The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy

Beatrice Wobiarueri Moore-Igwe; Ransom Baribefii Jacob; Serekara Gideon Christian; Evelyn Mgbeoma Eze

doi:doi:10.11648/j.bs.20220802.12

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The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy

Beatrice Wobiarueri Moore-Igwe, Ransom Baribefii Jacob, Serekara Gideon Christian, Evelyn Mgbeoma Eze

Published in Biomedical Sciences (Volume 8, Issue 2)

Received: 17 February 2022 Accepted: 15 March 2022 Published: 31 May 2022

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Abstract

Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively, we examined the effect of cART on the NLR in HIV+ patients presenting to begin cART in Rivers State University Teaching Hospital. Aim: This study is aimed at determining the effect of anti-retroviral therapy on Neutrophil Lymphocyte Ratio in Human Immunodeficiency Virus Positive Patients. Methods: Four (4) millilitre of blood sample each was collected using a vacutainer containing 0.5 ml of 1.2 mg/ml of K₂EDTA was collected from 40 subjects recruited for the study. Samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems). Results: Subjects mean age was 36.20 years, 14 (35%) of them were males and 26 (65%) were females. Mean Neutrophil: Lymphocyte ratio and HIV viral load (VL) at Month 0, 3 and 6 months were 1.539±1.094 and 215767.85±360338.04 cp/ml, 0.902±0.358 and 705.650±684.220cp/ml and 29.330±17.869cp/ml 0.676±0.171 respectively. There was a statistically significant increase (p < 0.001) in the measured parameters. Conclusion: There is a plethora of proof which this study agrees with and that is the fact that viral load and inflammation in HIV+ patients reduce considerably by cART. Study has validated the prognostic effect of NLR in the early detection of inflammation. It is therefore necessary to routinely review cART impact using NLR. It is therefore necessary to routinely review cART impact using NLR.

Published in	Biomedical Sciences (Volume 8, Issue 2)
DOI	10.11648/j.bs.20220802.12
Page(s)	57-62
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Neutrophil/Lymphocyte Ratio (NLR), Combined Antiretroviral Therapy (cART), Human Immunodeficiency Virus (HIV), Viral Load (VL)

References

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APA Style

Beatrice Wobiarueri Moore-Igwe, Ransom Baribefii Jacob, Serekara Gideon Christian, Evelyn Mgbeoma Eze. (2022). The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy. Biomedical Sciences, 8(2), 57-62. https://doi.org/10.11648/j.bs.20220802.12

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ACS Style

Beatrice Wobiarueri Moore-Igwe; Ransom Baribefii Jacob; Serekara Gideon Christian; Evelyn Mgbeoma Eze. The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy. Biomed. Sci. 2022, 8(2), 57-62. doi: 10.11648/j.bs.20220802.12

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AMA Style

Beatrice Wobiarueri Moore-Igwe, Ransom Baribefii Jacob, Serekara Gideon Christian, Evelyn Mgbeoma Eze. The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy. Biomed Sci. 2022;8(2):57-62. doi: 10.11648/j.bs.20220802.12

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@article{10.11648/j.bs.20220802.12,
  author = {Beatrice Wobiarueri Moore-Igwe and Ransom Baribefii Jacob and Serekara Gideon Christian and Evelyn Mgbeoma Eze},
  title = {The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy},
  journal = {Biomedical Sciences},
  volume = {8},
  number = {2},
  pages = {57-62},
  doi = {10.11648/j.bs.20220802.12},
  url = {https://doi.org/10.11648/j.bs.20220802.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20220802.12},
  abstract = {Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively, we examined the effect of cART on the NLR in HIV+ patients presenting to begin cART in Rivers State University Teaching Hospital. Aim: This study is aimed at determining the effect of anti-retroviral therapy on Neutrophil Lymphocyte Ratio in Human Immunodeficiency Virus Positive Patients. Methods: Four (4) millilitre of blood sample each was collected using a vacutainer containing 0.5 ml of 1.2 mg/ml of K2EDTA was collected from 40 subjects recruited for the study. Samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems). Results: Subjects mean age was 36.20 years, 14 (35%) of them were males and 26 (65%) were females. Mean Neutrophil: Lymphocyte ratio and HIV viral load (VL) at Month 0, 3 and 6 months were 1.539±1.094 and 215767.85±360338.04 cp/ml, 0.902±0.358 and 705.650±684.220cp/ml and 29.330±17.869cp/ml 0.676±0.171 respectively. There was a statistically significant increase (p Conclusion: There is a plethora of proof which this study agrees with and that is the fact that viral load and inflammation in HIV+ patients reduce considerably by cART. Study has validated the prognostic effect of NLR in the early detection of inflammation. It is therefore necessary to routinely review cART impact using NLR. It is therefore necessary to routinely review cART impact using NLR.},
 year = {2022}
}

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TY  - JOUR
T1  - The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy
AU  - Beatrice Wobiarueri Moore-Igwe
AU  - Ransom Baribefii Jacob
AU  - Serekara Gideon Christian
AU  - Evelyn Mgbeoma Eze
Y1  - 2022/05/31
PY  - 2022
N1  - https://doi.org/10.11648/j.bs.20220802.12
DO  - 10.11648/j.bs.20220802.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 57
EP  - 62
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20220802.12
AB  - Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively, we examined the effect of cART on the NLR in HIV+ patients presenting to begin cART in Rivers State University Teaching Hospital. Aim: This study is aimed at determining the effect of anti-retroviral therapy on Neutrophil Lymphocyte Ratio in Human Immunodeficiency Virus Positive Patients. Methods: Four (4) millilitre of blood sample each was collected using a vacutainer containing 0.5 ml of 1.2 mg/ml of K2EDTA was collected from 40 subjects recruited for the study. Samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems). Results: Subjects mean age was 36.20 years, 14 (35%) of them were males and 26 (65%) were females. Mean Neutrophil: Lymphocyte ratio and HIV viral load (VL) at Month 0, 3 and 6 months were 1.539±1.094 and 215767.85±360338.04 cp/ml, 0.902±0.358 and 705.650±684.220cp/ml and 29.330±17.869cp/ml 0.676±0.171 respectively. There was a statistically significant increase (p Conclusion: There is a plethora of proof which this study agrees with and that is the fact that viral load and inflammation in HIV+ patients reduce considerably by cART. Study has validated the prognostic effect of NLR in the early detection of inflammation. It is therefore necessary to routinely review cART impact using NLR. It is therefore necessary to routinely review cART impact using NLR.
VL  - 8
IS  - 2
ER  -

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Author Information

Beatrice Wobiarueri Moore-Igwe

Department of Medical Laboratory Science, Rivers State University, Port-Harcourt, Nigeria
Ransom Baribefii Jacob

Department of Medical Laboratory Science, Rivers State University, Port-Harcourt, Nigeria
Serekara Gideon Christian

Department of Medical Laboratory Science, Rivers State University, Port-Harcourt, Nigeria
Evelyn Mgbeoma Eze

Department of Medical Laboratory Science, Rivers State University, Port-Harcourt, Nigeria

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Beatrice Wobiarueri Moore-Igwe, Ransom Baribefii Jacob, Serekara Gideon Christian, Evelyn Mgbeoma Eze. (2022). The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy. Biomedical Sciences, 8(2), 57-62. https://doi.org/10.11648/j.bs.20220802.12

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ACS Style

Beatrice Wobiarueri Moore-Igwe; Ransom Baribefii Jacob; Serekara Gideon Christian; Evelyn Mgbeoma Eze. The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy. Biomed. Sci. 2022, 8(2), 57-62. doi: 10.11648/j.bs.20220802.12

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AMA Style

Beatrice Wobiarueri Moore-Igwe, Ransom Baribefii Jacob, Serekara Gideon Christian, Evelyn Mgbeoma Eze. The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy. Biomed Sci. 2022;8(2):57-62. doi: 10.11648/j.bs.20220802.12

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@article{10.11648/j.bs.20220802.12,
  author = {Beatrice Wobiarueri Moore-Igwe and Ransom Baribefii Jacob and Serekara Gideon Christian and Evelyn Mgbeoma Eze},
  title = {The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy},
  journal = {Biomedical Sciences},
  volume = {8},
  number = {2},
  pages = {57-62},
  doi = {10.11648/j.bs.20220802.12},
  url = {https://doi.org/10.11648/j.bs.20220802.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20220802.12},
  abstract = {Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively, we examined the effect of cART on the NLR in HIV+ patients presenting to begin cART in Rivers State University Teaching Hospital. Aim: This study is aimed at determining the effect of anti-retroviral therapy on Neutrophil Lymphocyte Ratio in Human Immunodeficiency Virus Positive Patients. Methods: Four (4) millilitre of blood sample each was collected using a vacutainer containing 0.5 ml of 1.2 mg/ml of K2EDTA was collected from 40 subjects recruited for the study. Samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems). Results: Subjects mean age was 36.20 years, 14 (35%) of them were males and 26 (65%) were females. Mean Neutrophil: Lymphocyte ratio and HIV viral load (VL) at Month 0, 3 and 6 months were 1.539±1.094 and 215767.85±360338.04 cp/ml, 0.902±0.358 and 705.650±684.220cp/ml and 29.330±17.869cp/ml 0.676±0.171 respectively. There was a statistically significant increase (p Conclusion: There is a plethora of proof which this study agrees with and that is the fact that viral load and inflammation in HIV+ patients reduce considerably by cART. Study has validated the prognostic effect of NLR in the early detection of inflammation. It is therefore necessary to routinely review cART impact using NLR. It is therefore necessary to routinely review cART impact using NLR.},
 year = {2022}
}

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TY  - JOUR
T1  - The Effect of cART on Neutrophil: Lymphocyte Ratio in HIV+ Patients Initiating Combined Antiretroviral Therapy
AU  - Beatrice Wobiarueri Moore-Igwe
AU  - Ransom Baribefii Jacob
AU  - Serekara Gideon Christian
AU  - Evelyn Mgbeoma Eze
Y1  - 2022/05/31
PY  - 2022
N1  - https://doi.org/10.11648/j.bs.20220802.12
DO  - 10.11648/j.bs.20220802.12
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 57
EP  - 62
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20220802.12
AB  - Background: Combined antiretroviral therapy (cART) has caused increased quality of life in Human immunodeficiency virus (HIV) positive patients and administration of this therapy comes with toxicity and possible inflammation. Neutrophil/Lymphocyte Ratio (NLR) is known to link with inflammation, atherosclerosis and platelet activation. Prospectively, we examined the effect of cART on the NLR in HIV+ patients presenting to begin cART in Rivers State University Teaching Hospital. Aim: This study is aimed at determining the effect of anti-retroviral therapy on Neutrophil Lymphocyte Ratio in Human Immunodeficiency Virus Positive Patients. Methods: Four (4) millilitre of blood sample each was collected using a vacutainer containing 0.5 ml of 1.2 mg/ml of K2EDTA was collected from 40 subjects recruited for the study. Samples were collected at entry into the study, after 3 months and 6 months on ART respectively for Full Blood Count using a 3-part Sysmex XP300 and HIV Viral Load with RT-PCR using Cobas TaqMan version 1.5 (Roche Molecular Systems). Results: Subjects mean age was 36.20 years, 14 (35%) of them were males and 26 (65%) were females. Mean Neutrophil: Lymphocyte ratio and HIV viral load (VL) at Month 0, 3 and 6 months were 1.539±1.094 and 215767.85±360338.04 cp/ml, 0.902±0.358 and 705.650±684.220cp/ml and 29.330±17.869cp/ml 0.676±0.171 respectively. There was a statistically significant increase (p Conclusion: There is a plethora of proof which this study agrees with and that is the fact that viral load and inflammation in HIV+ patients reduce considerably by cART. Study has validated the prognostic effect of NLR in the early detection of inflammation. It is therefore necessary to routinely review cART impact using NLR. It is therefore necessary to routinely review cART impact using NLR.
VL  - 8
IS  - 2
ER  -

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