Malaria infection is one of the most common disease of public health importance afflicting millions of people in sub-Saharan Africa. This study investigated haematological derrangement among malaria infected and non-infected patients attending some Primary Health Centres in Ardo-Kola LGA, Taraba State, Nigeria. 585 blood samples were collected and examined for Plasmodium falciparum infection. Packed Cell Volume (PCV) was done by microhaematocrit and Erythrocyte Sedimentation Rate (ESR) using Westergen methods. The overall result showed a prevalence of ESR by Westergern method. It was found that malaria with low intensity of parasitaemia infection, 217 (37.09%) was more than medium and high intensity of parasitaemia with no significant difference (χ2=9.34; P≥0.05). The mean value of haematological parameters of parasitized subjects were 0.29 for PCV and 124.3655 for platelets which were significantly lower than those of non-parasitized subjects, PCV=0.4577 and Platelets=198.7698 respectively. Erythrocyte Sedimentation Rate (ESR) was higher (33.0852) in parasitized subjects than non-parasitized (20.0504). The result of this study could be useful in identification of high-risk malaria population. This will target intervention and assessment of impact based on changes in haematological parameters associated with P. falciparum infection. Futhermore, preventive strategies like chemoprophylaxis, provision of iron supplementation and insecticide treated nets could be employed in the study area to curb the upsurge in transmission.
| Published in | Biomedical Sciences (Volume 6, Issue 3) |
| DOI | 10.11648/j.bs.20200603.15 |
| Page(s) | 67-73 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2020. Published by Science Publishing Group |
Haematological, Packed, Cell, Volume, Sedimentation
| [1] | WHO. World Malaria Report. Geneva, Switzerland: World Health Organization, 2017. Pp 32-42. |
| [2] | Smith, C., Teng, F. B. E., Chu, S., Joseph, K. S. Maternal and Perinatal Morbidity and Mortality Associated With Anemia in Pregnancy. Obstetrics & Gynecology, 2019; 134 (6): 1234-1244. doi: 10.1097/AOG.0000000000003557. |
| [3] | Edelu, B. O., Ndu, I. K., Igbokwe, O. O., Iloh, O. N. Severe falciparum malaria in children in Enugu, South East Nigeria. Nigerian Journal of Clinical Practice, 2018; 21: 1349-55. |
| [4] | Cheesbrough, M. District laboratory practice in tropical countries. New York-Cambridge Press. Part1, 2nd Edition, 2012; 249-258. |
| [5] | Dade, J. V. and Lewis, S. M. Practical hematology, 2001, 9th edition. London: Churchill Livingstone. |
| [6] | Plewes, K., Turner, G. D. H., Dondorp, A. M. Pathophysiology, clinical presentation, and treatment of coma and acute kidney injury complicating falciparum malaria, Current Opinion in Infectious Diseases, 2018; 31 (1): 69-77. doi: 10.1097/QCO.0000000000000419. |
| [7] | WHO. World Malaria Report, 2015. Pp 543. ISBN 978-924-156-515-8. |
| [8] | Henry, N. B., Sermé, S. S., Siciliano, G. et al Biology of Plasmodium falciparum gametocyte sex ratio and implications in malaria parasite transmission. Malar J 18, 70 (2019). https://doi.org/10.1186/s12936-019-2707-0 |
| [9] | Bakhubaira, S. “Haematological parameters in severe complicated Plasmodium falciparum malaria in adult in Aden,” Turkish Journal of Haematology, 2013; 30 (40): 394-399. |
| [10] | Draper, S. J., Sack, B. K., King, C. R. et al. Malaria Vaccines: Recent Advances and New Horizons. Cell Host Microbe. 2018; 24 (1): 43-56. doi: 10.1016/j.chom.2018.06.008. |
| [11] | Francis, U., Isaac, Z., Yakubu, A., Enosakhare, A., Felix, E. Haematological Parameters of Malaria Infected Patients in the University of Calabar Teaching Hospital, Calabar, Nigeria. Journal of Hematology & Thromboembolic Diseases, 2014; 2: 171. doi: 10.4172/2329-8790.1000171. |
| [12] | Omarine, N. N., Nange, T. B. Assessment of Hematological Parameters in Malaria, among Adult Patients Attending the Bamenda Regional Hospital. Anemia, 2020: 3814513. doi: 10.1155/2020/3814513. |
| [13] | Mohamed, A. S., Bushra, S. A., Ahmed, M., Ali, A. E. Parasitaemia and Its Relation to Hematological Parameters and Liver Function among Patients Malaria in Abs, Hajjah, Northwest Yemen. Interdisciplinary Perspectives on Infectious Diseases, 2016. Article ID 5954394, 5 pages http://dx.doi.org/10.1155/2016/5954394. |
| [14] | Chikezie, P. C, Okpara, R. T. Haematologic and biochemical indices of Plasmodium falciparum infected inhabitants of Owerri, Imo State, Nigeria. Journal of Medical Laboratory and Diagnosis, 4 (3): 38-44. DOI: 10.5897/JMLD2013.0068. |
| [15] | Alves-Junior, E. R., Gomes, L. T., Dombroski, T. C., Dallabona, N., Andréia, F., Vandresen-Filho, S., Nakazato, L., Fontes, Cor J. F., Rios-Santos, F. New laboratory perspectives for evaluation of vivax malaria infected patients: a useful tool for infection monitoring. Brazilian Journal of Infectious Diseases, 2020; 24 (2): 120-129. https://dx.doi.org/10.1016/j.bjid.2020.04.001. |
APA Style
Elkanah Obadiah Sambo, Obiorah Sylvester Chibuzor, Onyeuku Okechukwu Chinwe, Elkanah Deborah Sambo, Egeonu Stephen Ugoeze. (2020). Haematological Derrangement Due to P. falciparum Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State. Biomedical Sciences, 6(3), 67-73. https://doi.org/10.11648/j.bs.20200603.15
ACS Style
Elkanah Obadiah Sambo; Obiorah Sylvester Chibuzor; Onyeuku Okechukwu Chinwe; Elkanah Deborah Sambo; Egeonu Stephen Ugoeze. Haematological Derrangement Due to P. falciparum Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State. Biomed. Sci. 2020, 6(3), 67-73. doi: 10.11648/j.bs.20200603.15
AMA Style
Elkanah Obadiah Sambo, Obiorah Sylvester Chibuzor, Onyeuku Okechukwu Chinwe, Elkanah Deborah Sambo, Egeonu Stephen Ugoeze. Haematological Derrangement Due to P. falciparum Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State. Biomed Sci. 2020;6(3):67-73. doi: 10.11648/j.bs.20200603.15
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Download@article{10.11648/j.bs.20200603.15,
author = {Elkanah Obadiah Sambo and Obiorah Sylvester Chibuzor and Onyeuku Okechukwu Chinwe and Elkanah Deborah Sambo and Egeonu Stephen Ugoeze},
title = {Haematological Derrangement Due to P. falciparum Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State},
journal = {Biomedical Sciences},
volume = {6},
number = {3},
pages = {67-73},
doi = {10.11648/j.bs.20200603.15},
url = {https://doi.org/10.11648/j.bs.20200603.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20200603.15},
abstract = {Malaria infection is one of the most common disease of public health importance afflicting millions of people in sub-Saharan Africa. This study investigated haematological derrangement among malaria infected and non-infected patients attending some Primary Health Centres in Ardo-Kola LGA, Taraba State, Nigeria. 585 blood samples were collected and examined for Plasmodium falciparum infection. Packed Cell Volume (PCV) was done by microhaematocrit and Erythrocyte Sedimentation Rate (ESR) using Westergen methods. The overall result showed a prevalence of ESR by Westergern method. It was found that malaria with low intensity of parasitaemia infection, 217 (37.09%) was more than medium and high intensity of parasitaemia with no significant difference (χ2=9.34; P≥0.05). The mean value of haematological parameters of parasitized subjects were 0.29 for PCV and 124.3655 for platelets which were significantly lower than those of non-parasitized subjects, PCV=0.4577 and Platelets=198.7698 respectively. Erythrocyte Sedimentation Rate (ESR) was higher (33.0852) in parasitized subjects than non-parasitized (20.0504). The result of this study could be useful in identification of high-risk malaria population. This will target intervention and assessment of impact based on changes in haematological parameters associated with P. falciparum infection. Futhermore, preventive strategies like chemoprophylaxis, provision of iron supplementation and insecticide treated nets could be employed in the study area to curb the upsurge in transmission.},
year = {2020}
}
TY - JOUR T1 - Haematological Derrangement Due to P. falciparum Infection in Patients of Selected Health Centres in Ardo-Kola Local Government Area, Taraba State AU - Elkanah Obadiah Sambo AU - Obiorah Sylvester Chibuzor AU - Onyeuku Okechukwu Chinwe AU - Elkanah Deborah Sambo AU - Egeonu Stephen Ugoeze Y1 - 2020/09/19 PY - 2020 N1 - https://doi.org/10.11648/j.bs.20200603.15 DO - 10.11648/j.bs.20200603.15 T2 - Biomedical Sciences JF - Biomedical Sciences JO - Biomedical Sciences SP - 67 EP - 73 PB - Science Publishing Group SN - 2575-3932 UR - https://doi.org/10.11648/j.bs.20200603.15 AB - Malaria infection is one of the most common disease of public health importance afflicting millions of people in sub-Saharan Africa. This study investigated haematological derrangement among malaria infected and non-infected patients attending some Primary Health Centres in Ardo-Kola LGA, Taraba State, Nigeria. 585 blood samples were collected and examined for Plasmodium falciparum infection. Packed Cell Volume (PCV) was done by microhaematocrit and Erythrocyte Sedimentation Rate (ESR) using Westergen methods. The overall result showed a prevalence of ESR by Westergern method. It was found that malaria with low intensity of parasitaemia infection, 217 (37.09%) was more than medium and high intensity of parasitaemia with no significant difference (χ2=9.34; P≥0.05). The mean value of haematological parameters of parasitized subjects were 0.29 for PCV and 124.3655 for platelets which were significantly lower than those of non-parasitized subjects, PCV=0.4577 and Platelets=198.7698 respectively. Erythrocyte Sedimentation Rate (ESR) was higher (33.0852) in parasitized subjects than non-parasitized (20.0504). The result of this study could be useful in identification of high-risk malaria population. This will target intervention and assessment of impact based on changes in haematological parameters associated with P. falciparum infection. Futhermore, preventive strategies like chemoprophylaxis, provision of iron supplementation and insecticide treated nets could be employed in the study area to curb the upsurge in transmission. VL - 6 IS - 3 ER -
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