The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer

Hendrik Roos

doi:doi:10.11648/j.ijbecs.20220804.13

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The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer

Hendrik Roos

Published in International Journal of Biomedical Engineering and Clinical Science (Volume 8, Issue 4)

Received: 28 November 2022 Accepted: 23 December 2022 Published: 29 December 2022

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Abstract

There is a need for use of an antiseptic in wound care in individuals with diabetes mellitus where wounds can be infected with multiple drug resistant (MDR) pathogens in planktonic or biofilm forms. The antiseptic and appending wound dressing regimen should be non-toxic to cells and offer a simple yet effective solution to treat infection. An essential component of wound care is to debride wounds and the health care provider should consider the role of dressing type in assisting with debridement. The case studies describe the successful treatment of a diabetic foot ulcer (DFU) with a pharmaceutical grade hypochlorous acid (HOCl) solution in a 70-year-old female, and in a 45-year-old male, both with Type 1 diabetes mellitus. HOCl is an effective antiseptic against drug sensitive, as well as multiple drug resistant pathogens, has anti-biofilm properties and demonstrate inflammation modulation, which assist with healing. Both cases responded well to daily dressings of surgical gauze saturated with HOCl and retained with crepe bandage. The case representations suggest that satisfactory results can be obtained with conservative management of DFU. Patients can be treated at home using simple, yet effective gauze dressings saturated with pharmaceutical grade HOCl. Home treatment, monitored by the health care provider saves time and cost and improves patient compliance and quality of life.

Published in	International Journal of Biomedical Engineering and Clinical Science (Volume 8, Issue 4)
DOI	10.11648/j.ijbecs.20220804.13
Page(s)	53-56
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2022. Published by Science Publishing Group

Keywords

Diabetic Foot Ulcer (DFU), Biofilm, Healing Through Secondary Intention, Hypochlorous Acid, Trifectiv^® Plus Wound & Burn Care, Infection, Inflammation, Debridement

References

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[2]	International Working Group on the Diabetic Foot. International consensus on the diabetic foot. Maastricht: International Working Group on the Diabetic Foot, 1999.
[3]	Raymakers JT, Houben AJ, Van Der Heyden JJ, Tordoir JH, Kitslaar PJ, Schaper NC. The effect of diabetes and severe ischemia on the penetration of ceftazidime into tissues of the limb. Diabet Med 2001; 18: 229–34.
[4]	Fowler E, Vesely N, Pelfrey M, Jordan S, Amberry T. Wound care for persons with diabetes. Home Health Nurse 1999; 17: 437–44.
[5]	Nakae H, Inaba H. Effectiveness of electrolyzed oxidized water irrigation in a burn-wound infection model. J Trauma 2000; 49: 511–4.
[6]	Dumville JC, Lipsky BA, Hoey C, Cruciani M, Fiscon M, Xia J. Topical antimicrobial agents for treating foot ulcers in people with diabetes. Cochrane Database Syst Rev. 2017; 6 (6): CD011038. Published 2017 Jun 14. doi: 10.1002/14651858.CD011038.pub.
[7]	Senneville E. Antimicrobial interventions for the management of diabetic foot infections. Expert Opin Pharmacotherapy 2005; 6: 263–73.
[8]	DG Armstrong et al. Expert recommendations for the use of hypochlorous solution: Science and clinical application. Ostomy Wound Management (2015) 61: 5, 1-20.
[9]	Mekkawy, M., & Kamal, A. Randomized Clinical Trial: The Efficacy of Hypochlorous Acid on Septic Traumatic Wound. Journal of Education and Practice ISSN 2006; 2222-1735, Vol. 5.
[10]	https://trifectiv.com/251120-mrsa-results/; https://trifectiv.com/mdr-results/
[11]	https://trifectiv.com/antiviral-report/
[12]	Dayya D, O'Neill O, Habib N, et al. Debridement of diabetic foot ulcers: public health and clinical implications – a systematic review, meta-analysis, and meta-regression BMJ Surgery, Interventions, & Health Technologies 2022; 4: e000081. doi: 10.1136/bmjsit-2021-000081
[13]	Debridement Procedures for Managing Diabetic Foot Ulcers: A Review of Clinical Effectiveness, Cost-effectiveness, and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2014 Sep 15. PMID: 25411677.
[14]	Robson, M. C. Bacterial degradation of growth factors. J Appl Res, 2003; 4: 30–35.
[15]	Gajarawala SN, Pelkowski JN. Telehealth Benefits and Barriers. J Nurse Pract. 2021 Feb; 17 (2): 218-221. doi: 10.1016/j.nurpra.2020.09.013. Epub 2020 Oct 21. PMID: 33106751; PMCID: PMC7577680.

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APA Style

Hendrik Roos. (2022). The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer. International Journal of Biomedical Engineering and Clinical Science, 8(4), 53-56. https://doi.org/10.11648/j.ijbecs.20220804.13

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ACS Style

Hendrik Roos. The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer. Int. J. Biomed. Eng. Clin. Sci. 2022, 8(4), 53-56. doi: 10.11648/j.ijbecs.20220804.13

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AMA Style

Hendrik Roos. The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer. Int J Biomed Eng Clin Sci. 2022;8(4):53-56. doi: 10.11648/j.ijbecs.20220804.13

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@article{10.11648/j.ijbecs.20220804.13,
  author = {Hendrik Roos},
  title = {The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {8},
  number = {4},
  pages = {53-56},
  doi = {10.11648/j.ijbecs.20220804.13},
  url = {https://doi.org/10.11648/j.ijbecs.20220804.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20220804.13},
  abstract = {There is a need for use of an antiseptic in wound care in individuals with diabetes mellitus where wounds can be infected with multiple drug resistant (MDR) pathogens in planktonic or biofilm forms. The antiseptic and appending wound dressing regimen should be non-toxic to cells and offer a simple yet effective solution to treat infection. An essential component of wound care is to debride wounds and the health care provider should consider the role of dressing type in assisting with debridement. The case studies describe the successful treatment of a diabetic foot ulcer (DFU) with a pharmaceutical grade hypochlorous acid (HOCl) solution in a 70-year-old female, and in a 45-year-old male, both with Type 1 diabetes mellitus. HOCl is an effective antiseptic against drug sensitive, as well as multiple drug resistant pathogens, has anti-biofilm properties and demonstrate inflammation modulation, which assist with healing. Both cases responded well to daily dressings of surgical gauze saturated with HOCl and retained with crepe bandage. The case representations suggest that satisfactory results can be obtained with conservative management of DFU. Patients can be treated at home using simple, yet effective gauze dressings saturated with pharmaceutical grade HOCl. Home treatment, monitored by the health care provider saves time and cost and improves patient compliance and quality of life.},
 year = {2022}
}

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TY  - JOUR
T1  - The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer
AU  - Hendrik Roos
Y1  - 2022/12/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ijbecs.20220804.13
DO  - 10.11648/j.ijbecs.20220804.13
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 53
EP  - 56
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20220804.13
AB  - There is a need for use of an antiseptic in wound care in individuals with diabetes mellitus where wounds can be infected with multiple drug resistant (MDR) pathogens in planktonic or biofilm forms. The antiseptic and appending wound dressing regimen should be non-toxic to cells and offer a simple yet effective solution to treat infection. An essential component of wound care is to debride wounds and the health care provider should consider the role of dressing type in assisting with debridement. The case studies describe the successful treatment of a diabetic foot ulcer (DFU) with a pharmaceutical grade hypochlorous acid (HOCl) solution in a 70-year-old female, and in a 45-year-old male, both with Type 1 diabetes mellitus. HOCl is an effective antiseptic against drug sensitive, as well as multiple drug resistant pathogens, has anti-biofilm properties and demonstrate inflammation modulation, which assist with healing. Both cases responded well to daily dressings of surgical gauze saturated with HOCl and retained with crepe bandage. The case representations suggest that satisfactory results can be obtained with conservative management of DFU. Patients can be treated at home using simple, yet effective gauze dressings saturated with pharmaceutical grade HOCl. Home treatment, monitored by the health care provider saves time and cost and improves patient compliance and quality of life.
VL  - 8
IS  - 4
ER  -

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Author Information

Hendrik Roos

Trifectiv (Pty) Ltd, Stellenbosch, South Africa

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Plain Text BibTeX RIS

APA Style

Hendrik Roos. (2022). The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer. International Journal of Biomedical Engineering and Clinical Science, 8(4), 53-56. https://doi.org/10.11648/j.ijbecs.20220804.13

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ACS Style

Hendrik Roos. The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer. Int. J. Biomed. Eng. Clin. Sci. 2022, 8(4), 53-56. doi: 10.11648/j.ijbecs.20220804.13

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AMA Style

Hendrik Roos. The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer. Int J Biomed Eng Clin Sci. 2022;8(4):53-56. doi: 10.11648/j.ijbecs.20220804.13

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@article{10.11648/j.ijbecs.20220804.13,
  author = {Hendrik Roos},
  title = {The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer},
  journal = {International Journal of Biomedical Engineering and Clinical Science},
  volume = {8},
  number = {4},
  pages = {53-56},
  doi = {10.11648/j.ijbecs.20220804.13},
  url = {https://doi.org/10.11648/j.ijbecs.20220804.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbecs.20220804.13},
  abstract = {There is a need for use of an antiseptic in wound care in individuals with diabetes mellitus where wounds can be infected with multiple drug resistant (MDR) pathogens in planktonic or biofilm forms. The antiseptic and appending wound dressing regimen should be non-toxic to cells and offer a simple yet effective solution to treat infection. An essential component of wound care is to debride wounds and the health care provider should consider the role of dressing type in assisting with debridement. The case studies describe the successful treatment of a diabetic foot ulcer (DFU) with a pharmaceutical grade hypochlorous acid (HOCl) solution in a 70-year-old female, and in a 45-year-old male, both with Type 1 diabetes mellitus. HOCl is an effective antiseptic against drug sensitive, as well as multiple drug resistant pathogens, has anti-biofilm properties and demonstrate inflammation modulation, which assist with healing. Both cases responded well to daily dressings of surgical gauze saturated with HOCl and retained with crepe bandage. The case representations suggest that satisfactory results can be obtained with conservative management of DFU. Patients can be treated at home using simple, yet effective gauze dressings saturated with pharmaceutical grade HOCl. Home treatment, monitored by the health care provider saves time and cost and improves patient compliance and quality of life.},
 year = {2022}
}

Copy | Download

TY  - JOUR
T1  - The Use of Hypochlorous Acid in the Healing of a Diabetic Foot Ulcer
AU  - Hendrik Roos
Y1  - 2022/12/29
PY  - 2022
N1  - https://doi.org/10.11648/j.ijbecs.20220804.13
DO  - 10.11648/j.ijbecs.20220804.13
T2  - International Journal of Biomedical Engineering and Clinical Science
JF  - International Journal of Biomedical Engineering and Clinical Science
JO  - International Journal of Biomedical Engineering and Clinical Science
SP  - 53
EP  - 56
PB  - Science Publishing Group
SN  - 2472-1301
UR  - https://doi.org/10.11648/j.ijbecs.20220804.13
AB  - There is a need for use of an antiseptic in wound care in individuals with diabetes mellitus where wounds can be infected with multiple drug resistant (MDR) pathogens in planktonic or biofilm forms. The antiseptic and appending wound dressing regimen should be non-toxic to cells and offer a simple yet effective solution to treat infection. An essential component of wound care is to debride wounds and the health care provider should consider the role of dressing type in assisting with debridement. The case studies describe the successful treatment of a diabetic foot ulcer (DFU) with a pharmaceutical grade hypochlorous acid (HOCl) solution in a 70-year-old female, and in a 45-year-old male, both with Type 1 diabetes mellitus. HOCl is an effective antiseptic against drug sensitive, as well as multiple drug resistant pathogens, has anti-biofilm properties and demonstrate inflammation modulation, which assist with healing. Both cases responded well to daily dressings of surgical gauze saturated with HOCl and retained with crepe bandage. The case representations suggest that satisfactory results can be obtained with conservative management of DFU. Patients can be treated at home using simple, yet effective gauze dressings saturated with pharmaceutical grade HOCl. Home treatment, monitored by the health care provider saves time and cost and improves patient compliance and quality of life.
VL  - 8
IS  - 4
ER  -

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