Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media

Yuyun Widaningsih; Rosdiana Natsir; Mansyur Arif; Uleng Bahrun; Hasyim Kasim; Nursin Abdul Kadir; Fitri Hamka; Nadyah Haruna; Mochammad Hatta; Andi Nilawati Usman

doi:doi:10.11648/j.ijbmr.20170502.12

Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media

Yuyun Widaningsih, Rosdiana Natsir, Mansyur Arif, Uleng Bahrun, Hasyim Kasim, Nursin Abdul Kadir, Fitri Hamka, Nadyah Haruna, Mochammad Hatta, Andi Nilawati Usman

Published in International Journal of Biomedical Materials Research (Volume 5, Issue 2)

Received: 4 April 2017 Accepted: 21 April 2017 Published: 1 June 2017

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Abstract

Percutaneous Coronary Intervention (PCI) procedure increases the risk of inflammation risk and represents adverse effects to immune system in the human body. One of the functions in the human body in maintaining the balance of immune system is Foxp3 of regulatory T cells and the function of Foxp3 is seldom to be the subject of study in coronary patients from the administration of contrast agents after PCI. This study was conducted to analyze the comparison Foxp3 levels of regulatory T cells in blood serums in patients who experienced contrast induced nephrophaty (CIN) after PCI procedure for both the CIN group and the non-CIN group. The population of coronary patients after PCI. The sample size was 20 patients that consisted of 10 patients who experienced CIN and 10 patients who experienced the CIN group. Categorization of both the CIN and non-CIN group used Kidney Disease Improving Global Outcomes (KDIGO) and detection of Foxp3 levels in blood serums using Enzyme-linked immunosorbent assay (ELISA) technique. Result of this study indicated that the characteristics of patients between the CIN group and the non-CIN group did not reveal significant difference, except for the characteristic of age. Results of the analysis by using statistical pair and non-pair t-test showed that patients for both the CIN group and non-CIN group experienced significant reduction of Foxp3 levels of regulatory T cells in their blood serums. This indicated that the PCI procedure indeed led to inflammation and Foxp3 levels and it could not be used as the specific marker for CIN incidence, but it should be mediated by the inflammation marker.

Published in	International Journal of Biomedical Materials Research (Volume 5, Issue 2)
DOI	10.11648/j.ijbmr.20170502.12
Page(s)	25-28
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Percutaneous Coronary Intervention, Contrast Induced Nephrophaty, Foxp3

References

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[2]	Shoukat, S., et al., Contrast-induced nephropathy in patients undergoing percutaneous coronary intervention. Cardiol Res Pract, 2010. 2010.
[3]	Sadat, U., Radiographic contrast-media-induced acute kidney injury: pathophysiology and prophylactic strategies. ISRN Radiol, 2013. 2013: p. 496438.
[4]	Schrier, R. W., et al., Acute renal failure: definitions, diagnosis, pathogenesis, and therapy. J Clin Invest, 2004. 114 (1): p. 5-14.
[5]	Bonventre, J. V. and L. Yang, Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest, 2011. 121 (11): p. 4210-21.
[6]	Kinsey, G. R., R. Sharma, and M. D. Okusa, Regulatory T cells in AKI. J Am Soc Nephrol, 2013. 24 (11): p. 1720-6.
[7]	Kinsey, G. R. and M. D. Okusa, Expanding role of T cells in acute kidney injury. Curr Opin Nephrol Hypertens, 2014. 23 (1): p. 9-16.
[8]	Rudensky, A. Y., Regulatory T cells and Foxp3. Immunol Rev, 2011. 241 (1): p. 260-8.
[9]	Chong, E., et al., Risk factors and clinical outcomes for contrast-induced nephropathy after percutaneous coronary intervention in patients with normal serum creatinine. Ann Acad Med Singapore, 2010. 39 (5): p. 374-80.
[10]	Ando, G., et al., Age, glomerular filtration rate, ejection fraction, and the AGEF score predict contrast-induced nephropathy in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. Catheter Cardiovasc Interv, 2013. 82 (6): p. 878-85.
[11]	Munk, P. S., et al., Inflammatory response to percutaneous coronary intervention in stable coronary artery disease. J Thromb Thrombolysis, 2011. 31 (1): p. 92-8.
[12]	Valencia, X., et al., TNF downmodulates the function of human CD4+CD25hi T-regulatory cells. Blood, 2006. 108 (1): p. 253-61.
[13]	Nie, H., et al., Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-alpha in rheumatoid arthritis. Nat Med, 2013. 19 (3): p. 322-8.
[14]	Emoto, T., et al., Regulatory/Effector T-Cell Ratio Is Reduced in Coronary Artery Disease. Circulation Journal, 2014. 78 (12): p. 2935-2941.
[15]	Salgado Filho, W., et al., [Intracoronary inflammatory markers after percutaneous coronary interventions]. Arq Bras Cardiol, 2005. 85 (3): p. 180-5.
[16]	Saadeddin, S. M. and M. A. Habbab, Percutaneous coronary intervention in the context of systemic inflammation: more injury and worse outcome. Med Sci Monit, 2003. 9 (8): p. Ra193-7.

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APA Style

Yuyun Widaningsih, Rosdiana Natsir, Mansyur Arif, Uleng Bahrun, Hasyim Kasim, et al. (2017). Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media. International Journal of Biomedical Materials Research, 5(2), 25-28. https://doi.org/10.11648/j.ijbmr.20170502.12

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ACS Style

Yuyun Widaningsih; Rosdiana Natsir; Mansyur Arif; Uleng Bahrun; Hasyim Kasim, et al. Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media. Int. J. Biomed. Mater. Res. 2017, 5(2), 25-28. doi: 10.11648/j.ijbmr.20170502.12

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AMA Style

Yuyun Widaningsih, Rosdiana Natsir, Mansyur Arif, Uleng Bahrun, Hasyim Kasim, et al. Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media. Int J Biomed Mater Res. 2017;5(2):25-28. doi: 10.11648/j.ijbmr.20170502.12

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@article{10.11648/j.ijbmr.20170502.12,
  author = {Yuyun Widaningsih and Rosdiana Natsir and Mansyur Arif and Uleng Bahrun and Hasyim Kasim and Nursin Abdul Kadir and Fitri Hamka and Nadyah Haruna and Mochammad Hatta and Andi Nilawati Usman},
  title = {Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media},
  journal = {International Journal of Biomedical Materials Research},
  volume = {5},
  number = {2},
  pages = {25-28},
  doi = {10.11648/j.ijbmr.20170502.12},
  url = {https://doi.org/10.11648/j.ijbmr.20170502.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20170502.12},
  abstract = {Percutaneous Coronary Intervention (PCI) procedure increases the risk of inflammation risk and represents adverse effects to immune system in the human body. One of the functions in the human body in maintaining the balance of immune system is Foxp3 of regulatory T cells and the function of Foxp3 is seldom to be the subject of study in coronary patients from the administration of contrast agents after PCI. This study was conducted to analyze the comparison Foxp3 levels of regulatory T cells in blood serums in patients who experienced contrast induced nephrophaty (CIN) after PCI procedure for both the CIN group and the non-CIN group. The population of coronary patients after PCI. The sample size was 20 patients that consisted of 10 patients who experienced CIN and 10 patients who experienced the CIN group. Categorization of both the CIN and non-CIN group used Kidney Disease Improving Global Outcomes (KDIGO) and detection of Foxp3 levels in blood serums using Enzyme-linked immunosorbent assay (ELISA) technique. Result of this study indicated that the characteristics of patients between the CIN group and the non-CIN group did not reveal significant difference, except for the characteristic of age. Results of the analysis by using statistical pair and non-pair t-test showed that patients for both the CIN group and non-CIN group experienced significant reduction of Foxp3 levels of regulatory T cells in their blood serums. This indicated that the PCI procedure indeed led to inflammation and Foxp3 levels and it could not be used as the specific marker for CIN incidence, but it should be mediated by the inflammation marker.},
 year = {2017}
}

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TY  - JOUR
T1  - Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media
AU  - Yuyun Widaningsih
AU  - Rosdiana Natsir
AU  - Mansyur Arif
AU  - Uleng Bahrun
AU  - Hasyim Kasim
AU  - Nursin Abdul Kadir
AU  - Fitri Hamka
AU  - Nadyah Haruna
AU  - Mochammad Hatta
AU  - Andi Nilawati Usman
Y1  - 2017/06/01
PY  - 2017
N1  - https://doi.org/10.11648/j.ijbmr.20170502.12
DO  - 10.11648/j.ijbmr.20170502.12
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 25
EP  - 28
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20170502.12
AB  - Percutaneous Coronary Intervention (PCI) procedure increases the risk of inflammation risk and represents adverse effects to immune system in the human body. One of the functions in the human body in maintaining the balance of immune system is Foxp3 of regulatory T cells and the function of Foxp3 is seldom to be the subject of study in coronary patients from the administration of contrast agents after PCI. This study was conducted to analyze the comparison Foxp3 levels of regulatory T cells in blood serums in patients who experienced contrast induced nephrophaty (CIN) after PCI procedure for both the CIN group and the non-CIN group. The population of coronary patients after PCI. The sample size was 20 patients that consisted of 10 patients who experienced CIN and 10 patients who experienced the CIN group. Categorization of both the CIN and non-CIN group used Kidney Disease Improving Global Outcomes (KDIGO) and detection of Foxp3 levels in blood serums using Enzyme-linked immunosorbent assay (ELISA) technique. Result of this study indicated that the characteristics of patients between the CIN group and the non-CIN group did not reveal significant difference, except for the characteristic of age. Results of the analysis by using statistical pair and non-pair t-test showed that patients for both the CIN group and non-CIN group experienced significant reduction of Foxp3 levels of regulatory T cells in their blood serums. This indicated that the PCI procedure indeed led to inflammation and Foxp3 levels and it could not be used as the specific marker for CIN incidence, but it should be mediated by the inflammation marker.
VL  - 5
IS  - 2
ER  -

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Author Information

Yuyun Widaningsih

Department of Clinical Pathology, Hasanuddin University, Makassar City, Indonesia
Rosdiana Natsir

Department of Biochemistry, Hasanuddin University, Makassar City, Indonesia
Mansyur Arif

Department of Clinical Pathology, Hasanuddin University, Makassar City, Indonesia
Uleng Bahrun

Department of Clinical Pathology, Hasanuddin University, Makassar City, Indonesia
Hasyim Kasim

Department of Internal Medicine, Hasanuddin University, Makassar City, Indonesia
Nursin Abdul Kadir

Department of Clinical Pathology, Hasanuddin University, Makassar City, Indonesia
Fitri Hamka

Department of Clinical Pathology, Hasanuddin University, Makassar City, Indonesia
Nadyah Haruna

Department of Medicine, UIN Alauddin University, Makassar City, Indonesia
Mochammad Hatta

Department of Immunology and Biomolecular, Hasanuddin University, Makassar City, Indonesia
Andi Nilawati Usman

Halal Center of Public Health, Hasanuddin University, Makassar City, Indonesia

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Plain Text BibTeX RIS

APA Style

Yuyun Widaningsih, Rosdiana Natsir, Mansyur Arif, Uleng Bahrun, Hasyim Kasim, et al. (2017). Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media. International Journal of Biomedical Materials Research, 5(2), 25-28. https://doi.org/10.11648/j.ijbmr.20170502.12

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ACS Style

Yuyun Widaningsih; Rosdiana Natsir; Mansyur Arif; Uleng Bahrun; Hasyim Kasim, et al. Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media. Int. J. Biomed. Mater. Res. 2017, 5(2), 25-28. doi: 10.11648/j.ijbmr.20170502.12

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AMA Style

Yuyun Widaningsih, Rosdiana Natsir, Mansyur Arif, Uleng Bahrun, Hasyim Kasim, et al. Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media. Int J Biomed Mater Res. 2017;5(2):25-28. doi: 10.11648/j.ijbmr.20170502.12

Copy | Download

@article{10.11648/j.ijbmr.20170502.12,
  author = {Yuyun Widaningsih and Rosdiana Natsir and Mansyur Arif and Uleng Bahrun and Hasyim Kasim and Nursin Abdul Kadir and Fitri Hamka and Nadyah Haruna and Mochammad Hatta and Andi Nilawati Usman},
  title = {Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media},
  journal = {International Journal of Biomedical Materials Research},
  volume = {5},
  number = {2},
  pages = {25-28},
  doi = {10.11648/j.ijbmr.20170502.12},
  url = {https://doi.org/10.11648/j.ijbmr.20170502.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijbmr.20170502.12},
  abstract = {Percutaneous Coronary Intervention (PCI) procedure increases the risk of inflammation risk and represents adverse effects to immune system in the human body. One of the functions in the human body in maintaining the balance of immune system is Foxp3 of regulatory T cells and the function of Foxp3 is seldom to be the subject of study in coronary patients from the administration of contrast agents after PCI. This study was conducted to analyze the comparison Foxp3 levels of regulatory T cells in blood serums in patients who experienced contrast induced nephrophaty (CIN) after PCI procedure for both the CIN group and the non-CIN group. The population of coronary patients after PCI. The sample size was 20 patients that consisted of 10 patients who experienced CIN and 10 patients who experienced the CIN group. Categorization of both the CIN and non-CIN group used Kidney Disease Improving Global Outcomes (KDIGO) and detection of Foxp3 levels in blood serums using Enzyme-linked immunosorbent assay (ELISA) technique. Result of this study indicated that the characteristics of patients between the CIN group and the non-CIN group did not reveal significant difference, except for the characteristic of age. Results of the analysis by using statistical pair and non-pair t-test showed that patients for both the CIN group and non-CIN group experienced significant reduction of Foxp3 levels of regulatory T cells in their blood serums. This indicated that the PCI procedure indeed led to inflammation and Foxp3 levels and it could not be used as the specific marker for CIN incidence, but it should be mediated by the inflammation marker.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Foxp3 Serum Levels in Contrast Induced Nephrophaty Patients After the Administration of Contrast Media
AU  - Yuyun Widaningsih
AU  - Rosdiana Natsir
AU  - Mansyur Arif
AU  - Uleng Bahrun
AU  - Hasyim Kasim
AU  - Nursin Abdul Kadir
AU  - Fitri Hamka
AU  - Nadyah Haruna
AU  - Mochammad Hatta
AU  - Andi Nilawati Usman
Y1  - 2017/06/01
PY  - 2017
N1  - https://doi.org/10.11648/j.ijbmr.20170502.12
DO  - 10.11648/j.ijbmr.20170502.12
T2  - International Journal of Biomedical Materials Research
JF  - International Journal of Biomedical Materials Research
JO  - International Journal of Biomedical Materials Research
SP  - 25
EP  - 28
PB  - Science Publishing Group
SN  - 2330-7579
UR  - https://doi.org/10.11648/j.ijbmr.20170502.12
AB  - Percutaneous Coronary Intervention (PCI) procedure increases the risk of inflammation risk and represents adverse effects to immune system in the human body. One of the functions in the human body in maintaining the balance of immune system is Foxp3 of regulatory T cells and the function of Foxp3 is seldom to be the subject of study in coronary patients from the administration of contrast agents after PCI. This study was conducted to analyze the comparison Foxp3 levels of regulatory T cells in blood serums in patients who experienced contrast induced nephrophaty (CIN) after PCI procedure for both the CIN group and the non-CIN group. The population of coronary patients after PCI. The sample size was 20 patients that consisted of 10 patients who experienced CIN and 10 patients who experienced the CIN group. Categorization of both the CIN and non-CIN group used Kidney Disease Improving Global Outcomes (KDIGO) and detection of Foxp3 levels in blood serums using Enzyme-linked immunosorbent assay (ELISA) technique. Result of this study indicated that the characteristics of patients between the CIN group and the non-CIN group did not reveal significant difference, except for the characteristic of age. Results of the analysis by using statistical pair and non-pair t-test showed that patients for both the CIN group and non-CIN group experienced significant reduction of Foxp3 levels of regulatory T cells in their blood serums. This indicated that the PCI procedure indeed led to inflammation and Foxp3 levels and it could not be used as the specific marker for CIN incidence, but it should be mediated by the inflammation marker.
VL  - 5
IS  - 2
ER  -

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