Antiproliferative Effects of <i>Ferula assa-foetida’s</i> Extract on PC12 and MCF7 Cancer Cells

Mina Abroudi; Amir Ganji Fard; Ghazaleh Dadashizadeh; Omid Gholami; Davood Mahdian

doi:doi:10.11648/j.ijbecs.20200603.12

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Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells

Mina Abroudi, Amir Ganji Fard, Ghazaleh Dadashizadeh, Omid Gholami, Davood Mahdian

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 6, Issue 3)

Received: 3 August 2020 Accepted: 17 August 2020 Published: 30 October 2020

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Abstract

Background: Ferula assa-foetida is a herbaceous plant of the Umbelliferae family having a broad spectrum of biological activities such as antiseptic, antibacterial, anti-inflammation, and, anti-tumor activity against a wide range of cancers. Among these features, antitumor activity has become more important in recent years and it still demands more investigations to address the underlying mechanisms. Purpose: This current study was conducted to evaluate the anti-proliferative effect of Ferula assa-foetida on PC12 and MCF7 cells as well as examining its mechanisms. Materials and Methods: Cells were cultured in DMEM medium with 10% fetal bovine serum, 100 units/ml penicillin, and 100 µg/ml streptomycin. Cells incubated with different concentrations of the ethanolic extract of Ferula assa-foetida. Notably, cytotoxicity and apoptosis assay were measured by MTT and PI staining, respectively. Results: The MTT results showed that the ethanolic extract of Ferula assa-foetida in concentrations of 10, 7, 5, and 2.5 μM on both PC12 and MCF7 cells had a significant effect in cell viability and apoptosis induction in comparison to control group. Conclusion: In this study, it was determined that Ferula assa-fetida through the induction of apoptosis prevented the growth of PC12 and MCF7 cells and made a reduction in cell viability with different concentrations in a time- and dose-dependent manner. However, more studies are needed to reveal the mechanisms of Ferula assa-foetida’s extract in apoptosis induction.

Published in	International Journal of Biomedical Engineering and Clinical Science (Volume 6, Issue 3)
DOI	10.11648/j.ijbecs.20200603.12
Page(s)	60-67
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Ferula assa-foetida, Apoptosis, Cytotoxicity, Cancer, MCF7, PC12

References

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APA Style

Mina Abroudi, Amir Ganji Fard, Ghazaleh Dadashizadeh, Omid Gholami, Davood Mahdian. (2020). Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells. International Journal of Biomedical Engineering and Clinical Science, 6(3), 60-67. https://doi.org/10.11648/j.ijbecs.20200603.12

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ACS Style

Mina Abroudi; Amir Ganji Fard; Ghazaleh Dadashizadeh; Omid Gholami; Davood Mahdian. Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells. Int. J. Biomed. Eng. Clin. Sci. 2020, 6(3), 60-67. doi: 10.11648/j.ijbecs.20200603.12

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AMA Style

Mina Abroudi, Amir Ganji Fard, Ghazaleh Dadashizadeh, Omid Gholami, Davood Mahdian. Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells. Int J Biomed Eng Clin Sci. 2020;6(3):60-67. doi: 10.11648/j.ijbecs.20200603.12

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@article{10.11648/j.ijbecs.20200603.12,
  author = {Mina Abroudi and Amir Ganji Fard and Ghazaleh Dadashizadeh and Omid Gholami and Davood Mahdian},
  title = {Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {6},
  number = {3},
  pages = {60-67},
  doi = {10.11648/j.ijbecs.20200603.12},
  url = {https://doi.org/10.11648/j.ijbecs.20200603.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20200603.12},
  abstract = {Background: Ferula assa-foetida is a herbaceous plant of the Umbelliferae family having a broad spectrum of biological activities such as antiseptic, antibacterial, anti-inflammation, and, anti-tumor activity against a wide range of cancers. Among these features, antitumor activity has become more important in recent years and it still demands more investigations to address the underlying mechanisms. Purpose: This current study was conducted to evaluate the anti-proliferative effect of Ferula assa-foetida on PC12 and MCF7 cells as well as examining its mechanisms. Materials and Methods: Cells were cultured in DMEM medium with 10% fetal bovine serum, 100 units/ml penicillin, and 100 µg/ml streptomycin. Cells incubated with different concentrations of the ethanolic extract of Ferula assa-foetida. Notably, cytotoxicity and apoptosis assay were measured by MTT and PI staining, respectively. Results: The MTT results showed that the ethanolic extract of Ferula assa-foetida in concentrations of 10, 7, 5, and 2.5 μM on both PC12 and MCF7 cells had a significant effect in cell viability and apoptosis induction in comparison to control group. Conclusion: In this study, it was determined that Ferula assa-fetida through the induction of apoptosis prevented the growth of PC12 and MCF7 cells and made a reduction in cell viability with different concentrations in a time- and dose-dependent manner. However, more studies are needed to reveal the mechanisms of Ferula assa-foetida’s extract in apoptosis induction.},
 year = {2020}
}

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TY  - JOUR
T1  - Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells
AU  - Mina Abroudi
AU  - Amir Ganji Fard
AU  - Ghazaleh Dadashizadeh
AU  - Omid Gholami
AU  - Davood Mahdian
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ijbecs.20200603.12
DO  - 10.11648/j.ijbecs.20200603.12
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 60
EP  - 67
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20200603.12
AB  - Background: Ferula assa-foetida is a herbaceous plant of the Umbelliferae family having a broad spectrum of biological activities such as antiseptic, antibacterial, anti-inflammation, and, anti-tumor activity against a wide range of cancers. Among these features, antitumor activity has become more important in recent years and it still demands more investigations to address the underlying mechanisms. Purpose: This current study was conducted to evaluate the anti-proliferative effect of Ferula assa-foetida on PC12 and MCF7 cells as well as examining its mechanisms. Materials and Methods: Cells were cultured in DMEM medium with 10% fetal bovine serum, 100 units/ml penicillin, and 100 µg/ml streptomycin. Cells incubated with different concentrations of the ethanolic extract of Ferula assa-foetida. Notably, cytotoxicity and apoptosis assay were measured by MTT and PI staining, respectively. Results: The MTT results showed that the ethanolic extract of Ferula assa-foetida in concentrations of 10, 7, 5, and 2.5 μM on both PC12 and MCF7 cells had a significant effect in cell viability and apoptosis induction in comparison to control group. Conclusion: In this study, it was determined that Ferula assa-fetida through the induction of apoptosis prevented the growth of PC12 and MCF7 cells and made a reduction in cell viability with different concentrations in a time- and dose-dependent manner. However, more studies are needed to reveal the mechanisms of Ferula assa-foetida’s extract in apoptosis induction.
VL  - 6
IS  - 3
ER  -

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Author Information

Mina Abroudi

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
Amir Ganji Fard

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
Ghazaleh Dadashizadeh

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
Omid Gholami

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran
Davood Mahdian

Cellular and Molecular Research Center, Sabzevar University of Medical Sciences, Sabzevar, Iran

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APA Style

Mina Abroudi, Amir Ganji Fard, Ghazaleh Dadashizadeh, Omid Gholami, Davood Mahdian. (2020). Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells. International Journal of Biomedical Engineering and Clinical Science, 6(3), 60-67. https://doi.org/10.11648/j.ijbecs.20200603.12

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ACS Style

Mina Abroudi; Amir Ganji Fard; Ghazaleh Dadashizadeh; Omid Gholami; Davood Mahdian. Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells. Int. J. Biomed. Eng. Clin. Sci. 2020, 6(3), 60-67. doi: 10.11648/j.ijbecs.20200603.12

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AMA Style

Mina Abroudi, Amir Ganji Fard, Ghazaleh Dadashizadeh, Omid Gholami, Davood Mahdian. Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells. Int J Biomed Eng Clin Sci. 2020;6(3):60-67. doi: 10.11648/j.ijbecs.20200603.12

Copy | Download

@article{10.11648/j.ijbecs.20200603.12,
  author = {Mina Abroudi and Amir Ganji Fard and Ghazaleh Dadashizadeh and Omid Gholami and Davood Mahdian},
  title = {Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {6},
  number = {3},
  pages = {60-67},
  doi = {10.11648/j.ijbecs.20200603.12},
  url = {https://doi.org/10.11648/j.ijbecs.20200603.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20200603.12},
  abstract = {Background: Ferula assa-foetida is a herbaceous plant of the Umbelliferae family having a broad spectrum of biological activities such as antiseptic, antibacterial, anti-inflammation, and, anti-tumor activity against a wide range of cancers. Among these features, antitumor activity has become more important in recent years and it still demands more investigations to address the underlying mechanisms. Purpose: This current study was conducted to evaluate the anti-proliferative effect of Ferula assa-foetida on PC12 and MCF7 cells as well as examining its mechanisms. Materials and Methods: Cells were cultured in DMEM medium with 10% fetal bovine serum, 100 units/ml penicillin, and 100 µg/ml streptomycin. Cells incubated with different concentrations of the ethanolic extract of Ferula assa-foetida. Notably, cytotoxicity and apoptosis assay were measured by MTT and PI staining, respectively. Results: The MTT results showed that the ethanolic extract of Ferula assa-foetida in concentrations of 10, 7, 5, and 2.5 μM on both PC12 and MCF7 cells had a significant effect in cell viability and apoptosis induction in comparison to control group. Conclusion: In this study, it was determined that Ferula assa-fetida through the induction of apoptosis prevented the growth of PC12 and MCF7 cells and made a reduction in cell viability with different concentrations in a time- and dose-dependent manner. However, more studies are needed to reveal the mechanisms of Ferula assa-foetida’s extract in apoptosis induction.},
 year = {2020}
}

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TY  - JOUR
T1  - Antiproliferative Effects of Ferula assa-foetida’s Extract on PC12 and MCF7 Cancer Cells
AU  - Mina Abroudi
AU  - Amir Ganji Fard
AU  - Ghazaleh Dadashizadeh
AU  - Omid Gholami
AU  - Davood Mahdian
Y1  - 2020/10/30
PY  - 2020
N1  - https://doi.org/10.11648/j.ijbecs.20200603.12
DO  - 10.11648/j.ijbecs.20200603.12
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 60
EP  - 67
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20200603.12
AB  - Background: Ferula assa-foetida is a herbaceous plant of the Umbelliferae family having a broad spectrum of biological activities such as antiseptic, antibacterial, anti-inflammation, and, anti-tumor activity against a wide range of cancers. Among these features, antitumor activity has become more important in recent years and it still demands more investigations to address the underlying mechanisms. Purpose: This current study was conducted to evaluate the anti-proliferative effect of Ferula assa-foetida on PC12 and MCF7 cells as well as examining its mechanisms. Materials and Methods: Cells were cultured in DMEM medium with 10% fetal bovine serum, 100 units/ml penicillin, and 100 µg/ml streptomycin. Cells incubated with different concentrations of the ethanolic extract of Ferula assa-foetida. Notably, cytotoxicity and apoptosis assay were measured by MTT and PI staining, respectively. Results: The MTT results showed that the ethanolic extract of Ferula assa-foetida in concentrations of 10, 7, 5, and 2.5 μM on both PC12 and MCF7 cells had a significant effect in cell viability and apoptosis induction in comparison to control group. Conclusion: In this study, it was determined that Ferula assa-fetida through the induction of apoptosis prevented the growth of PC12 and MCF7 cells and made a reduction in cell viability with different concentrations in a time- and dose-dependent manner. However, more studies are needed to reveal the mechanisms of Ferula assa-foetida’s extract in apoptosis induction.
VL  - 6
IS  - 3
ER  -

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