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Rules Regulating the Change in Physiological Parameters of Rats Under Simulated Microgravity and Different Ambient Temperatures

Received: 18 January 2019     Published: 28 April 2019
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Abstract

To investigate the rules regulating changes in mean chest temperature (MCT), mean rectal temperature (MRT) and mean body weight (MW)in rats at simulated microgravity and different ambient temperatures (ATs). The −30º rat tail suspension (TS) method was used to simulate microgravity over a 7 day period at 18°C, 20°C, 23°C and 26°C AT through comparison between the TS group and control group. Each group contained six male SD rats (including one verification rat). MCT and MRT of TS group rats increased at all four levels of AT. MCT and MRT reached maximum growth rates of 0.315 and 0.118 at ATs of 20°C and 23°C, respectively. MW was reduced at ATs of 20°C and 23°C, whereas it increased at 18°C and 26°C AT in the TS group. The rates of changes of MCT, MRT and MW at different ATs were analyzed using linear regression analysis for both the control (Equation 1) and TS (Equation 2) groups. Using A new equation (Equation 3) without the influence of other factors was derived after Equation 1 minus Equation 2 to derive. The result shows that the coefficients of Equation 3 are different under the four ATs. TS and AT have coupling effects on the MCT, MRT and MW of rats.

Published in American Journal of Civil Engineering (Volume 7, Issue 1)
DOI 10.11648/j.ajce.20190701.15
Page(s) 27-34
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Tail Suspended Rats, Mean Chest Temperature, Mean Rectal Temperature, Mean Body Weight, Ambient Temperature

References
[1] Drummer, C., Heer, M., Dressendorfer, R. A., Strasburger, C. J. andGerzer, R., Reduced natriuresis during weightlessness. Clin. Investig.,1993,71, 678-686.
[2] Drummer, C., Gerzer, R., Baisch, F. andHeer, M., Body fluid regulation in μ-gravity differs from Earth: an overview. Pflugers Arch., 2000, 441, 66-72.
[3] Leach, C. S., Alfrey, C. P., Suki, W. N., Leonard, J. I., Rambaut, P. C., Inners, L. D., Smith, S. M., Lane, H. W. andKrauhs, J. M., Regulation of body fluid compartments during short-term spaceflight. J. Appl. Physiol., 1996, 8, 105-116.
[4] Zhuang, X. and Chen, F., Weightlessness Physiology. People's Military Medical Press, China, 1990. (in Chinese).
[5] Shen, S., Weightlessness physiology technology and progress. National Defense Industry Press, China, 2007. (in Chinese).
[6] Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J. andVernikos. J., From space to Earth: advances in human physiology from 20 years of bed rest studies (1986–2006). Eur. J. Appl. Physiol., 2007,101, 143-194.
[7] Klein-Nulend, J., Bacabac, R. G., Veldhuijzen, J. P. andvan Loon, J. J., Microgravity and bone cell mechanosensitivity. Adv. Space Res., 2003, 32, 1551-1559.
[8] McGarry, J. G., Klein-Nulend, J., Mullender, M. G. and Prendergast, P. J., A comparison of strain and fluid shear stress in stimulating bone cell responses: a computational and experimental study. FASEB J., 2005, 19, 482-484.
[9] Burger, E. H., Klein-Nulend, J. and Smit, T. H., Strain-derived canalicular fluid flow regulates osteoclast activity in a remodelling osteon: a proposal. J. Biomech., 2003, 36, 1453-1459.
[10] Convertino, V. A., Bloomfield, S. A. andGreenleaf, J. E., An overview of the issues: physiological effects of bed rest and restricted physical activity. Med. Sci. Sports Exerc., 1997, 29, 187-190.
[11] Ferretti, G., Girardis, M., Moia, C. andAntonutto, G., Effects of prolonged bed rest on cardiovascular oxygen transport during submaximal exercise in humans. Eur. J. Appl. Physiol. Occup. Physiol., 1998, 78, 398-402.
[12] Greenleaf, J. E., Intensive exercise training during bed rest attenuates deconditioning. Med. Sci. Sports Exerc., 1997, 29, 191-196.
[13] Iwasaki, K. I., Zhang, R., Zuckerman, J. H., Pawelczyk, J. A. and Levine, B. D., Effect of head-down-tilt bed rest and hypovolemia on dynamic regulation of heart rate and blood pressure. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2000, 279, 2189-2199.
[14] Hirayanagi, K., Iwase, S., Kamiya, A., Sasaki, T., Mano, T. andYajima, K., Functional changes in autonomic nervous system and baroreceptor reflex induced by 14 days of 6 degrees head-down bed rest. Eur. J. Appl. Physiol., 2004, 92, 160-167.
[15] Linnarsson, D., Spaak, J. andSundblad, P., Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest. Eur. J. Appl. Physiol., 2006, 96, 37-45.
[16] Xiao, X., Mukkamala, R., Sheynberg, N., Williams, G. H. and Cohen, R. J., Effects of prolonged bed rest on the total peripheral resistance baroreflex. Comput. Cardiol., 2002, 29, 53-56.
[17] Kimmerly, D. S. and Shoemaker, J. K., Hypovolemia and neurovascular control during orthostatic stress. Am. J. Physiol. Heart Circ. Physiol., 2002, 282, 645-655.
[18] Kamiya, A., Iwase, S., Kitazawa, H., Mano, T., Vinogradova, O. L. and Kharchenko, I. B., Baroreflex control of muscle sympathetic nerve activity after 120 days of 6 degrees head-down bed rest. Am. J. Physiol. Regulatory Integrative Comp. Physiol., 2000,278, 445-452.
[19] Meck, J. V., Waters, W. W., Ziegler, M. G., deBlock, H. F., Mills, P. J., Robertson, D. and Huang, P. L., Mechanisms of postspaceflight orthostatic hypotension: low alpha1- adrenergic receptor responses before flight and central autonomic dysregulation postflight. Am. J. Physiol. Heart Circ. Physiol., 2004, 286, 1486-1495.
[20] Blaber, A. P., Bondar, R. L. andKassam, M. S., Heart rate variability and short duration spaceflight: relationship to post-flight orthostatic intolerance. BMC Physiol., 2004,27, 4-6.
[21] Li, W. T., Huang, Y. F., Sun, L. W., Luan, H. Q. and Zhu, B. Z., Would interstitial fluid flow be responsible for skeletal maintenance in tail-suspended rats?. Microgravity Sci. Technol., 2017, 29, 107-114.
[22] Kang, H., Sun, L., Huang, Y., Wang, Z., Zhao, P., Fan, Y. andDeng, X., Regional specific adaptation of the endothelial glycocalyx dimension in tail-suspended rats. PflugersArch., 2015, 467, 1291-1301.
[23] Atkov, O. Y. andBednenko, V. S., Hypokinesia and weightlessness: clinical and physiologic aspects. International University Press, 1992.
[24] Gharib, C., Gauquelin, G., Pequignot, J. M., Geelen, G., Bizollon, C. A. andGuell, A., Early hormonal effects of head-down tilt (-10 degrees) in humans. Aviat. Space Environ. Med., 1988,59, 624-629.
[25] Greenleaf, J. E., Physiology of fluid and electrolyte responses during inactivity: water immersion and bed rest. Med. Sci. Sports Exerc., 1984,16, 20-25.
[26] Stahn, A. C., Werner, A., Opatz, O., Maggioni, M. A., Steinach, M., von Ahlefeld, V. W., Moore, A., Crucian, B. E., Smith, S. M., Zwart, S. R., Schlabs, T., Mendt, S., Trippel, T., Koralewski, E., Koch, J., Choukèr, A., Reitz, G., Shang, P., Rőcker, L., Kirsch, K. A. and Gunga, H. C., Increased core body temperature in astronauts during long-duration space missions. Sci. Rep., 2017, 7, 16180.
[27] Nicogossian, A. E., Leach, H. C. and Pool, S. L., Space physiology and medicine. Philadelphia, PA; Lea &Febiger, 1994.
[28] Zheng Jie, Chen Liang, Li Baizhan, et al. Indoor thermal comfort studies based on physiological parameter measurement and questionnaire investigation [J]. Journal of Central South University of Technology . 2006, 13(4): 404-407.
[29] Zheng Jie, Zhang Yu, Yao Runming. Impact of indoor thermal comfort on physiological parameters of human body [J]. Journal of Central South University of Technology. 2009, 16(s1): 024-027.
[30] P. O. Fanger, O. Östberg, A. G. McK. Nicholl, et al. Thermal comfort conditions during day and night [J]. European Journal of Applied Physiology and Occupational Physiology. 1974, Vol33: 255–263.
[31] P. O. Fanger, J. Højbjerre, J. O. B. Thomsen. Thermal comfort conditions in the morning and in the evening [J]. International Journal of Biometeorology. 1974, Vol18:16–22.
Cite This Article
  • APA Style

    Jie Qian, Gengxin Xie, Jie Zheng, Bo Duan, Yajun Cao, et al. (2019). Rules Regulating the Change in Physiological Parameters of Rats Under Simulated Microgravity and Different Ambient Temperatures. American Journal of Civil Engineering, 7(1), 27-34. https://doi.org/10.11648/j.ajce.20190701.15

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    ACS Style

    Jie Qian; Gengxin Xie; Jie Zheng; Bo Duan; Yajun Cao, et al. Rules Regulating the Change in Physiological Parameters of Rats Under Simulated Microgravity and Different Ambient Temperatures. Am. J. Civ. Eng. 2019, 7(1), 27-34. doi: 10.11648/j.ajce.20190701.15

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    AMA Style

    Jie Qian, Gengxin Xie, Jie Zheng, Bo Duan, Yajun Cao, et al. Rules Regulating the Change in Physiological Parameters of Rats Under Simulated Microgravity and Different Ambient Temperatures. Am J Civ Eng. 2019;7(1):27-34. doi: 10.11648/j.ajce.20190701.15

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  • @article{10.11648/j.ajce.20190701.15,
      author = {Jie Qian and Gengxin Xie and Jie Zheng and Bo Duan and Yajun Cao and Xi Wang and Fengjie Li and Changpeng Hu},
      title = {Rules Regulating the Change in Physiological Parameters of Rats Under Simulated Microgravity and Different Ambient Temperatures},
      journal = {American Journal of Civil Engineering},
      volume = {7},
      number = {1},
      pages = {27-34},
      doi = {10.11648/j.ajce.20190701.15},
      url = {https://doi.org/10.11648/j.ajce.20190701.15},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajce.20190701.15},
      abstract = {To investigate the rules regulating changes in mean chest temperature (MCT), mean rectal temperature (MRT) and mean body weight (MW)in rats at simulated microgravity and different ambient temperatures (ATs). The −30º rat tail suspension (TS) method was used to simulate microgravity over a 7 day period at 18°C, 20°C, 23°C and 26°C AT through comparison between the TS group and control group. Each group contained six male SD rats (including one verification rat). MCT and MRT of TS group rats increased at all four levels of AT. MCT and MRT reached maximum growth rates of 0.315 and 0.118 at ATs of 20°C and 23°C, respectively. MW was reduced at ATs of 20°C and 23°C, whereas it increased at 18°C and 26°C AT in the TS group. The rates of changes of MCT, MRT and MW at different ATs were analyzed using linear regression analysis for both the control (Equation 1) and TS (Equation 2) groups. Using A new equation (Equation 3) without the influence of other factors was derived after Equation 1 minus Equation 2 to derive. The result shows that the coefficients of Equation 3 are different under the four ATs. TS and AT have coupling effects on the MCT, MRT and MW of rats.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Rules Regulating the Change in Physiological Parameters of Rats Under Simulated Microgravity and Different Ambient Temperatures
    AU  - Jie Qian
    AU  - Gengxin Xie
    AU  - Jie Zheng
    AU  - Bo Duan
    AU  - Yajun Cao
    AU  - Xi Wang
    AU  - Fengjie Li
    AU  - Changpeng Hu
    Y1  - 2019/04/28
    PY  - 2019
    N1  - https://doi.org/10.11648/j.ajce.20190701.15
    DO  - 10.11648/j.ajce.20190701.15
    T2  - American Journal of Civil Engineering
    JF  - American Journal of Civil Engineering
    JO  - American Journal of Civil Engineering
    SP  - 27
    EP  - 34
    PB  - Science Publishing Group
    SN  - 2330-8737
    UR  - https://doi.org/10.11648/j.ajce.20190701.15
    AB  - To investigate the rules regulating changes in mean chest temperature (MCT), mean rectal temperature (MRT) and mean body weight (MW)in rats at simulated microgravity and different ambient temperatures (ATs). The −30º rat tail suspension (TS) method was used to simulate microgravity over a 7 day period at 18°C, 20°C, 23°C and 26°C AT through comparison between the TS group and control group. Each group contained six male SD rats (including one verification rat). MCT and MRT of TS group rats increased at all four levels of AT. MCT and MRT reached maximum growth rates of 0.315 and 0.118 at ATs of 20°C and 23°C, respectively. MW was reduced at ATs of 20°C and 23°C, whereas it increased at 18°C and 26°C AT in the TS group. The rates of changes of MCT, MRT and MW at different ATs were analyzed using linear regression analysis for both the control (Equation 1) and TS (Equation 2) groups. Using A new equation (Equation 3) without the influence of other factors was derived after Equation 1 minus Equation 2 to derive. The result shows that the coefficients of Equation 3 are different under the four ATs. TS and AT have coupling effects on the MCT, MRT and MW of rats.
    VL  - 7
    IS  - 1
    ER  - 

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Author Information
  • School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing, China

  • School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing, China

  • School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing, China

  • School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing, China

  • School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing, China

  • School of Urban Construction and Environmental Engineering, Chongqing University, Chongqing, China

  • Department of Pharmacy, The Second Affiliated Hospital, Army Medical University, Chongqing, China

  • Department of Pharmacy, The Second Affiliated Hospital, Army Medical University, Chongqing, China

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