Khaya senegalensis belonging to family Meliaceae. This plant has been used as traditional medicine for several disease such as pain, inflammation, malaria, anemia, diabetic and gastrointestinal diseases. The objective of this study to carry out phytochemical screening, determination of chemical composition and determine antioxidant activity of plant extracts. Many of secondary metabolites were investigated in leaves extract include alkaloids, flavonoids, sterols and saponins while the bark extract includes sterols, triterpines, tannins and saponins. The antioxidant potential of ethanol extract of leaves and bark was determined on the basis of their scavenging activity of the stable 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical. Antioxidant activity of leaves extract was higher than bark with (42.69%) and (36.36%) respectively. The quantitative analysis of chemical composition was determined by Gas Chromatography–Mass Spectrometry (GC-MS). A number of bioactive compounds were present in the leaves and bark of K.senegalensis. The highest compound in both extracts represented the reducing sugar 4-O-Methyl mannose (66.47 and 14.73%) in bark and leaves respectively. Fatty acids and phenols were presented in high percentage in both extract include; n-Hexadecanoic acid, 9,12,15-Octadecatrienoic acid, Oleic Acid and Catechol.
Published in | Advances in Biochemistry (Volume 6, Issue 4) |
DOI | 10.11648/j.ab.20180604.12 |
Page(s) | 32-38 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2018. Published by Science Publishing Group |
Khaya senegalensis, Leaves, Bark, Phytochemical Screening, GC-MS Analysis, Antioxidant Activity
[1] | World Health Organization. Essential medicines and health products, Traditional and complementary medicine; 2014 Jun [cited 2016 Jul 3]. |
[2] | Qazi, M and Molvi, K. Herbal Medicine. International Journal of Pharmaceutical Research; 2016. 8(2): 1-3. |
[3] | Xiao, m., Stephanie, j. et al. Chemopreventive Effects of Khaya senegalensis Bark Extract on Human Colorectal Cancer. Anticancer research. 2006; 26: 2397. |
[4] | Elisha, I. L., Makoshi, M. S., Makama, S., Dawurung, C. J., Offiah, N. V., Gotep, J. G., Oladipo, O. and Shamaki, D. Antidiarrheal evaluation of aqueous and ethanolic stem bark extracts of Khaya senegalensis A. Juss (Meliaceae) in albino rats. Pak. Vet. J., 2013; 33(1): 32-36. |
[5] | Trease, G. E., Evans, W. C. Textbook of Pharmacognosy. 15th Ed.,2002. Saunders Publishers, London. |
[6] | Sood A, Kaur P, Gupta R (2012). Phytochemical screening and antimicrobial assay of various seeds extract of Cucurbitaceae family. Int. J. Appl. Bio. Pharm. Technol. 3(3):401-409. |
[7] | Alrasheid, A. A., Abdallah, B. S., Ali. A. O. (2018). In Vitro Antimicrobial Activity and GC-MS Analysis of Seed Extracts from Pimpinella anisum L. Journal of Drug Design and Medicinal Chemistry., 4( 2):16-21. |
[8] | Shimada, K., Fujikawa, K., Yahara, K. and Nakamura, T. Antioxidative properties of xanthan on the antioxidation of soybean oil in cyclodextrin emulsion. J Agric. Food Chem., 1992. 40:945-948. |
[9] | Braca A, Tommasi ND, Bari LD, Pizza C, Politi M, Morelli I (2001). Natural anti-oxidants from plant material in phenolic compounds in food and their effects on health. J. Nat. Prod., 64: 892-895. |
[10] | Okwu DE (2004). Phytochemicals and vitamins content of indigenous spices of South Eastern Nigeria. J. Sustain. Agric. Environ. 6:30-34. |
[11] | Aguoru, C. U., Bashayi, C. G and Ogbonna, I. O (2017). Phytochemical profile of stem bark extracts of Khaya senegalensisby Gas Chromatography-Mass Spectrometry (GC-MS) analysis. Journal of Pharmacognosy and Phytotherapy;9(3):35-43. |
[12] | Nyamai DW, Arika W, Ogola PE, Njagi ENN, Ngugi MP (2016). Medicinally important phytochemicals: An updated research avenue. Research and Reviews: J. Pharmacogn. Phytochem. 4(1):35-49. |
[13] | Makut MD, Gyar SD, Pennap GRI, Anthony P (2007). Phytochemical screening and antimicrobial activity of the ethanolic and methanolic extracts of the leaf and bark of Khayasenegalensis. Afr. J. Biotechnol. 7(9):1216-1219. |
[14] | Wakirwa JH, Idris S, Madu SJ, Dibal M, Malgwi T (2013). Assessment of the In-vitro antimicrobial potential of Khaya senegalensi sethanol leaf extract. J. Chem. Pharm. Res. 5(7):182-186. |
[15] | Kuta, F. A., Tsado, D. J., Garba, S. A and Saidu, A. N (2015). Antibacterial activity of the leaf and stem bark crude extracts of Khaya senegalensis. Med. and Aromatic Plant Res. J., 3(1): 9-15. 2015. |
[16] | Van de Venter M, Roux S, Bungu LC, et al. Antidiabetic screening and scoring of 11plants traditionally used in South Africa. JEthnopharmacol2008; 119: 81–86. |
[17] | Ibrahim. M. A., Koorbanally, N. A and Islam, M. S. Anti-oxidative activity and inhibition of key enzymes linked to type 2 diabetes (α-glucosidase and α-amylase) by Khaya senegalensis Records of Natural Products. 2013, 195-200. |
[18] | Wagner H., Pure Appl. Chem, 1990, 62-190. |
[19] | Shittu LAJ, Bankole MA, Ahmed T, Bankole MN, Shittu RK, Saalu CL, Ashiru OA (2007). Antibacterial and antifungal activities of essential oils of crude extracts of Sesame radiatum against some common pathogenic microorganisms. Iran J. Pharmacol. Ther. 6:165-170. |
[20] | Abalaka, M. E., Daniyan, S. Y., Akpor, O. B. and Inyinbor, A. A (2016). Antimicrobial, In-vitro Free Radical Scavenging, Antioxidant Properties of Leaf, Bark and Root Extracts from Khaya senegalensis. Journal of Microbiology Research, 1(1):54. |
APA Style
Marvit Osman Widdat Allah, Ayat Ahmed Alrasheid, Altayeb Suliman Elamin. (2018). Phytochemical Screening, Chemical Composition and Antioxidant Activity of Leaves and Bark Extracts from Khaya senegalensis. Advances in Biochemistry, 6(4), 32-38. https://doi.org/10.11648/j.ab.20180604.12
ACS Style
Marvit Osman Widdat Allah; Ayat Ahmed Alrasheid; Altayeb Suliman Elamin. Phytochemical Screening, Chemical Composition and Antioxidant Activity of Leaves and Bark Extracts from Khaya senegalensis. Adv. Biochem. 2018, 6(4), 32-38. doi: 10.11648/j.ab.20180604.12
AMA Style
Marvit Osman Widdat Allah, Ayat Ahmed Alrasheid, Altayeb Suliman Elamin. Phytochemical Screening, Chemical Composition and Antioxidant Activity of Leaves and Bark Extracts from Khaya senegalensis. Adv Biochem. 2018;6(4):32-38. doi: 10.11648/j.ab.20180604.12
@article{10.11648/j.ab.20180604.12, author = {Marvit Osman Widdat Allah and Ayat Ahmed Alrasheid and Altayeb Suliman Elamin}, title = {Phytochemical Screening, Chemical Composition and Antioxidant Activity of Leaves and Bark Extracts from Khaya senegalensis}, journal = {Advances in Biochemistry}, volume = {6}, number = {4}, pages = {32-38}, doi = {10.11648/j.ab.20180604.12}, url = {https://doi.org/10.11648/j.ab.20180604.12}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20180604.12}, abstract = {Khaya senegalensis belonging to family Meliaceae. This plant has been used as traditional medicine for several disease such as pain, inflammation, malaria, anemia, diabetic and gastrointestinal diseases. The objective of this study to carry out phytochemical screening, determination of chemical composition and determine antioxidant activity of plant extracts. Many of secondary metabolites were investigated in leaves extract include alkaloids, flavonoids, sterols and saponins while the bark extract includes sterols, triterpines, tannins and saponins. The antioxidant potential of ethanol extract of leaves and bark was determined on the basis of their scavenging activity of the stable 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical. Antioxidant activity of leaves extract was higher than bark with (42.69%) and (36.36%) respectively. The quantitative analysis of chemical composition was determined by Gas Chromatography–Mass Spectrometry (GC-MS). A number of bioactive compounds were present in the leaves and bark of K.senegalensis. The highest compound in both extracts represented the reducing sugar 4-O-Methyl mannose (66.47 and 14.73%) in bark and leaves respectively. Fatty acids and phenols were presented in high percentage in both extract include; n-Hexadecanoic acid, 9,12,15-Octadecatrienoic acid, Oleic Acid and Catechol.}, year = {2018} }
TY - JOUR T1 - Phytochemical Screening, Chemical Composition and Antioxidant Activity of Leaves and Bark Extracts from Khaya senegalensis AU - Marvit Osman Widdat Allah AU - Ayat Ahmed Alrasheid AU - Altayeb Suliman Elamin Y1 - 2018/11/01 PY - 2018 N1 - https://doi.org/10.11648/j.ab.20180604.12 DO - 10.11648/j.ab.20180604.12 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 32 EP - 38 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20180604.12 AB - Khaya senegalensis belonging to family Meliaceae. This plant has been used as traditional medicine for several disease such as pain, inflammation, malaria, anemia, diabetic and gastrointestinal diseases. The objective of this study to carry out phytochemical screening, determination of chemical composition and determine antioxidant activity of plant extracts. Many of secondary metabolites were investigated in leaves extract include alkaloids, flavonoids, sterols and saponins while the bark extract includes sterols, triterpines, tannins and saponins. The antioxidant potential of ethanol extract of leaves and bark was determined on the basis of their scavenging activity of the stable 1, 1-diphenyl-2-picryl hydrazyl (DPPH) free radical. Antioxidant activity of leaves extract was higher than bark with (42.69%) and (36.36%) respectively. The quantitative analysis of chemical composition was determined by Gas Chromatography–Mass Spectrometry (GC-MS). A number of bioactive compounds were present in the leaves and bark of K.senegalensis. The highest compound in both extracts represented the reducing sugar 4-O-Methyl mannose (66.47 and 14.73%) in bark and leaves respectively. Fatty acids and phenols were presented in high percentage in both extract include; n-Hexadecanoic acid, 9,12,15-Octadecatrienoic acid, Oleic Acid and Catechol. VL - 6 IS - 4 ER -