Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science.
| Published in | Cancer Research Journal (Volume 6, Issue 2) |
| DOI | 10.11648/j.crj.20180602.11 |
| Page(s) | 38-46 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2018. Published by Science Publishing Group |
Anticancer Agent, Antiproliferative Activity, Sorghum bicolor, Phytochemicals
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APA Style
Francis Agada, Chika Muhammad, Ahmad Uba, Halilu Emmanuel Mshelia, Halima Lawal Zubairu. (2018). Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus. Cancer Research Journal, 6(2), 38-46. https://doi.org/10.11648/j.crj.20180602.11
ACS Style
Francis Agada; Chika Muhammad; Ahmad Uba; Halilu Emmanuel Mshelia; Halima Lawal Zubairu. Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus. Cancer Res. J. 2018, 6(2), 38-46. doi: 10.11648/j.crj.20180602.11
AMA Style
Francis Agada, Chika Muhammad, Ahmad Uba, Halilu Emmanuel Mshelia, Halima Lawal Zubairu. Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus. Cancer Res J. 2018;6(2):38-46. doi: 10.11648/j.crj.20180602.11
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Download@article{10.11648/j.crj.20180602.11,
author = {Francis Agada and Chika Muhammad and Ahmad Uba and Halilu Emmanuel Mshelia and Halima Lawal Zubairu},
title = {Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus},
journal = {Cancer Research Journal},
volume = {6},
number = {2},
pages = {38-46},
doi = {10.11648/j.crj.20180602.11},
url = {https://doi.org/10.11648/j.crj.20180602.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20180602.11},
abstract = {Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science.},
year = {2018}
}
TY - JOUR T1 - Comparative Antiproliferative Activity of Leaf and Stem Bark Extracts of Detarium senegalense and Leaf of Cymbopogon citratus AU - Francis Agada AU - Chika Muhammad AU - Ahmad Uba AU - Halilu Emmanuel Mshelia AU - Halima Lawal Zubairu Y1 - 2018/03/07 PY - 2018 N1 - https://doi.org/10.11648/j.crj.20180602.11 DO - 10.11648/j.crj.20180602.11 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 38 EP - 46 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20180602.11 AB - Malignant cancer cells exhibit uncontrollable high proliferation similarly to meristematic cells of seeds, this led to the establishment that agents capable of producing antiproliferative effects are potential anticancer agents. The experimental plant used for this research was Sorghum bicolor seeds. The sole aim of this research work is to unveil the antiproliferative potential of Detarium senegalense and to evaluate the antiproliferative activity of leaf extract of Cymbopogon citratus on radicle length of Sorghum bicolor seeds. The three extracts were prepared at concentrations of 10, 20, 40, 60, 80 and 100 mg/cm3 as well as methotrexate (reference standard) at concentration of 0.05 mg/cm3. The growth lengths were measured at 24, 48 and 72 hours of the experiment and expressed as percentage inhibition and percentage growth. The extracts produced considerable amount of antiproliferative effect on the radicle length of the seeds. The antiproliferative activity of the three extracts were concentration (dose) dependent, as the concentration of the extracts of leaves of D. senegalense increases, the percentage inhibition also increases, with a percentage of 89.47 % at an optimum concentration of 100 mg/cm3. Similarly, D. senegalense stem bark and C. citratus leaves showed percentage inhibition which corresponds to 73.68 % at optimum concentration of 100 mg/cm3 and 86.84 % at an optimum concentration of 80 mg/cm3 after the 72 hours of the incubation period. This research work however, has unveiled the use of D. senegalense as potential therapeutics for cancer treatment especially in developing countries, and has added a new-found knowledge to science. VL - 6 IS - 2 ER -
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