Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm. At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.
| Published in | Advances in Bioscience and Bioengineering (Volume 2, Issue 1) |
| DOI | 10.11648/j.abb.20140201.11 |
| Page(s) | 1-7 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2014. Published by Science Publishing Group |
Virulence, Autoinducers, CAI-1, AI-2, LuxO, HapR, Aph A, QS Inhibitors
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APA Style
Bashir Mohammed Abubakar, Jibrin Ndejiko Mohammed, Abdulrahman Idris, Hamzat Ibiyeye Tijani, Saidu Haruna, et al. (2014). The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence. Advances in Bioscience and Bioengineering, 2(1), 1-7. https://doi.org/10.11648/j.abb.20140201.11
ACS Style
Bashir Mohammed Abubakar; Jibrin Ndejiko Mohammed; Abdulrahman Idris; Hamzat Ibiyeye Tijani; Saidu Haruna, et al. The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence. Adv. BioSci. Bioeng. 2014, 2(1), 1-7. doi: 10.11648/j.abb.20140201.11
AMA Style
Bashir Mohammed Abubakar, Jibrin Ndejiko Mohammed, Abdulrahman Idris, Hamzat Ibiyeye Tijani, Saidu Haruna, et al. The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence. Adv BioSci Bioeng. 2014;2(1):1-7. doi: 10.11648/j.abb.20140201.11
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Download@article{10.11648/j.abb.20140201.11,
author = {Bashir Mohammed Abubakar and Jibrin Ndejiko Mohammed and Abdulrahman Idris and Hamzat Ibiyeye Tijani and Saidu Haruna and Yusuf Hindatu and Mohammed Sulaiman},
title = {The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence},
journal = {Advances in Bioscience and Bioengineering},
volume = {2},
number = {1},
pages = {1-7},
doi = {10.11648/j.abb.20140201.11},
url = {https://doi.org/10.11648/j.abb.20140201.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20140201.11},
abstract = {Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm. At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system.},
year = {2014}
}
TY - JOUR T1 - The Significant Role of Quorum Sensing in the Control of Vibrio Cholerae Virulence AU - Bashir Mohammed Abubakar AU - Jibrin Ndejiko Mohammed AU - Abdulrahman Idris AU - Hamzat Ibiyeye Tijani AU - Saidu Haruna AU - Yusuf Hindatu AU - Mohammed Sulaiman Y1 - 2014/02/20 PY - 2014 N1 - https://doi.org/10.11648/j.abb.20140201.11 DO - 10.11648/j.abb.20140201.11 T2 - Advances in Bioscience and Bioengineering JF - Advances in Bioscience and Bioengineering JO - Advances in Bioscience and Bioengineering SP - 1 EP - 7 PB - Science Publishing Group SN - 2330-4162 UR - https://doi.org/10.11648/j.abb.20140201.11 AB - Quorum sensing (QS) plays a vital role in controlling virulence in bacterial species. Vibrio cholerae, the main causative agent of cholera uses chemical signals to control virulence and biofilm formation. QS Always depend on the secretion and detection of signaling molecules known as auto inducers. Contrary to other bacteria that cause virulence at High cell density (HCD) when they attain a specific threshold, reverse is the case for V. Cholerae. At Low cell density (LCD), activation in the expression of virulence gene by V. cholerae destabilizes HapR while stabilizing AphA. The activation of AphA structural genes result in the expression of CT and TCP virulence together with the formation of biofilm. At HCD, the coherence of the two quorum-sensing auto-inducers (CAI-1 and AI-2) represses the expression of the virulence genes by activating HapR which in turn synthesizes Hap protease that acts as a detachase to get rid of the virulence genes and biofilm formation. In this review, we outline the QS mechanism used by Vibrio cholerae to cause infection by the production of virulence factors. In addition, we examine how this infection can be minimize through the use of chemicals which act as either inhibitors or agonist to the QS system. VL - 2 IS - 1 ER -
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