A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model
| Published in | Advances in Bioscience and Bioengineering (Volume 1, Issue 1) |
| DOI | 10.11648/j.abb.20130101.11 |
| Page(s) | 1-7 |
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This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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NANO-Encapsulation, Bone, NMR, Micro-CT
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APA Style
Qingwen Ni, Hong Dixon, Gloria Gutierrez, Long Bi, Yi-Xian Qin. (2014). Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT. Advances in Bioscience and Bioengineering, 1(1), 1-7. https://doi.org/10.11648/j.abb.20130101.11
ACS Style
Qingwen Ni; Hong Dixon; Gloria Gutierrez; Long Bi; Yi-Xian Qin. Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT. Adv. BioSci. Bioeng. 2014, 1(1), 1-7. doi: 10.11648/j.abb.20130101.11
AMA Style
Qingwen Ni, Hong Dixon, Gloria Gutierrez, Long Bi, Yi-Xian Qin. Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT. Adv BioSci Bioeng. 2014;1(1):1-7. doi: 10.11648/j.abb.20130101.11
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Download@article{10.11648/j.abb.20130101.11,
author = {Qingwen Ni and Hong Dixon and Gloria Gutierrez and Long Bi and Yi-Xian Qin},
title = {Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT},
journal = {Advances in Bioscience and Bioengineering},
volume = {1},
number = {1},
pages = {1-7},
doi = {10.11648/j.abb.20130101.11},
url = {https://doi.org/10.11648/j.abb.20130101.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20130101.11},
abstract = {A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model},
year = {2014}
}
TY - JOUR T1 - Characterization of Synthesized NANO-encapsulated Drug for Bone Loss on Hind Limb Suspension Rat Model by NMR and Micro-CT AU - Qingwen Ni AU - Hong Dixon AU - Gloria Gutierrez AU - Long Bi AU - Yi-Xian Qin Y1 - 2014/06/14 PY - 2014 N1 - https://doi.org/10.11648/j.abb.20130101.11 DO - 10.11648/j.abb.20130101.11 T2 - Advances in Bioscience and Bioengineering JF - Advances in Bioscience and Bioengineering JO - Advances in Bioscience and Bioengineering SP - 1 EP - 7 PB - Science Publishing Group SN - 2330-4162 UR - https://doi.org/10.11648/j.abb.20130101.11 AB - A formulation of nano-encapsulated enantiomer of (+) promethazine with desired release rate has been synthesized for establish a localized drug delivery system. It was tested on a hind limb suspension (HLS) disuse rat model, and by using a non-destructive Nuclear Magnetic Resonance (NMR) relaxation technique, and micro computed tomography (Micro-CT) analysis technique to qualitatively evaluate the effectiveness of the new bone formations as well as to compare the current commercial anti-bone loss drug Alendeonate. Our studies suggest that nano-encapsulated (+) promethazine in controlled release formulations conjugating bone-targeting functional groups are effective in promoting bone growth in a disuse rat model VL - 1 IS - 1 ER -
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