This article focuses mainly on DNA mixture from two contributors, a victim and an unknown culprit. There are two areas I believe will be of interest to forensic scientists, police and a Jury. These areas are identification of an individual in a DNA mixture and familial DNA database searching of a culprit through a relative. In this article, I looked at identification of individuals in a mixture using Single Nucleotide Polymorphisms (SNPs) markers. SNPs are starting to be used for forensic identification; I employed them as they produce incredible results for identification in a two-person mixture. The conservative method I employed here is the random man not excluded probability – P (RMNE) approach, an inclusion probability method generally considered as a frequentist approach. It was found that an optimum allele frequency of 0.2 is required to produce almost certain identification with much distortion in identifying an individual even when inbreeding is up to 50% in a population. Another interesting thing is that relatives of a suspect whom are actual contributors to the DNA mixture can also be identified. In a case where there are relatives in the mixture it was found that twice the number of SNP panels is required to identify an individual than in a case where no relative is involved. And lastly, typing more SNP panels helps to improve identification and therefore produce forensically useful results.
| Published in | International Journal of Genetics and Genomics (Volume 5, Issue 3) |
| DOI | 10.11648/j.ijgg.20170503.11 |
| Page(s) | 27-35 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
SNP Markers, DNA Mixture, Allele Frequency, Likelihood Ratio, Hardy-Weinberg Equilibrium
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APA Style
Abdulwasiu Ibrahim. (2017). Identification of Individuals in a DNA Mixture Using SNP Markers. International Journal of Genetics and Genomics, 5(3), 27-35. https://doi.org/10.11648/j.ijgg.20170503.11
ACS Style
Abdulwasiu Ibrahim. Identification of Individuals in a DNA Mixture Using SNP Markers. Int. J. Genet. Genomics 2017, 5(3), 27-35. doi: 10.11648/j.ijgg.20170503.11
AMA Style
Abdulwasiu Ibrahim. Identification of Individuals in a DNA Mixture Using SNP Markers. Int J Genet Genomics. 2017;5(3):27-35. doi: 10.11648/j.ijgg.20170503.11
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Download@article{10.11648/j.ijgg.20170503.11,
author = {Abdulwasiu Ibrahim},
title = {Identification of Individuals in a DNA Mixture Using SNP Markers},
journal = {International Journal of Genetics and Genomics},
volume = {5},
number = {3},
pages = {27-35},
doi = {10.11648/j.ijgg.20170503.11},
url = {https://doi.org/10.11648/j.ijgg.20170503.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijgg.20170503.11},
abstract = {This article focuses mainly on DNA mixture from two contributors, a victim and an unknown culprit. There are two areas I believe will be of interest to forensic scientists, police and a Jury. These areas are identification of an individual in a DNA mixture and familial DNA database searching of a culprit through a relative. In this article, I looked at identification of individuals in a mixture using Single Nucleotide Polymorphisms (SNPs) markers. SNPs are starting to be used for forensic identification; I employed them as they produce incredible results for identification in a two-person mixture. The conservative method I employed here is the random man not excluded probability – P (RMNE) approach, an inclusion probability method generally considered as a frequentist approach. It was found that an optimum allele frequency of 0.2 is required to produce almost certain identification with much distortion in identifying an individual even when inbreeding is up to 50% in a population. Another interesting thing is that relatives of a suspect whom are actual contributors to the DNA mixture can also be identified. In a case where there are relatives in the mixture it was found that twice the number of SNP panels is required to identify an individual than in a case where no relative is involved. And lastly, typing more SNP panels helps to improve identification and therefore produce forensically useful results.},
year = {2017}
}
TY - JOUR T1 - Identification of Individuals in a DNA Mixture Using SNP Markers AU - Abdulwasiu Ibrahim Y1 - 2017/07/10 PY - 2017 N1 - https://doi.org/10.11648/j.ijgg.20170503.11 DO - 10.11648/j.ijgg.20170503.11 T2 - International Journal of Genetics and Genomics JF - International Journal of Genetics and Genomics JO - International Journal of Genetics and Genomics SP - 27 EP - 35 PB - Science Publishing Group SN - 2376-7359 UR - https://doi.org/10.11648/j.ijgg.20170503.11 AB - This article focuses mainly on DNA mixture from two contributors, a victim and an unknown culprit. There are two areas I believe will be of interest to forensic scientists, police and a Jury. These areas are identification of an individual in a DNA mixture and familial DNA database searching of a culprit through a relative. In this article, I looked at identification of individuals in a mixture using Single Nucleotide Polymorphisms (SNPs) markers. SNPs are starting to be used for forensic identification; I employed them as they produce incredible results for identification in a two-person mixture. The conservative method I employed here is the random man not excluded probability – P (RMNE) approach, an inclusion probability method generally considered as a frequentist approach. It was found that an optimum allele frequency of 0.2 is required to produce almost certain identification with much distortion in identifying an individual even when inbreeding is up to 50% in a population. Another interesting thing is that relatives of a suspect whom are actual contributors to the DNA mixture can also be identified. In a case where there are relatives in the mixture it was found that twice the number of SNP panels is required to identify an individual than in a case where no relative is involved. And lastly, typing more SNP panels helps to improve identification and therefore produce forensically useful results. VL - 5 IS - 3 ER -
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