Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2

Wenjie Liu; Qinyuan Wang; Zhaokai Wang; Defeng Wu; Wenhua Liu; Juan Wang

doi:doi:10.11648/j.bio.20150306.16

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Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2

Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, Juan Wang

Published in American Journal of Bioscience and Bioengineering (Volume 3, Issue 6)

Received: 23 December 2015 Published: 23 December 2015

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Abstract

Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10^-8 M), BPA (10^-12, 10^-11, 10^-10, 10^-9, 10^-8, 10^-7, 10^-6 M), N P (10^-12, 10^-11, 10^-10, 10^-9, 10^-8, 10^-7, 10^-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.

Published in	American Journal of Bioscience and Bioengineering (Volume 3, Issue 6)
DOI	10.11648/j.bio.20150306.16
Page(s)	178-182
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Xenoestrogens, Cellproliferation, Shp2, MCF-7 Cell

References

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APA Style

Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, et al. (2015). Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. American Journal of Bioscience and Bioengineering, 3(6), 178-182. https://doi.org/10.11648/j.bio.20150306.16

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ACS Style

Wenjie Liu; Qinyuan Wang; Zhaokai Wang; Defeng Wu; Wenhua Liu, et al. Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. Am. J. BioSci. Bioeng. 2015, 3(6), 178-182. doi: 10.11648/j.bio.20150306.16

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AMA Style

Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, et al. Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. Am J BioSci Bioeng. 2015;3(6):178-182. doi: 10.11648/j.bio.20150306.16

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@article{10.11648/j.bio.20150306.16,
  author = {Wenjie Liu and Qinyuan Wang and Zhaokai Wang and Defeng Wu and Wenhua Liu and Juan Wang},
  title = {Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {6},
  pages = {178-182},
  doi = {10.11648/j.bio.20150306.16},
  url = {https://doi.org/10.11648/j.bio.20150306.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20150306.16},
  abstract = {Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.},
 year = {2015}
}

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TY  - JOUR
T1  - Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2
AU  - Wenjie Liu
AU  - Qinyuan Wang
AU  - Zhaokai Wang
AU  - Defeng Wu
AU  - Wenhua Liu
AU  - Juan Wang
Y1  - 2015/12/23
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20150306.16
DO  - 10.11648/j.bio.20150306.16
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 178
EP  - 182
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20150306.16
AB  - Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.
VL  - 3
IS  - 6
ER  -

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Author Information

Wenjie Liu

School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
Qinyuan Wang

School of Pharmaceutical Sciences, Xiamen University, Xiamen, China
Zhaokai Wang

Third Institute of Oceanography, State Oceanic Administration, Xiamen, China
Defeng Wu

College of Animal Science, Fujian Agriculture and Forestry University, Fuzhou, China
Wenhua Liu

Third People's Hospital of Pingdu, Pingdu, China
Juan Wang

Third People's Hospital of Pingdu, Pingdu, China

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APA Style

Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, et al. (2015). Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. American Journal of Bioscience and Bioengineering, 3(6), 178-182. https://doi.org/10.11648/j.bio.20150306.16

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ACS Style

Wenjie Liu; Qinyuan Wang; Zhaokai Wang; Defeng Wu; Wenhua Liu, et al. Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. Am. J. BioSci. Bioeng. 2015, 3(6), 178-182. doi: 10.11648/j.bio.20150306.16

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AMA Style

Wenjie Liu, Qinyuan Wang, Zhaokai Wang, Defeng Wu, Wenhua Liu, et al. Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2. Am J BioSci Bioeng. 2015;3(6):178-182. doi: 10.11648/j.bio.20150306.16

Copy | Download

@article{10.11648/j.bio.20150306.16,
  author = {Wenjie Liu and Qinyuan Wang and Zhaokai Wang and Defeng Wu and Wenhua Liu and Juan Wang},
  title = {Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2},
  journal = {American Journal of Bioscience and Bioengineering},
  volume = {3},
  number = {6},
  pages = {178-182},
  doi = {10.11648/j.bio.20150306.16},
  url = {https://doi.org/10.11648/j.bio.20150306.16},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bio.20150306.16},
  abstract = {Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.},
 year = {2015}
}

Copy | Download

TY  - JOUR
T1  - Increased Cell Proliferation by Various Doses of Xenoestrogen in MFC-7 Cell Through Tyrosine Phosphatase Shp2
AU  - Wenjie Liu
AU  - Qinyuan Wang
AU  - Zhaokai Wang
AU  - Defeng Wu
AU  - Wenhua Liu
AU  - Juan Wang
Y1  - 2015/12/23
PY  - 2015
N1  - https://doi.org/10.11648/j.bio.20150306.16
DO  - 10.11648/j.bio.20150306.16
T2  - American Journal of Bioscience and Bioengineering
JF  - American Journal of Bioscience and Bioengineering
JO  - American Journal of Bioscience and Bioengineering
SP  - 178
EP  - 182
PB  - Science Publishing Group
SN  - 2328-5893
UR  - https://doi.org/10.11648/j.bio.20150306.16
AB  - Our previous study demonstrated that tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer. However, consumer research suggests that the Xenoestrogens exposure in breast tumorigenesisis more important. The present study examined the consequences of different concentrations xenoestrogens exposure to Bisphenol A (BPA) and Nonyl Phenol (NP) on cell proliferation and shp2 expression in MCF-7 cell. Phps1 (2x10-8 M), BPA (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M), N P (10-12, 10-11, 10-10, 10-9, 10-8, 10-7, 10-6 M) and was administered in MCF-7 cell, respectively. Results showed the exposure of various concentrations xenoestrogens significantly elevated cell proliferation (P<0.05). Proliferation of MCF-7 cells was down regulated by Phps1 (a Shp2 inhibitor) when cells were treated for 1 h. In addition, the tyrosine phosphatase Shp2 levels were higher in BPA- and NP-exposed indicating that Shp2 plays a crutial role for Xenoestrogens exposure facilitating breast tumorigenesis properties.
VL  - 3
IS  - 6
ER  -

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