Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients

Tehseen Hassan; Wasim Qureshi; Showkat Ahmad Bhat; Sabhiya Majid; Manzoor R. Mir; Purnima Shrivastava

doi:doi:10.11648/j.ijcocr.20170204.12

| Peer-Reviewed

Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients

Tehseen Hassan, Wasim Qureshi, Showkat Ahmad Bhat, Sabhiya Majid, Manzoor R. Mir, Purnima Shrivastava

Published in International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 4)

Received: 2 July 2017 Accepted: 13 July 2017 Published: 15 August 2017

Views: Downloads:

Download PDF

Share This Article

Twitter
Linked In
Facebook

Abstract

Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentration of Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) in breast cancer (BC) patients and healthy individuals by using atomic absorption spectrophotometer. Results: There was a significant (p<0.05) decline in the concentration of Se in serum samples of BC patients as on comparison with the healthy individuals. Concentration of Cu of BC patients was increased significantly (p<0.05) on comparison with the healthy individuals. There was a significant (p<0.05) decline in the concentration of Zn in BC patients on comparison with the healthy individuals. Level of difference of Fe remain insignificant (p>0.05) in serum of BC patients. There was a significant decline in the concentration of Se and Zn while high level of serum copper in breast cancer patients, as compared with normal healthy controls. Conclusion: We found a significant association between trace elements (serum selenium, zinc and copper) with breast cancer.

Published in	International Journal of Clinical Oncology and Cancer Research (Volume 2, Issue 4)
DOI	10.11648/j.ijcocr.20170204.12
Page(s)	82-85
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Breast Cancer (BC), Serum Minerals, Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe)

References

[1]	Tehseen Hassan, Showkat Ahmad Bhat, Sabhiya Majid, et al. BRCA1 Promoter Hypermethylationas an Early Diagnostic Tool for Breast Cancer. Cancer Research Journal, 2017; 5 (2): 9-13.
[2]	Showkat Ahmad Bhat, Manzoor R Mir, Sabhiya Majid, et al. Serum lipid profile of breast cancer patients in Kashmir. J Invest Biochem. 2013; 2 (1): 26-31.
[3]	Kilic E, Saraymen R, Demiroglu A and Ok E. Chromium and manganese levels in the scalp hair of normals and patients with breast cancer. Biol Trace Elem Res 2004; 102: 19-25.
[4]	Farhan, AR. Evaluation of Chromium and Selenium in Serum of Female Patients with Breast Tumor. International Journal of Dental and Medical Sciences, 2013; 11 (6) 36-40.
[5]	Sancak B, Unal A, Candan S, Coskun U, Gunel N. Association between oxidative stress and selenium levels in patients with breast cancer at different clinical stages. J Trace Elem Exp Med 2003; 16: 87-94.
[6]	Wu HD, Chou SY, Chen DR and Kuo HW. Differentiation of serum levels of trace elements in normal and malignant breast patients. Biol Trace Elem Res 2006; 113: 9-18.
[7]	Rayman MP and Dipple A: Studies of the mechanism of tumour initiation. Br J Cancer 1: 85, 1973.
[8]	Challis BC and Rayman MP: Potential alkylating agents from the oxidation of carcinogenetic cyclic N-nitrosamines. Br J Cancer 1: 84, 1973.
[9]	Kallistratos G, Evangelou A, Seferiadis K, Vezyraki P and Barboutis K: Selenium and haemodialysis: serum selenium levels in healthy persons, non-cancer and cancer patients with chronic renal failure. Nephron 41: 217-222, 1985.
[10]	Rayman M: The importance of selenium to humans and health. Cancer 356: 233-241, 2000.
[11]	Rayman M: Selenium in cancer prevention: a review of the evidence and mechanism of action. Proc Nutr Soc 64: 527-542, 2005.
[12]	Rayman MP and Rayman MP: The argument for increasing selenium intake. Proc Nutr Soc 61 (2): 203-215, 2002.
[13]	Toyokuni S. Iron-induced carcinogenesis: the role of Redox regulation. Free Radic Biol Med. 1996; 20 (4): 553–566.
[14]	Stevens RG, Kalkwarf DR. Iron, radiation, and cancer. Environ Health Persp. 1990; 87:291–300.
[15]	Massa EM and Giulivi C. Alkoxyl and methyl radical formation during cleavage of ter tbutyl hydroperoxide by a mitochondrial membrane-band redox active copper pool: An EPP study. Free Radic. Biol. Med. 1993. 14: 559-565.
[16]	Clogg, M. S., C. L. Keen and I. S. Hurley. Biochemical pathologies of zinc deficiencies. In: Mills, CF. (Eds), Zinc in human biology. International life Science Institute, London. 1989.
[17]	Kaim, W. and B. Schwederski. Bioinorganic chemistry: Inorganic Elements in the chemistry of life. John Wiley and Sons, New York. 1994.
[18]	Burke, J. P. and M. R. Fenton. Effect of a zinc deficient diet on lipid peroxidation in liver and tumour subcellular membranes. P Soc. Exp. biol. Med. 1985, 179:187-197.
[19]	Prasad AS. Impact of the discovery of human zinc deficiency on health. J Am Coll Nutr, 2009; 928, 257-65.
[20]	K Charalabopoulos, A Kotsalos, A Batistatou, et al. Selenium in serum and neoplastic tissue in breast cancer. British Journal of Cancer (2006) 95 (6), 674 – 676.
[21]	Charalabopoulos K, Kotsalos A, Karkabounas S, Vezyraki, et al. Low selenium levels in serum and increased concentration in neoplastic tissues in patients with colorectal cancer: correlation with serum carcinoembryonic antigen. Scand J Gastroenterol 41: 359-360, 2006.
[22]	Mazdak H, Yazdekhasti F, Movahedian A, Mirkheshti N, Shafieian M (2010). The comparative study of serum iron, copper, and zinc levels between bladder cancer patients and a control group. Int Urol Nephrol, 42, 89–93.
[23]	Yiicel I, Arpaci F, Ozet A et al. Serum copper and zinc levels and copper/zinc ratio in patients with breast cancer. Biol Trace Elem 1994; 40: 31-38.
[24]	Gupta SK, Shukla VK, Vaidya MP, Roy SK, Gupta S. Serum and tissue trace elements in colorectal cancer. J Surg Oncol 1993; 52: 172-175.
[25]	Liu XG. Serum and tissue copper, zinc and selenium levels in patients with breast carcinoma. Chung Hua Chung Liu Tsa Chih 1991; 13: 93-96.
[26]	Massa EM and Giulivi C. Alkoxyl and methyl radical formation during cleavage of tert butyl hydroperoxide by a mitochondrial membrane-band redox active copper pool: An EPP study. Free Radic. Biol. Med. 1993. 14: 559-565.
[27]	Linder, MC and M. Hazegh Azam. Copper biochemistry and molecular biology. Am. J. Clin. Nutr. 1996. 63: 797-811.
[28]	ML Adeoti, AS Oguntola, EO Akanni, OS Agodirin, et al. Trace elements; copper, zinc and selenium, in breast cancer afflicted female patients in LAUTECH Osogbo, Nigeria. Indian Journal of Cancer, 2015: 52: 1, 106-109.
[29]	Alatise OI, Schrauzer GN. Lead exposure: A contributing cause of the current breast cancer epidemic in Nigerian women. Biol Trace Elem Res 2010; 136: 127-39.
[30]	Ajayi GO. Copper and zinc concentrations in Nigerian women with breast cancer. Eur J Gynaecol Oncol 2011; 32: 307-8.
[31]	Burke, J. P. and M. R. Fenton. Effect of a zinc deficient diet on lipid peroxidation in liver and tumour subcellular membranes. P Soc. Exp. biol. Med. 1985, 179: 187-197.
[32]	Kaim, W. and B. Schwederski. Bioinorganic chemistry: Inorganic Elements in the chemistry of life. John Wiley and Sons, New York. 1994.
[33]	Prasad AS, Clinical, biochemical and nutritional spectrum of zinc deficiency in human subjects: An update. Nutr. Rev, 1983; 41: 187-208.
[34]	Weinberg and E. D. The role of iron in cancer. Eur. J. Cancer prevention. 1996. 5: 19-36.

Cite This Article

Plain Text BibTeX RIS

APA Style

Tehseen Hassan, Wasim Qureshi, Showkat Ahmad Bhat, Sabhiya Majid, Manzoor R. Mir, et al. (2017). Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients. International Journal of Clinical Oncology and Cancer Research, 2(4), 82-85. https://doi.org/10.11648/j.ijcocr.20170204.12

Copy | Download

ACS Style

Tehseen Hassan; Wasim Qureshi; Showkat Ahmad Bhat; Sabhiya Majid; Manzoor R. Mir, et al. Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients. Int. J. Clin. Oncol. Cancer Res. 2017, 2(4), 82-85. doi: 10.11648/j.ijcocr.20170204.12

Copy | Download

AMA Style

Tehseen Hassan, Wasim Qureshi, Showkat Ahmad Bhat, Sabhiya Majid, Manzoor R. Mir, et al. Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients. Int J Clin Oncol Cancer Res. 2017;2(4):82-85. doi: 10.11648/j.ijcocr.20170204.12

Copy | Download

@article{10.11648/j.ijcocr.20170204.12,
  author = {Tehseen Hassan and Wasim Qureshi and Showkat Ahmad Bhat and Sabhiya Majid and Manzoor R. Mir and Purnima Shrivastava},
  title = {Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {2},
  number = {4},
  pages = {82-85},
  doi = {10.11648/j.ijcocr.20170204.12},
  url = {https://doi.org/10.11648/j.ijcocr.20170204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170204.12},
  abstract = {Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentration of Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) in breast cancer (BC) patients and healthy individuals by using atomic absorption spectrophotometer. Results: There was a significant (p0.05) in serum of BC patients. There was a significant decline in the concentration of Se and Zn while high level of serum copper in breast cancer patients, as compared with normal healthy controls. Conclusion: We found a significant association between trace elements (serum selenium, zinc and copper) with breast cancer.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients
AU  - Tehseen Hassan
AU  - Wasim Qureshi
AU  - Showkat Ahmad Bhat
AU  - Sabhiya Majid
AU  - Manzoor R. Mir
AU  - Purnima Shrivastava
Y1  - 2017/08/15
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20170204.12
DO  - 10.11648/j.ijcocr.20170204.12
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 82
EP  - 85
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20170204.12
AB  - Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentration of Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) in breast cancer (BC) patients and healthy individuals by using atomic absorption spectrophotometer. Results: There was a significant (p0.05) in serum of BC patients. There was a significant decline in the concentration of Se and Zn while high level of serum copper in breast cancer patients, as compared with normal healthy controls. Conclusion: We found a significant association between trace elements (serum selenium, zinc and copper) with breast cancer.
VL  - 2
IS  - 4
ER  -

Copy | Download

Author Information

Tehseen Hassan

Department of Biochemistry, Govt. Medical College, Srinagar, India
Wasim Qureshi

Registrar Academics, Govt. Medical College, Srinagar, India
Showkat Ahmad Bhat

Department of Biochemistry, Govt. Medical College, Srinagar, India
Sabhiya Majid

Department of Biochemistry, Govt. Medical College, Srinagar, India
Manzoor R. Mir

Division of Vety. Biochemistry, Faculty of Veterinary Sciences, & Animal Husbandry, SKAUST-K, Shuhama, Srinagar, India
Purnima Shrivastava

Director Research, Bhagwant University, Sikar Road Ajmer, Rajasthan, India

Download PDF

Sections

Plain Text BibTeX RIS

APA Style

Tehseen Hassan, Wasim Qureshi, Showkat Ahmad Bhat, Sabhiya Majid, Manzoor R. Mir, et al. (2017). Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients. International Journal of Clinical Oncology and Cancer Research, 2(4), 82-85. https://doi.org/10.11648/j.ijcocr.20170204.12

Copy | Download

ACS Style

Tehseen Hassan; Wasim Qureshi; Showkat Ahmad Bhat; Sabhiya Majid; Manzoor R. Mir, et al. Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients. Int. J. Clin. Oncol. Cancer Res. 2017, 2(4), 82-85. doi: 10.11648/j.ijcocr.20170204.12

Copy | Download

AMA Style

Tehseen Hassan, Wasim Qureshi, Showkat Ahmad Bhat, Sabhiya Majid, Manzoor R. Mir, et al. Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients. Int J Clin Oncol Cancer Res. 2017;2(4):82-85. doi: 10.11648/j.ijcocr.20170204.12

Copy | Download

@article{10.11648/j.ijcocr.20170204.12,
  author = {Tehseen Hassan and Wasim Qureshi and Showkat Ahmad Bhat and Sabhiya Majid and Manzoor R. Mir and Purnima Shrivastava},
  title = {Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients},
  journal = {International Journal of Clinical Oncology and Cancer Research},
  volume = {2},
  number = {4},
  pages = {82-85},
  doi = {10.11648/j.ijcocr.20170204.12},
  url = {https://doi.org/10.11648/j.ijcocr.20170204.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcocr.20170204.12},
  abstract = {Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentration of Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) in breast cancer (BC) patients and healthy individuals by using atomic absorption spectrophotometer. Results: There was a significant (p0.05) in serum of BC patients. There was a significant decline in the concentration of Se and Zn while high level of serum copper in breast cancer patients, as compared with normal healthy controls. Conclusion: We found a significant association between trace elements (serum selenium, zinc and copper) with breast cancer.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Study of Serum Levels of Trace Elements (Selenium, Copper, Zinc, and Iron) in Breast Cancer Patients
AU  - Tehseen Hassan
AU  - Wasim Qureshi
AU  - Showkat Ahmad Bhat
AU  - Sabhiya Majid
AU  - Manzoor R. Mir
AU  - Purnima Shrivastava
Y1  - 2017/08/15
PY  - 2017
N1  - https://doi.org/10.11648/j.ijcocr.20170204.12
DO  - 10.11648/j.ijcocr.20170204.12
T2  - International Journal of Clinical Oncology and Cancer Research
JF  - International Journal of Clinical Oncology and Cancer Research
JO  - International Journal of Clinical Oncology and Cancer Research
SP  - 82
EP  - 85
PB  - Science Publishing Group
SN  - 2578-9511
UR  - https://doi.org/10.11648/j.ijcocr.20170204.12
AB  - Purpose: Malignancy of the breast is one of the commonest causes of death in women aged between 40-45 years. The aim of this study was to carry out a comparative study to investigate the effect of minerals on the risk of a woman developing breast cancer. Materials and methods: Three hundred blood samples were used to analyze the status of concentration of Selenium (Se), Copper (Cu), Zinc (Zn) and Iron (Fe) in breast cancer (BC) patients and healthy individuals by using atomic absorption spectrophotometer. Results: There was a significant (p0.05) in serum of BC patients. There was a significant decline in the concentration of Se and Zn while high level of serum copper in breast cancer patients, as compared with normal healthy controls. Conclusion: We found a significant association between trace elements (serum selenium, zinc and copper) with breast cancer.
VL  - 2
IS  - 4
ER  -

Copy | Download