GATA3, IKZF1, and ARID5B polymorphisms are validated risks of pediatric acute lymphoblastic leukemia (ALL) in numerous ethnicities, whilst, their role in adult patients with acute leukemia is less well defined. Objective: The study aims to investigate the association between the GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) and the susceptibility to adult acute leukemia, as well as their impact on the treatment outcome. Methods: Real-time PCR was performed for the 5 SNPs in 91 patients (53 ALL and 38 AML) and 194 healthy controls. Results: IKZF1 rs4132601 G allele, G/G and G/T genotypes, as well as G/A haplotype of IKZF1 rs4132601/rs11978267 were significantly higher in ALL vs. healthy controls (p-values were <0.001, 0.001, 0.012, and 0.036, respectively) and in AML vs. healthy controls (p-values were <0.001, 0.001, 0.001, and 0.005, respectively). ARID5B rs10821936 C allele, C/C and C/T genotypes, as well as C/A haplotype of rs10821936/rs10994982 were significantly higher in ALL vs. healthy controls (p-values were <0.001, <0.001, 0.005, and 0.036, respectively), and only C allele and C/C genotype in AML vs. healthy controls (p-values were 0.002 and 0.017, respectively). Shorter Overall Survival (p = 0.003) and lack of remission (p=0.041) were significantly higher in ALL patients harboring IKZF1 rs4132601 G/G genotype. Conclusion: IKZF1 rs4132601 and ARID5B rs10821936 are potential risky SNPs for the development of acute leukemia in Egyptian adults. Furthermore, ALL patients with the IKZF1 rs4132601 GG genotype are probably more prone to poor outcome.
| Published in | Cancer Research Journal (Volume 11, Issue 4) |
| DOI | 10.11648/j.crj.20231104.14 |
| Page(s) | 142-155 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
GATA3 rs3824662, IKZF1 rs4132601, IKZF1rs11978267, ARID5B rs10821936, ARID5B rs10994982, ALL, AML
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APA Style
Attallah, S. M., Mosaad, Y. M., Taalab, M. M., Eisa, N. N., Hammad, A. M., et al. (2023). GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia. Cancer Research Journal, 11(4), 142-155. https://doi.org/10.11648/j.crj.20231104.14
ACS Style
Attallah, S. M.; Mosaad, Y. M.; Taalab, M. M.; Eisa, N. N.; Hammad, A. M., et al. GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia. Cancer Res. J. 2023, 11(4), 142-155. doi: 10.11648/j.crj.20231104.14
AMA Style
Attallah SM, Mosaad YM, Taalab MM, Eisa NN, Hammad AM, et al. GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia. Cancer Res J. 2023;11(4):142-155. doi: 10.11648/j.crj.20231104.14
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Download@article{10.11648/j.crj.20231104.14,
author = {Samy Mohammed Attallah and Youssef Mohammed Mosaad and Mona Mohamed Taalab and Noha Nasser Eisa and Amal Mahmoud Hammad and Iman Mohammed Fawzy and Nada Youssef and Ashraf Antar Elghzaly},
title = {GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia},
journal = {Cancer Research Journal},
volume = {11},
number = {4},
pages = {142-155},
doi = {10.11648/j.crj.20231104.14},
url = {https://doi.org/10.11648/j.crj.20231104.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20231104.14},
abstract = {GATA3, IKZF1, and ARID5B polymorphisms are validated risks of pediatric acute lymphoblastic leukemia (ALL) in numerous ethnicities, whilst, their role in adult patients with acute leukemia is less well defined. Objective: The study aims to investigate the association between the GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) and the susceptibility to adult acute leukemia, as well as their impact on the treatment outcome. Methods: Real-time PCR was performed for the 5 SNPs in 91 patients (53 ALL and 38 AML) and 194 healthy controls. Results: IKZF1 rs4132601 G allele, G/G and G/T genotypes, as well as G/A haplotype of IKZF1 rs4132601/rs11978267 were significantly higher in ALL vs. healthy controls (p-values were Conclusion: IKZF1 rs4132601 and ARID5B rs10821936 are potential risky SNPs for the development of acute leukemia in Egyptian adults. Furthermore, ALL patients with the IKZF1 rs4132601 GG genotype are probably more prone to poor outcome.
},
year = {2023}
}
TY - JOUR T1 - GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) Gene Polymorphisms in Egyptian Adult Patients with Acute Leukemia AU - Samy Mohammed Attallah AU - Youssef Mohammed Mosaad AU - Mona Mohamed Taalab AU - Noha Nasser Eisa AU - Amal Mahmoud Hammad AU - Iman Mohammed Fawzy AU - Nada Youssef AU - Ashraf Antar Elghzaly Y1 - 2023/12/08 PY - 2023 N1 - https://doi.org/10.11648/j.crj.20231104.14 DO - 10.11648/j.crj.20231104.14 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 142 EP - 155 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20231104.14 AB - GATA3, IKZF1, and ARID5B polymorphisms are validated risks of pediatric acute lymphoblastic leukemia (ALL) in numerous ethnicities, whilst, their role in adult patients with acute leukemia is less well defined. Objective: The study aims to investigate the association between the GATA3 rs3824662, IKZF1 (rs4132601& rs11978267), and ARID5B (rs10821936 & rs10994982) and the susceptibility to adult acute leukemia, as well as their impact on the treatment outcome. Methods: Real-time PCR was performed for the 5 SNPs in 91 patients (53 ALL and 38 AML) and 194 healthy controls. Results: IKZF1 rs4132601 G allele, G/G and G/T genotypes, as well as G/A haplotype of IKZF1 rs4132601/rs11978267 were significantly higher in ALL vs. healthy controls (p-values were Conclusion: IKZF1 rs4132601 and ARID5B rs10821936 are potential risky SNPs for the development of acute leukemia in Egyptian adults. Furthermore, ALL patients with the IKZF1 rs4132601 GG genotype are probably more prone to poor outcome. VL - 11 IS - 4 ER -
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Hematology Laboratory Departments, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Clinical Pathology Department, Mansoura Research centre for Cord stem cells (MARC_CSC), Faculty of medicine, Mansoura University, Mansoura, Egypt
Internal Medicine Department, Oncology Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Internal Medicine Department, Oncology Centre, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Biochemistry Department, Faculty of Medicine, Damietta-Al-Azhar University, Damietta, Egypt
Laboratory Medicine Department, Mansoura Fever Hospital, Ministry of Health, Mansoura, Egypt
Intern and graduate of Mansoura Manchester Program for Medical Education, Faculty of Medicine, Mansoura University, Mansoura, Egypt
Clinical Pathology Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt; Clinical Pathology Department, Mansoura Research centre for Cord stem cells (MARC_CSC), Faculty of medicine, Mansoura University, Mansoura, Egypt
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