Background To study the evolution of platelet count during patient treatment with Extra-Corporeal Membrane Oxygenation (ECMO) and the causes of Membrane Oxygenation (MO) exchange. Assessment of the morbidity and mortality rate was our secondary objective. Methods A single center retrospective study was conducted from January 2014 to December 2015. One-hundred and thirty-nine MO exchanges were studied over 73 patients who received 66 MO exchange. Alterations in biological parameters were compared before and after each MO exchange, to study the device-related platelet count evolution. Results Mean patient age was 56.8±13.4 years. The mean duration of the MO was 5.9±3.1 days, exchanged 26 times (68%) after clot formation. The median Survival After Veno-arterial ECMO score (SAVE score) was -3.5 [-4; -1] interquartile range [IQR]. The median Respiratory Extra-corporeal membrane Oxygenation Survival Prediction score (RESP score) was -1 [-3; 0] [IQR]. A significant decrease (p<0.001) in platelet count between the first and second MO exchange was observed in comparison with the baseline. Yet a steady decline was noted after the third MO exchange, afterwards, normalization was observed after ECMO weaning. During ECMO, a decrease in platelet count from the baseline was found after the first MO on day 2 (p<0.001), the delta was 58.000±19.000 //µL, followed by an additional significant decrease on day 3 (p=0.001). The average platelet transfusion was 0.6±1.4 units. Interestingly, the more MO was exchanged, the lesser blood products transfusion was done. The overall mortality rate was 39%; in Veno- Arterial ECMO (VA-ECMO) it was 34.48% and 41.38% in Veno-Venous ECMO (VV-ECMO). Conclusion Clot formation is the leading cause of MO exchange during ECMO. Therefore, there is a significant decrease in platelets count starting from day 2 that indicates platelets transfusions in order to prevent complications of hemostasis.
| Published in | International Journal of Cardiovascular and Thoracic Surgery (Volume 8, Issue 1) |
| DOI | 10.11648/j.ijcts.20220801.11 |
| Page(s) | 1-7 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2022. Published by Science Publishing Group |
Platelets, Membrane Oxygenation, ECMO, ECLS, SAVE Score, RESP Score, Cardiac Surgery
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APA Style
Alaa Azhari, Ehab Kasem, Mohammed Miny, Adama Sawadogo, Nicolas D’ostrevy, et al. (2022). Platelets Count During Circulatory Assistance: Involvement in the Changes of Oxygenation Membrane. International Journal of Cardiovascular and Thoracic Surgery, 8(1), 1-7. https://doi.org/10.11648/j.ijcts.20220801.11
ACS Style
Alaa Azhari; Ehab Kasem; Mohammed Miny; Adama Sawadogo; Nicolas D’ostrevy, et al. Platelets Count During Circulatory Assistance: Involvement in the Changes of Oxygenation Membrane. Int. J. Cardiovasc. Thorac. Surg. 2022, 8(1), 1-7. doi: 10.11648/j.ijcts.20220801.11
AMA Style
Alaa Azhari, Ehab Kasem, Mohammed Miny, Adama Sawadogo, Nicolas D’ostrevy, et al. Platelets Count During Circulatory Assistance: Involvement in the Changes of Oxygenation Membrane. Int J Cardiovasc Thorac Surg. 2022;8(1):1-7. doi: 10.11648/j.ijcts.20220801.11
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Download@article{10.11648/j.ijcts.20220801.11,
author = {Alaa Azhari and Ehab Kasem and Mohammed Miny and Adama Sawadogo and Nicolas D’ostrevy and Celine Lambert and Bruno Pereira and Kazra Azarnoush and Lionel Camilleri},
title = {Platelets Count During Circulatory Assistance: Involvement in the Changes of Oxygenation Membrane},
journal = {International Journal of Cardiovascular and Thoracic Surgery},
volume = {8},
number = {1},
pages = {1-7},
doi = {10.11648/j.ijcts.20220801.11},
url = {https://doi.org/10.11648/j.ijcts.20220801.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcts.20220801.11},
abstract = {Background To study the evolution of platelet count during patient treatment with Extra-Corporeal Membrane Oxygenation (ECMO) and the causes of Membrane Oxygenation (MO) exchange. Assessment of the morbidity and mortality rate was our secondary objective. Methods A single center retrospective study was conducted from January 2014 to December 2015. One-hundred and thirty-nine MO exchanges were studied over 73 patients who received 66 MO exchange. Alterations in biological parameters were compared before and after each MO exchange, to study the device-related platelet count evolution. Results Mean patient age was 56.8±13.4 years. The mean duration of the MO was 5.9±3.1 days, exchanged 26 times (68%) after clot formation. The median Survival After Veno-arterial ECMO score (SAVE score) was -3.5 [-4; -1] interquartile range [IQR]. The median Respiratory Extra-corporeal membrane Oxygenation Survival Prediction score (RESP score) was -1 [-3; 0] [IQR]. A significant decrease (p<0.001) in platelet count between the first and second MO exchange was observed in comparison with the baseline. Yet a steady decline was noted after the third MO exchange, afterwards, normalization was observed after ECMO weaning. During ECMO, a decrease in platelet count from the baseline was found after the first MO on day 2 (p<0.001), the delta was 58.000±19.000 //µL, followed by an additional significant decrease on day 3 (p=0.001). The average platelet transfusion was 0.6±1.4 units. Interestingly, the more MO was exchanged, the lesser blood products transfusion was done. The overall mortality rate was 39%; in Veno- Arterial ECMO (VA-ECMO) it was 34.48% and 41.38% in Veno-Venous ECMO (VV-ECMO). Conclusion Clot formation is the leading cause of MO exchange during ECMO. Therefore, there is a significant decrease in platelets count starting from day 2 that indicates platelets transfusions in order to prevent complications of hemostasis.},
year = {2022}
}
TY - JOUR T1 - Platelets Count During Circulatory Assistance: Involvement in the Changes of Oxygenation Membrane AU - Alaa Azhari AU - Ehab Kasem AU - Mohammed Miny AU - Adama Sawadogo AU - Nicolas D’ostrevy AU - Celine Lambert AU - Bruno Pereira AU - Kazra Azarnoush AU - Lionel Camilleri Y1 - 2022/01/12 PY - 2022 N1 - https://doi.org/10.11648/j.ijcts.20220801.11 DO - 10.11648/j.ijcts.20220801.11 T2 - International Journal of Cardiovascular and Thoracic Surgery JF - International Journal of Cardiovascular and Thoracic Surgery JO - International Journal of Cardiovascular and Thoracic Surgery SP - 1 EP - 7 PB - Science Publishing Group SN - 2575-4882 UR - https://doi.org/10.11648/j.ijcts.20220801.11 AB - Background To study the evolution of platelet count during patient treatment with Extra-Corporeal Membrane Oxygenation (ECMO) and the causes of Membrane Oxygenation (MO) exchange. Assessment of the morbidity and mortality rate was our secondary objective. Methods A single center retrospective study was conducted from January 2014 to December 2015. One-hundred and thirty-nine MO exchanges were studied over 73 patients who received 66 MO exchange. Alterations in biological parameters were compared before and after each MO exchange, to study the device-related platelet count evolution. Results Mean patient age was 56.8±13.4 years. The mean duration of the MO was 5.9±3.1 days, exchanged 26 times (68%) after clot formation. The median Survival After Veno-arterial ECMO score (SAVE score) was -3.5 [-4; -1] interquartile range [IQR]. The median Respiratory Extra-corporeal membrane Oxygenation Survival Prediction score (RESP score) was -1 [-3; 0] [IQR]. A significant decrease (p<0.001) in platelet count between the first and second MO exchange was observed in comparison with the baseline. Yet a steady decline was noted after the third MO exchange, afterwards, normalization was observed after ECMO weaning. During ECMO, a decrease in platelet count from the baseline was found after the first MO on day 2 (p<0.001), the delta was 58.000±19.000 //µL, followed by an additional significant decrease on day 3 (p=0.001). The average platelet transfusion was 0.6±1.4 units. Interestingly, the more MO was exchanged, the lesser blood products transfusion was done. The overall mortality rate was 39%; in Veno- Arterial ECMO (VA-ECMO) it was 34.48% and 41.38% in Veno-Venous ECMO (VV-ECMO). Conclusion Clot formation is the leading cause of MO exchange during ECMO. Therefore, there is a significant decrease in platelets count starting from day 2 that indicates platelets transfusions in order to prevent complications of hemostasis. VL - 8 IS - 1 ER -
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