@article{10.11648/j.frontiers.20210104.17,
  author = {Hossam Mohamed and Houda Almansour and Dalal Alsaadoun and Mariam Almansour},
  title = {Visceral Fat-Glycation Interaction Deciphers the Hidden Roots of the Refractory Type of Osteoporosis: US Patent Review},
  journal = {Frontiers},
  volume = {1},
  number = {4},
  pages = {100-111},
  doi = {10.11648/j.frontiers.20210104.17},
  url = {https://doi.org/10.11648/j.frontiers.20210104.17},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.frontiers.20210104.17},
  abstract = {Osteoporosis is a chronic disease of the bone in the elderly causing its liability to fracture on a mild trauma. The metabolic type of osteoporosis is the commonest. Its relation with hyperinsulinemia and/or diabetes Mellitus II (DM II) is poorly understood. The most hazardous effect of either hyperinsulinemia or DM II is the glycation process. The US patent (US9801905) discovered a very important link between the glycation process and the down-regulation of the insulin receptors on the osteocytes. Moreover, it was very clear that hyperinsulinemia even without diabetic manifestations sometimes has a more dangerous effect than DM II. The possible explanation is that hyperinsulinemia may raise glucose concentration inside the tissues despite its blood level might be still within its normal range. This would come at the expense of high insulin levels that maintain blood sugar within its normal ranges. On the other hand, DM II has high blood sugar but the sugar inside the tissue may be much less in most cases. Therefore, the glycation process is more likely to occur with silent hyperinsulinemia than in DM II. Furthermore, the incidence of hyperinsulinemia is much more common than DM II. Roughly, hyperinsulinemia is at least 3 times more common than DM II. Lastly, the glycation process causes down-regulation of the insulin receptors on the cell membrane of the osteocytes leading to starvation of these cells. Subsequently, the new bone formation would be greatly reduced predisposing for osteoporosis. By this paper, the very fine link between hyperinsulinemia and osteoporosis could be updated. The new lines of treatment could also be updated according to the patented data (US9801905).},
 year = {2021}
}

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TY  - JOUR
T1  - Visceral Fat-Glycation Interaction Deciphers the Hidden Roots of the Refractory Type of Osteoporosis: US Patent Review
AU  - Hossam Mohamed
AU  - Houda Almansour
AU  - Dalal Alsaadoun
AU  - Mariam Almansour
Y1  - 2021/12/09
PY  - 2021
N1  - https://doi.org/10.11648/j.frontiers.20210104.17
DO  - 10.11648/j.frontiers.20210104.17
T2  - Frontiers
JF  - Frontiers
JO  - Frontiers
SP  - 100
EP  - 111
PB  - Science Publishing Group
SN  - 2994-7197
UR  - https://doi.org/10.11648/j.frontiers.20210104.17
AB  - Osteoporosis is a chronic disease of the bone in the elderly causing its liability to fracture on a mild trauma. The metabolic type of osteoporosis is the commonest. Its relation with hyperinsulinemia and/or diabetes Mellitus II (DM II) is poorly understood. The most hazardous effect of either hyperinsulinemia or DM II is the glycation process. The US patent (US9801905) discovered a very important link between the glycation process and the down-regulation of the insulin receptors on the osteocytes. Moreover, it was very clear that hyperinsulinemia even without diabetic manifestations sometimes has a more dangerous effect than DM II. The possible explanation is that hyperinsulinemia may raise glucose concentration inside the tissues despite its blood level might be still within its normal range. This would come at the expense of high insulin levels that maintain blood sugar within its normal ranges. On the other hand, DM II has high blood sugar but the sugar inside the tissue may be much less in most cases. Therefore, the glycation process is more likely to occur with silent hyperinsulinemia than in DM II. Furthermore, the incidence of hyperinsulinemia is much more common than DM II. Roughly, hyperinsulinemia is at least 3 times more common than DM II. Lastly, the glycation process causes down-regulation of the insulin receptors on the cell membrane of the osteocytes leading to starvation of these cells. Subsequently, the new bone formation would be greatly reduced predisposing for osteoporosis. By this paper, the very fine link between hyperinsulinemia and osteoporosis could be updated. The new lines of treatment could also be updated according to the patented data (US9801905).
VL  - 1
IS  - 4
ER  - 

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