Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique

Md. Zillur Rahman Bhuiyan; Mamun Or Rashid; Sadia Sharmin; Moshiur Rahman; Samia Ahmed

doi:doi:10.11648/j.crj.20200802.11

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Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique

Md. Zillur Rahman Bhuiyan, Mamun Or Rashid, Sadia Sharmin, Moshiur Rahman, Samia Ahmed

Published in Cancer Research Journal (Volume 8, Issue 2)

Received: 4 January 2020 Accepted: 19 March 2020 Published: 23 April 2020

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Abstract

Background: Carcinoma of the cervix is the fourth most common cancer in women in the world.In 2018,an estimated 570000 women were diagnosed with cervical cancer worldwide and about 311000 women died from the disease. Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women due to lack of screening, high prevalence of risk factors and poor socio-economic condition. Methods: In this prospective observational study total 90 number of subjects were enrolled to compare the effectiveness of external beam radiation therapy by four field box technique versus two field technique in the treatment of locally advanced carcinoma of uterine cervix. Clinically and histologically diagnosed squamous cell carcinoma of uterine cervix patients were selected as study population. Results: In this study the highest number of patients were in between 46 to 55 years. Most of the subject used Oral contraceptive pill more than 5 years. Most of the patients were in stage IIB.Most of the patients were presented with postcoital bleeding, anemia, vaginal discharge , loss of appetite , Intermenstrual bleeding and pelvic pain. After completion of treatment follow-up per vaginal examination revealed that 73.33% subjects had complete response in four field group (Arm A). In two field group (Arm B), 57.78% had complete response. Common toxicities related to treatment were nausea, vomiting, diarrhea, skin reaction, anemia, leucopenia, bladder toxicity and rectal toxicity. Conclusion: From this study it can be concluded that four field box technique in EBRT was statistically effective in relieving symptoms and achieving complete response than two field technique in the treatment of locally advanced carcinoma of uterine cervix.

Published in	Cancer Research Journal (Volume 8, Issue 2)
DOI	10.11648/j.crj.20200802.11
Page(s)	20-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

CCRT (Concurrent Chemo-Radiation), EBRT (External Beam Radiation Therapy), RT (Radiotherapy), BT (Brachytherapy)

References

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[4]	Duenas-G A, Cetina L, Mariscal ! and Garza J 2003, "Modem Management of Locally Advanced Cervical Carcinoma: Cancer Treatment Reviews”, vol. 29. pp. 389-399.
[5]	FIGO Committee on Gynecologic Oncology 2009. "Revised FIGO staging for carcinoma of the vulva, cervix, and endometrium”. International Journal of Gynecology and Obstetrics, vol. 105, pp. 103-104.
[6]	Halperin EC, Perez CA, Brady LW 2013, Perez and Brady's Principles and Practice of Oncology, 6th edition; Lippincot Williams & Wilkins.
[7]	IARC 2007, International Agency for Research on Cancer and Globocan. Available at http://wwwdep.iarc.fr/.
[8]	Keys MM, Roberts JA, Brunetto VL, 2004. A phase III trial of surgery with or without adjunctive external pelvic radiation therapy in intermediate risk endometrial adenocarcinoma: a Gynecologic Oncology Group study. Gynecol Oncol, vol 92. no. 3, pp. 744-51.
[9]	Maula KJ 2010, “Recent managemen of cervical cancer. 22nd AGM and Scientific seminar-2010 (2011. February 5)‘ Ba lgladesh cancer society, pp. 36.
[10]	Pazdur R, Wagman LD, Camhauscn KA, Hoskins WJ. Cancer Management: A Multidisciplinary Approach, 13th edition, 2010 UBM Medica LLC, New York.
[11]	Randall ME, Filiaci VL, Muss H, Spirtos NM, Mannel RS, Fowler J 2006,. "Randomized phase III trial of whole-abdominal irradiation versus doxorubicin and cisplatin chemotherapy in advanced endometrial carcinoma”: a Gynecologic Oncology Group Study. J Clin Oncol, vol. 24, no. l, pp. 36-40.
[12]	Rubin P, Williams JP. Cli cal Oncology, A Multidisciplinary Approach for Physicians and Students, 8th edition, 2001 W. B. Saunders Company, Newyork. London, Sydney.
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[15]	Stewart AJ, Viswanathan AN 2006. Current controversies in high-dose-ratc versus low-dose-rate brachytherapy for cervical cancer vol. 107, no. 5, pp. 908-15.
[16]	WHO/ICO Innformation center on HPV and Cervical Cancer (HPV information Center). Human papillomavirus and related cancers in Bangladesh. Summary report 2010.
[17]	Xunino S, Rosato O, Lucino S, Jaur gui E, Rossi L, Venencia D. Anatomic study of the pelvis in carcinoma of uterine cervix as releated to the box technique. Int J Radial Oncol Biol Phys 1999, vol. 44, pp. 53-59.
[18]	Zhang X, Dai, B. Zhang. B. Wang, Z 2011, Risk of cervical cancer: A meta-analysis. Gynecologic oncology vol. 124. no. 2, pp. 366-73.

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Md. Zillur Rahman Bhuiyan, Mamun Or Rashid, Sadia Sharmin, Moshiur Rahman, Samia Ahmed. (2020). Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique. Cancer Research Journal, 8(2), 20-25. https://doi.org/10.11648/j.crj.20200802.11

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ACS Style

Md. Zillur Rahman Bhuiyan; Mamun Or Rashid; Sadia Sharmin; Moshiur Rahman; Samia Ahmed. Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique. Cancer Res. J. 2020, 8(2), 20-25. doi: 10.11648/j.crj.20200802.11

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AMA Style

Md. Zillur Rahman Bhuiyan, Mamun Or Rashid, Sadia Sharmin, Moshiur Rahman, Samia Ahmed. Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique. Cancer Res J. 2020;8(2):20-25. doi: 10.11648/j.crj.20200802.11

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@article{10.11648/j.crj.20200802.11,
  author = {Md. Zillur Rahman Bhuiyan and Mamun Or Rashid and Sadia Sharmin and Moshiur Rahman and Samia Ahmed},
  title = {Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique},
  journal = {Cancer Research Journal},
  volume = {8},
  number = {2},
  pages = {20-25},
  doi = {10.11648/j.crj.20200802.11},
  url = {https://doi.org/10.11648/j.crj.20200802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200802.11},
  abstract = {Background: Carcinoma of the cervix is the fourth most common cancer in women in the world.In 2018,an estimated 570000 women were diagnosed with cervical cancer worldwide and about 311000 women died from the disease.  Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women due to lack of screening, high prevalence of risk factors and poor socio-economic condition. Methods: In this prospective observational study total 90 number of subjects were enrolled to compare the effectiveness of external beam radiation therapy by four field box technique versus two field technique in the treatment of locally advanced carcinoma of uterine cervix. Clinically and histologically diagnosed squamous cell carcinoma of uterine cervix patients were selected as study population. Results: In this study the highest number of patients were  in between 46 to 55 years. Most of the subject used Oral contraceptive pill more than 5 years. Most of the patients were in stage IIB.Most of the patients were presented with postcoital bleeding, anemia, vaginal discharge , loss of appetite , Intermenstrual bleeding  and pelvic pain. After completion of treatment follow-up per vaginal examination revealed that 73.33% subjects had complete response in four field group (Arm A). In two field group (Arm B), 57.78% had complete response. Common toxicities related to treatment were nausea, vomiting, diarrhea, skin reaction, anemia, leucopenia, bladder toxicity and rectal toxicity. Conclusion: From this study it can be concluded that four field box technique in EBRT was statistically effective in relieving symptoms and  achieving complete response than two field technique in the treatment of locally advanced carcinoma of uterine cervix.},
 year = {2020}
}

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TY  - JOUR
T1  - Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique
AU  - Md. Zillur Rahman Bhuiyan
AU  - Mamun Or Rashid
AU  - Sadia Sharmin
AU  - Moshiur Rahman
AU  - Samia Ahmed
Y1  - 2020/04/23
PY  - 2020
N1  - https://doi.org/10.11648/j.crj.20200802.11
DO  - 10.11648/j.crj.20200802.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20200802.11
AB  - Background: Carcinoma of the cervix is the fourth most common cancer in women in the world.In 2018,an estimated 570000 women were diagnosed with cervical cancer worldwide and about 311000 women died from the disease.  Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women due to lack of screening, high prevalence of risk factors and poor socio-economic condition. Methods: In this prospective observational study total 90 number of subjects were enrolled to compare the effectiveness of external beam radiation therapy by four field box technique versus two field technique in the treatment of locally advanced carcinoma of uterine cervix. Clinically and histologically diagnosed squamous cell carcinoma of uterine cervix patients were selected as study population. Results: In this study the highest number of patients were  in between 46 to 55 years. Most of the subject used Oral contraceptive pill more than 5 years. Most of the patients were in stage IIB.Most of the patients were presented with postcoital bleeding, anemia, vaginal discharge , loss of appetite , Intermenstrual bleeding  and pelvic pain. After completion of treatment follow-up per vaginal examination revealed that 73.33% subjects had complete response in four field group (Arm A). In two field group (Arm B), 57.78% had complete response. Common toxicities related to treatment were nausea, vomiting, diarrhea, skin reaction, anemia, leucopenia, bladder toxicity and rectal toxicity. Conclusion: From this study it can be concluded that four field box technique in EBRT was statistically effective in relieving symptoms and  achieving complete response than two field technique in the treatment of locally advanced carcinoma of uterine cervix.
VL  - 8
IS  - 2
ER  -

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Author Information

Md. Zillur Rahman Bhuiyan

Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Mamun Or Rashid

Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Sadia Sharmin

Department of Oncology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Moshiur Rahman

Department of Radiation Oncology, National Institute of Cancer Research Hospital, Dhaka, Bangladesh
Samia Ahmed

Department of Radiation Oncology, National Institute of Cancer Research Hospital, Dhaka, Bangladesh

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Md. Zillur Rahman Bhuiyan, Mamun Or Rashid, Sadia Sharmin, Moshiur Rahman, Samia Ahmed. (2020). Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique. Cancer Research Journal, 8(2), 20-25. https://doi.org/10.11648/j.crj.20200802.11

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ACS Style

Md. Zillur Rahman Bhuiyan; Mamun Or Rashid; Sadia Sharmin; Moshiur Rahman; Samia Ahmed. Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique. Cancer Res. J. 2020, 8(2), 20-25. doi: 10.11648/j.crj.20200802.11

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AMA Style

Md. Zillur Rahman Bhuiyan, Mamun Or Rashid, Sadia Sharmin, Moshiur Rahman, Samia Ahmed. Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique. Cancer Res J. 2020;8(2):20-25. doi: 10.11648/j.crj.20200802.11

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@article{10.11648/j.crj.20200802.11,
  author = {Md. Zillur Rahman Bhuiyan and Mamun Or Rashid and Sadia Sharmin and Moshiur Rahman and Samia Ahmed},
  title = {Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique},
  journal = {Cancer Research Journal},
  volume = {8},
  number = {2},
  pages = {20-25},
  doi = {10.11648/j.crj.20200802.11},
  url = {https://doi.org/10.11648/j.crj.20200802.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200802.11},
  abstract = {Background: Carcinoma of the cervix is the fourth most common cancer in women in the world.In 2018,an estimated 570000 women were diagnosed with cervical cancer worldwide and about 311000 women died from the disease.  Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women due to lack of screening, high prevalence of risk factors and poor socio-economic condition. Methods: In this prospective observational study total 90 number of subjects were enrolled to compare the effectiveness of external beam radiation therapy by four field box technique versus two field technique in the treatment of locally advanced carcinoma of uterine cervix. Clinically and histologically diagnosed squamous cell carcinoma of uterine cervix patients were selected as study population. Results: In this study the highest number of patients were  in between 46 to 55 years. Most of the subject used Oral contraceptive pill more than 5 years. Most of the patients were in stage IIB.Most of the patients were presented with postcoital bleeding, anemia, vaginal discharge , loss of appetite , Intermenstrual bleeding  and pelvic pain. After completion of treatment follow-up per vaginal examination revealed that 73.33% subjects had complete response in four field group (Arm A). In two field group (Arm B), 57.78% had complete response. Common toxicities related to treatment were nausea, vomiting, diarrhea, skin reaction, anemia, leucopenia, bladder toxicity and rectal toxicity. Conclusion: From this study it can be concluded that four field box technique in EBRT was statistically effective in relieving symptoms and  achieving complete response than two field technique in the treatment of locally advanced carcinoma of uterine cervix.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Treatment Modality with Concurrent Chemo-Radiation for Locally Advanced Carcinoma Cervix, Four Field Technique EBRT Is Better Responsive than Two Field Technique
AU  - Md. Zillur Rahman Bhuiyan
AU  - Mamun Or Rashid
AU  - Sadia Sharmin
AU  - Moshiur Rahman
AU  - Samia Ahmed
Y1  - 2020/04/23
PY  - 2020
N1  - https://doi.org/10.11648/j.crj.20200802.11
DO  - 10.11648/j.crj.20200802.11
T2  - Cancer Research Journal
JF  - Cancer Research Journal
JO  - Cancer Research Journal
SP  - 20
EP  - 25
PB  - Science Publishing Group
SN  - 2330-8214
UR  - https://doi.org/10.11648/j.crj.20200802.11
AB  - Background: Carcinoma of the cervix is the fourth most common cancer in women in the world.In 2018,an estimated 570000 women were diagnosed with cervical cancer worldwide and about 311000 women died from the disease.  Bangladesh has the highest level of incidence and mortality rates due to cervical cancer among women due to lack of screening, high prevalence of risk factors and poor socio-economic condition. Methods: In this prospective observational study total 90 number of subjects were enrolled to compare the effectiveness of external beam radiation therapy by four field box technique versus two field technique in the treatment of locally advanced carcinoma of uterine cervix. Clinically and histologically diagnosed squamous cell carcinoma of uterine cervix patients were selected as study population. Results: In this study the highest number of patients were  in between 46 to 55 years. Most of the subject used Oral contraceptive pill more than 5 years. Most of the patients were in stage IIB.Most of the patients were presented with postcoital bleeding, anemia, vaginal discharge , loss of appetite , Intermenstrual bleeding  and pelvic pain. After completion of treatment follow-up per vaginal examination revealed that 73.33% subjects had complete response in four field group (Arm A). In two field group (Arm B), 57.78% had complete response. Common toxicities related to treatment were nausea, vomiting, diarrhea, skin reaction, anemia, leucopenia, bladder toxicity and rectal toxicity. Conclusion: From this study it can be concluded that four field box technique in EBRT was statistically effective in relieving symptoms and  achieving complete response than two field technique in the treatment of locally advanced carcinoma of uterine cervix.
VL  - 8
IS  - 2
ER  -

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