Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions

Md. Abdul Alim; Quazi Billur Rahman; Shakhawat Hossain

doi:doi:10.11648/j.ijdm.20150101.12

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Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions

Md. Abdul Alim, Quazi Billur Rahman, Shakhawat Hossain

Published in International Journal of Dental Medicine (Volume 1, Issue 1)

Received: 15 April 2015 Accepted: 21 April 2015 Published: 24 April 2015

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Abstract

Background: This study also will help to identify the specific site of biopsy of oral pre-malignant and malignant lesions and to correlate lugol’s iodine solution staining of oral tissue with histological findings. Objective: The aim of this study to detect any suspicious of oral cancerous and pre-cancerous lesions as an early diagnostic tool. Methods: Sixty cases of oral lesions were selected irrespective of age, sex, religion or socioeconomic status of the patient considering the inclusion and exclusion criteria. Patient selection was based on history, clinical examination and oral ulcers that do not heal more than two weeks. After staining of oral ulcer by Lugol’s iodine, histopathological examination was done from lightly staining area (Lugol’s iodine positive area) and another was deeply brown staining area (Lugol’s iodine negative area). Results: Out of 60 patients, 59(98.3%) patients were lightly stain, out of 59 patients, 35 were diagnosed as squamous cell carcinoma (34 squamous cell carcinoma and one verrucous carcinoma), 22(36.7%) patients were pre-malignant (17 leukoplakias, 4 oral lichen planus and one erythroplakia) and 2(3.3%) patients were others (one hyperplastic change and one normal oral epithelium).One patient was deeply brown stain which was histopathologically normal oral epithelium. According to early screening of oral pre malignant and malignant lesions by Lugol’s iodine enhanced attention of the clinician to a suspicious site of malignant and pre-malignant lesions in oral cavity. Conclusion: Lugol’s iodine staining is more accurate than clinical or visual diagnosis.

Published in	International Journal of Dental Medicine (Volume 1, Issue 1)
DOI	10.11648/j.ijdm.20150101.12
Page(s)	8-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2015. Published by Science Publishing Group

Keywords

Lugol’s Iodine, Early Screening, Oral Premalignant, Malignant Lesions

References

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APA Style

Md. Abdul Alim, Quazi Billur Rahman, Shakhawat Hossain. (2015). Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions. International Journal of Dental Medicine, 1(1), 8-12. https://doi.org/10.11648/j.ijdm.20150101.12

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ACS Style

Md. Abdul Alim; Quazi Billur Rahman; Shakhawat Hossain. Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions. Int. J. Dent. Med. 2015, 1(1), 8-12. doi: 10.11648/j.ijdm.20150101.12

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AMA Style

Md. Abdul Alim, Quazi Billur Rahman, Shakhawat Hossain. Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions. Int J Dent Med. 2015;1(1):8-12. doi: 10.11648/j.ijdm.20150101.12

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@article{10.11648/j.ijdm.20150101.12,
  author = {Md. Abdul Alim and Quazi Billur Rahman and Shakhawat Hossain},
  title = {Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions},
  journal = {International Journal of Dental Medicine},
  volume = {1},
  number = {1},
  pages = {8-12},
  doi = {10.11648/j.ijdm.20150101.12},
  url = {https://doi.org/10.11648/j.ijdm.20150101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdm.20150101.12},
  abstract = {Background: This study also will help to identify the specific site of biopsy of oral pre-malignant and malignant lesions and to correlate lugol’s iodine solution staining of oral tissue with histological findings. Objective: The aim of this study to detect any suspicious of oral cancerous and pre-cancerous lesions as an early diagnostic tool. Methods: Sixty cases of oral lesions were selected irrespective of age, sex, religion or socioeconomic status of the patient considering the inclusion and exclusion criteria. Patient selection was based on history, clinical examination and oral ulcers that do not heal more than two weeks. After staining of oral ulcer by Lugol’s iodine, histopathological examination was done from lightly staining area (Lugol’s iodine positive area) and another was deeply brown staining area (Lugol’s iodine negative area). Results: Out of 60 patients, 59(98.3%) patients were lightly stain, out of 59 patients, 35 were diagnosed as squamous cell carcinoma (34 squamous cell carcinoma and one verrucous carcinoma), 22(36.7%) patients were pre-malignant (17 leukoplakias, 4 oral lichen planus and one erythroplakia) and 2(3.3%) patients were others (one hyperplastic change and one normal oral epithelium).One patient was deeply brown stain which was histopathologically normal oral epithelium. According to early screening of oral pre malignant and malignant lesions by Lugol’s iodine enhanced attention of the clinician to a suspicious site of malignant and pre-malignant lesions in oral cavity. Conclusion: Lugol’s iodine staining is more accurate than clinical or visual diagnosis.},
 year = {2015}
}

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TY  - JOUR
T1  - Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions
AU  - Md. Abdul Alim
AU  - Quazi Billur Rahman
AU  - Shakhawat Hossain
Y1  - 2015/04/24
PY  - 2015
N1  - https://doi.org/10.11648/j.ijdm.20150101.12
DO  - 10.11648/j.ijdm.20150101.12
T2  - International Journal of Dental Medicine
JF  - International Journal of Dental Medicine
JO  - International Journal of Dental Medicine
SP  - 8
EP  - 12
PB  - Science Publishing Group
SN  - 2472-1387
UR  - https://doi.org/10.11648/j.ijdm.20150101.12
AB  - Background: This study also will help to identify the specific site of biopsy of oral pre-malignant and malignant lesions and to correlate lugol’s iodine solution staining of oral tissue with histological findings. Objective: The aim of this study to detect any suspicious of oral cancerous and pre-cancerous lesions as an early diagnostic tool. Methods: Sixty cases of oral lesions were selected irrespective of age, sex, religion or socioeconomic status of the patient considering the inclusion and exclusion criteria. Patient selection was based on history, clinical examination and oral ulcers that do not heal more than two weeks. After staining of oral ulcer by Lugol’s iodine, histopathological examination was done from lightly staining area (Lugol’s iodine positive area) and another was deeply brown staining area (Lugol’s iodine negative area). Results: Out of 60 patients, 59(98.3%) patients were lightly stain, out of 59 patients, 35 were diagnosed as squamous cell carcinoma (34 squamous cell carcinoma and one verrucous carcinoma), 22(36.7%) patients were pre-malignant (17 leukoplakias, 4 oral lichen planus and one erythroplakia) and 2(3.3%) patients were others (one hyperplastic change and one normal oral epithelium).One patient was deeply brown stain which was histopathologically normal oral epithelium. According to early screening of oral pre malignant and malignant lesions by Lugol’s iodine enhanced attention of the clinician to a suspicious site of malignant and pre-malignant lesions in oral cavity. Conclusion: Lugol’s iodine staining is more accurate than clinical or visual diagnosis.
VL  - 1
IS  - 1
ER  -

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Author Information

Md. Abdul Alim

Department of Oral and Maxillofacial Surgery, MH Samorita Medical College & Dental Unit, Dhaka, Bangladesh
Quazi Billur Rahman

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Shakhawat Hossain

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

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APA Style

Md. Abdul Alim, Quazi Billur Rahman, Shakhawat Hossain. (2015). Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions. International Journal of Dental Medicine, 1(1), 8-12. https://doi.org/10.11648/j.ijdm.20150101.12

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ACS Style

Md. Abdul Alim; Quazi Billur Rahman; Shakhawat Hossain. Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions. Int. J. Dent. Med. 2015, 1(1), 8-12. doi: 10.11648/j.ijdm.20150101.12

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AMA Style

Md. Abdul Alim, Quazi Billur Rahman, Shakhawat Hossain. Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions. Int J Dent Med. 2015;1(1):8-12. doi: 10.11648/j.ijdm.20150101.12

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@article{10.11648/j.ijdm.20150101.12,
  author = {Md. Abdul Alim and Quazi Billur Rahman and Shakhawat Hossain},
  title = {Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions},
  journal = {International Journal of Dental Medicine},
  volume = {1},
  number = {1},
  pages = {8-12},
  doi = {10.11648/j.ijdm.20150101.12},
  url = {https://doi.org/10.11648/j.ijdm.20150101.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdm.20150101.12},
  abstract = {Background: This study also will help to identify the specific site of biopsy of oral pre-malignant and malignant lesions and to correlate lugol’s iodine solution staining of oral tissue with histological findings. Objective: The aim of this study to detect any suspicious of oral cancerous and pre-cancerous lesions as an early diagnostic tool. Methods: Sixty cases of oral lesions were selected irrespective of age, sex, religion or socioeconomic status of the patient considering the inclusion and exclusion criteria. Patient selection was based on history, clinical examination and oral ulcers that do not heal more than two weeks. After staining of oral ulcer by Lugol’s iodine, histopathological examination was done from lightly staining area (Lugol’s iodine positive area) and another was deeply brown staining area (Lugol’s iodine negative area). Results: Out of 60 patients, 59(98.3%) patients were lightly stain, out of 59 patients, 35 were diagnosed as squamous cell carcinoma (34 squamous cell carcinoma and one verrucous carcinoma), 22(36.7%) patients were pre-malignant (17 leukoplakias, 4 oral lichen planus and one erythroplakia) and 2(3.3%) patients were others (one hyperplastic change and one normal oral epithelium).One patient was deeply brown stain which was histopathologically normal oral epithelium. According to early screening of oral pre malignant and malignant lesions by Lugol’s iodine enhanced attention of the clinician to a suspicious site of malignant and pre-malignant lesions in oral cavity. Conclusion: Lugol’s iodine staining is more accurate than clinical or visual diagnosis.},
 year = {2015}
}

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TY  - JOUR
T1  - Use of Lugol’s Iodine Solution in Screening of Oral Premalignant and Malignant Lesions
AU  - Md. Abdul Alim
AU  - Quazi Billur Rahman
AU  - Shakhawat Hossain
Y1  - 2015/04/24
PY  - 2015
N1  - https://doi.org/10.11648/j.ijdm.20150101.12
DO  - 10.11648/j.ijdm.20150101.12
T2  - International Journal of Dental Medicine
JF  - International Journal of Dental Medicine
JO  - International Journal of Dental Medicine
SP  - 8
EP  - 12
PB  - Science Publishing Group
SN  - 2472-1387
UR  - https://doi.org/10.11648/j.ijdm.20150101.12
AB  - Background: This study also will help to identify the specific site of biopsy of oral pre-malignant and malignant lesions and to correlate lugol’s iodine solution staining of oral tissue with histological findings. Objective: The aim of this study to detect any suspicious of oral cancerous and pre-cancerous lesions as an early diagnostic tool. Methods: Sixty cases of oral lesions were selected irrespective of age, sex, religion or socioeconomic status of the patient considering the inclusion and exclusion criteria. Patient selection was based on history, clinical examination and oral ulcers that do not heal more than two weeks. After staining of oral ulcer by Lugol’s iodine, histopathological examination was done from lightly staining area (Lugol’s iodine positive area) and another was deeply brown staining area (Lugol’s iodine negative area). Results: Out of 60 patients, 59(98.3%) patients were lightly stain, out of 59 patients, 35 were diagnosed as squamous cell carcinoma (34 squamous cell carcinoma and one verrucous carcinoma), 22(36.7%) patients were pre-malignant (17 leukoplakias, 4 oral lichen planus and one erythroplakia) and 2(3.3%) patients were others (one hyperplastic change and one normal oral epithelium).One patient was deeply brown stain which was histopathologically normal oral epithelium. According to early screening of oral pre malignant and malignant lesions by Lugol’s iodine enhanced attention of the clinician to a suspicious site of malignant and pre-malignant lesions in oral cavity. Conclusion: Lugol’s iodine staining is more accurate than clinical or visual diagnosis.
VL  - 1
IS  - 1
ER  -

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