Background – Primitive neurocetodermal tumor / Ewing’s sarcoma (PNET/ES) of uterine cervix is extremely rare tumor and only 27 cases have so far been reported in the literature. We hereby present one case report diagnosed by histopathology and IHC and review of literature. Objective –A young girl aged 20 years was admitted. Her routine investigations and CT and MRI scan of chest, abdomen and pelvis were performed. Biopsy was taken from vaginal mass and histopathologist reported as round cell tumor. The slides were reviewed by another pathologist and found to be rhabdomyosarcoma. Thus immunohistopathology was done and a diagnosis of PNET/ES was established. Methods – The patient presented with complains of vaginal bleeding, generalized body ache, poor nutritional intake, found extensive loco regional disease with metastases to liver, lung and multiple bones, stage FIGO IV, performance score ECOG -4. Owing to her low general condition, we could not plan any anti-cancer treatment like chemotherapy or radiation therapy. She was discharged on symptomatic treatment. Results – Her biopsy and immunohistopathology turn out to be PNET/ES of uterine cervix. Conclusion - The rarity of this entity poses a challenge to pathologists and oncologists. The PNET/ES of uterine cervix can be potentially curable if presented at an early stage and found operable. IHC plays an important role in establishing this rare diagnosis.
| Published in | Cancer Research Journal (Volume 8, Issue 4) |
| DOI | 10.11648/j.crj.20200804.12 |
| Page(s) | 62-67 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
PNET, PNET Cervix Uteri, Immunohistochemistry, Peripheral, Neuroepithelioma, Uterine Cervix
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APA Style
Rajendra Kumar Tanwar, Bharti Saxena, Harsh Goyal, Shagufta Siddiqui, Rakesh Kumar Singh, et al. (2020). Primitive Neuroectodermal Tumor of Cervix: Report of a Rare Case and Review of Literature. Cancer Research Journal, 8(4), 62-67. https://doi.org/10.11648/j.crj.20200804.12
ACS Style
Rajendra Kumar Tanwar; Bharti Saxena; Harsh Goyal; Shagufta Siddiqui; Rakesh Kumar Singh, et al. Primitive Neuroectodermal Tumor of Cervix: Report of a Rare Case and Review of Literature. Cancer Res. J. 2020, 8(4), 62-67. doi: 10.11648/j.crj.20200804.12
AMA Style
Rajendra Kumar Tanwar, Bharti Saxena, Harsh Goyal, Shagufta Siddiqui, Rakesh Kumar Singh, et al. Primitive Neuroectodermal Tumor of Cervix: Report of a Rare Case and Review of Literature. Cancer Res J. 2020;8(4):62-67. doi: 10.11648/j.crj.20200804.12
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Download@article{10.11648/j.crj.20200804.12,
author = {Rajendra Kumar Tanwar and Bharti Saxena and Harsh Goyal and Shagufta Siddiqui and Rakesh Kumar Singh and Ravindra Singh Gothwal and Madhu Saxena},
title = {Primitive Neuroectodermal Tumor of Cervix: Report of a Rare Case and Review of Literature},
journal = {Cancer Research Journal},
volume = {8},
number = {4},
pages = {62-67},
doi = {10.11648/j.crj.20200804.12},
url = {https://doi.org/10.11648/j.crj.20200804.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20200804.12},
abstract = {Background – Primitive neurocetodermal tumor / Ewing’s sarcoma (PNET/ES) of uterine cervix is extremely rare tumor and only 27 cases have so far been reported in the literature. We hereby present one case report diagnosed by histopathology and IHC and review of literature. Objective –A young girl aged 20 years was admitted. Her routine investigations and CT and MRI scan of chest, abdomen and pelvis were performed. Biopsy was taken from vaginal mass and histopathologist reported as round cell tumor. The slides were reviewed by another pathologist and found to be rhabdomyosarcoma. Thus immunohistopathology was done and a diagnosis of PNET/ES was established. Methods – The patient presented with complains of vaginal bleeding, generalized body ache, poor nutritional intake, found extensive loco regional disease with metastases to liver, lung and multiple bones, stage FIGO IV, performance score ECOG -4. Owing to her low general condition, we could not plan any anti-cancer treatment like chemotherapy or radiation therapy. She was discharged on symptomatic treatment. Results – Her biopsy and immunohistopathology turn out to be PNET/ES of uterine cervix. Conclusion - The rarity of this entity poses a challenge to pathologists and oncologists. The PNET/ES of uterine cervix can be potentially curable if presented at an early stage and found operable. IHC plays an important role in establishing this rare diagnosis.},
year = {2020}
}
TY - JOUR T1 - Primitive Neuroectodermal Tumor of Cervix: Report of a Rare Case and Review of Literature AU - Rajendra Kumar Tanwar AU - Bharti Saxena AU - Harsh Goyal AU - Shagufta Siddiqui AU - Rakesh Kumar Singh AU - Ravindra Singh Gothwal AU - Madhu Saxena Y1 - 2020/11/16 PY - 2020 N1 - https://doi.org/10.11648/j.crj.20200804.12 DO - 10.11648/j.crj.20200804.12 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 62 EP - 67 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20200804.12 AB - Background – Primitive neurocetodermal tumor / Ewing’s sarcoma (PNET/ES) of uterine cervix is extremely rare tumor and only 27 cases have so far been reported in the literature. We hereby present one case report diagnosed by histopathology and IHC and review of literature. Objective –A young girl aged 20 years was admitted. Her routine investigations and CT and MRI scan of chest, abdomen and pelvis were performed. Biopsy was taken from vaginal mass and histopathologist reported as round cell tumor. The slides were reviewed by another pathologist and found to be rhabdomyosarcoma. Thus immunohistopathology was done and a diagnosis of PNET/ES was established. Methods – The patient presented with complains of vaginal bleeding, generalized body ache, poor nutritional intake, found extensive loco regional disease with metastases to liver, lung and multiple bones, stage FIGO IV, performance score ECOG -4. Owing to her low general condition, we could not plan any anti-cancer treatment like chemotherapy or radiation therapy. She was discharged on symptomatic treatment. Results – Her biopsy and immunohistopathology turn out to be PNET/ES of uterine cervix. Conclusion - The rarity of this entity poses a challenge to pathologists and oncologists. The PNET/ES of uterine cervix can be potentially curable if presented at an early stage and found operable. IHC plays an important role in establishing this rare diagnosis. VL - 8 IS - 4 ER -
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