Worldwide, the frequency of chronic inflammatory bowel disease (CIBD), including ulcerative colitis (UC) and Crohn's disease (CD) increased rapidly through the last century making their histopathological diagnosis daily task for all pathologists. The accurate histopathological diagnosis of UC and CD requires an intimate correlations between the clinical, laboratory and endoscopic findings in conjunction to the suitable obtained biopsy material, as there are several diagnostic confusions between CIBD and non CIBD forms. The aim of this study was to focus and analyze certain practically selected histopathological features for the diagnosis of UC and CD including crypt architectural abnormalities, inflammation and an associated dysplasia or adenocarcinoma. This present study was performed on 100 specimens of tissue samples taken from small and large bowel including 3 ileocecal resections which were done for suspected an IBD. All the tissue samples received fixed in 10% neutral buffered formalin fixative solution, and paraffin-embedded tissue sections were prepared and examined microscopically for the histopathological features which distinguishing CIBD from non CIBD colitis. This study revealed 95 cases CIBD, among them 55 cases CD and 40 cases were UC, whereas the remaining 5 cases were non CIBD colitis. This study concluded that the diagnosis of IBD needs interdepartmental correlations to avoid under- or over-diagnosis. As well as the accurate discrimination of CIBD from non CIBD forms, differentiate UC from CD, and to identify any dysplastic lesions which is the backbone for therapeutic and prognostic strategies.
| Published in | International Journal of Clinical and Developmental Anatomy (Volume 1, Issue 1) |
| DOI | 10.11648/j.ijcda.20150101.11 |
| Page(s) | 1-7 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2015. Published by Science Publishing Group |
IBD, UC, CD, Anatomical, and Histopathological
| [1] | Tanaka T (2009): Colorectal carcinogenesis: Review of human and experimental animal studies. J Carcinog; 8:5. |
| [2] | Burisch J, Jess T, Martinato M and Lakatos PL (2013): The burden of inflammatory bowel disease in Europe. J Crohns Colitis; 7:322-37. |
| [3] | Ng SC, Bernstein CN, Vatn MH, Lakatos PL, Loftus EV, Jr., Tysk C, O'Morain C, Moum B and Colombel JF (2013): Geographical variability and environmental risk factors in inflammatory bowel disease. Gut, 62:630-49. |
| [4] | Schumacher G, Kollberg B, and Sandstedt B (1994): A prospective study of first attacks of inflammatory bowel disease and infectious colitis.Histologic course during the 1st year after presentation. Scand J Gastroenterol; 29:318–332. |
| [5] | Jenkins D, Balsitis M, Gallivan S, Dixon MF, Gilmour HM, Shepherd NA, Theodossi A, and Williams GT (1997): Guidelines for the initial biopsy diagnosis of suspected chronic idiopathic inflammatory bowel disease. The British Society of Gastro-enterology Initiative. J Clin Pathol; 50: 93-105. |
| [6] | Bernstein CN, Nugent Z, Longobardi T, and Blanchard JF (2009): Isotretinoin is not associated with inflammatory bowel disease: a population-based case-control study. Am J Gastroenterol. Nov; 104(11):2774-8. |
| [7] | Cornaggia M, Leutner M, Mescoli C, Sturniolo GC, and Gullotta R (2011): Chronic idiopathic inflammatory bowel diseases: the histology report. Dig Liver Dis.; 43 Suppl 4:293–303. |
| [8] | Russell RK, and Satsangi J (2004). IBD: A Family Affair. Best Pract Res Clin Gastroenterol; Jun; 18(3):525-39 |
| [9] | Noomen CG, Hommes DW, and Fidder HH, (2009): Update on genetics in infammatory disease. Best Pract Res Clin Gastroenterol; 23(2):233-243. |
| [10] | Van AG, Axel D, Bernd B, Silvio D, Paolo G, Gabriele M, Laurent B et al. (2013): The second European evidence-based consensus on the diagnosis and management of Ulcerative Colitis Part 3: special situations. Journal of Crohn’s& Colitis, February; 7(1):1-33 |
| [11] | Harpaz N, and Polydorides A D (2010): Colorectal Dysplasia in Chronic Inflammatory Bowel Disease Pathology, Clinical Implications, and Pathogenesis. Arch Pathol Lab Med.; 134:876–895 |
| [12] | Villanacci V, Antonelli E, Geboes K, Casella G, and Bassotti G, (2013): Histological healing in inflammatory bowel disease: A still unfulfilled promise. World J Gastroenterol; 19(7): 968-978. |
| [13] | Seldenrijk CA, Morson BC, Meuwissen SG, Schipper NW, Lindeman J, and Meijer CJ (1991): Histopathological evaluation of colonic mucosal biopsy specimens in chronic inflammatory bowel disease: diagnostic implications. Gut; 32: 1514-1520. |
| [14] | Scott BB, Goodall A, Stephenson P, and Jenkins D (1983): Rectal mucosal plasma cells in inflammatory bowel disease. Gut; 24: 519-524. |
| [15] | Rubio CA, Johansson C, Uribe A, and KockY (1984): A quantitative method of estimating inflammation in the rectal mucosa. IV. Ulcerative colitis in remission. Scand J Gastroenterol; 19: 525-530. |
| [16] | Margo F, Langner C, Driessen A, Ensari A, Geboes K, Mantzaris GJ, Villanacci V, Becheanu G, BorralhoNunes, Cathomas G, Fries W, et al. (2013): European consensus on the histopathology of inflammatory bowel disease. Journal of Crohn's and Colitis; 7, 827–851. |
| [17] | Hoffmann JC, Preiss JC, Autschbach F, et al. (2008): Clinical practice guideline on diagnosis and treatment of Crohn's disease. Z Gastroenterol; 46:1094–146. |
| [18] | Bentley E, Jenkins D, Campbell F, and Warren B (2002): How could pathologists improve the initial diagnosis of colitis? Evidence from an international workshop. J Clin Pathol; 55:955–60. |
| [19] | Geboes K, Colombel JF, Greenstein A, A, Jewell DP, Sandborn WJ, Vatn MH, and Warren B (2008): Indeterminate Colitis: A Review of the Concept – What’s in a Name? Inflamm Bowel Dis.; 14:850–57. |
| [20] | Kugathasan S, Judd RH, Hoffmann RG, HeikenenJ, Telega G, Khan F, et al (2003): Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin: a statewide population based study. J Pediatr; 143:525–31. |
| [21] | Malaty HM, Bincy PA, Mehta S,Garnett EA, and Ferry FD (2013): The natural history of ulcerative colitis in a pediatric population: a follow-up population-based cohort study. Clin Exp Gastroenterol. 2013; 6: 77–83. |
| [22] | Jenkins D, Goodall A, Drew K, and Scott BB (1988): What is colitis? Statistical approach to distinguishing clinically important inflammatory change in rectal biopsy specimens. J ClinPathol; 41: 72-79. |
| [23] | Bataille F, Klebl F, Rummele P, Straub RH, Wild P, Schölmerich J, and Hofstädter F (2003): Histopathological parameters as predictors for the course of Crohn's disease. Virchows Arch; 443:501–7. |
| [24] | Geboes K (2003). Histopathology of Crohn’s Disease and Ulcerative Colitis. IBD 4th ed. 18. New York: Churchill-Livingstone; (255-275). |
| [25] | Swan NC, Geoghegan JG, O'Donoghue DP, Hyland JM, and Sheahan K (1994): Fulminant colitis in inflammatory bowel disease: detailed pathologic and clinical analysis. Dis Colon Rectum; 41: 1511–5. |
| [26] | Tobin JM, Sinha B, Ramani P, Saleh AR, and Murphy MS (2001): Upper gastrointestinal mucosal disease in pediatric Crohn's disease and ulcerative colitis: a blinded, controlled study. J Pediatr Gastroenterol Nutr; 32:443–8. |
| [27] | Konuma Y, Tanaka M, Saito H, Munakata A, Yoshida Y (1995): A study of the histological criteria for ulcerative colitis: retrospective evaluation of multiple colonic biopsies. J Gastroenterol; 30:189–94. |
| [28] | Berre NL, Heresbach D, Kerbaol M, Caulet S, Bretagne JF, Chaperon J, Gosselin M, and Ramee MP,(1995): Histological discrimination of idiopathic inflammatory bowel disease from other types of colitis. J Clin Pathol; 48:749-753. |
| [29] | Surawicz CM, Haggit RC, Husseman M, McFarland LV, (1994): Mucosal biopsy diagnosis of colitis: acute self-limited colitis and idiopathic inflammatory bowel disease. Gastroenterology; 107:755-63. |
| [30] | Yano Y, Matsui T, Hirai F, Okado Y, Sato Y, Tsurumi K, Ishikawa S, Beppu T, Koga A, Yoshizawa N, Higashi D and Futami K (2013): Cancer risk in Japanese Crohn's disease patients: Investigation of the standardized incidence ratio. J Gastroenterol Hepatol 2013. |
| [31] | Raithel M, Weidenhiller M, Schwab D, Muller S and Hahn EG (2001): Pathobiology of dysplasia in chronic inflammatory bowel disease: Current recommendations for surveillance of dysplasia. Z Gastroenterol, 39:861-75. |
APA Style
Ahmed M. S. Hegazy, Mohammed M. Mosaed, Taha M. M. Hassan. (2015). Inflammatory Bowel Disease: Anatomical and Histopathological Study. International Journal of Clinical and Developmental Anatomy, 1(1), 1-7. https://doi.org/10.11648/j.ijcda.20150101.11
ACS Style
Ahmed M. S. Hegazy; Mohammed M. Mosaed; Taha M. M. Hassan. Inflammatory Bowel Disease: Anatomical and Histopathological Study. Int. J. Clin. Dev. Anat. 2015, 1(1), 1-7. doi: 10.11648/j.ijcda.20150101.11
AMA Style
Ahmed M. S. Hegazy, Mohammed M. Mosaed, Taha M. M. Hassan. Inflammatory Bowel Disease: Anatomical and Histopathological Study. Int J Clin Dev Anat. 2015;1(1):1-7. doi: 10.11648/j.ijcda.20150101.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.ijcda.20150101.11,
author = {Ahmed M. S. Hegazy and Mohammed M. Mosaed and Taha M. M. Hassan},
title = {Inflammatory Bowel Disease: Anatomical and Histopathological Study},
journal = {International Journal of Clinical and Developmental Anatomy},
volume = {1},
number = {1},
pages = {1-7},
doi = {10.11648/j.ijcda.20150101.11},
url = {https://doi.org/10.11648/j.ijcda.20150101.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcda.20150101.11},
abstract = {Worldwide, the frequency of chronic inflammatory bowel disease (CIBD), including ulcerative colitis (UC) and Crohn's disease (CD) increased rapidly through the last century making their histopathological diagnosis daily task for all pathologists. The accurate histopathological diagnosis of UC and CD requires an intimate correlations between the clinical, laboratory and endoscopic findings in conjunction to the suitable obtained biopsy material, as there are several diagnostic confusions between CIBD and non CIBD forms. The aim of this study was to focus and analyze certain practically selected histopathological features for the diagnosis of UC and CD including crypt architectural abnormalities, inflammation and an associated dysplasia or adenocarcinoma. This present study was performed on 100 specimens of tissue samples taken from small and large bowel including 3 ileocecal resections which were done for suspected an IBD. All the tissue samples received fixed in 10% neutral buffered formalin fixative solution, and paraffin-embedded tissue sections were prepared and examined microscopically for the histopathological features which distinguishing CIBD from non CIBD colitis. This study revealed 95 cases CIBD, among them 55 cases CD and 40 cases were UC, whereas the remaining 5 cases were non CIBD colitis. This study concluded that the diagnosis of IBD needs interdepartmental correlations to avoid under- or over-diagnosis. As well as the accurate discrimination of CIBD from non CIBD forms, differentiate UC from CD, and to identify any dysplastic lesions which is the backbone for therapeutic and prognostic strategies.},
year = {2015}
}
TY - JOUR T1 - Inflammatory Bowel Disease: Anatomical and Histopathological Study AU - Ahmed M. S. Hegazy AU - Mohammed M. Mosaed AU - Taha M. M. Hassan Y1 - 2015/05/07 PY - 2015 N1 - https://doi.org/10.11648/j.ijcda.20150101.11 DO - 10.11648/j.ijcda.20150101.11 T2 - International Journal of Clinical and Developmental Anatomy JF - International Journal of Clinical and Developmental Anatomy JO - International Journal of Clinical and Developmental Anatomy SP - 1 EP - 7 PB - Science Publishing Group SN - 2469-8008 UR - https://doi.org/10.11648/j.ijcda.20150101.11 AB - Worldwide, the frequency of chronic inflammatory bowel disease (CIBD), including ulcerative colitis (UC) and Crohn's disease (CD) increased rapidly through the last century making their histopathological diagnosis daily task for all pathologists. The accurate histopathological diagnosis of UC and CD requires an intimate correlations between the clinical, laboratory and endoscopic findings in conjunction to the suitable obtained biopsy material, as there are several diagnostic confusions between CIBD and non CIBD forms. The aim of this study was to focus and analyze certain practically selected histopathological features for the diagnosis of UC and CD including crypt architectural abnormalities, inflammation and an associated dysplasia or adenocarcinoma. This present study was performed on 100 specimens of tissue samples taken from small and large bowel including 3 ileocecal resections which were done for suspected an IBD. All the tissue samples received fixed in 10% neutral buffered formalin fixative solution, and paraffin-embedded tissue sections were prepared and examined microscopically for the histopathological features which distinguishing CIBD from non CIBD colitis. This study revealed 95 cases CIBD, among them 55 cases CD and 40 cases were UC, whereas the remaining 5 cases were non CIBD colitis. This study concluded that the diagnosis of IBD needs interdepartmental correlations to avoid under- or over-diagnosis. As well as the accurate discrimination of CIBD from non CIBD forms, differentiate UC from CD, and to identify any dysplastic lesions which is the backbone for therapeutic and prognostic strategies. VL - 1 IS - 1 ER -
Information
Email: