Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice

Mohammad Farhadur Rahman; Nargish Jahan Ara; Mohammad Mesbah Uddin; Mohammad Zakir Sultan

doi:doi:10.11648/j.ijnfs.20170605.11

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Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice

Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan

Published in International Journal of Nutrition and Food Sciences (Volume 6, Issue 5)

Received: 18 June 2017 Accepted: 5 July 2017 Published: 31 July 2017

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Abstract

The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.

Published in	International Journal of Nutrition and Food Sciences (Volume 6, Issue 5)
DOI	10.11648/j.ijnfs.20170605.11
Page(s)	187-193
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

In Vivo, Reactive Dyes, Levafix Blue CA, Levafix Amber CA, Toxicity

References

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APA Style

Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan. (2017). Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. International Journal of Nutrition and Food Sciences, 6(5), 187-193. https://doi.org/10.11648/j.ijnfs.20170605.11

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ACS Style

Mohammad Farhadur Rahman; Nargish Jahan Ara; Mohammad Mesbah Uddin; Mohammad Zakir Sultan. Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. Int. J. Nutr. Food Sci. 2017, 6(5), 187-193. doi: 10.11648/j.ijnfs.20170605.11

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AMA Style

Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan. Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. Int J Nutr Food Sci. 2017;6(5):187-193. doi: 10.11648/j.ijnfs.20170605.11

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@article{10.11648/j.ijnfs.20170605.11,
  author = {Mohammad Farhadur Rahman and Nargish Jahan Ara and Mohammad Mesbah Uddin and Mohammad Zakir Sultan},
  title = {Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {6},
  number = {5},
  pages = {187-193},
  doi = {10.11648/j.ijnfs.20170605.11},
  url = {https://doi.org/10.11648/j.ijnfs.20170605.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20170605.11},
  abstract = {The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.},
 year = {2017}
}

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TY  - JOUR
T1  - Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice
AU  - Mohammad Farhadur Rahman
AU  - Nargish Jahan Ara
AU  - Mohammad Mesbah Uddin
AU  - Mohammad Zakir Sultan
Y1  - 2017/07/31
PY  - 2017
N1  - https://doi.org/10.11648/j.ijnfs.20170605.11
DO  - 10.11648/j.ijnfs.20170605.11
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 187
EP  - 193
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20170605.11
AB  - The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.
VL  - 6
IS  - 5
ER  -

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Author Information

Mohammad Farhadur Rahman

Department of Chemistry, Bangladesh University of Textiles, Dhaka, Bangladesh
Nargish Jahan Ara

Department of Chemistry, Bangladesh University of Textiles, Dhaka, Bangladesh
Mohammad Mesbah Uddin

Department of Clinical Pathology, Dhaka Medical College, Dhaka, Bangladesh
Mohammad Zakir Sultan

Centre for Advanced Research in Sciences, University of Dhaka, Dhaka, Bangladesh

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Plain Text BibTeX RIS

APA Style

Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan. (2017). Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. International Journal of Nutrition and Food Sciences, 6(5), 187-193. https://doi.org/10.11648/j.ijnfs.20170605.11

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ACS Style

Mohammad Farhadur Rahman; Nargish Jahan Ara; Mohammad Mesbah Uddin; Mohammad Zakir Sultan. Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. Int. J. Nutr. Food Sci. 2017, 6(5), 187-193. doi: 10.11648/j.ijnfs.20170605.11

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AMA Style

Mohammad Farhadur Rahman, Nargish Jahan Ara, Mohammad Mesbah Uddin, Mohammad Zakir Sultan. Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice. Int J Nutr Food Sci. 2017;6(5):187-193. doi: 10.11648/j.ijnfs.20170605.11

Copy | Download

@article{10.11648/j.ijnfs.20170605.11,
  author = {Mohammad Farhadur Rahman and Nargish Jahan Ara and Mohammad Mesbah Uddin and Mohammad Zakir Sultan},
  title = {Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {6},
  number = {5},
  pages = {187-193},
  doi = {10.11648/j.ijnfs.20170605.11},
  url = {https://doi.org/10.11648/j.ijnfs.20170605.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20170605.11},
  abstract = {The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.},
 year = {2017}
}

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TY  - JOUR
T1  - Toxic Effects of Levafix Blue CA and Levafix Amber CA Reactive Dyes on Liver and Kidney in Mice
AU  - Mohammad Farhadur Rahman
AU  - Nargish Jahan Ara
AU  - Mohammad Mesbah Uddin
AU  - Mohammad Zakir Sultan
Y1  - 2017/07/31
PY  - 2017
N1  - https://doi.org/10.11648/j.ijnfs.20170605.11
DO  - 10.11648/j.ijnfs.20170605.11
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 187
EP  - 193
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20170605.11
AB  - The healthy life of human depends on healthy foods as well as food safety. But unethical practice of textile dyes as adulterant damages the safety of food chain. Textile industries also uses textile dyes to full-fill increase demand of textile products, which produce large waste dye as effluent in ground water due to inefficiency of dying process and causes serious environmental pollution. In this study, we investigated the toxic effects of two textile reactive dyes Levafix Blue CA and Levafix Amber CA by in vivo experiments in mice. Mice were administered Levafix Blue CA and Levafix Amber CA textile dyes at a single oral dose of 0.04 g/kg daily for 21 days to observe any toxic effect of those dyes in mice. The toxic effects were evaluated by measuring the serum activity of aspartate amino-transferase (AST), glutamate pyruvate transaminase (ALT), serum total bilirubin (STBI), serum creatinine (SCR), serum urea (SBUN) and also histopathology of liver and kidney. The levels of AST, ALT, STBI, SBUN and SCR were found to be increased by both Levafix Blue CA and Levafix Amber CA. Histopathological examination of liver and kidney revealed inflammation in mice.
VL  - 6
IS  - 5
ER  -

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