This review article aims at demonstration of complexity or multiplicity of long noncoding RNA. The presentations of the meeting cover variety of biomedical sciences to indicate significance of long noncoding RNA in each field. The achievements of the meeting are to confirm a point of view of long noncoding RNAs in living cells. It should be in complexity. We will be able to analyze complicated phenomena of lncRNA biological actions and might have resolved the vailed rules in divergent biological programs. In the plant system, its long noncoding RNAs possesses unique property compared to mammalian systems, but tells us an unveiled fundamental principle behind all creatures in the globe. Then, experimental data from structural biology mainly by NMR analysis show that interaction of nucleic acids to RNA binding proteins focusing on TLS/FUS. Analyses of TLS are also performed by biochemistry and molecular biology to indicate precise figures of RNA binding specificity and also methylation effect on TLS. Biological meaning of the DNA local conformation like G-quadruplex is presented. XIST, one of the best known long noncoding RNA, related to X chromosome inactivation, has been linked to novel finding in epigenetic functional redundancy such as long noncoding RNA -chromatin associations. In the iPS cells, their long noncoding RNA s have been identified as a potential marker for chemical stress responses. Cellular differentiation is also regulated by specific long noncoding RNA. Computational analysis is another approach to make progress. Transcriptome mining indicates an association between aging and sets of long noncoding RNAs with previously unidentified function. Molecular dynamics simulation of RNA presents unprecedented pathway to future of the field. The data in the manuscript are based upon the 2nd Annual Meeting of the long noncoding RNA study group. On Thursday, May 24 in 2018, 2nd Annual Meeting of the long noncoding RNA study group was held at Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo in Japan. The purpose of the meeting is to present recent data and have discussion regarding long noncoding RNA and related topics. We had thirteen sessions and exciting and fruitful debates there. The meeting has been successfully prorogued. We utilize the data to boost the activity of the field of long noncoding RNA.
| Published in | Biomedical Sciences (Volume 4, Issue 2) |
| DOI | 10.11648/j.bs.20180402.11 |
| Page(s) | 18-23 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Long Noncoding RNA, RNA-binding Protein, Amyotrophic Lateral Sclerosis, TLS, FUS, X Chromosome Inactivation, LINEs, Molecular Dynamics
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APA Style
Riki Kurokawa, Reina Komiya, Takanori Oyoshi, Yoko Matsuno, Hidenori Tani, et al. (2018). Multiplicity in Long Noncoding RNA in Living Cells. Biomedical Sciences, 4(2), 18-23. https://doi.org/10.11648/j.bs.20180402.11
ACS Style
Riki Kurokawa; Reina Komiya; Takanori Oyoshi; Yoko Matsuno; Hidenori Tani, et al. Multiplicity in Long Noncoding RNA in Living Cells. Biomed. Sci. 2018, 4(2), 18-23. doi: 10.11648/j.bs.20180402.11
AMA Style
Riki Kurokawa, Reina Komiya, Takanori Oyoshi, Yoko Matsuno, Hidenori Tani, et al. Multiplicity in Long Noncoding RNA in Living Cells. Biomed Sci. 2018;4(2):18-23. doi: 10.11648/j.bs.20180402.11
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author = {Riki Kurokawa and Reina Komiya and Takanori Oyoshi and Yoko Matsuno and Hidenori Tani and Masato Katahira and Keisuke Hitachi and Yuji Iwashita and Takefumi Yamashita and Keiko Kondo and Ryoma Yoneda and Yudai Yamaoki and Naomi Ueda and Tsukasa Mashima and Naohiro Kobayashi and Takashi Nagata and Ayaka Kiyoishi and Masayuki Miyake and Fumi Kano and Masayuki Murata and Nesreen Hamad and Kohei Sasaki and Naoyuki Shoji},
title = {Multiplicity in Long Noncoding RNA in Living Cells},
journal = {Biomedical Sciences},
volume = {4},
number = {2},
pages = {18-23},
doi = {10.11648/j.bs.20180402.11},
url = {https://doi.org/10.11648/j.bs.20180402.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20180402.11},
abstract = {This review article aims at demonstration of complexity or multiplicity of long noncoding RNA. The presentations of the meeting cover variety of biomedical sciences to indicate significance of long noncoding RNA in each field. The achievements of the meeting are to confirm a point of view of long noncoding RNAs in living cells. It should be in complexity. We will be able to analyze complicated phenomena of lncRNA biological actions and might have resolved the vailed rules in divergent biological programs. In the plant system, its long noncoding RNAs possesses unique property compared to mammalian systems, but tells us an unveiled fundamental principle behind all creatures in the globe. Then, experimental data from structural biology mainly by NMR analysis show that interaction of nucleic acids to RNA binding proteins focusing on TLS/FUS. Analyses of TLS are also performed by biochemistry and molecular biology to indicate precise figures of RNA binding specificity and also methylation effect on TLS. Biological meaning of the DNA local conformation like G-quadruplex is presented. XIST, one of the best known long noncoding RNA, related to X chromosome inactivation, has been linked to novel finding in epigenetic functional redundancy such as long noncoding RNA -chromatin associations. In the iPS cells, their long noncoding RNA s have been identified as a potential marker for chemical stress responses. Cellular differentiation is also regulated by specific long noncoding RNA. Computational analysis is another approach to make progress. Transcriptome mining indicates an association between aging and sets of long noncoding RNAs with previously unidentified function. Molecular dynamics simulation of RNA presents unprecedented pathway to future of the field. The data in the manuscript are based upon the 2nd Annual Meeting of the long noncoding RNA study group. On Thursday, May 24 in 2018, 2nd Annual Meeting of the long noncoding RNA study group was held at Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo in Japan. The purpose of the meeting is to present recent data and have discussion regarding long noncoding RNA and related topics. We had thirteen sessions and exciting and fruitful debates there. The meeting has been successfully prorogued. We utilize the data to boost the activity of the field of long noncoding RNA.},
year = {2018}
}
TY - JOUR T1 - Multiplicity in Long Noncoding RNA in Living Cells AU - Riki Kurokawa AU - Reina Komiya AU - Takanori Oyoshi AU - Yoko Matsuno AU - Hidenori Tani AU - Masato Katahira AU - Keisuke Hitachi AU - Yuji Iwashita AU - Takefumi Yamashita AU - Keiko Kondo AU - Ryoma Yoneda AU - Yudai Yamaoki AU - Naomi Ueda AU - Tsukasa Mashima AU - Naohiro Kobayashi AU - Takashi Nagata AU - Ayaka Kiyoishi AU - Masayuki Miyake AU - Fumi Kano AU - Masayuki Murata AU - Nesreen Hamad AU - Kohei Sasaki AU - Naoyuki Shoji Y1 - 2018/08/16 PY - 2018 N1 - https://doi.org/10.11648/j.bs.20180402.11 DO - 10.11648/j.bs.20180402.11 T2 - Biomedical Sciences JF - Biomedical Sciences JO - Biomedical Sciences SP - 18 EP - 23 PB - Science Publishing Group SN - 2575-3932 UR - https://doi.org/10.11648/j.bs.20180402.11 AB - This review article aims at demonstration of complexity or multiplicity of long noncoding RNA. The presentations of the meeting cover variety of biomedical sciences to indicate significance of long noncoding RNA in each field. The achievements of the meeting are to confirm a point of view of long noncoding RNAs in living cells. It should be in complexity. We will be able to analyze complicated phenomena of lncRNA biological actions and might have resolved the vailed rules in divergent biological programs. In the plant system, its long noncoding RNAs possesses unique property compared to mammalian systems, but tells us an unveiled fundamental principle behind all creatures in the globe. Then, experimental data from structural biology mainly by NMR analysis show that interaction of nucleic acids to RNA binding proteins focusing on TLS/FUS. Analyses of TLS are also performed by biochemistry and molecular biology to indicate precise figures of RNA binding specificity and also methylation effect on TLS. Biological meaning of the DNA local conformation like G-quadruplex is presented. XIST, one of the best known long noncoding RNA, related to X chromosome inactivation, has been linked to novel finding in epigenetic functional redundancy such as long noncoding RNA -chromatin associations. In the iPS cells, their long noncoding RNA s have been identified as a potential marker for chemical stress responses. Cellular differentiation is also regulated by specific long noncoding RNA. Computational analysis is another approach to make progress. Transcriptome mining indicates an association between aging and sets of long noncoding RNAs with previously unidentified function. Molecular dynamics simulation of RNA presents unprecedented pathway to future of the field. The data in the manuscript are based upon the 2nd Annual Meeting of the long noncoding RNA study group. On Thursday, May 24 in 2018, 2nd Annual Meeting of the long noncoding RNA study group was held at Research Center for Advanced Science and Technology (RCAST), the University of Tokyo, Tokyo in Japan. The purpose of the meeting is to present recent data and have discussion regarding long noncoding RNA and related topics. We had thirteen sessions and exciting and fruitful debates there. The meeting has been successfully prorogued. We utilize the data to boost the activity of the field of long noncoding RNA. VL - 4 IS - 2 ER -
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