Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou

Fabienne Marie Soudre; Raoul Karfo; Alice Kiba; Arnaud Kouraogo; Rachid Sougue; Elie Kabre; Jean Sakande

doi:doi:10.11648/j.ab.20231102.11

| Peer-Reviewed

Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou

Fabienne Marie Soudre, Raoul Karfo, Alice Kiba, Arnaud Kouraogo, Rachid Sougue, Elie Kabre, Jean Sakande

Published in Advances in Biochemistry (Volume 11, Issue 2)

Received: 10 May 2023 Accepted: 13 June 2023 Published: 27 June 2023

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Accidental acute poisoning (AAP) in children is a significant public health problem worldwide. Their adequate management requires relevant biological elements. The objective of this study was to evaluate ionic disturbances during acute poisoning in children aged from 0 to 15 years admitted to the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) of Ouagadougou, Burkina Faso. A retrospective descriptive and analytical study was therefore conducted over a period of 3 years at CHUP-CDG. It was performed in the pediatric, intensive care and laboratory departments of the CHUP-CDG, and involved children aged from 0 to 15 years with complete clinical records. A total of 193 patients were included, with a mean age of 18.82±24.85 months and M/F sex ratio of 1.38. The hospital incidence of AAP was 2.43% and the mortality rate 16.06%. Phytomedicinal intoxications were the most common (39.38%), followed by caustic products (19.69%). On admission, serum electrolytes showed hypobicarbonatemia (64.23%), hyperchloremia (55.24%), hyponatremia (33.78%), hypoproteinemia (21.47%) and hyperkalemia (12.16%). At control, hypobicarbonatemia (28.57%), hyperchloremia (75%), hypoproteinemia (28.57%), hyperkalemia (12.50%) and here hypernatremia (25%) were found. The deceased patients had significantly lower natremia (p=0.0442), chloremia (p=0.0007) and proteinemia (p=0.0004) than the other patients in the study. The high death rate was related to herbal medicines and caustic intoxications. Many hydroelectric disorders were found in the study. These disorders could be explain par digestive losses. Indeed, the main clinical signs found in the study were vomiting and diarrhea in children. In addition, acute renal failure in patients could also explain these ionic disturbances. AAP are at the root of multiple ionic disorders, which may be responsible for life-threatening complications in patients.

Published in	Advances in Biochemistry (Volume 11, Issue 2)
DOI	10.11648/j.ab.20231102.11
Page(s)	15-21
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Electrolytes, Sodium, Bicarbonates, Accidental Acute Poisoning, Child, CHUP-CDG, Burkina Faso

References

[1]	Yalew Melkamu Molla, Kassahun Denekew Belachew, Gashaw Walle Ayehu & Assefa Agegnehu Teshome. (2022). Acute poisoning in children in Ethiopia: a cross-sectional study. Scientific Reports, 12, 18750. https://doi.org/10.1038/s41598-022-23193-x
[2]	Fariba Tarhani, Alireza Nezami, Ghobad Heidari & Nazanin Hosseinizadeh-Salavati. (2022). Epidemiological Study of Acute Unintentional Poisoning Among Children in Iran. Drug Research, 72, 306–11. https://doi.org/10.1055/a-1819-6453
[3]	Paolo Maurizio Soave, Antonietta Curatola, Serena Ferretti, Vincenzo Raitano, Giorgio Conti, Antonio Gatto et al. (2022). Acute poisoning in children admitted to pediatric emergency department: a five-years retrospective analysis. Acta Bio-Medica: Atenei Parmensis, 93, e2022004. https://doi.org/10.23750/abm.v93i1.11602
[4]	Mehmedali Azemi, Majlinda Berisha, Selim Kolgeci & Bejiqi. (2012). Frequency, etiology and several sociodemographic characteristics of acute poisoning in children treated in the intensive care unit. Materia Socio-Medica, 24, 76–80. https://doi.org/10.5455/msm.2012.24.76-80.
[5]	Isab elleClaudet. (2016). Intoxications domestiques accidentelles de l’enfant. Journal de Pédiatrie et de Puériculture, Elsevier. 29, 244–68. https://doi.org/10.1016/j.jpp.2016.08.003
[6]	Jaafari M, Labib S, Harandou M, Mamarti RA & Hida M. (2013). Les intoxications aigues graves de l’enfant en reanimation [thèse de médecine]. Universite Sidi Mohammed Ben Abdellah, [Maroc].
[7]	Maiga F. (2019). Aspects epidemio-cliniques des intoxications aigues chez les enfants de 1 à 15 ans au service des urgences pediatriques du CHU Gabriel Toure [Thèse de DES pédiatrie]. Université des Sciences, des Techniques et des Technologies de Bamako, [Mali].
[8]	Koueta, F., Dao, L., Yé, D., Fayama, Z. & Sawadogo, A. (2009). Les intoxications aiguës accidentelles de l’enfant : aspects épidémiologiques, étiologiques et évolutifs au CHU pédiatrique Charles-de-Gaulle de Ouagadougou (Burkina Faso). Cahiers d’études et de Recherches Francophones / Santé, 19, 55–9. https://doi.org/10.1684/san.2009.0157
[9]	Cessouma, K. R., Gandema, S., Maiga, N. N., Kissou, S. & Nacro, B. (2017). Les intoxications aiguës accidentelles de l’enfant au Centre Hospitalier Universitaire Sourô Sanou de Bobo-Dioulasso, Burkina Faso. Research, 4. https://doi.org/10.13070/rs.fr.4.2411
[10]	Rhalem N, Aghandous R & Chaoui H. (2012). Les intoxications chez l’enfant : Entre mésinformation et négligence. n°12, Toxicologie Maroc. Maroc. 2.
[11]	Laforge M, Levillain P, Gourlain H, Buneaux F & Galliot-Guilley M. (2000). Analyses biologiques : Critères indirects d’une intoxication aiguë. 42–5.
[12]	Yapo, Toto, Diomande & Abadjinan. (1983). Conditions à respecter pour une utilisation rationnelle du sérum pour la détermination de la glycémie et l’ionogramme sanguin. Rev Méd Côte d’Ivoire, 65, 37–8.
[13]	Simon, W., Ammann, D., Anker, P., Oesch, U. & Band, D. M. (1984). Ion-Selective Electrodes and Their Clinical Application in the Continuous Ion Monitoringa. Annals of the New York Academy of Sciences, 428, 279–85. https://doi.org/10.1111/j.1749-6632.1984.tb12303.x
[14]	Roger L. Forrester, Lester J. Wataji, Donald A. Silverman & Pierre. (1976). Enzymatic method for determination of CO₂ in serum. Clinical Chemistry, 22, 243–5.
[15]	Michael M. Lubran. (1978). The measurement of total serum proteins by the Biuret method. Annals of Clinical and Laboratory Science, 8, 106–10.
[16]	Michael E. Mullins & Jeffrey A. Kraut. (2022). The Role of the Nephrologist in Management of Poisoning and Intoxication: Core Curriculum 2022. American Journal of Kidney Diseases: The Official Journal of the National Kidney Foundation, 79, 877–89. https://doi.org/10.1053/j.ajkd.2021.06.030
[17]	Swethapriya Chaparala, Rafael C. Da Silva & John Paul Papadopoulos. (2021). Severe Lactic Acidosis Due to Acute Intoxication by Emtricitabine/Tenofovir Alafenamide. Cureus, 13, e19008. https://doi.org/10.7759/cureus.19008
[18]	Rui Seixas, Diogo Lopes, Marta Couto, José Pereira & José Paiva. (2021). Severe Colchicine Intoxication: A Case Report and Review of Literature in Adults. Cureus, 13, e19151. https://doi.org/10.7759/cureus.19151
[19]	Klodia Hermez & Carla Dudash-Mion. (2021). Profound Metabolic Acidosis due to Metformin Intoxication Requiring Dialysis. Case Reports in Nephrology, 2021, 9914982. https://doi.org/10.1155/2021/9914982
[20]	Renata Reis Carvalho, Camila Dermínio Donadel, Arthur Fernandes Cortez, Vitor Ribeiro Gomes de Almeida Valviesse, Pedro Felipe de Almeida Vianna & Bruno Bordallo Corrêa. (2017). Syndrome of inappropriate antidiuretic hormone secretion induced by the phytotherapy Harpagophytum procumbers: case report. Brazilian Journal of Nephrology, Sociedade Brasileira de Nefrologia. 39, 79–81. https://doi.org/10.5935/0101-2800.20170013
[21]	Melvin Bonilla-Félix. (2017). Potassium regulation in the neonate. Pediatric Nephrology, 32, 2037–49. https://doi.org/10.1007/s00467-017-3635-2
[22]	Julie Cosserat & Martine Gayraud. (1999). Démarche diagnostique devant une hypoalbuminémie responsable d’un syndrome œdémateux. Médecine Thérapeutique, 5, 557–66.
[23]	Spasovski, G., Vanholder, R., Allolio, B., Annane, D., Ball, S., Bichet, D. et al. (2014). Clinical practice guideline on diagnosis and treatment of hyponatraemia. Intensive Care Medicine, 40, 320–31. https://doi.org/10.1007/s00134-014-3210-2
[24]	Katerinis, I. & Fumeaux, Z. (2007). [Hypokalemia: diagnosis and treatment]. Revue Medicale Suisse, 3, 579–82.
[25]	Bielecka-Dabrowa, A., Mikhailidis, D. P., Jones, L., Rysz, J., Aronow, W. S. & Banach, M. (2012). The meaning of hypokalemia in heart failure. International Journal of Cardiology, 158, 12–7. https://doi.org/10.1016/j.ijcard.2011.06.121

Cite This Article

Plain Text BibTeX RIS

APA Style

Fabienne Marie Soudre, Raoul Karfo, Alice Kiba, Arnaud Kouraogo, Rachid Sougue, et al. (2023). Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou. Advances in Biochemistry, 11(2), 15-21. https://doi.org/10.11648/j.ab.20231102.11

Copy | Download

ACS Style

Fabienne Marie Soudre; Raoul Karfo; Alice Kiba; Arnaud Kouraogo; Rachid Sougue, et al. Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou. Adv. Biochem. 2023, 11(2), 15-21. doi: 10.11648/j.ab.20231102.11

Copy | Download

AMA Style

Fabienne Marie Soudre, Raoul Karfo, Alice Kiba, Arnaud Kouraogo, Rachid Sougue, et al. Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou. Adv Biochem. 2023;11(2):15-21. doi: 10.11648/j.ab.20231102.11

Copy | Download

@article{10.11648/j.ab.20231102.11,
  author = {Fabienne Marie Soudre and Raoul Karfo and Alice Kiba and Arnaud Kouraogo and Rachid Sougue and Elie Kabre and Jean Sakande},
  title = {Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou},
  journal = {Advances in Biochemistry},
  volume = {11},
  number = {2},
  pages = {15-21},
  doi = {10.11648/j.ab.20231102.11},
  url = {https://doi.org/10.11648/j.ab.20231102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20231102.11},
  abstract = {Accidental acute poisoning (AAP) in children is a significant public health problem worldwide. Their adequate management requires relevant biological elements. The objective of this study was to evaluate ionic disturbances during acute poisoning in children aged from 0 to 15 years admitted to the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) of Ouagadougou, Burkina Faso. A retrospective descriptive and analytical study was therefore conducted over a period of 3 years at CHUP-CDG. It was performed in the pediatric, intensive care and laboratory departments of the CHUP-CDG, and involved children aged from 0 to 15 years with complete clinical records. A total of 193 patients were included, with a mean age of 18.82±24.85 months and M/F sex ratio of 1.38. The hospital incidence of AAP was 2.43% and the mortality rate 16.06%. Phytomedicinal intoxications were the most common (39.38%), followed by caustic products (19.69%). On admission, serum electrolytes showed hypobicarbonatemia (64.23%), hyperchloremia (55.24%), hyponatremia (33.78%), hypoproteinemia (21.47%) and hyperkalemia (12.16%). At control, hypobicarbonatemia (28.57%), hyperchloremia (75%), hypoproteinemia (28.57%), hyperkalemia (12.50%) and here hypernatremia (25%) were found. The deceased patients had significantly lower natremia (p=0.0442), chloremia (p=0.0007) and proteinemia (p=0.0004) than the other patients in the study. The high death rate was related to herbal medicines and caustic intoxications. Many hydroelectric disorders were found in the study. These disorders could be explain par digestive losses. Indeed, the main clinical signs found in the study were vomiting and diarrhea in children. In addition, acute renal failure in patients could also explain these ionic disturbances. AAP are at the root of multiple ionic disorders, which may be responsible for life-threatening complications in patients.},
 year = {2023}
}

Copy | Download

TY - JOUR
T1 - Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou
AU - Fabienne Marie Soudre
AU - Raoul Karfo
AU - Alice Kiba
AU - Arnaud Kouraogo
AU - Rachid Sougue
AU - Elie Kabre
AU - Jean Sakande
Y1 - 2023/06/27
PY - 2023
N1 - https://doi.org/10.11648/j.ab.20231102.11
DO - 10.11648/j.ab.20231102.11
T2 - Advances in Biochemistry
JF - Advances in Biochemistry
JO - Advances in Biochemistry
SP - 15
EP - 21
PB - Science Publishing Group
SN - 2329-0862
UR - https://doi.org/10.11648/j.ab.20231102.11
AB - Accidental acute poisoning (AAP) in children is a significant public health problem worldwide. Their adequate management requires relevant biological elements. The objective of this study was to evaluate ionic disturbances during acute poisoning in children aged from 0 to 15 years admitted to the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) of Ouagadougou, Burkina Faso. A retrospective descriptive and analytical study was therefore conducted over a period of 3 years at CHUP-CDG. It was performed in the pediatric, intensive care and laboratory departments of the CHUP-CDG, and involved children aged from 0 to 15 years with complete clinical records. A total of 193 patients were included, with a mean age of 18.82±24.85 months and M/F sex ratio of 1.38. The hospital incidence of AAP was 2.43% and the mortality rate 16.06%. Phytomedicinal intoxications were the most common (39.38%), followed by caustic products (19.69%). On admission, serum electrolytes showed hypobicarbonatemia (64.23%), hyperchloremia (55.24%), hyponatremia (33.78%), hypoproteinemia (21.47%) and hyperkalemia (12.16%). At control, hypobicarbonatemia (28.57%), hyperchloremia (75%), hypoproteinemia (28.57%), hyperkalemia (12.50%) and here hypernatremia (25%) were found. The deceased patients had significantly lower natremia (p=0.0442), chloremia (p=0.0007) and proteinemia (p=0.0004) than the other patients in the study. The high death rate was related to herbal medicines and caustic intoxications. Many hydroelectric disorders were found in the study. These disorders could be explain par digestive losses. Indeed, the main clinical signs found in the study were vomiting and diarrhea in children. In addition, acute renal failure in patients could also explain these ionic disturbances. AAP are at the root of multiple ionic disorders, which may be responsible for life-threatening complications in patients.
VL - 11
IS - 2
ER -

Copy | Download

Author Information

Fabienne Marie Soudre

Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Raoul Karfo

Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Alice Kiba

Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Arnaud Kouraogo

Institute of Health Sciences, Nazi Boni University, Bobo-Dioulasso, Burkina Faso
Rachid Sougue

Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Elie Kabre

Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso
Jean Sakande

Training and Research Unit in Health Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Fabienne Marie Soudre, Raoul Karfo, Alice Kiba, Arnaud Kouraogo, Rachid Sougue, et al. (2023). Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou. Advances in Biochemistry, 11(2), 15-21. https://doi.org/10.11648/j.ab.20231102.11

Copy | Download

ACS Style

Fabienne Marie Soudre; Raoul Karfo; Alice Kiba; Arnaud Kouraogo; Rachid Sougue, et al. Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou. Adv. Biochem. 2023, 11(2), 15-21. doi: 10.11648/j.ab.20231102.11

Copy | Download

AMA Style

Fabienne Marie Soudre, Raoul Karfo, Alice Kiba, Arnaud Kouraogo, Rachid Sougue, et al. Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou. Adv Biochem. 2023;11(2):15-21. doi: 10.11648/j.ab.20231102.11

Copy | Download

@article{10.11648/j.ab.20231102.11,
  author = {Fabienne Marie Soudre and Raoul Karfo and Alice Kiba and Arnaud Kouraogo and Rachid Sougue and Elie Kabre and Jean Sakande},
  title = {Serum Electrolytes Profile During Accidental Acute Poisoning in Children at Charles De Gaulle Pediatric University Hospital of Ouagadougou},
  journal = {Advances in Biochemistry},
  volume = {11},
  number = {2},
  pages = {15-21},
  doi = {10.11648/j.ab.20231102.11},
  url = {https://doi.org/10.11648/j.ab.20231102.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20231102.11},
  abstract = {Accidental acute poisoning (AAP) in children is a significant public health problem worldwide. Their adequate management requires relevant biological elements. The objective of this study was to evaluate ionic disturbances during acute poisoning in children aged from 0 to 15 years admitted to the Charles De Gaulle Pediatric University Hospital (CHUP-CDG) of Ouagadougou, Burkina Faso. A retrospective descriptive and analytical study was therefore conducted over a period of 3 years at CHUP-CDG. It was performed in the pediatric, intensive care and laboratory departments of the CHUP-CDG, and involved children aged from 0 to 15 years with complete clinical records. A total of 193 patients were included, with a mean age of 18.82±24.85 months and M/F sex ratio of 1.38. The hospital incidence of AAP was 2.43% and the mortality rate 16.06%. Phytomedicinal intoxications were the most common (39.38%), followed by caustic products (19.69%). On admission, serum electrolytes showed hypobicarbonatemia (64.23%), hyperchloremia (55.24%), hyponatremia (33.78%), hypoproteinemia (21.47%) and hyperkalemia (12.16%). At control, hypobicarbonatemia (28.57%), hyperchloremia (75%), hypoproteinemia (28.57%), hyperkalemia (12.50%) and here hypernatremia (25%) were found. The deceased patients had significantly lower natremia (p=0.0442), chloremia (p=0.0007) and proteinemia (p=0.0004) than the other patients in the study. The high death rate was related to herbal medicines and caustic intoxications. Many hydroelectric disorders were found in the study. These disorders could be explain par digestive losses. Indeed, the main clinical signs found in the study were vomiting and diarrhea in children. In addition, acute renal failure in patients could also explain these ionic disturbances. AAP are at the root of multiple ionic disorders, which may be responsible for life-threatening complications in patients.},
 year = {2023}
}

Copy | Download