Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes

Semi Oh; Min-Seok Kim; Beom-Rae Noh; Hyung-Hwan Baik; Kyoung-Kook Kim

doi:doi:10.11648/j.bs.20210702.12

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Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes

Semi Oh, Min-Seok Kim, Beom-Rae Noh, Hyung-Hwan Baik, Kyoung-Kook Kim

Published in Biomedical Sciences (Volume 7, Issue 2)

Received: 15 April 2021 Accepted: 30 April 2021 Published: 14 May 2021

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Abstract

Many diabetic mellitus patients envision a non-invasive method of blood glucose measurement since they require periodic monitoring of their blood glucose levels to ensure that it is stable and within the normal range. In this study, we detected glucose concentration using commercial light emitting diodes (LEDs) with a wavelength of 700–1600 nm. Light of long wavelengths (e.g. NIR) infiltrate human skin and reach the blood vessel lining, thereby aiding in the non-invasive measurement of blood glucose concentration. To demonstrate this, the concentration of glucose solutions was measured using red and NIR-LEDs in a non-invasive manner. The sensitivity of glucose detection was greater when light of wavelength below 1000 nm was used, owing to the absorption of wavelengths above 1000 nm by water. Furthermore, we controlled the input current of the red and NIR-LEDs to confirm the light intensity deviation with increasing glucose concentrations and suggested the optimum wavelength of light using this in-vitro system. Among various LEDs, the 700 nm LED showed higher light intensity deviation with change in injection current compared to LEDs with the other wavelengths. In particular, compared to other LEDs, a stark difference was observed in the light intensity of the 700 nm LED while measuring glucose concentrations in the range of 50–100 mg/dl.

Published in	Biomedical Sciences (Volume 7, Issue 2)
DOI	10.11648/j.bs.20210702.12
Page(s)	47-52
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Non-Invasive, Glucose, NIR-LED, Diabetic Mellitus, Water Absorption

References

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APA Style

Semi Oh, Min-Seok Kim, Beom-Rae Noh, Hyung-Hwan Baik, Kyoung-Kook Kim. (2021). Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes. Biomedical Sciences, 7(2), 47-52. https://doi.org/10.11648/j.bs.20210702.12

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ACS Style

Semi Oh; Min-Seok Kim; Beom-Rae Noh; Hyung-Hwan Baik; Kyoung-Kook Kim. Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes. Biomed. Sci. 2021, 7(2), 47-52. doi: 10.11648/j.bs.20210702.12

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AMA Style

Semi Oh, Min-Seok Kim, Beom-Rae Noh, Hyung-Hwan Baik, Kyoung-Kook Kim. Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes. Biomed Sci. 2021;7(2):47-52. doi: 10.11648/j.bs.20210702.12

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@article{10.11648/j.bs.20210702.12,
  author = {Semi Oh and Min-Seok Kim and Beom-Rae Noh and Hyung-Hwan Baik and Kyoung-Kook Kim},
  title = {Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes},
  journal = {Biomedical Sciences},
  volume = {7},
  number = {2},
  pages = {47-52},
  doi = {10.11648/j.bs.20210702.12},
  url = {https://doi.org/10.11648/j.bs.20210702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20210702.12},
  abstract = {Many diabetic mellitus patients envision a non-invasive method of blood glucose measurement since they require periodic monitoring of their blood glucose levels to ensure that it is stable and within the normal range. In this study, we detected glucose concentration using commercial light emitting diodes (LEDs) with a wavelength of 700–1600 nm. Light of long wavelengths (e.g. NIR) infiltrate human skin and reach the blood vessel lining, thereby aiding in the non-invasive measurement of blood glucose concentration. To demonstrate this, the concentration of glucose solutions was measured using red and NIR-LEDs in a non-invasive manner. The sensitivity of glucose detection was greater when light of wavelength below 1000 nm was used, owing to the absorption of wavelengths above 1000 nm by water. Furthermore, we controlled the input current of the red and NIR-LEDs to confirm the light intensity deviation with increasing glucose concentrations and suggested the optimum wavelength of light using this in-vitro system. Among various LEDs, the 700 nm LED showed higher light intensity deviation with change in injection current compared to LEDs with the other wavelengths. In particular, compared to other LEDs, a stark difference was observed in the light intensity of the 700 nm LED while measuring glucose concentrations in the range of 50–100 mg/dl.},
 year = {2021}
}

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TY  - JOUR
T1  - Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes
AU  - Semi Oh
AU  - Min-Seok Kim
AU  - Beom-Rae Noh
AU  - Hyung-Hwan Baik
AU  - Kyoung-Kook Kim
Y1  - 2021/05/14
PY  - 2021
N1  - https://doi.org/10.11648/j.bs.20210702.12
DO  - 10.11648/j.bs.20210702.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 47
EP  - 52
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20210702.12
AB  - Many diabetic mellitus patients envision a non-invasive method of blood glucose measurement since they require periodic monitoring of their blood glucose levels to ensure that it is stable and within the normal range. In this study, we detected glucose concentration using commercial light emitting diodes (LEDs) with a wavelength of 700–1600 nm. Light of long wavelengths (e.g. NIR) infiltrate human skin and reach the blood vessel lining, thereby aiding in the non-invasive measurement of blood glucose concentration. To demonstrate this, the concentration of glucose solutions was measured using red and NIR-LEDs in a non-invasive manner. The sensitivity of glucose detection was greater when light of wavelength below 1000 nm was used, owing to the absorption of wavelengths above 1000 nm by water. Furthermore, we controlled the input current of the red and NIR-LEDs to confirm the light intensity deviation with increasing glucose concentrations and suggested the optimum wavelength of light using this in-vitro system. Among various LEDs, the 700 nm LED showed higher light intensity deviation with change in injection current compared to LEDs with the other wavelengths. In particular, compared to other LEDs, a stark difference was observed in the light intensity of the 700 nm LED while measuring glucose concentrations in the range of 50–100 mg/dl.
VL  - 7
IS  - 2
ER  -

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Author Information

Semi Oh

Department of Medicine, Kyung Hee University, Seoul, Republic of Korea
Min-Seok Kim

Department of Medicine, Kyung Hee University, Seoul, Republic of Korea
Beom-Rae Noh

Department of Nano & Semiconductor Engineering, Korea Polytechnic University, Siheung, Republic of Korea
Hyung-Hwan Baik

Department of Medicine, Kyung Hee University, Seoul, Republic of Korea
Kyoung-Kook Kim

Department of Nano & Semiconductor Engineering, Korea Polytechnic University, Siheung, Republic of Korea

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APA Style

Semi Oh, Min-Seok Kim, Beom-Rae Noh, Hyung-Hwan Baik, Kyoung-Kook Kim. (2021). Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes. Biomedical Sciences, 7(2), 47-52. https://doi.org/10.11648/j.bs.20210702.12

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ACS Style

Semi Oh; Min-Seok Kim; Beom-Rae Noh; Hyung-Hwan Baik; Kyoung-Kook Kim. Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes. Biomed. Sci. 2021, 7(2), 47-52. doi: 10.11648/j.bs.20210702.12

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AMA Style

Semi Oh, Min-Seok Kim, Beom-Rae Noh, Hyung-Hwan Baik, Kyoung-Kook Kim. Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes. Biomed Sci. 2021;7(2):47-52. doi: 10.11648/j.bs.20210702.12

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@article{10.11648/j.bs.20210702.12,
  author = {Semi Oh and Min-Seok Kim and Beom-Rae Noh and Hyung-Hwan Baik and Kyoung-Kook Kim},
  title = {Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes},
  journal = {Biomedical Sciences},
  volume = {7},
  number = {2},
  pages = {47-52},
  doi = {10.11648/j.bs.20210702.12},
  url = {https://doi.org/10.11648/j.bs.20210702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20210702.12},
  abstract = {Many diabetic mellitus patients envision a non-invasive method of blood glucose measurement since they require periodic monitoring of their blood glucose levels to ensure that it is stable and within the normal range. In this study, we detected glucose concentration using commercial light emitting diodes (LEDs) with a wavelength of 700–1600 nm. Light of long wavelengths (e.g. NIR) infiltrate human skin and reach the blood vessel lining, thereby aiding in the non-invasive measurement of blood glucose concentration. To demonstrate this, the concentration of glucose solutions was measured using red and NIR-LEDs in a non-invasive manner. The sensitivity of glucose detection was greater when light of wavelength below 1000 nm was used, owing to the absorption of wavelengths above 1000 nm by water. Furthermore, we controlled the input current of the red and NIR-LEDs to confirm the light intensity deviation with increasing glucose concentrations and suggested the optimum wavelength of light using this in-vitro system. Among various LEDs, the 700 nm LED showed higher light intensity deviation with change in injection current compared to LEDs with the other wavelengths. In particular, compared to other LEDs, a stark difference was observed in the light intensity of the 700 nm LED while measuring glucose concentrations in the range of 50–100 mg/dl.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Non-Invasive Measurement of Glucose Concentration Using Red and Near-Infrared Light-Emitting Diodes
AU  - Semi Oh
AU  - Min-Seok Kim
AU  - Beom-Rae Noh
AU  - Hyung-Hwan Baik
AU  - Kyoung-Kook Kim
Y1  - 2021/05/14
PY  - 2021
N1  - https://doi.org/10.11648/j.bs.20210702.12
DO  - 10.11648/j.bs.20210702.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 47
EP  - 52
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20210702.12
AB  - Many diabetic mellitus patients envision a non-invasive method of blood glucose measurement since they require periodic monitoring of their blood glucose levels to ensure that it is stable and within the normal range. In this study, we detected glucose concentration using commercial light emitting diodes (LEDs) with a wavelength of 700–1600 nm. Light of long wavelengths (e.g. NIR) infiltrate human skin and reach the blood vessel lining, thereby aiding in the non-invasive measurement of blood glucose concentration. To demonstrate this, the concentration of glucose solutions was measured using red and NIR-LEDs in a non-invasive manner. The sensitivity of glucose detection was greater when light of wavelength below 1000 nm was used, owing to the absorption of wavelengths above 1000 nm by water. Furthermore, we controlled the input current of the red and NIR-LEDs to confirm the light intensity deviation with increasing glucose concentrations and suggested the optimum wavelength of light using this in-vitro system. Among various LEDs, the 700 nm LED showed higher light intensity deviation with change in injection current compared to LEDs with the other wavelengths. In particular, compared to other LEDs, a stark difference was observed in the light intensity of the 700 nm LED while measuring glucose concentrations in the range of 50–100 mg/dl.
VL  - 7
IS  - 2
ER  -

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