Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line

Angelo De Martino; Piera Torricelli; Hanan Mahmoud Abu-Zeid; Anna Shevchenko; Alberto Siciliano; Simone Beninati

doi:doi:10.11648/j.crj.20160402.11

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Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line

Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, Simone Beninati

Published in Cancer Research Journal (Volume 4, Issue 2)

Received: 2 February 2016 Accepted: 18 February 2016 Published: 1 March 2016

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Abstract

Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.

Published in	Cancer Research Journal (Volume 4, Issue 2)
DOI	10.11648/j.crj.20160402.11
Page(s)	28-31
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Water Garlic Extract, Copper, HepG2, p53, p21, AIF

References

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APA Style

Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, et al. (2016). Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Research Journal, 4(2), 28-31. https://doi.org/10.11648/j.crj.20160402.11

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ACS Style

Angelo De Martino; Piera Torricelli; Hanan Mahmoud Abu-Zeid; Anna Shevchenko; Alberto Siciliano, et al. Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Res. J. 2016, 4(2), 28-31. doi: 10.11648/j.crj.20160402.11

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AMA Style

Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, et al. Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Res J. 2016;4(2):28-31. doi: 10.11648/j.crj.20160402.11

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@article{10.11648/j.crj.20160402.11,
  author = {Angelo De Martino and Piera Torricelli and Hanan Mahmoud Abu-Zeid and Anna Shevchenko and Alberto Siciliano and Simone Beninati},
  title = {Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line},
  journal = {Cancer Research Journal},
  volume = {4},
  number = {2},
  pages = {28-31},
  doi = {10.11648/j.crj.20160402.11},
  url = {https://doi.org/10.11648/j.crj.20160402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160402.11},
  abstract = {Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.},
 year = {2016}
}

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TY  - JOUR
T1  - Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line
AU  - Angelo De Martino
AU  - Piera Torricelli
AU  - Hanan Mahmoud Abu-Zeid
AU  - Anna Shevchenko
AU  - Alberto Siciliano
AU  - Simone Beninati
Y1  - 2016/03/01
PY  - 2016
N1  - https://doi.org/10.11648/j.crj.20160402.11
DO  - 10.11648/j.crj.20160402.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 28
EP  - 31
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20160402.11
AB  - Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.
VL  - 4
IS  - 2
ER  -

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Author Information

Angelo De Martino

Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
Piera Torricelli

Department SPES, University of Molise, Campobasso, Italy
Hanan Mahmoud Abu-Zeid

Faculty of Science, Botany Department, Alexandria University, Alexandria, Egypt
Anna Shevchenko

People’s Friendship University of Russia, Moscow, Russia
Alberto Siciliano

Department of Biology, University of Rome “Tor Vergata”, Rome, Italy
Simone Beninati

Department of Biology, University of Rome “Tor Vergata”, Rome, Italy

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Plain Text BibTeX RIS

APA Style

Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, et al. (2016). Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Research Journal, 4(2), 28-31. https://doi.org/10.11648/j.crj.20160402.11

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ACS Style

Angelo De Martino; Piera Torricelli; Hanan Mahmoud Abu-Zeid; Anna Shevchenko; Alberto Siciliano, et al. Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Res. J. 2016, 4(2), 28-31. doi: 10.11648/j.crj.20160402.11

Copy | Download

AMA Style

Angelo De Martino, Piera Torricelli, Hanan Mahmoud Abu-Zeid, Anna Shevchenko, Alberto Siciliano, et al. Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line. Cancer Res J. 2016;4(2):28-31. doi: 10.11648/j.crj.20160402.11

Copy | Download

@article{10.11648/j.crj.20160402.11,
  author = {Angelo De Martino and Piera Torricelli and Hanan Mahmoud Abu-Zeid and Anna Shevchenko and Alberto Siciliano and Simone Beninati},
  title = {Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line},
  journal = {Cancer Research Journal},
  volume = {4},
  number = {2},
  pages = {28-31},
  doi = {10.11648/j.crj.20160402.11},
  url = {https://doi.org/10.11648/j.crj.20160402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20160402.11},
  abstract = {Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.},
 year = {2016}
}

Copy | Download

TY  - JOUR
T1  - Synergistic Anticancer Potential of Water Garlic Extract and Copper in a Human Hepatocarcinoma Cell Line
AU  - Angelo De Martino
AU  - Piera Torricelli
AU  - Hanan Mahmoud Abu-Zeid
AU  - Anna Shevchenko
AU  - Alberto Siciliano
AU  - Simone Beninati
Y1  - 2016/03/01
PY  - 2016
N1  - https://doi.org/10.11648/j.crj.20160402.11
DO  - 10.11648/j.crj.20160402.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 28
EP  - 31
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20160402.11
AB  - Garlic extract in water, supplemented with copper, exerts an enhanced anti-proliferative and a caspase-independent apoptotic activity in a human hepatocarcinoma HepG2 cancer cell line. Furthermore, a DNA double strand break downstream, likely responsible for the observed cell death in HepG2 cell, was evidenced by an early over expression of p53 and p21. This observed synergistic antiproliferative and antitumor capability of water garlic extract, in the presence of copper, might be useful as new tool in cancer prevention and therapy.
VL  - 4
IS  - 2
ER  -

Copy | Download