Giant Cell Tumor of Bone (GCTB) is a common intermediate tumor, and the specific molecular mechanisms of this disease have not been fully elucidated. It exhibits strong heterogeneity in terms of targets, regulatory mechanisms, cell types, states, and subset distributions in the immune microenvironment. Traditional collective-level analyses cannot accurately reveal these differences. Single-cell sequencing technology is a technique that sequences the genome, transcriptome, and epigenome of diseases at the single-cell level. Single-cell sequencing can utilize a higher pixel resolution to reveal characteristic states of different cell subpopulations, contributing to broadening new perspectives for the study of GCTB heterogeneity. It holds significant value for the precise diagnosis of GCTB, identification of potential immunotherapy targets, and prognosis assessment. This study primarily reviews research related to GCTB, single-cell high-throughput sequencing technology, GCTB immune microenvironment, GCTB heterogeneity, and the construction of GCTB cell maps. It aims to provide theoretical reference for research on single-cell sequencing technology in GCTB and offers a theoretical basis for in-depth exploration of the mechanisms and treatment of GCTB.
| Published in | Cancer Research Journal (Volume 12, Issue 1) |
| DOI | 10.11648/j.crj.20241201.12 |
| Page(s) | 5-9 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Giant Cell Tumor of Bone, Single-Cell Sequencing, Tumor Microenvironment, Heterogeneity
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APA Style
Liu, Y., Ye, D. (2024). Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone. Cancer Research Journal, 12(1), 5-9. https://doi.org/10.11648/j.crj.20241201.12
ACS Style
Liu, Y.; Ye, D. Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone. Cancer Res. J. 2024, 12(1), 5-9. doi: 10.11648/j.crj.20241201.12
AMA Style
Liu Y, Ye D. Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone. Cancer Res J. 2024;12(1):5-9. doi: 10.11648/j.crj.20241201.12
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Download@article{10.11648/j.crj.20241201.12,
author = {Yiming Liu and Dongping Ye},
title = {Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone},
journal = {Cancer Research Journal},
volume = {12},
number = {1},
pages = {5-9},
doi = {10.11648/j.crj.20241201.12},
url = {https://doi.org/10.11648/j.crj.20241201.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.crj.20241201.12},
abstract = {Giant Cell Tumor of Bone (GCTB) is a common intermediate tumor, and the specific molecular mechanisms of this disease have not been fully elucidated. It exhibits strong heterogeneity in terms of targets, regulatory mechanisms, cell types, states, and subset distributions in the immune microenvironment. Traditional collective-level analyses cannot accurately reveal these differences. Single-cell sequencing technology is a technique that sequences the genome, transcriptome, and epigenome of diseases at the single-cell level. Single-cell sequencing can utilize a higher pixel resolution to reveal characteristic states of different cell subpopulations, contributing to broadening new perspectives for the study of GCTB heterogeneity. It holds significant value for the precise diagnosis of GCTB, identification of potential immunotherapy targets, and prognosis assessment. This study primarily reviews research related to GCTB, single-cell high-throughput sequencing technology, GCTB immune microenvironment, GCTB heterogeneity, and the construction of GCTB cell maps. It aims to provide theoretical reference for research on single-cell sequencing technology in GCTB and offers a theoretical basis for in-depth exploration of the mechanisms and treatment of GCTB.
},
year = {2024}
}
TY - JOUR T1 - Research Progress of Single-Cell Sequencing Technology in Giant Cell Tumor of Bone AU - Yiming Liu AU - Dongping Ye Y1 - 2024/01/18 PY - 2024 N1 - https://doi.org/10.11648/j.crj.20241201.12 DO - 10.11648/j.crj.20241201.12 T2 - Cancer Research Journal JF - Cancer Research Journal JO - Cancer Research Journal SP - 5 EP - 9 PB - Science Publishing Group SN - 2330-8214 UR - https://doi.org/10.11648/j.crj.20241201.12 AB - Giant Cell Tumor of Bone (GCTB) is a common intermediate tumor, and the specific molecular mechanisms of this disease have not been fully elucidated. It exhibits strong heterogeneity in terms of targets, regulatory mechanisms, cell types, states, and subset distributions in the immune microenvironment. Traditional collective-level analyses cannot accurately reveal these differences. Single-cell sequencing technology is a technique that sequences the genome, transcriptome, and epigenome of diseases at the single-cell level. Single-cell sequencing can utilize a higher pixel resolution to reveal characteristic states of different cell subpopulations, contributing to broadening new perspectives for the study of GCTB heterogeneity. It holds significant value for the precise diagnosis of GCTB, identification of potential immunotherapy targets, and prognosis assessment. This study primarily reviews research related to GCTB, single-cell high-throughput sequencing technology, GCTB immune microenvironment, GCTB heterogeneity, and the construction of GCTB cell maps. It aims to provide theoretical reference for research on single-cell sequencing technology in GCTB and offers a theoretical basis for in-depth exploration of the mechanisms and treatment of GCTB. VL - 12 IS - 1 ER -
Guangzhou Red Cross Hospital, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China
Guangzhou Red Cross Hospital, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, China
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