In addition to its role in phosphocalcic and bone metabolism, vitamin D also plays a global role in health. Despite high levels of sunshine, vitamin D deficiency remains a public health problem in sub-Saharan Africa, where sickle cell disease predominates. This study aimed to investigate an association between serum vitamin D (25(OH)D) levels and the occurrence of clinical and biological complications. The study was carried out in children with SS sickle cell disease aged 1 to 17 years (75 patients) matched to 17 AA controls. Plasma 25(OH)D concentration was obtained by immunoassay. The clinical complications studied were caso-occlusive crisis, osteomyelitis, osteonecrosis, acute chest syndrome, and priapism. Biological parameters included blood count, ionized calcium, and phosphorus. Statistical analysis was performed using R Studio 4.1.2 software. The significance threshold was 5%. Our study revealed a high prevalence of vaso-occlusive crisis (97%). Vitamin D deficiency was found in 4% of patients (3 SS patients) and 36% (27 SS patients) had a plasma concentration between 10 and 30 ng/ml. The association study revealed a negative association between vitamin D and the number of vaso-occlusive crises (r = -0.51; p < 0.001). We noted a positive association between vitamin D and blood calcium (r = 0.347; p < 0.002), phosphatemia (r = 0.347; p < 0.002), and hemoglobin (r = 0.243; p < 0.035). Vitamin D is correlated with certain clinical and biological complications. Vitamin D supplementation in children with sickle cell disease (SS) would therefore be relevant for better management of this disease.
Published in | Advances in Biochemistry (Volume 12, Issue 2) |
DOI | 10.11648/j.ab.20241202.15 |
Page(s) | 85-91 |
Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Sickle Cell Disease, Vitamin D, CVO, Ionized Calcium, Hemoglobin
Clinical manifestations | Effective (N) | Percentage (%) |
---|---|---|
VOCs | 73 | 97.33 |
ACS | 05 | 6.66 |
Osteonecrosis | 15 | 20 |
Osteomyelitis | 15 | 20 |
Priapism | 01 | 1.33 |
Parameters | Case (N=75) | Controls AA (N=17) | p |
---|---|---|---|
GB (103/mm3) | 17.42±6.34 | 9.15±5.27 | 0.03* |
Hb (g/dl) | 7.94±1.54 | 10.97±1.49 | 0.003* |
MCV (fl) | 85.06±7.88 | 80.12±7.7 | 0.0109* |
MCH (pg) | 28.75±3.35 | 24.24±3.15 | 0.05 |
MCHC (g/dl) | 33.77±1.96 | 30.09±2.20 | 0.120 |
Vitamin D (ng/ml) | 37.91±13.41 | 35.16±13.33 | 0.44 |
Ionized calcium (mmol/l) | 0.86±0.12 | 1.0 ±0.11 | 0.0094* |
Phosphatemia (mg/l) | 51.80±16.87 | 38.33±10.19 | 0.0022* |
25(OH)D (ng/mL) | ||
---|---|---|
VOC | r | 0,51 |
p-value | < 0,001** | |
Osteomyelitis | r | 1 |
p-value | ||
Osteonecrosis | r | 1 |
p-value | ||
Ca2+ (mmol/L) | r | 0,347** |
p-value | 0,002** | |
Phosphatemia (mg/l) | r | 0,347** |
p-value | 0,002** | |
Hb (mg/dl) | r | 0,243* |
p-value | 0,035* |
VOC | Vaso-Occlusive Crisis |
ACS | Acute Chest Syndrome |
BMD | Bone Mineral Density |
ABMD | Apparent Bone Mineral Density |
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APA Style
Tall, F. G., Kandji, P. M., Ndour, E. H. M., Mbancké, S. S., Djité, M., et al. (2024). Association Between Serum 25(OH)D Concentration and Clinical and Biological Complications in Pediatric Patients with Sickle Cell Disease. Advances in Biochemistry, 12(2), 85-91. https://doi.org/10.11648/j.ab.20241202.15
ACS Style
Tall, F. G.; Kandji, P. M.; Ndour, E. H. M.; Mbancké, S. S.; Djité, M., et al. Association Between Serum 25(OH)D Concentration and Clinical and Biological Complications in Pediatric Patients with Sickle Cell Disease. Adv. Biochem. 2024, 12(2), 85-91. doi: 10.11648/j.ab.20241202.15
AMA Style
Tall FG, Kandji PM, Ndour EHM, Mbancké SS, Djité M, et al. Association Between Serum 25(OH)D Concentration and Clinical and Biological Complications in Pediatric Patients with Sickle Cell Disease. Adv Biochem. 2024;12(2):85-91. doi: 10.11648/j.ab.20241202.15
@article{10.11648/j.ab.20241202.15, author = {Fatou Gueye Tall and Pape Matar Kandji and El Hadji Malick Ndour and Serigne Saliou Mbancké and Moustapha Djité and Oumou Kesso Barry and Aynina Cissé and Philoméne Lopez Sall and Papa Madièye Gueye}, title = {Association Between Serum 25(OH)D Concentration and Clinical and Biological Complications in Pediatric Patients with Sickle Cell Disease }, journal = {Advances in Biochemistry}, volume = {12}, number = {2}, pages = {85-91}, doi = {10.11648/j.ab.20241202.15}, url = {https://doi.org/10.11648/j.ab.20241202.15}, eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ab.20241202.15}, abstract = {In addition to its role in phosphocalcic and bone metabolism, vitamin D also plays a global role in health. Despite high levels of sunshine, vitamin D deficiency remains a public health problem in sub-Saharan Africa, where sickle cell disease predominates. This study aimed to investigate an association between serum vitamin D (25(OH)D) levels and the occurrence of clinical and biological complications. The study was carried out in children with SS sickle cell disease aged 1 to 17 years (75 patients) matched to 17 AA controls. Plasma 25(OH)D concentration was obtained by immunoassay. The clinical complications studied were caso-occlusive crisis, osteomyelitis, osteonecrosis, acute chest syndrome, and priapism. Biological parameters included blood count, ionized calcium, and phosphorus. Statistical analysis was performed using R Studio 4.1.2 software. The significance threshold was 5%. Our study revealed a high prevalence of vaso-occlusive crisis (97%). Vitamin D deficiency was found in 4% of patients (3 SS patients) and 36% (27 SS patients) had a plasma concentration between 10 and 30 ng/ml. The association study revealed a negative association between vitamin D and the number of vaso-occlusive crises (r = -0.51; p < 0.001). We noted a positive association between vitamin D and blood calcium (r = 0.347; p < 0.002), phosphatemia (r = 0.347; p < 0.002), and hemoglobin (r = 0.243; p < 0.035). Vitamin D is correlated with certain clinical and biological complications. Vitamin D supplementation in children with sickle cell disease (SS) would therefore be relevant for better management of this disease. }, year = {2024} }
TY - JOUR T1 - Association Between Serum 25(OH)D Concentration and Clinical and Biological Complications in Pediatric Patients with Sickle Cell Disease AU - Fatou Gueye Tall AU - Pape Matar Kandji AU - El Hadji Malick Ndour AU - Serigne Saliou Mbancké AU - Moustapha Djité AU - Oumou Kesso Barry AU - Aynina Cissé AU - Philoméne Lopez Sall AU - Papa Madièye Gueye Y1 - 2024/06/19 PY - 2024 N1 - https://doi.org/10.11648/j.ab.20241202.15 DO - 10.11648/j.ab.20241202.15 T2 - Advances in Biochemistry JF - Advances in Biochemistry JO - Advances in Biochemistry SP - 85 EP - 91 PB - Science Publishing Group SN - 2329-0862 UR - https://doi.org/10.11648/j.ab.20241202.15 AB - In addition to its role in phosphocalcic and bone metabolism, vitamin D also plays a global role in health. Despite high levels of sunshine, vitamin D deficiency remains a public health problem in sub-Saharan Africa, where sickle cell disease predominates. This study aimed to investigate an association between serum vitamin D (25(OH)D) levels and the occurrence of clinical and biological complications. The study was carried out in children with SS sickle cell disease aged 1 to 17 years (75 patients) matched to 17 AA controls. Plasma 25(OH)D concentration was obtained by immunoassay. The clinical complications studied were caso-occlusive crisis, osteomyelitis, osteonecrosis, acute chest syndrome, and priapism. Biological parameters included blood count, ionized calcium, and phosphorus. Statistical analysis was performed using R Studio 4.1.2 software. The significance threshold was 5%. Our study revealed a high prevalence of vaso-occlusive crisis (97%). Vitamin D deficiency was found in 4% of patients (3 SS patients) and 36% (27 SS patients) had a plasma concentration between 10 and 30 ng/ml. The association study revealed a negative association between vitamin D and the number of vaso-occlusive crises (r = -0.51; p < 0.001). We noted a positive association between vitamin D and blood calcium (r = 0.347; p < 0.002), phosphatemia (r = 0.347; p < 0.002), and hemoglobin (r = 0.243; p < 0.035). Vitamin D is correlated with certain clinical and biological complications. Vitamin D supplementation in children with sickle cell disease (SS) would therefore be relevant for better management of this disease. VL - 12 IS - 2 ER -