Background: Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 2–3%. Psoriasis is caused by a complex interplay among the immune system, genetic background, auto-antigens, and environmental factors. Trace elements are required for the normal functioning of many enzymes and play a significant role in the development of many diseases. Objective: To assess the serum levels of zinc, copper, magnesium, iron and folate in patients with psoriasis compared to healthy controls. Patients and Methods: A total of 41 patients with psoriasis vulgaris were compared with 50 age and sex matched healthy subjects. Serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and folate were measured in both groups and compared. Psoriasis Area and Severity Index (PASI) were used to measure the severity of the disease. Results: The mean serum level of Zn was 142.2±52 in patients compared to 90.2±18.9 in the controls (P=.000), serum level of Cu was 161.1±58.5 in patients versus 156.3±42.8 in control group (P=.650). Serum Mg was 2.4±0.5 in patients and 1.9±0.2 in control subjects (P=.000). Serum Fe was 90.8±50 in patients as compared to 116.9±32.4 in control subjects (P=.004), whereas, serum folate was 6.6±3.9 in patients and 9.5±5.3 in control subjects (P=.005). There was no significant direct correlation between levels of trace elements under study and PASI scoring. Conclusions: Trace elements particularly Zn, Cu, and Mg appear to be elevated in psoriasis patients, while Fe and folate were low in psoriatic patients, however, they can't serve as biomarkers for disease activity.
| Published in | International Journal of Clinical Dermatology (Volume 3, Issue 1) |
| DOI | 10.11648/j.ijcd.20200301.14 |
| Page(s) | 15-18 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2020. Published by Science Publishing Group |
Psoriasis Vulgaris, Trace Elements, PASI
| [1] | Hawkes J. E., Chan T. C. and Krueger J. G. Psoriasis pathogenesis and the development of novel targeted immune therapies. J. Allergy Clin. Immunol. 2017; 140, 645–653. |
| [2] | Nigam P K. Serum zinc and copper levels and Cu: Zn ratio in psoriasis. Indian J Dermatol Venereol Leprol 2005; 71: 205-6. |
| [3] | Basavaraj KH, Darshan MS, Shanmugavelu P, Rashmi R, Mhatre AY, Dhanabal SP, Rao KS. Study on the levels of trace elements in mild and severe psoriasis. Clin Chim Acta. 2009; 405 (1-2): 66-70. |
| [4] | Wacewicz M, Socha K, Soroczyńska J, Niczyporuk M, Aleksiejczuk P, Ostrowska J, Borawska MH. Concentration of selenium, zinc, copper, Cu/Zn ratio, total antioxidant status and c-reactive protein in the serum of patients with psoriasis treated by narrow-band ultraviolet B phototherapy: A case-control study. J Trace Elem Med Biol. 2017; 44: 109-114. |
| [5] | Butnaru C., Pascu M., Mircea C. Serum zinc and copper levels in some dermatological diseases. Rev. Med. Chir. Soc. Med. Nat. Iasi. 2008; (1): 253-57. |
| [6] | Darlenski R, Hristakieva E, Aydin U, Gancheva D, Gancheva T, Zheleva A, Gadjeva V, Fluhr JW. Epidermal barrier and oxidative stress parameters improve during in 311 nm narrow band UVB phototherapy of plaque type psoriasis. Dermatol Sci. 2018; 91 (1): 28-34. |
| [7] | Elhaddad H, Morsy R, Mourad B, Elnimr T. A comprehensive study on the content of serum trace elements in psoriasis. J. Elem. 2017; (1): 31-42. |
| [8] | Sheikh G, Masood Q, Majeed S, Hassan I. Comparison of levels of serum copper, zinc, albumin, globulin and alkaline phosphatase in psoriatic patients and controls: A hospital based case control study. Indian Dermatol Online J 2015; 6: 81-3. |
| [9] | Shahidi-Dadras M, Namazi N, Younespour S. Comparative Analysis of Serum Copper, Iron, Ceruloplasmin, and Transferrin Levels in Mild and Severe Psoriasis Vulgaris in Iranian Patients. Indian Dermatol Online J. 2017; 8 (4): 250-253. |
| [10] | Rashmi R, Yuti AM, Basavaraj KH. Relevance of copper and ceruloplasmin in psoriasis. Clin Chim Acta 2010; 411: 1390-2. |
| [11] | Ala S, Shokrzadeh M, Golpour M, Salehifar E, Alami M, Ahmadi A. Zinc and copper levels in Iranian patients with psoriasis: A case control study. Biol Trace Elem Res 2013; 153: 22-7. |
| [12] | Gaetke L. M., Chow C. K. Copper toxicity, oxidative stress, and antioxidant nutrients. Toxicology, 2003; (1-2): 147-163. |
| [13] | Madadi A, Sethi N, Bhandari S. A study of serum zinc, copper, magnesium, proteins and enzyme superoxide dismutase in psoriasis. Indian J Dermatol Venereol Leprol. 1994; 60: 319-322. |
| [14] | Rashmi R., Yuti A. M., Basavaraj K. H. Enhanced ferritin/iron ratio in psoriasis. Ind. J. Med. Res. 2012; 135 (5): 662-665. |
| [15] | Sato S. Iron deficiency: structural and microchemical changes in hair, nails, and skin. Semin. Dermatol. 1991; 10 (4): 313-19. |
| [16] | Tsai TY, Yen H, Huang YC. Serum homocysteine, folate and vitamin B12 levels in patients with psoriasis: a systematic review and meta-analysis. Br J Dermatol. 2019; 180 (2): 382-389. |
| [17] | Brazzelli V, Grasso V, Fornara L, Moggio E, Gamba G, Villani S, Borroni G. Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity. Int J Immunopathol Pharmacol. 2010; 23 (3): 911-6. |
| [18] | Malerba, M., Gisondi, P., Radaeli, A., Sala, R., Calzavara Pinton, P. G. and Girolomoni, G. Plasma homocysteine and folate levels in patients with chronic plaque psoriasis. Br. J. Dermatol. 2006; 155, 1165–1169. |
| [19] | Lin X, Meng X, Song Z. Homocysteine and psoriasis. Biosci Rep. 2019; 39 (11). |
APA Style
Nadia Abdalhafid El Sherif, Salwa Abdalsalam El-Dibany. (2020). Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study. International Journal of Clinical Dermatology, 3(1), 15-18. https://doi.org/10.11648/j.ijcd.20200301.14
ACS Style
Nadia Abdalhafid El Sherif; Salwa Abdalsalam El-Dibany. Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study. Int. J. Clin. Dermatol. 2020, 3(1), 15-18. doi: 10.11648/j.ijcd.20200301.14
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Download@article{10.11648/j.ijcd.20200301.14,
author = {Nadia Abdalhafid El Sherif and Salwa Abdalsalam El-Dibany},
title = {Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study},
journal = {International Journal of Clinical Dermatology},
volume = {3},
number = {1},
pages = {15-18},
doi = {10.11648/j.ijcd.20200301.14},
url = {https://doi.org/10.11648/j.ijcd.20200301.14},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcd.20200301.14},
abstract = {Background: Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 2–3%. Psoriasis is caused by a complex interplay among the immune system, genetic background, auto-antigens, and environmental factors. Trace elements are required for the normal functioning of many enzymes and play a significant role in the development of many diseases. Objective: To assess the serum levels of zinc, copper, magnesium, iron and folate in patients with psoriasis compared to healthy controls. Patients and Methods: A total of 41 patients with psoriasis vulgaris were compared with 50 age and sex matched healthy subjects. Serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and folate were measured in both groups and compared. Psoriasis Area and Severity Index (PASI) were used to measure the severity of the disease. Results: The mean serum level of Zn was 142.2±52 in patients compared to 90.2±18.9 in the controls (P=.000), serum level of Cu was 161.1±58.5 in patients versus 156.3±42.8 in control group (P=.650). Serum Mg was 2.4±0.5 in patients and 1.9±0.2 in control subjects (P=.000). Serum Fe was 90.8±50 in patients as compared to 116.9±32.4 in control subjects (P=.004), whereas, serum folate was 6.6±3.9 in patients and 9.5±5.3 in control subjects (P=.005). There was no significant direct correlation between levels of trace elements under study and PASI scoring. Conclusions: Trace elements particularly Zn, Cu, and Mg appear to be elevated in psoriasis patients, while Fe and folate were low in psoriatic patients, however, they can't serve as biomarkers for disease activity.},
year = {2020}
}
TY - JOUR T1 - Estimation of Serum Trace Elements Levels in Libyan Patients with Psoriasis Vulgaris: A Case Control Study AU - Nadia Abdalhafid El Sherif AU - Salwa Abdalsalam El-Dibany Y1 - 2020/06/09 PY - 2020 N1 - https://doi.org/10.11648/j.ijcd.20200301.14 DO - 10.11648/j.ijcd.20200301.14 T2 - International Journal of Clinical Dermatology JF - International Journal of Clinical Dermatology JO - International Journal of Clinical Dermatology SP - 15 EP - 18 PB - Science Publishing Group SN - 2995-1305 UR - https://doi.org/10.11648/j.ijcd.20200301.14 AB - Background: Psoriasis is a chronic autoimmune skin disease with a worldwide prevalence of 2–3%. Psoriasis is caused by a complex interplay among the immune system, genetic background, auto-antigens, and environmental factors. Trace elements are required for the normal functioning of many enzymes and play a significant role in the development of many diseases. Objective: To assess the serum levels of zinc, copper, magnesium, iron and folate in patients with psoriasis compared to healthy controls. Patients and Methods: A total of 41 patients with psoriasis vulgaris were compared with 50 age and sex matched healthy subjects. Serum levels of zinc (Zn), copper (Cu), magnesium (Mg), iron (Fe) and folate were measured in both groups and compared. Psoriasis Area and Severity Index (PASI) were used to measure the severity of the disease. Results: The mean serum level of Zn was 142.2±52 in patients compared to 90.2±18.9 in the controls (P=.000), serum level of Cu was 161.1±58.5 in patients versus 156.3±42.8 in control group (P=.650). Serum Mg was 2.4±0.5 in patients and 1.9±0.2 in control subjects (P=.000). Serum Fe was 90.8±50 in patients as compared to 116.9±32.4 in control subjects (P=.004), whereas, serum folate was 6.6±3.9 in patients and 9.5±5.3 in control subjects (P=.005). There was no significant direct correlation between levels of trace elements under study and PASI scoring. Conclusions: Trace elements particularly Zn, Cu, and Mg appear to be elevated in psoriasis patients, while Fe and folate were low in psoriatic patients, however, they can't serve as biomarkers for disease activity. VL - 3 IS - 1 ER -
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