Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case

Manar A. Abdul Aziz; Mohamed A. Shawky; Mohammed Atef

doi:doi:10.11648/j.ijdm.20180402.11

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Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case

Manar A. Abdul Aziz, Mohamed A. Shawky, Mohammed Atef

Published in International Journal of Dental Medicine (Volume 4, Issue 2)

Received: 28 August 2018 Accepted: 10 September 2018 Published: 10 October 2018

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Abstract

Papillon–Lefèvre syndrome (PLS) is a rare genodermatosis caused by mutation in CTSC gene which is expressed in epithelial cells as well as in various immune cells including PMNs, macrophages, and their precursors. Such mutation results in palmoplantar hyperkeratosis, early onset periodontitis, susceptibility to infection and rarely mucocutaneous carcinomas. In this study, we aim to perform a systematic review on the incidence of oral squamous cell carcinoma in the association with Papillon-Lefevre syndrome and to introduce the first case report. An electronic search without date and language restrictions in three data bases, Pubmed, Cochrane Library, and Google Scholar in addition to a hand-searching were performed in August 2018. The review of the current literature revealed that such association has not been previously reported. We concluded that patients with Papillon-Lefevre syndrome are susceptible to develop different mucocutaneous carcinomas including OSCC.

Published in	International Journal of Dental Medicine (Volume 4, Issue 2)
DOI	10.11648/j.ijdm.20180402.11
Page(s)	31-35
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Papillon-Lefevre Syndrome, Oral Squamous Cell Carcinoma, Palmoplantar Keratosis, Periodontitis

References

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[9]	Ikeshima A. Papillon-Lefevre syndrome: a highly-suspected case. Journal of oral science 2006; 48: 257-60. https://www.slideshare.net/.../papillonlefevre-syndrome-a-case-report.
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[13]	Bullón P, Castejón-Vega B, Román-Malo L, Jimenez-Guerrero MP, Cotán D, Forbes-Hernandez TY, Varela-López A, Pérez-Pulido AJ, Giampieri F, Quiles JL, Battino M, Sánchez-Alcázar JA, Cordero MD. Autophagic dysfunction in patients with Papillon-Lefèvre syndrome is restored by recombinant cathepsin C treatment. J Allergy Clin Immunol. 2018: S0091-6749(18)30144-1. doi: 10.1016/j.jaci.2018.01.018.
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APA Style

Manar A. Abdul Aziz, Mohamed A. Shawky, Mohammed Atef. (2018). Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case. International Journal of Dental Medicine, 4(2), 31-35. https://doi.org/10.11648/j.ijdm.20180402.11

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ACS Style

Manar A. Abdul Aziz; Mohamed A. Shawky; Mohammed Atef. Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case. Int. J. Dent. Med. 2018, 4(2), 31-35. doi: 10.11648/j.ijdm.20180402.11

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AMA Style

Manar A. Abdul Aziz, Mohamed A. Shawky, Mohammed Atef. Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case. Int J Dent Med. 2018;4(2):31-35. doi: 10.11648/j.ijdm.20180402.11

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@article{10.11648/j.ijdm.20180402.11,
  author = {Manar A. Abdul Aziz and Mohamed A. Shawky and Mohammed Atef},
  title = {Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case},
  journal = {International Journal of Dental Medicine},
  volume = {4},
  number = {2},
  pages = {31-35},
  doi = {10.11648/j.ijdm.20180402.11},
  url = {https://doi.org/10.11648/j.ijdm.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdm.20180402.11},
  abstract = {Papillon–Lefèvre syndrome (PLS) is a rare genodermatosis caused by mutation in CTSC gene which is expressed in epithelial cells as well as in various immune cells including PMNs, macrophages, and their precursors. Such mutation results in palmoplantar hyperkeratosis, early onset periodontitis, susceptibility to infection and rarely mucocutaneous carcinomas. In this study, we aim to perform a systematic review on the incidence of oral squamous cell carcinoma in the association with Papillon-Lefevre syndrome and to introduce the first case report. An electronic search without date and language restrictions in three data bases, Pubmed, Cochrane Library, and Google Scholar in addition to a hand-searching were performed in August 2018. The review of the current literature revealed that such association has not been previously reported. We concluded that patients with Papillon-Lefevre syndrome are susceptible to develop different mucocutaneous carcinomas including OSCC.},
 year = {2018}
}

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TY - JOUR
T1 - Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case
AU - Manar A. Abdul Aziz
AU - Mohamed A. Shawky
AU - Mohammed Atef
Y1 - 2018/10/10
PY - 2018
N1 - https://doi.org/10.11648/j.ijdm.20180402.11
DO - 10.11648/j.ijdm.20180402.11
T2 - International Journal of Dental Medicine
JF - International Journal of Dental Medicine
JO - International Journal of Dental Medicine
SP - 31
EP - 35
PB - Science Publishing Group
SN - 2472-1387
UR - https://doi.org/10.11648/j.ijdm.20180402.11
AB - Papillon–Lefèvre syndrome (PLS) is a rare genodermatosis caused by mutation in CTSC gene which is expressed in epithelial cells as well as in various immune cells including PMNs, macrophages, and their precursors. Such mutation results in palmoplantar hyperkeratosis, early onset periodontitis, susceptibility to infection and rarely mucocutaneous carcinomas. In this study, we aim to perform a systematic review on the incidence of oral squamous cell carcinoma in the association with Papillon-Lefevre syndrome and to introduce the first case report. An electronic search without date and language restrictions in three data bases, Pubmed, Cochrane Library, and Google Scholar in addition to a hand-searching were performed in August 2018. The review of the current literature revealed that such association has not been previously reported. We concluded that patients with Papillon-Lefevre syndrome are susceptible to develop different mucocutaneous carcinomas including OSCC.
VL - 4
IS - 2
ER -

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Author Information

Manar A. Abdul Aziz

Oral and Maxillofacial Pathology Department, Faculty of Dentistry, Cairo University, Cairo, Egypt
Mohamed A. Shawky

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt
Mohammed Atef

Oral and Maxillofacial Surgery Department, Faculty of Dentistry, Cairo University, Cairo, Egypt

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APA Style

Manar A. Abdul Aziz, Mohamed A. Shawky, Mohammed Atef. (2018). Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case. International Journal of Dental Medicine, 4(2), 31-35. https://doi.org/10.11648/j.ijdm.20180402.11

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ACS Style

Manar A. Abdul Aziz; Mohamed A. Shawky; Mohammed Atef. Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case. Int. J. Dent. Med. 2018, 4(2), 31-35. doi: 10.11648/j.ijdm.20180402.11

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AMA Style

Manar A. Abdul Aziz, Mohamed A. Shawky, Mohammed Atef. Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case. Int J Dent Med. 2018;4(2):31-35. doi: 10.11648/j.ijdm.20180402.11

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@article{10.11648/j.ijdm.20180402.11,
  author = {Manar A. Abdul Aziz and Mohamed A. Shawky and Mohammed Atef},
  title = {Oral Squamous Cell Carcinoma Associated withPapillon-Lefevre Syndrome: Systematic Review and the First Reported Case},
  journal = {International Journal of Dental Medicine},
  volume = {4},
  number = {2},
  pages = {31-35},
  doi = {10.11648/j.ijdm.20180402.11},
  url = {https://doi.org/10.11648/j.ijdm.20180402.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdm.20180402.11},
  abstract = {Papillon–Lefèvre syndrome (PLS) is a rare genodermatosis caused by mutation in CTSC gene which is expressed in epithelial cells as well as in various immune cells including PMNs, macrophages, and their precursors. Such mutation results in palmoplantar hyperkeratosis, early onset periodontitis, susceptibility to infection and rarely mucocutaneous carcinomas. In this study, we aim to perform a systematic review on the incidence of oral squamous cell carcinoma in the association with Papillon-Lefevre syndrome and to introduce the first case report. An electronic search without date and language restrictions in three data bases, Pubmed, Cochrane Library, and Google Scholar in addition to a hand-searching were performed in August 2018. The review of the current literature revealed that such association has not been previously reported. We concluded that patients with Papillon-Lefevre syndrome are susceptible to develop different mucocutaneous carcinomas including OSCC.},
 year = {2018}
}

Copy | Download