Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia

Alias Tesfamariam; Menakath Menon; Tedla Kebede; Solomon Genet

doi:doi:10.11648/j.ab.20180602.11

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Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia

Alias Tesfamariam, Menakath Menon, Tedla Kebede, Solomon Genet

Published in Advances in Biochemistry (Volume 6, Issue 2)

Received: 24 March 2018 Accepted: 19 May 2018 Published: 11 June 2018

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Abstract

Type 2 diabetes is characterized by hyperglycemia due to defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Aim of this study was to compare efficacy of incretin-based versus non-incretin based therapies on type-2 diabetic patients and a hospital based cross-sectional comparative study was conducted. Sixty type-2 diabetic patients who received non-incretin and thirty who received incretin based therapies were randomly selected for the study. The mean total cholesterol, triglyceride, low density lipoprotein, serum urea and serum creatinine were significantly lower in patients who received incretin-based therapies than those who received non-incretin based therapies. The mean high density lipoprotein was also significantly increased among the incretin based treated group. The mean body mass index and fasting blood sugar were lower in the incretin-based compared to non-incretin based treated patients. Female had insignificantly higher level of blood sugar, triglyceride, low density lipoprotein, serum urea, body mass index and lower level of total cholesterol, high density lipoprotein and serum creatinine compared to male in both groups. Incretin-based therapy helps normalize lipid profiles, blood sugar level, body mass index and also improves kidney clearance pattern.

Published in	Advances in Biochemistry (Volume 6, Issue 2)
DOI	10.11648/j.ab.20180602.11
Page(s)	10-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Type-2 Diabetes, Lipid Profile, Renal Function Test, Incretin-Based Therapy, BMI

References

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APA Style

Alias Tesfamariam, Menakath Menon, Tedla Kebede, Solomon Genet. (2018). Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Advances in Biochemistry, 6(2), 10-18. https://doi.org/10.11648/j.ab.20180602.11

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ACS Style

Alias Tesfamariam; Menakath Menon; Tedla Kebede; Solomon Genet. Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Adv. Biochem. 2018, 6(2), 10-18. doi: 10.11648/j.ab.20180602.11

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AMA Style

Alias Tesfamariam, Menakath Menon, Tedla Kebede, Solomon Genet. Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Adv Biochem. 2018;6(2):10-18. doi: 10.11648/j.ab.20180602.11

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@article{10.11648/j.ab.20180602.11,
  author = {Alias Tesfamariam and Menakath Menon and Tedla Kebede and Solomon Genet},
  title = {Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia},
  journal = {Advances in Biochemistry},
  volume = {6},
  number = {2},
  pages = {10-18},
  doi = {10.11648/j.ab.20180602.11},
  url = {https://doi.org/10.11648/j.ab.20180602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20180602.11},
  abstract = {Type 2 diabetes is characterized by hyperglycemia due to defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Aim of this study was to compare efficacy of incretin-based versus non-incretin based therapies on type-2 diabetic patients and a hospital based cross-sectional comparative study was conducted. Sixty type-2 diabetic patients who received non-incretin and thirty who received incretin based therapies were randomly selected for the study. The mean total cholesterol, triglyceride, low density lipoprotein, serum urea and serum creatinine were significantly lower in patients who received incretin-based therapies than those who received non-incretin based therapies. The mean high density lipoprotein was also significantly increased among the incretin based treated group. The mean body mass index and fasting blood sugar were lower in the incretin-based compared to non-incretin based treated patients. Female had insignificantly higher level of blood sugar, triglyceride, low density lipoprotein, serum urea, body mass index and lower level of total cholesterol, high density lipoprotein and serum creatinine compared to male in both groups. Incretin-based therapy helps normalize lipid profiles, blood sugar level, body mass index and also improves kidney clearance pattern.},
 year = {2018}
}

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TY  - JOUR
T1  - Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia
AU  - Alias Tesfamariam
AU  - Menakath Menon
AU  - Tedla Kebede
AU  - Solomon Genet
Y1  - 2018/06/11
PY  - 2018
N1  - https://doi.org/10.11648/j.ab.20180602.11
DO  - 10.11648/j.ab.20180602.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20180602.11
AB  - Type 2 diabetes is characterized by hyperglycemia due to defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Aim of this study was to compare efficacy of incretin-based versus non-incretin based therapies on type-2 diabetic patients and a hospital based cross-sectional comparative study was conducted. Sixty type-2 diabetic patients who received non-incretin and thirty who received incretin based therapies were randomly selected for the study. The mean total cholesterol, triglyceride, low density lipoprotein, serum urea and serum creatinine were significantly lower in patients who received incretin-based therapies than those who received non-incretin based therapies. The mean high density lipoprotein was also significantly increased among the incretin based treated group. The mean body mass index and fasting blood sugar were lower in the incretin-based compared to non-incretin based treated patients. Female had insignificantly higher level of blood sugar, triglyceride, low density lipoprotein, serum urea, body mass index and lower level of total cholesterol, high density lipoprotein and serum creatinine compared to male in both groups. Incretin-based therapy helps normalize lipid profiles, blood sugar level, body mass index and also improves kidney clearance pattern.
VL  - 6
IS  - 2
ER  -

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Author Information

Alias Tesfamariam

Department of Medical Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Menakath Menon

Department of Medical Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia
Tedla Kebede

Department of Internal Medicine, Addis Ababa University, Addis Ababa, Ethiopia
Solomon Genet

Department of Medical Biochemistry, Addis Ababa University, Addis Ababa, Ethiopia

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APA Style

Alias Tesfamariam, Menakath Menon, Tedla Kebede, Solomon Genet. (2018). Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Advances in Biochemistry, 6(2), 10-18. https://doi.org/10.11648/j.ab.20180602.11

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ACS Style

Alias Tesfamariam; Menakath Menon; Tedla Kebede; Solomon Genet. Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Adv. Biochem. 2018, 6(2), 10-18. doi: 10.11648/j.ab.20180602.11

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AMA Style

Alias Tesfamariam, Menakath Menon, Tedla Kebede, Solomon Genet. Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia. Adv Biochem. 2018;6(2):10-18. doi: 10.11648/j.ab.20180602.11

Copy | Download

@article{10.11648/j.ab.20180602.11,
  author = {Alias Tesfamariam and Menakath Menon and Tedla Kebede and Solomon Genet},
  title = {Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia},
  journal = {Advances in Biochemistry},
  volume = {6},
  number = {2},
  pages = {10-18},
  doi = {10.11648/j.ab.20180602.11},
  url = {https://doi.org/10.11648/j.ab.20180602.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20180602.11},
  abstract = {Type 2 diabetes is characterized by hyperglycemia due to defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Aim of this study was to compare efficacy of incretin-based versus non-incretin based therapies on type-2 diabetic patients and a hospital based cross-sectional comparative study was conducted. Sixty type-2 diabetic patients who received non-incretin and thirty who received incretin based therapies were randomly selected for the study. The mean total cholesterol, triglyceride, low density lipoprotein, serum urea and serum creatinine were significantly lower in patients who received incretin-based therapies than those who received non-incretin based therapies. The mean high density lipoprotein was also significantly increased among the incretin based treated group. The mean body mass index and fasting blood sugar were lower in the incretin-based compared to non-incretin based treated patients. Female had insignificantly higher level of blood sugar, triglyceride, low density lipoprotein, serum urea, body mass index and lower level of total cholesterol, high density lipoprotein and serum creatinine compared to male in both groups. Incretin-based therapy helps normalize lipid profiles, blood sugar level, body mass index and also improves kidney clearance pattern.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Comparative Study of Incretin Versus Non- Incretin Based Therapies on Type 2 Diabetes Patients in Addis Ababa, Ethiopia
AU  - Alias Tesfamariam
AU  - Menakath Menon
AU  - Tedla Kebede
AU  - Solomon Genet
Y1  - 2018/06/11
PY  - 2018
N1  - https://doi.org/10.11648/j.ab.20180602.11
DO  - 10.11648/j.ab.20180602.11
T2  - Advances in Biochemistry
JF  - Advances in Biochemistry
JO  - Advances in Biochemistry
SP  - 10
EP  - 18
PB  - Science Publishing Group
SN  - 2329-0862
UR  - https://doi.org/10.11648/j.ab.20180602.11
AB  - Type 2 diabetes is characterized by hyperglycemia due to defects in insulin secretion or insulin action. Over the years, attempts to regulate diabetics therapeutically through glycemic control have reduced complications and trauma associated with the disease. Aim of this study was to compare efficacy of incretin-based versus non-incretin based therapies on type-2 diabetic patients and a hospital based cross-sectional comparative study was conducted. Sixty type-2 diabetic patients who received non-incretin and thirty who received incretin based therapies were randomly selected for the study. The mean total cholesterol, triglyceride, low density lipoprotein, serum urea and serum creatinine were significantly lower in patients who received incretin-based therapies than those who received non-incretin based therapies. The mean high density lipoprotein was also significantly increased among the incretin based treated group. The mean body mass index and fasting blood sugar were lower in the incretin-based compared to non-incretin based treated patients. Female had insignificantly higher level of blood sugar, triglyceride, low density lipoprotein, serum urea, body mass index and lower level of total cholesterol, high density lipoprotein and serum creatinine compared to male in both groups. Incretin-based therapy helps normalize lipid profiles, blood sugar level, body mass index and also improves kidney clearance pattern.
VL  - 6
IS  - 2
ER  -

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