases, where as no significant increase were seen in MI, HT, smokers and obesity cases. A statistically significant decrease in serum HDL were seen in all five groups including MI, HT, DM, Smokers and obesity cases. In special investigations, there is significant increase in MDA, Lipoprotein (a) levels and significant decrease of antioxidants such as blood glutathione, Serum vitamin E, vitamin C and vitamin A in cases of coronary heart diseases and also in cases with risk factors for Coronary heart diseases including hypertension, diabetes mellitus, smoking and obesity. Hence, it is therefore concluded that MDA, Lipoprotein (a) and antioxidants like glutathione, vitamin E, Vitamin C and Vitamin A, be evaluated as biochemical parameters for preclinical assessment of “at risk group” for Coronary heart diseases and for assessing and monitoring cases of Coronary heart diseases. VL - 2 IS - 1 ER -
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