Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes

Moustapha Djite; Néné Oumou Kesso Barry; Jean Pascal Demba Diop; Fatoumata Binta Bah; Pape Matar Kandji; El Hadji Malick Ndour; Fatou Gueye-tall; Dominique Doupa; Rokhaya Ndiaye diallo; Philomène Lopez Sall; Aynina Cisse; Pape Amadou Diop; Papa Madièye Gueye

doi:doi:10.11648/j.ab.20180606.11

Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes

Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, El Hadji Malick Ndour, Fatou Gueye-tall, Dominique Doupa, Rokhaya Ndiaye diallo, Philomène Lopez Sall, Aynina Cisse, Pape Amadou Diop, Papa Madièye Gueye

Published in Advances in Biochemistry (Volume 6, Issue 6)

Received: 17 February 2019 Accepted: 8 April 2019 Published: 29 April 2019

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Abstract

The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.

Published in	Advances in Biochemistry (Volume 6, Issue 6)
DOI	10.11648/j.ab.20180606.11
Page(s)	47-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Stroke, Polymorphism of the Haptoglobin Gene, Lipid Balance

References

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APA Style

Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, et al. (2019). Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Advances in Biochemistry, 6(6), 47-52. https://doi.org/10.11648/j.ab.20180606.11

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ACS Style

Moustapha Djite; Néné Oumou Kesso Barry; Jean Pascal Demba Diop; Fatoumata Binta Bah; Pape Matar Kandji, et al. Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Adv. Biochem. 2019, 6(6), 47-52. doi: 10.11648/j.ab.20180606.11

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AMA Style

Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, et al. Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Adv Biochem. 2019;6(6):47-52. doi: 10.11648/j.ab.20180606.11

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@article{10.11648/j.ab.20180606.11,
  author = {Moustapha Djite and Néné Oumou Kesso Barry and Jean Pascal Demba Diop and Fatoumata Binta Bah and Pape Matar Kandji and El Hadji Malick Ndour and Fatou Gueye-tall and Dominique Doupa and Rokhaya Ndiaye diallo and Philomène Lopez Sall and Aynina Cisse and Pape Amadou Diop and Papa Madièye Gueye},
  title = {Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes},
  journal = {Advances in Biochemistry},
  volume = {6},
  number = {6},
  pages = {47-52},
  doi = {10.11648/j.ab.20180606.11},
  url = {https://doi.org/10.11648/j.ab.20180606.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20180606.11},
  abstract = {The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.},
 year = {2019}
}

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TY - JOUR
T1 - Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes
AU - Moustapha Djite
AU - Néné Oumou Kesso Barry
AU - Jean Pascal Demba Diop
AU - Fatoumata Binta Bah
AU - Pape Matar Kandji
AU - El Hadji Malick Ndour
AU - Fatou Gueye-tall
AU - Dominique Doupa
AU - Rokhaya Ndiaye diallo
AU - Philomène Lopez Sall
AU - Aynina Cisse
AU - Pape Amadou Diop
AU - Papa Madièye Gueye
Y1 - 2019/04/29
PY - 2019
N1 - https://doi.org/10.11648/j.ab.20180606.11
DO - 10.11648/j.ab.20180606.11
T2 - Advances in Biochemistry
JF - Advances in Biochemistry
JO - Advances in Biochemistry
SP - 47
EP - 52
PB - Science Publishing Group
SN - 2329-0862
UR - https://doi.org/10.11648/j.ab.20180606.11
AB - The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.
VL - 6
IS - 6
ER -

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Author Information

Moustapha Djite

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Néné Oumou Kesso Barry

Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Jean Pascal Demba Diop

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Fatoumata Binta Bah

Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
Pape Matar Kandji

Laboratory of Biochemistry, University Hospital Fann, Dakar, Senegal
El Hadji Malick Ndour

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Fatou Gueye-tall

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Dominique Doupa

Department of Medical Biochemistry, Saint-Louis University, Saint-Louis, Senegal
Rokhaya Ndiaye diallo

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Philomène Lopez Sall

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Aynina Cisse

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Pape Amadou Diop

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal
Papa Madièye Gueye

Laboratory of Pharmaceutical Biochemistry, Faculty of Medicine, Pharmacy, University Cheikh Anta DIOP, Dakar, Senegal

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APA Style

Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, et al. (2019). Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Advances in Biochemistry, 6(6), 47-52. https://doi.org/10.11648/j.ab.20180606.11

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ACS Style

Moustapha Djite; Néné Oumou Kesso Barry; Jean Pascal Demba Diop; Fatoumata Binta Bah; Pape Matar Kandji, et al. Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Adv. Biochem. 2019, 6(6), 47-52. doi: 10.11648/j.ab.20180606.11

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AMA Style

Moustapha Djite, Néné Oumou Kesso Barry, Jean Pascal Demba Diop, Fatoumata Binta Bah, Pape Matar Kandji, et al. Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes. Adv Biochem. 2019;6(6):47-52. doi: 10.11648/j.ab.20180606.11

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@article{10.11648/j.ab.20180606.11,
  author = {Moustapha Djite and Néné Oumou Kesso Barry and Jean Pascal Demba Diop and Fatoumata Binta Bah and Pape Matar Kandji and El Hadji Malick Ndour and Fatou Gueye-tall and Dominique Doupa and Rokhaya Ndiaye diallo and Philomène Lopez Sall and Aynina Cisse and Pape Amadou Diop and Papa Madièye Gueye},
  title = {Haptoglobin Polymorphism and Disturbance of Lipid Parameters in Victims of Strokes},
  journal = {Advances in Biochemistry},
  volume = {6},
  number = {6},
  pages = {47-52},
  doi = {10.11648/j.ab.20180606.11},
  url = {https://doi.org/10.11648/j.ab.20180606.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20180606.11},
  abstract = {The objective of our study was to determine the frequency of the main genotypes of haptoglobin and their association with lipid parameters in subjects with stroke. This is a prospective, analytical and case-control study. 46 stroke patients and 46 matched controls were included by sex and age ± 2 years. Genotyping of Hp was performed using standard PCR with Proflex System PCR (Biosystems, Spain) and lipid parameters were assayed using enzymatic techniques with the Cobas c311 system (Roche, Germany). The mean age of our patients was 63 ± 14 years and the sex ratio was 0.70. Ischemic stroke was predominant with a frequency of 60.87% against 30.43% for hemorrhagic stroke. Allelic distribution in patients showed a high frequency of the Hp2 allele (51.09%) compared to control subjects (26.61%) (p <0,0001). The Hp2-2 genotype was more found in stroke subjects (36.96%) than in controls (17.39%) with a p = 0.002. A combination of the Hp2-2 genotype and the increase in mean LDL-c (p = 0.02), Triglycerides (p <0.005) and a decrease in mean HDL-c (p = 0.007) were found. Our study shows that the Hp2-2 genotype would be a predisposing factor to ischemic stroke. Its association with lipid parameters is found and could be considered as an additional risk factor.},
 year = {2019}
}

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