Fatty Acids Effect on T Helper Differentiation in Vitro

Aissouda Hossein zade; Maryam Moogooei; Shayan Mostafaei; Hossein Rahavi; Reza Mansouri; Sepideh Soukhtezari; Mojgan Ghaedi

doi:doi:10.11648/j.ijnfs.20160506.11

Fatty Acids Effect on T Helper Differentiation in Vitro

Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, Sepideh Soukhtezari, Mojgan Ghaedi

Published in International Journal of Nutrition and Food Sciences (Volume 5, Issue 6)

Received: 16 September 2016 Accepted: 26 September 2016 Published: 17 October 2016

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Abstract

Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4⁺ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).

Published in	International Journal of Nutrition and Food Sciences (Volume 5, Issue 6)
DOI	10.11648/j.ijnfs.20160506.11
Page(s)	372-377
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

T Helper Cells, Differentiation, Metabolism, Fatty Acids, Mtor

References

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APA Style

Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, et al. (2016). Fatty Acids Effect on T Helper Differentiation in Vitro. International Journal of Nutrition and Food Sciences, 5(6), 372-377. https://doi.org/10.11648/j.ijnfs.20160506.11

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ACS Style

Aissouda Hossein zade; Maryam Moogooei; Shayan Mostafaei; Hossein Rahavi; Reza Mansouri, et al. Fatty Acids Effect on T Helper Differentiation in Vitro. Int. J. Nutr. Food Sci. 2016, 5(6), 372-377. doi: 10.11648/j.ijnfs.20160506.11

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AMA Style

Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, et al. Fatty Acids Effect on T Helper Differentiation in Vitro. Int J Nutr Food Sci. 2016;5(6):372-377. doi: 10.11648/j.ijnfs.20160506.11

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@article{10.11648/j.ijnfs.20160506.11,
  author = {Aissouda Hossein zade and Maryam Moogooei and Shayan Mostafaei and Hossein Rahavi and Reza Mansouri and Sepideh Soukhtezari and Mojgan Ghaedi},
  title = {Fatty Acids Effect on T Helper Differentiation in Vitro},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {5},
  number = {6},
  pages = {372-377},
  doi = {10.11648/j.ijnfs.20160506.11},
  url = {https://doi.org/10.11648/j.ijnfs.20160506.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20160506.11},
  abstract = {Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).},
 year = {2016}
}

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TY - JOUR
T1 - Fatty Acids Effect on T Helper Differentiation in Vitro
AU - Aissouda Hossein zade
AU - Maryam Moogooei
AU - Shayan Mostafaei
AU - Hossein Rahavi
AU - Reza Mansouri
AU - Sepideh Soukhtezari
AU - Mojgan Ghaedi
Y1 - 2016/10/17
PY - 2016
N1 - https://doi.org/10.11648/j.ijnfs.20160506.11
DO - 10.11648/j.ijnfs.20160506.11
T2 - International Journal of Nutrition and Food Sciences
JF - International Journal of Nutrition and Food Sciences
JO - International Journal of Nutrition and Food Sciences
SP - 372
EP - 377
PB - Science Publishing Group
SN - 2327-2716
UR - https://doi.org/10.11648/j.ijnfs.20160506.11
AB - Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).
VL - 5
IS - 6
ER -

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Author Information

Aissouda Hossein zade

Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Maryam Moogooei

Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Shayan Mostafaei

Department of Biostatistics, Tarbiat Modares University, Tehran, Iran
Hossein Rahavi

Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Reza Mansouri

Department of Immunology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Sepideh Soukhtezari

Department of Medical Biotechnology, Tarbiat Modares Univesity, Tehran, Iran
Mojgan Ghaedi

Department of Immunology, Tehran University of Medical Sciences, Tehran, Iran

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APA Style

Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, et al. (2016). Fatty Acids Effect on T Helper Differentiation in Vitro. International Journal of Nutrition and Food Sciences, 5(6), 372-377. https://doi.org/10.11648/j.ijnfs.20160506.11

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ACS Style

Aissouda Hossein zade; Maryam Moogooei; Shayan Mostafaei; Hossein Rahavi; Reza Mansouri, et al. Fatty Acids Effect on T Helper Differentiation in Vitro. Int. J. Nutr. Food Sci. 2016, 5(6), 372-377. doi: 10.11648/j.ijnfs.20160506.11

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AMA Style

Aissouda Hossein zade, Maryam Moogooei, Shayan Mostafaei, Hossein Rahavi, Reza Mansouri, et al. Fatty Acids Effect on T Helper Differentiation in Vitro. Int J Nutr Food Sci. 2016;5(6):372-377. doi: 10.11648/j.ijnfs.20160506.11

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@article{10.11648/j.ijnfs.20160506.11,
  author = {Aissouda Hossein zade and Maryam Moogooei and Shayan Mostafaei and Hossein Rahavi and Reza Mansouri and Sepideh Soukhtezari and Mojgan Ghaedi},
  title = {Fatty Acids Effect on T Helper Differentiation in Vitro},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {5},
  number = {6},
  pages = {372-377},
  doi = {10.11648/j.ijnfs.20160506.11},
  url = {https://doi.org/10.11648/j.ijnfs.20160506.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20160506.11},
  abstract = {Autoimmunity shows a concerning growth recently. It seems that role of diet is important for development of autoimmunity. Nutritional elements can affect immune system functions. Oversupply or deficiency of specific metabolites may change performance of immune cells, especially that of T helper lymphocytes. For example, glucose, omega 3 and poly unsaturated fatty acids can induce specific Th subsets which play a critical role in autoimmune diseases. T lymphocytes, mostly T CD4+ (Th cells) not only play a critical role in orchestrating immune responses, but also they have major role in pathogenesis of some autoimmune disease. Hence, we designed a research to find out effects of oleic and palmitic acids on differentiation of Th cells. We added oleic acid, palmitic acids and combination of them on peripheral blood mononuclear cells (PBMC) culture and cells were harvested for RT-PCR and flow cytometry analysis after seven days. Our results showed that palmitic and oleic acids induce Th1 and Th17 subsets (p-valu <0.05).},
 year = {2016}
}

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