Natural products and their derivatives have always been the major source of bioactive compounds used for the treatment of new and existing diseases. The present study was carried out to investigate the antibacterial activity of the crude extract of an endophytic fungus isolated from the leaves of Picralima nitida, a medicinal plant of the Apocynaceae family and to isolate and identify the molecule responsible for this activity. Thus, secalonic acid B isolated from the crude extract of an endophytic fungus was tested on six (06) pathogenic bacterial strains by agar diffusion method for strain susceptibility test. And the liquid diffusion test was used to determine the antibacterial parameters (BMC and MIC). The isolated endophytic fungus was identified by molecular biology methods as a strain of Clonotachys sp. The antibacterial test performed with the Clonotachys sp. extract showed inhibitory activity on Staphylococcus aureus (ATCC 25923, 931/18 and 934/18) and Klebsiella pneumoniae (815/18) strains with inhibition diameters ranging from 18.43±1.05 to 7.56±0.73 mm. This extract has a bactericidal power on these strains. As for the secalonic acid B isolated from this fungal extract, it also showed efficacy against Staphylococcus aureus and Klebsiella pneumoniae with bactericidal power. The endophytic fungus Clonotachys sp. is therefore a potential source of antibacterial compounds.
| Published in | Advances in Bioscience and Bioengineering (Volume 9, Issue 3) |
| DOI | 10.11648/j.abb.20210903.12 |
| Page(s) | 75-80 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Picralima nitida, Endophyte, Clonotachys sp., Antibacterial Activity
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APA Style
Kpan Nestor Gono, Dodehe Yeo, Abale Anatole Toty, You Christiane Essoh, Kacou Adele NDouba, et al. (2021). Antibacterial Activity of Secalonic Acid B Produced by Clonotachys sp., an Endophytic Fungus Isolated from Picralima nitida Leaves. Advances in Bioscience and Bioengineering, 9(3), 75-80. https://doi.org/10.11648/j.abb.20210903.12
ACS Style
Kpan Nestor Gono; Dodehe Yeo; Abale Anatole Toty; You Christiane Essoh; Kacou Adele NDouba, et al. Antibacterial Activity of Secalonic Acid B Produced by Clonotachys sp., an Endophytic Fungus Isolated from Picralima nitida Leaves. Adv. BioSci. Bioeng. 2021, 9(3), 75-80. doi: 10.11648/j.abb.20210903.12
AMA Style
Kpan Nestor Gono, Dodehe Yeo, Abale Anatole Toty, You Christiane Essoh, Kacou Adele NDouba, et al. Antibacterial Activity of Secalonic Acid B Produced by Clonotachys sp., an Endophytic Fungus Isolated from Picralima nitida Leaves. Adv BioSci Bioeng. 2021;9(3):75-80. doi: 10.11648/j.abb.20210903.12
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Download@article{10.11648/j.abb.20210903.12,
author = {Kpan Nestor Gono and Dodehe Yeo and Abale Anatole Toty and You Christiane Essoh and Kacou Adele NDouba and Gilles-Alex Pakora},
title = {Antibacterial Activity of Secalonic Acid B Produced by Clonotachys sp., an Endophytic Fungus Isolated from Picralima nitida Leaves},
journal = {Advances in Bioscience and Bioengineering},
volume = {9},
number = {3},
pages = {75-80},
doi = {10.11648/j.abb.20210903.12},
url = {https://doi.org/10.11648/j.abb.20210903.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.abb.20210903.12},
abstract = {Natural products and their derivatives have always been the major source of bioactive compounds used for the treatment of new and existing diseases. The present study was carried out to investigate the antibacterial activity of the crude extract of an endophytic fungus isolated from the leaves of Picralima nitida, a medicinal plant of the Apocynaceae family and to isolate and identify the molecule responsible for this activity. Thus, secalonic acid B isolated from the crude extract of an endophytic fungus was tested on six (06) pathogenic bacterial strains by agar diffusion method for strain susceptibility test. And the liquid diffusion test was used to determine the antibacterial parameters (BMC and MIC). The isolated endophytic fungus was identified by molecular biology methods as a strain of Clonotachys sp. The antibacterial test performed with the Clonotachys sp. extract showed inhibitory activity on Staphylococcus aureus (ATCC 25923, 931/18 and 934/18) and Klebsiella pneumoniae (815/18) strains with inhibition diameters ranging from 18.43±1.05 to 7.56±0.73 mm. This extract has a bactericidal power on these strains. As for the secalonic acid B isolated from this fungal extract, it also showed efficacy against Staphylococcus aureus and Klebsiella pneumoniae with bactericidal power. The endophytic fungus Clonotachys sp. is therefore a potential source of antibacterial compounds.},
year = {2021}
}
TY - JOUR T1 - Antibacterial Activity of Secalonic Acid B Produced by Clonotachys sp., an Endophytic Fungus Isolated from Picralima nitida Leaves AU - Kpan Nestor Gono AU - Dodehe Yeo AU - Abale Anatole Toty AU - You Christiane Essoh AU - Kacou Adele NDouba AU - Gilles-Alex Pakora Y1 - 2021/08/09 PY - 2021 N1 - https://doi.org/10.11648/j.abb.20210903.12 DO - 10.11648/j.abb.20210903.12 T2 - Advances in Bioscience and Bioengineering JF - Advances in Bioscience and Bioengineering JO - Advances in Bioscience and Bioengineering SP - 75 EP - 80 PB - Science Publishing Group SN - 2330-4162 UR - https://doi.org/10.11648/j.abb.20210903.12 AB - Natural products and their derivatives have always been the major source of bioactive compounds used for the treatment of new and existing diseases. The present study was carried out to investigate the antibacterial activity of the crude extract of an endophytic fungus isolated from the leaves of Picralima nitida, a medicinal plant of the Apocynaceae family and to isolate and identify the molecule responsible for this activity. Thus, secalonic acid B isolated from the crude extract of an endophytic fungus was tested on six (06) pathogenic bacterial strains by agar diffusion method for strain susceptibility test. And the liquid diffusion test was used to determine the antibacterial parameters (BMC and MIC). The isolated endophytic fungus was identified by molecular biology methods as a strain of Clonotachys sp. The antibacterial test performed with the Clonotachys sp. extract showed inhibitory activity on Staphylococcus aureus (ATCC 25923, 931/18 and 934/18) and Klebsiella pneumoniae (815/18) strains with inhibition diameters ranging from 18.43±1.05 to 7.56±0.73 mm. This extract has a bactericidal power on these strains. As for the secalonic acid B isolated from this fungal extract, it also showed efficacy against Staphylococcus aureus and Klebsiella pneumoniae with bactericidal power. The endophytic fungus Clonotachys sp. is therefore a potential source of antibacterial compounds. VL - 9 IS - 3 ER -
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