Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)

Mohamed Hilmi; Ehab Mohamed; Albara Ahmed; Sahar Elderdiri Gafar Osman

doi:doi:10.11648/j.ijcts.20210705.11

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Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)

Mohamed Hilmi, Ehab Mohamed, Albara Ahmed, Sahar Elderdiri Gafar Osman

Published in International Journal of Cardiovascular and Thoracic Surgery (Volume 7, Issue 5)

Received: 26 May 2021 Accepted: 17 June 2021 Published: 12 October 2021

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Abstract

Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.

Published in	International Journal of Cardiovascular and Thoracic Surgery (Volume 7, Issue 5)
DOI	10.11648/j.ijcts.20210705.11
Page(s)	50-54
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Antiphospholipid Antibody (Anti PLP Antibody), Acute Myocardial Infraction (Acute MI), Coagulation Cascade

References

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[2]	Varner CK, Marquardt CW, Pickens PV. Antiphosphatidylserine Antibody as a Cause of Multiple Dural Venous Sinus Thromboses and ST-Elevation Myocardial Infarction. Am J Case Rep. 2018; 19: 1042-1046. Published 2018 Aug 31. doi: 10.12659/AJCR.909698.
[3]	Ayan M, Alshebani Y, Tantoush H, Salih M, Abusnina W, Khaddr M, Smer A. Acute myocardial infarction in a young man with large left ventricular thrombus and the antiphospholipid syndrome. Proc (Bayl Univ Med Cent). 2018 Nov 13; 32 (1): 110-112. doi: 10.1080/08998280.2018.1503479. PMID: 30956601; PMCID: PMC6442880.
[4]	Tidsskr Nor Laegeforen. Role of phospholipids in hemostasis 1993 Aug 10; 113 (18): 2238-41. PMID: 8362386.
[5]	Sletnes KE. Fosfolipidenesrolleihemostasen [Role of phospholipids in hemostasis]. Tidsskr Nor Laegeforen. 1993 Aug 10; 113 (18): 2238-41. Norwegian. PMID: 8362386.
[6]	Shruti Chaturvedi and Keith R. McCrae. The antiphospholipid syndrome: still an enigma (2016 May 24) doi: 10.1182/asheducation-2015.1.53. PMCID: PMC4877624 NIHMSID: NIHMS786511 PMID: 26637701.
[7]	Semczuk-Kaczmarek K, Platek AE, Ryś-Czaporowska A, Szymanski FM, Filipiak KJ. Acute Myocardial Infarction Due to Antiphospholipid Syndrome - Case Report and Review of the Literature. Curr Probl Cardiol. 2021 Mar; 46 (3): 100552. doi: 10.1016/j.cpcardiol.2020.100552. Epub 2020 Feb 20. PMID: 32216971.
[8]	Y. Adler, Y. Finkelstein, G. Zandeman-Goddard, M. Blank, M. Lorber, A. Lorber, D. Faden, Y. Shoenfeld Lupus, et al The presence of antiphospholipid antibodies in acute myocardial infarction Review Article (Aug 1, 1995) vol. 4, 4: pp. 309-313.
[9]	Vaarala, Department of Biochemistry, National Public Health Institute, Helsinki, Finland Antiphospholipid antibodies and myocardial infarction Review Article (February 1, 1998) Vol 7, Issue 2_suppl.Sega journals.
[10]	Rolf T Urbanus PhD, Bob Siegerink MSc, Mark Roest PhD, Frist R Rosendaal MD, Philip G de Groot Phd, Ale Algra MD, et al (2009 Nov; 8) The Lancet Neurology Volume 8, Pages 998-1005.
[11]	J. Font, R. Cervera, et al Cardiac Manifestations in the Antiphospholipid Syndrome (2000)- Hughes Syndrome pp 32-42\| Cite a978-1-85233-232-7.
[12]	Lóczi L, Kappelmayer J, Tarr T, Bagoly Z. Antiphospholipid syndrome and the risk of myocardial infarction: current evidence and uncertainties. Kardiol Pol. 2020 Jan 24; 78 (1): 6-14. doi: 10.33963/KP.15090. Epub 2019 Dec 6. PMID: 31808421.
[13]	Abid L, Frikha F, Bahloul Z, Kammoun S. Acute myocardial infarction in young adults with antiphospholipid syndrome: report of two cases and literature review. Pan Afr Med J. 2011; 8: 13. doi: 10.4314/pamj.v8i1.71062.
[14]	Polytarchou K, Varvarousis D, Manolis AS. Cardiovascular Disease in Antiphospholipid Syndrome. Curr Vasc Pharmacol. 2020; 18 (6): 538-548. doi: 10.2174/1570161117666190830101341.PMID:31530257.
[15]	Riga JP, Leone A, Lambot F, Cappeliez O, Friart A. A microvascular myocardial infarction in a 16-year-old girl with antiphospholipid syndrome: a case report. Acta Clin Belg. 2019 Oct; 74 (5): 351-354. doi: 10.1080/17843286.2018.1516182. Epub 2018 Aug 30. PMID: 30160190.

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APA Style

Mohamed Hilmi, Ehab Mohamed, Albara Ahmed, Sahar Elderdiri Gafar Osman. (2021). Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time). International Journal of Cardiovascular and Thoracic Surgery, 7(5), 50-54. https://doi.org/10.11648/j.ijcts.20210705.11

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ACS Style

Mohamed Hilmi; Ehab Mohamed; Albara Ahmed; Sahar Elderdiri Gafar Osman. Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time). Int. J. Cardiovasc. Thorac. Surg. 2021, 7(5), 50-54. doi: 10.11648/j.ijcts.20210705.11

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AMA Style

Mohamed Hilmi, Ehab Mohamed, Albara Ahmed, Sahar Elderdiri Gafar Osman. Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time). Int J Cardiovasc Thorac Surg. 2021;7(5):50-54. doi: 10.11648/j.ijcts.20210705.11

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@article{10.11648/j.ijcts.20210705.11,
  author = {Mohamed Hilmi and Ehab Mohamed and Albara Ahmed and Sahar Elderdiri Gafar Osman},
  title = {Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)},
  journal = {International Journal of Cardiovascular and Thoracic Surgery},
  volume = {7},
  number = {5},
  pages = {50-54},
  doi = {10.11648/j.ijcts.20210705.11},
  url = {https://doi.org/10.11648/j.ijcts.20210705.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20210705.11},
  abstract = {Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.},
 year = {2021}
}

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TY  - JOUR
T1  - Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)
AU  - Mohamed Hilmi
AU  - Ehab Mohamed
AU  - Albara Ahmed
AU  - Sahar Elderdiri Gafar Osman
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcts.20210705.11
DO  - 10.11648/j.ijcts.20210705.11
T2  - International Journal of Cardiovascular and Thoracic Surgery
JF  - International Journal of Cardiovascular and Thoracic Surgery
JO  - International Journal of Cardiovascular and Thoracic Surgery
SP  - 50
EP  - 54
PB  - Science Publishing Group
SN  - 2575-4882
UR  - https://doi.org/10.11648/j.ijcts.20210705.11
AB  - Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.
VL  - 7
IS  - 5
ER  -

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Author Information

Mohamed Hilmi

Faculty of Medical Laboratory Science, National University, Khartoum, Sudan
Ehab Mohamed

Faculty of Medical Laboratory Sciences, Dongola University, Dongola, Sudan
Albara Ahmed

Medical Laboratory Science Program, Alfajr College for Science and Technology, Khartoum, Sudan
Sahar Elderdiri Gafar Osman

Medical Laboratory Science Program, Alfajr College for Science and Technology, Khartoum, Sudan

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APA Style

Mohamed Hilmi, Ehab Mohamed, Albara Ahmed, Sahar Elderdiri Gafar Osman. (2021). Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time). International Journal of Cardiovascular and Thoracic Surgery, 7(5), 50-54. https://doi.org/10.11648/j.ijcts.20210705.11

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ACS Style

Mohamed Hilmi; Ehab Mohamed; Albara Ahmed; Sahar Elderdiri Gafar Osman. Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time). Int. J. Cardiovasc. Thorac. Surg. 2021, 7(5), 50-54. doi: 10.11648/j.ijcts.20210705.11

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AMA Style

Mohamed Hilmi, Ehab Mohamed, Albara Ahmed, Sahar Elderdiri Gafar Osman. Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time). Int J Cardiovasc Thorac Surg. 2021;7(5):50-54. doi: 10.11648/j.ijcts.20210705.11

Copy | Download

@article{10.11648/j.ijcts.20210705.11,
  author = {Mohamed Hilmi and Ehab Mohamed and Albara Ahmed and Sahar Elderdiri Gafar Osman},
  title = {Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)},
  journal = {International Journal of Cardiovascular and Thoracic Surgery},
  volume = {7},
  number = {5},
  pages = {50-54},
  doi = {10.11648/j.ijcts.20210705.11},
  url = {https://doi.org/10.11648/j.ijcts.20210705.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20210705.11},
  abstract = {Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.},
 year = {2021}
}

Copy | Download

TY  - JOUR
T1  - Determination of Antiphospholipid Antibody Levels Among Patients with Acute Myocardial Infraction in Khartoum State (Time)
AU  - Mohamed Hilmi
AU  - Ehab Mohamed
AU  - Albara Ahmed
AU  - Sahar Elderdiri Gafar Osman
Y1  - 2021/10/12
PY  - 2021
N1  - https://doi.org/10.11648/j.ijcts.20210705.11
DO  - 10.11648/j.ijcts.20210705.11
T2  - International Journal of Cardiovascular and Thoracic Surgery
JF  - International Journal of Cardiovascular and Thoracic Surgery
JO  - International Journal of Cardiovascular and Thoracic Surgery
SP  - 50
EP  - 54
PB  - Science Publishing Group
SN  - 2575-4882
UR  - https://doi.org/10.11648/j.ijcts.20210705.11
AB  - Background: Antiphospholipid antibodies (Anti PLP Antibody) are a group of autoimmune antibodies that targeting an individual's own proteins in an autoimmune response against phospholipids. Which released from plasma membrane to make prothrombinase complex and provide suitable environment for biological activity. In Antiphospholipid syndrome anti PLP antibodies attacks phospholipid in surface of plasma membrane and release PLP into the circulation which can activate coagulation cascade and form thrombi that leads to myocardial infraction (MI). Objectives: The current study was aimed to assess the antiphospholipid antibodies among patients with acute myocardial infraction in Khartoum state 2021 and compared to normal adult healthy control. Methods: An analytical case and control study was conducted in Yastapshiron hospital lab in Khartoum states laboratory in the period from from October 2020 to January 2021 on a total of 50 patients with acute MI (according to protocol/criteria/ scoring systrm,…) as case group and compared with another 50 healthy adults as control group, for both groups serum antiphospholipid was assessed using ELISA manual (AESKU), data were collected and then analyzed using SPssDD version. Result: from the study; the gender distribution was 35 male and 15 female among case group with age of 61.1 year. Among case group; 3 patients (6%) showed positive antiphospholipid while the remaining 47 (94%) was negative, the antiphospholipid antibodies mean concentration was significantly higher among case compared to the control 0.293±0.17 and 0.226±0.15 (unit) respectively, P.value was 0.042. It was found space in age the lowest age was 35 and highest age was 94 and the correlation was 0.154.
VL  - 7
IS  - 5
ER  -

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