Donovanosis (Granuloma inguinale) is a sexually transmitted bacterial infection affecting the genital, perineal, and perianal regions. It is caused by Klebsiella granulomatis, formerly known as Donovania granulomatis and Calymmatobacterium granulomatis. Without treatment, the infection followed a chronic progressive course with the formation of ulcerations. Upon chronification, severe tissue destruction occurs and malignant transformation is possible. Healing is complete with timely diagnosis and treatment. Donovanosis has not been reported in Bulgaria and herein, we present the first clinical case of this "exotic" for our country sexually transmitted bacterial infection. Our patient was a 38-year-old man of Nigerian origin. The dermatological status is represented by papular and erosive-ulcerative lesions on the skin of the foreskin, the body of the penis, the scrotum and the lower abdomen. Upon Giemsa staining of ulcus material, Donovan corpuscles are found in monocytes. The histopathological examination a lesion demonstrated irregular acanthosis, focal dyskeratosis in the lower epidermal segment, moderate spongiosis, papillary oedema, edema swollen endothelium obstructing the vessels of small and medium caliber, abundant granulomatous tuberculoid infiltrate of epithelioid cells and lymphocytes around the blood vessels in the middle dermis and interstitial. Infectious granulomas are represented by tissue macrophages, epithelioid cells and lymphocytes located around areas of collagen necrosis. Based on the anamnesis, dermatological status and examinations, the diagnosis of donovanosis was made. Epithelialization of the ulks occurred after an extended course of systemic treatment with doxycyclin for 20 days, followed by azax for 7 days. The topical treatment included baths with potassium permanganate and fusidine cream.
| Published in | International Journal of Clinical Dermatology (Volume 6, Issue 1) |
| DOI | 10.11648/j.ijcd.20230601.12 |
| Page(s) | 10-13 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2023. Published by Science Publishing Group |
Donovanosis, Sexually Transmitted Infection, Genital Ulceration, Diagnosis, Treatment
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| [10] | Martins S, Jardim MML. Donovanose. In: Belda W. Jr, Di Chiacchio N., Criado P. R., editors. Tratado de Dermatologia. Ed Atheneu; São Paulo: 2018: 1587–1592. |
| [11] | Goldberg J. Studies on Granuloma inguinale V. Isolation of a bacterium resembling donovania granulomatis from the faeces of a patient with granuloma inguinale. Br J Vener Dis. 1962; 38: 99–102. |
| [12] | Santiago-Wickey JN, Crosby B. Granuloma Inguinale. 2022 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2022 Jan–. PMID: 30020678. |
| [13] | Carter JS, Bowden FJ, et al. Phylogenetic evidence for reclassification of Calymatobacterium granulomatis as Klebsiella granulomatis comb. noev. Int J Syst Bacteriol. 1999; 49: 1695–1700. |
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APA Style
Hristo Mangarov, Valentina Broshtilova, Atanas Batashki, Yoanna Velevska, Petar Vatov, et al. (2023). Donovanosis – A Case Report with a Review of Literature. International Journal of Clinical Dermatology, 6(1), 10-13. https://doi.org/10.11648/j.ijcd.20230601.12
ACS Style
Hristo Mangarov; Valentina Broshtilova; Atanas Batashki; Yoanna Velevska; Petar Vatov, et al. Donovanosis – A Case Report with a Review of Literature. Int. J. Clin. Dermatol. 2023, 6(1), 10-13. doi: 10.11648/j.ijcd.20230601.12
AMA Style
Hristo Mangarov, Valentina Broshtilova, Atanas Batashki, Yoanna Velevska, Petar Vatov, et al. Donovanosis – A Case Report with a Review of Literature. Int J Clin Dermatol. 2023;6(1):10-13. doi: 10.11648/j.ijcd.20230601.12
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Download@article{10.11648/j.ijcd.20230601.12,
author = {Hristo Mangarov and Valentina Broshtilova and Atanas Batashki and Yoanna Velevska and Petar Vatov and Svetlana Bezhanova and Irina Iungareva and Sonya Marina},
title = {Donovanosis – A Case Report with a Review of Literature},
journal = {International Journal of Clinical Dermatology},
volume = {6},
number = {1},
pages = {10-13},
doi = {10.11648/j.ijcd.20230601.12},
url = {https://doi.org/10.11648/j.ijcd.20230601.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcd.20230601.12},
abstract = {Donovanosis (Granuloma inguinale) is a sexually transmitted bacterial infection affecting the genital, perineal, and perianal regions. It is caused by Klebsiella granulomatis, formerly known as Donovania granulomatis and Calymmatobacterium granulomatis. Without treatment, the infection followed a chronic progressive course with the formation of ulcerations. Upon chronification, severe tissue destruction occurs and malignant transformation is possible. Healing is complete with timely diagnosis and treatment. Donovanosis has not been reported in Bulgaria and herein, we present the first clinical case of this "exotic" for our country sexually transmitted bacterial infection. Our patient was a 38-year-old man of Nigerian origin. The dermatological status is represented by papular and erosive-ulcerative lesions on the skin of the foreskin, the body of the penis, the scrotum and the lower abdomen. Upon Giemsa staining of ulcus material, Donovan corpuscles are found in monocytes. The histopathological examination a lesion demonstrated irregular acanthosis, focal dyskeratosis in the lower epidermal segment, moderate spongiosis, papillary oedema, edema swollen endothelium obstructing the vessels of small and medium caliber, abundant granulomatous tuberculoid infiltrate of epithelioid cells and lymphocytes around the blood vessels in the middle dermis and interstitial. Infectious granulomas are represented by tissue macrophages, epithelioid cells and lymphocytes located around areas of collagen necrosis. Based on the anamnesis, dermatological status and examinations, the diagnosis of donovanosis was made. Epithelialization of the ulks occurred after an extended course of systemic treatment with doxycyclin for 20 days, followed by azax for 7 days. The topical treatment included baths with potassium permanganate and fusidine cream.},
year = {2023}
}
TY - JOUR T1 - Donovanosis – A Case Report with a Review of Literature AU - Hristo Mangarov AU - Valentina Broshtilova AU - Atanas Batashki AU - Yoanna Velevska AU - Petar Vatov AU - Svetlana Bezhanova AU - Irina Iungareva AU - Sonya Marina Y1 - 2023/07/06 PY - 2023 N1 - https://doi.org/10.11648/j.ijcd.20230601.12 DO - 10.11648/j.ijcd.20230601.12 T2 - International Journal of Clinical Dermatology JF - International Journal of Clinical Dermatology JO - International Journal of Clinical Dermatology SP - 10 EP - 13 PB - Science Publishing Group SN - 2995-1305 UR - https://doi.org/10.11648/j.ijcd.20230601.12 AB - Donovanosis (Granuloma inguinale) is a sexually transmitted bacterial infection affecting the genital, perineal, and perianal regions. It is caused by Klebsiella granulomatis, formerly known as Donovania granulomatis and Calymmatobacterium granulomatis. Without treatment, the infection followed a chronic progressive course with the formation of ulcerations. Upon chronification, severe tissue destruction occurs and malignant transformation is possible. Healing is complete with timely diagnosis and treatment. Donovanosis has not been reported in Bulgaria and herein, we present the first clinical case of this "exotic" for our country sexually transmitted bacterial infection. Our patient was a 38-year-old man of Nigerian origin. The dermatological status is represented by papular and erosive-ulcerative lesions on the skin of the foreskin, the body of the penis, the scrotum and the lower abdomen. Upon Giemsa staining of ulcus material, Donovan corpuscles are found in monocytes. The histopathological examination a lesion demonstrated irregular acanthosis, focal dyskeratosis in the lower epidermal segment, moderate spongiosis, papillary oedema, edema swollen endothelium obstructing the vessels of small and medium caliber, abundant granulomatous tuberculoid infiltrate of epithelioid cells and lymphocytes around the blood vessels in the middle dermis and interstitial. Infectious granulomas are represented by tissue macrophages, epithelioid cells and lymphocytes located around areas of collagen necrosis. Based on the anamnesis, dermatological status and examinations, the diagnosis of donovanosis was made. Epithelialization of the ulks occurred after an extended course of systemic treatment with doxycyclin for 20 days, followed by azax for 7 days. The topical treatment included baths with potassium permanganate and fusidine cream. VL - 6 IS - 1 ER -
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