Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review

Kenneth Chinedu Ugoeze; Inderbir Singh Bakshi; Bruno Chukwuemeka Chinko; Kennedy Emeka Oluigbo; Ngozi Augustine Okoronkwo; Christian Arerusuoghene Alalor

doi:doi:10.11648/j.bs.20230901.14

Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review

Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, Christian Arerusuoghene Alalor

Published in Biomedical Sciences (Volume 9, Issue 1)

Received: 11 February 2023 Accepted: 27 February 2023 Published: 9 March 2023

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Abstract

In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.

Published in	Biomedical Sciences (Volume 9, Issue 1)
DOI	10.11648/j.bs.20230901.14
Page(s)	18-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2023. Published by Science Publishing Group

Keywords

Resveratrol, 3,4′,5-trihydroxy-trans-stilbene, Antioxidant, Phytopharmaceutical

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Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. (2023). Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomedical Sciences, 9(1), 18-29. https://doi.org/10.11648/j.bs.20230901.14

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Kenneth Chinedu Ugoeze; Inderbir Singh Bakshi; Bruno Chukwuemeka Chinko; Kennedy Emeka Oluigbo; Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed. Sci. 2023, 9(1), 18-29. doi: 10.11648/j.bs.20230901.14

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Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed Sci. 2023;9(1):18-29. doi: 10.11648/j.bs.20230901.14

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@article{10.11648/j.bs.20230901.14,
  author = {Kenneth Chinedu Ugoeze and Inderbir Singh Bakshi and Bruno Chukwuemeka Chinko and Kennedy Emeka Oluigbo and Ngozi Augustine Okoronkwo and Christian Arerusuoghene Alalor},
  title = {Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {1},
  pages = {18-29},
  doi = {10.11648/j.bs.20230901.14},
  url = {https://doi.org/10.11648/j.bs.20230901.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230901.14},
  abstract = {In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.},
 year = {2023}
}

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TY  - JOUR
T1  - Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review
AU  - Kenneth Chinedu Ugoeze
AU  - Inderbir Singh Bakshi
AU  - Bruno Chukwuemeka Chinko
AU  - Kennedy Emeka Oluigbo
AU  - Ngozi Augustine Okoronkwo
AU  - Christian Arerusuoghene Alalor
Y1  - 2023/03/09
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230901.14
DO  - 10.11648/j.bs.20230901.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230901.14
AB  - In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.
VL  - 9
IS  - 1
ER  -

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Author Information

Kenneth Chinedu Ugoeze

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Inderbir Singh Bakshi

Department of Pharmaceutics, Chitkara College of Pharmacy, Chitkara University, Punjab, India
Bruno Chukwuemeka Chinko

Department of Human Physiology, Faculty of Basic Medical Sciences, University of Port Harcourt, Port Harcourt, Nigeria
Kennedy Emeka Oluigbo

Department of Clinical Pharmacy and Biopharmaceutics, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani City, Nigeria
Ngozi Augustine Okoronkwo

Department of Zoology & Environmental Biology, Michael Okpara University of Agriculture, Umudike, Nigeria
Christian Arerusuoghene Alalor

Department of Pharmaceutics and Industrial Pharmacy, Delta State University, Abraka, Nigeria

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APA Style

Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. (2023). Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomedical Sciences, 9(1), 18-29. https://doi.org/10.11648/j.bs.20230901.14

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ACS Style

Kenneth Chinedu Ugoeze; Inderbir Singh Bakshi; Bruno Chukwuemeka Chinko; Kennedy Emeka Oluigbo; Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed. Sci. 2023, 9(1), 18-29. doi: 10.11648/j.bs.20230901.14

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AMA Style

Kenneth Chinedu Ugoeze, Inderbir Singh Bakshi, Bruno Chukwuemeka Chinko, Kennedy Emeka Oluigbo, Ngozi Augustine Okoronkwo, et al. Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review. Biomed Sci. 2023;9(1):18-29. doi: 10.11648/j.bs.20230901.14

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@article{10.11648/j.bs.20230901.14,
  author = {Kenneth Chinedu Ugoeze and Inderbir Singh Bakshi and Bruno Chukwuemeka Chinko and Kennedy Emeka Oluigbo and Ngozi Augustine Okoronkwo and Christian Arerusuoghene Alalor},
  title = {Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review},
  journal = {Biomedical Sciences},
  volume = {9},
  number = {1},
  pages = {18-29},
  doi = {10.11648/j.bs.20230901.14},
  url = {https://doi.org/10.11648/j.bs.20230901.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bs.20230901.14},
  abstract = {In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.},
 year = {2023}
}

Copy | Download

TY  - JOUR
T1  - Phytopharmaceutical Benefits of Resveratrol in the Management of Diseases and Health Maintenance: A Review
AU  - Kenneth Chinedu Ugoeze
AU  - Inderbir Singh Bakshi
AU  - Bruno Chukwuemeka Chinko
AU  - Kennedy Emeka Oluigbo
AU  - Ngozi Augustine Okoronkwo
AU  - Christian Arerusuoghene Alalor
Y1  - 2023/03/09
PY  - 2023
N1  - https://doi.org/10.11648/j.bs.20230901.14
DO  - 10.11648/j.bs.20230901.14
T2  - Biomedical Sciences
JF  - Biomedical Sciences
JO  - Biomedical Sciences
SP  - 18
EP  - 29
PB  - Science Publishing Group
SN  - 2575-3932
UR  - https://doi.org/10.11648/j.bs.20230901.14
AB  - In the last few decades, natural products have enjoyed an extensive range of acceptability for the prevention, treatment and management of various health conditions. Resveratrol (3,4′,5-trihydroxy-trans-stilbene) is a common phytoalexin found in grapes, peanuts, cocoa, and berries of Vaccinium species, together with blueberries, bilberries, and cranberries. Research interest in resveratrol has been increasing due to growing evidence of its many health benefits. This review is aimed at highlighting the various benefits of resveratrol in health and diseases. The present study reviewed published advances in the health-promoting benefits of resveratrol in human clinical trials as well as in animal experimental models with a focus on postulated molecular mechanisms of action. We discussed the sources, biochemistry, bioavailability and biological effects such as antioxidant, anti-inflammatory, anti-cancer, anti-platelet, anti-diabetic, immunomodulatory and cardio-protective, anti-obesity and neuroprotective effects. The study observed that these varieties of biotic influences are initiated by multiple molecular targets and pathways involving cyclooxygenases/lipooxygenases, kinases, sirtuins, transcription factors, cytokines, DNA polymerase, adenylyl cyclase, ribonucleotide reductase and aromatase and thus, enhancing their potential to influence many physiological processes. The study concludes that resveratrol has demonstrated a potent effect against several disease conditions, however, its low bioavailability greatly limits its applications. This review recommends further research direction in the development of health maintenance and therapeutic agents from resveratrol.
VL  - 9
IS  - 1
ER  -

Copy | Download