,
Adam Fimbo,
Danstan Hipolite,
Revocatus Makonope,
Saxon Mwambene,
Yonah Hebron,
Kissa Mwamwitwa,
Raphael Zozimus Sangeda
The global impact of antimicrobial resistance (AMR) includes increased morbidity and mortality rates and healthcare costs, particularly in low- and middle-income countries (LMICs), and it has dire economic and security implications. This study assessed the resistance of clinical isolates responsible for urinary tract infections (UTI) to antibacterial agents for treating UTIs in selected healthcare facilities in Tanzania. A total of 151 clinical isolates of E. coli and S. aureus isolated from urine samples in selected health facilities were analyzed for antimicrobial susceptibility to establish the presence of individual and multi-drug resistance (MDR). The results revealed that E. Coli displayed a significant difference in resistance (χ2 =12.808, p =0.002) across the selected antibiotics, in which E. coli showed the highest resistance to amoxicillin (AML) and the least resistance to meropenem (p <0.005). In contrast, S. aureus isolates showed a significant difference. (χ2=53.627, p-value<0.001) in resistance across the selected antibiotics, in which S. aureus showed the highest resistance to AML, peaking at more than 91%, and least resistant (4%) to nitrofurantoin (NIT) (4%). When p-value<0.005, both E. coli and S. aureus demonstrated MDR against selected antibiotics in all health facilities under study, in which Morogoro Regional Referral Hospital showed the highest (65.4%) for E. coli and Benjamin Mkapa Hospital showed the highest (83.3%) for S. aureus. Similarly, Maweni Regional Referral Hospital demonstrated the lowest MDR for E. coli (23%) and S. aureus (13%). Finding suggest that some antibiotics are still in used in clinical practice despite of the evidence of emerging resistance against them hence it call for effective regular AMR surveillance and antimicrobial stewardship implementation to optimize antibiotics use in clinical practice and exclude less efficacious ones.
| Published in | American Journal of Life Sciences (Volume 12, Issue 6) |
| DOI | 10.11648/j.ajls.20241206.18 |
| Page(s) | 170-180 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Antimicrobial Resistance, Clinical Isolates, Urinary Tract Infections, E. coli and S. aureus, Tanzania Healthcare Facilities
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APA Style
Mtenga, A. B., Fimbo, A., Hipolite, D., Makonope, R., Mwambene, S., et al. (2024). Assessment of Antibiotics Resistance from Isolates Responsible for UTI in Four Regional Referral Hospitals in Tanzania. American Journal of Life Sciences, 12(6), 170-180. https://doi.org/10.11648/j.ajls.20241206.18
ACS Style
Mtenga, A. B.; Fimbo, A.; Hipolite, D.; Makonope, R.; Mwambene, S., et al. Assessment of Antibiotics Resistance from Isolates Responsible for UTI in Four Regional Referral Hospitals in Tanzania. Am. J. Life Sci. 2024, 12(6), 170-180. doi: 10.11648/j.ajls.20241206.18
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Download@article{10.11648/j.ajls.20241206.18,
author = {Adelard Bartholomew Mtenga and Adam Fimbo and Danstan Hipolite and Revocatus Makonope and Saxon Mwambene and Yonah Hebron and Kissa Mwamwitwa and Raphael Zozimus Sangeda},
title = {Assessment of Antibiotics Resistance from Isolates Responsible for UTI in Four Regional Referral Hospitals in Tanzania
},
journal = {American Journal of Life Sciences},
volume = {12},
number = {6},
pages = {170-180},
doi = {10.11648/j.ajls.20241206.18},
url = {https://doi.org/10.11648/j.ajls.20241206.18},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajls.20241206.18},
abstract = {The global impact of antimicrobial resistance (AMR) includes increased morbidity and mortality rates and healthcare costs, particularly in low- and middle-income countries (LMICs), and it has dire economic and security implications. This study assessed the resistance of clinical isolates responsible for urinary tract infections (UTI) to antibacterial agents for treating UTIs in selected healthcare facilities in Tanzania. A total of 151 clinical isolates of E. coli and S. aureus isolated from urine samples in selected health facilities were analyzed for antimicrobial susceptibility to establish the presence of individual and multi-drug resistance (MDR). The results revealed that E. Coli displayed a significant difference in resistance (χ2 =12.808, p =0.002) across the selected antibiotics, in which E. coli showed the highest resistance to amoxicillin (AML) and the least resistance to meropenem (p S. aureus isolates showed a significant difference. (χ2=53.627, p-valueS. aureus showed the highest resistance to AML, peaking at more than 91%, and least resistant (4%) to nitrofurantoin (NIT) (4%). When p-valueE. coli and S. aureus demonstrated MDR against selected antibiotics in all health facilities under study, in which Morogoro Regional Referral Hospital showed the highest (65.4%) for E. coli and Benjamin Mkapa Hospital showed the highest (83.3%) for S. aureus. Similarly, Maweni Regional Referral Hospital demonstrated the lowest MDR for E. coli (23%) and S. aureus (13%). Finding suggest that some antibiotics are still in used in clinical practice despite of the evidence of emerging resistance against them hence it call for effective regular AMR surveillance and antimicrobial stewardship implementation to optimize antibiotics use in clinical practice and exclude less efficacious ones.
},
year = {2024}
}
TY - JOUR T1 - Assessment of Antibiotics Resistance from Isolates Responsible for UTI in Four Regional Referral Hospitals in Tanzania AU - Adelard Bartholomew Mtenga AU - Adam Fimbo AU - Danstan Hipolite AU - Revocatus Makonope AU - Saxon Mwambene AU - Yonah Hebron AU - Kissa Mwamwitwa AU - Raphael Zozimus Sangeda Y1 - 2024/12/31 PY - 2024 N1 - https://doi.org/10.11648/j.ajls.20241206.18 DO - 10.11648/j.ajls.20241206.18 T2 - American Journal of Life Sciences JF - American Journal of Life Sciences JO - American Journal of Life Sciences SP - 170 EP - 180 PB - Science Publishing Group SN - 2328-5737 UR - https://doi.org/10.11648/j.ajls.20241206.18 AB - The global impact of antimicrobial resistance (AMR) includes increased morbidity and mortality rates and healthcare costs, particularly in low- and middle-income countries (LMICs), and it has dire economic and security implications. This study assessed the resistance of clinical isolates responsible for urinary tract infections (UTI) to antibacterial agents for treating UTIs in selected healthcare facilities in Tanzania. A total of 151 clinical isolates of E. coli and S. aureus isolated from urine samples in selected health facilities were analyzed for antimicrobial susceptibility to establish the presence of individual and multi-drug resistance (MDR). The results revealed that E. Coli displayed a significant difference in resistance (χ2 =12.808, p =0.002) across the selected antibiotics, in which E. coli showed the highest resistance to amoxicillin (AML) and the least resistance to meropenem (p S. aureus isolates showed a significant difference. (χ2=53.627, p-valueS. aureus showed the highest resistance to AML, peaking at more than 91%, and least resistant (4%) to nitrofurantoin (NIT) (4%). When p-valueE. coli and S. aureus demonstrated MDR against selected antibiotics in all health facilities under study, in which Morogoro Regional Referral Hospital showed the highest (65.4%) for E. coli and Benjamin Mkapa Hospital showed the highest (83.3%) for S. aureus. Similarly, Maweni Regional Referral Hospital demonstrated the lowest MDR for E. coli (23%) and S. aureus (13%). Finding suggest that some antibiotics are still in used in clinical practice despite of the evidence of emerging resistance against them hence it call for effective regular AMR surveillance and antimicrobial stewardship implementation to optimize antibiotics use in clinical practice and exclude less efficacious ones. VL - 12 IS - 6 ER -
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Tanzania Medicines and Medical Devices Authority, Dar es Salaam, Tanzania
Department of Pharmaceutical Microbiology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania
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