Hepatoprotective Effect of an <i>Antrodia cinnamomea</i> Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Hong-Ying Hsiao; Yih-Ming Weng

doi:doi:10.11648/j.ijnfs.20180704.14

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Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats

Hong-Ying Hsiao, Yih-Ming Weng

Published in International Journal of Nutrition and Food Sciences (Volume 7, Issue 4)

Received: 9 August 2018 Published: 13 August 2018

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Abstract

Antrodia cinnamomea, causing a brown heart rot of Cinnamomum kanehirai Hay. endemic to Taiwan, was reported to have several biological activities for treating liver diseases, inflammation, tumors, et al. It was believed that wild or wood-cultured A.cinnamomea on C.kanehirai Hay. was better than by other means. However, C.kanehirai Hay. was rare and expensive, that resulted in a higher price of wild or wood-cultured A.cinnamomea. Hence, a novel process was developed to spray solid-state-cultured A.cinnamomea extracts on wood-cultured A.cinnamomea powder to make a high quality and low price product. The purpose of the study was to evaluate its hepatoprotection against carbon tetrachloride-induced hepatotoxicity in rats. Results revealed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of Sprague Dawley rats administered 20% carbon tetrachloride (CCl₄) twice a week, when the rats was also administered 413.4 or 1033.5 mg/kg body weight (BW) A.cinnamomea daily for 8 weeks, were significantly reduced in serum. Administration of 1033.5 mg/kg BW A.cinnamomea daily would not only reduce the rats’ liver and spleen swelling, liver fibrosis, and level of hydroxyproline, but increase activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione. In conclusion, the A.cinnamomea product via the novel process at 1033.5 mg/kg BW had hepatoprotective effects on carbon tetrachloride-induced hepatotoxicity in rats.

Published in	International Journal of Nutrition and Food Sciences (Volume 7, Issue 4)
DOI	10.11648/j.ijnfs.20180704.14
Page(s)	134-141
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2018. Published by Science Publishing Group

Keywords

Antrodia cinnamomea, Hepatoprotection, Novel Process, Carbon Tetrachloride

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Hong-Ying Hsiao, Yih-Ming Weng. (2018). Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats. International Journal of Nutrition and Food Sciences, 7(4), 134-141. https://doi.org/10.11648/j.ijnfs.20180704.14

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ACS Style

Hong-Ying Hsiao; Yih-Ming Weng. Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Int. J. Nutr. Food Sci. 2018, 7(4), 134-141. doi: 10.11648/j.ijnfs.20180704.14

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AMA Style

Hong-Ying Hsiao, Yih-Ming Weng. Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Int J Nutr Food Sci. 2018;7(4):134-141. doi: 10.11648/j.ijnfs.20180704.14

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@article{10.11648/j.ijnfs.20180704.14,
  author = {Hong-Ying Hsiao and Yih-Ming Weng},
  title = {Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {7},
  number = {4},
  pages = {134-141},
  doi = {10.11648/j.ijnfs.20180704.14},
  url = {https://doi.org/10.11648/j.ijnfs.20180704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20180704.14},
  abstract = {Antrodia cinnamomea, causing a brown heart rot of Cinnamomum kanehirai Hay. endemic to Taiwan, was reported to have several biological activities for treating liver diseases, inflammation, tumors, et al. It was believed that wild or wood-cultured A.cinnamomea on C.kanehirai Hay. was better than by other means. However, C.kanehirai Hay. was rare and expensive, that resulted in a higher price of wild or wood-cultured A.cinnamomea. Hence, a novel process was developed to spray solid-state-cultured A.cinnamomea extracts on wood-cultured A.cinnamomea powder to make a high quality and low price product. The purpose of the study was to evaluate its hepatoprotection against carbon tetrachloride-induced hepatotoxicity in rats. Results revealed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of Sprague Dawley rats administered 20% carbon tetrachloride (CCl4) twice a week, when the rats was also administered 413.4 or 1033.5 mg/kg body weight (BW) A.cinnamomea daily for 8 weeks, were significantly reduced in serum. Administration of 1033.5 mg/kg BW A.cinnamomea daily would not only reduce the rats’ liver and spleen swelling, liver fibrosis, and level of hydroxyproline, but increase activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione. In conclusion, the A.cinnamomea product via the novel process at 1033.5 mg/kg BW had hepatoprotective effects on carbon tetrachloride-induced hepatotoxicity in rats.},
 year = {2018}
}

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TY  - JOUR
T1  - Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats
AU  - Hong-Ying Hsiao
AU  - Yih-Ming Weng
Y1  - 2018/08/13
PY  - 2018
N1  - https://doi.org/10.11648/j.ijnfs.20180704.14
DO  - 10.11648/j.ijnfs.20180704.14
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 134
EP  - 141
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20180704.14
AB  - Antrodia cinnamomea, causing a brown heart rot of Cinnamomum kanehirai Hay. endemic to Taiwan, was reported to have several biological activities for treating liver diseases, inflammation, tumors, et al. It was believed that wild or wood-cultured A.cinnamomea on C.kanehirai Hay. was better than by other means. However, C.kanehirai Hay. was rare and expensive, that resulted in a higher price of wild or wood-cultured A.cinnamomea. Hence, a novel process was developed to spray solid-state-cultured A.cinnamomea extracts on wood-cultured A.cinnamomea powder to make a high quality and low price product. The purpose of the study was to evaluate its hepatoprotection against carbon tetrachloride-induced hepatotoxicity in rats. Results revealed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of Sprague Dawley rats administered 20% carbon tetrachloride (CCl4) twice a week, when the rats was also administered 413.4 or 1033.5 mg/kg body weight (BW) A.cinnamomea daily for 8 weeks, were significantly reduced in serum. Administration of 1033.5 mg/kg BW A.cinnamomea daily would not only reduce the rats’ liver and spleen swelling, liver fibrosis, and level of hydroxyproline, but increase activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione. In conclusion, the A.cinnamomea product via the novel process at 1033.5 mg/kg BW had hepatoprotective effects on carbon tetrachloride-induced hepatotoxicity in rats.
VL  - 7
IS  - 4
ER  -

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Author Information

Hong-Ying Hsiao

Department of Food Science, National Chiayi University, Chiayi, Taiwan
Yih-Ming Weng

Department of Food Science, National Chiayi University, Chiayi, Taiwan

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Hong-Ying Hsiao, Yih-Ming Weng. (2018). Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats. International Journal of Nutrition and Food Sciences, 7(4), 134-141. https://doi.org/10.11648/j.ijnfs.20180704.14

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ACS Style

Hong-Ying Hsiao; Yih-Ming Weng. Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Int. J. Nutr. Food Sci. 2018, 7(4), 134-141. doi: 10.11648/j.ijnfs.20180704.14

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AMA Style

Hong-Ying Hsiao, Yih-Ming Weng. Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats. Int J Nutr Food Sci. 2018;7(4):134-141. doi: 10.11648/j.ijnfs.20180704.14

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@article{10.11648/j.ijnfs.20180704.14,
  author = {Hong-Ying Hsiao and Yih-Ming Weng},
  title = {Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats},
  journal = {International Journal of Nutrition and Food Sciences},
  volume = {7},
  number = {4},
  pages = {134-141},
  doi = {10.11648/j.ijnfs.20180704.14},
  url = {https://doi.org/10.11648/j.ijnfs.20180704.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijnfs.20180704.14},
  abstract = {Antrodia cinnamomea, causing a brown heart rot of Cinnamomum kanehirai Hay. endemic to Taiwan, was reported to have several biological activities for treating liver diseases, inflammation, tumors, et al. It was believed that wild or wood-cultured A.cinnamomea on C.kanehirai Hay. was better than by other means. However, C.kanehirai Hay. was rare and expensive, that resulted in a higher price of wild or wood-cultured A.cinnamomea. Hence, a novel process was developed to spray solid-state-cultured A.cinnamomea extracts on wood-cultured A.cinnamomea powder to make a high quality and low price product. The purpose of the study was to evaluate its hepatoprotection against carbon tetrachloride-induced hepatotoxicity in rats. Results revealed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of Sprague Dawley rats administered 20% carbon tetrachloride (CCl4) twice a week, when the rats was also administered 413.4 or 1033.5 mg/kg body weight (BW) A.cinnamomea daily for 8 weeks, were significantly reduced in serum. Administration of 1033.5 mg/kg BW A.cinnamomea daily would not only reduce the rats’ liver and spleen swelling, liver fibrosis, and level of hydroxyproline, but increase activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione. In conclusion, the A.cinnamomea product via the novel process at 1033.5 mg/kg BW had hepatoprotective effects on carbon tetrachloride-induced hepatotoxicity in rats.},
 year = {2018}
}

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TY  - JOUR
T1  - Hepatoprotective Effect of an Antrodia cinnamomea Product Via a Novel Process on Carbon Tetrachloride-Induced Hepatotoxicity in Rats
AU  - Hong-Ying Hsiao
AU  - Yih-Ming Weng
Y1  - 2018/08/13
PY  - 2018
N1  - https://doi.org/10.11648/j.ijnfs.20180704.14
DO  - 10.11648/j.ijnfs.20180704.14
T2  - International Journal of Nutrition and Food Sciences
JF  - International Journal of Nutrition and Food Sciences
JO  - International Journal of Nutrition and Food Sciences
SP  - 134
EP  - 141
PB  - Science Publishing Group
SN  - 2327-2716
UR  - https://doi.org/10.11648/j.ijnfs.20180704.14
AB  - Antrodia cinnamomea, causing a brown heart rot of Cinnamomum kanehirai Hay. endemic to Taiwan, was reported to have several biological activities for treating liver diseases, inflammation, tumors, et al. It was believed that wild or wood-cultured A.cinnamomea on C.kanehirai Hay. was better than by other means. However, C.kanehirai Hay. was rare and expensive, that resulted in a higher price of wild or wood-cultured A.cinnamomea. Hence, a novel process was developed to spray solid-state-cultured A.cinnamomea extracts on wood-cultured A.cinnamomea powder to make a high quality and low price product. The purpose of the study was to evaluate its hepatoprotection against carbon tetrachloride-induced hepatotoxicity in rats. Results revealed that aspartate aminotransferase (AST) and alanine aminotransferase (ALT) of Sprague Dawley rats administered 20% carbon tetrachloride (CCl4) twice a week, when the rats was also administered 413.4 or 1033.5 mg/kg body weight (BW) A.cinnamomea daily for 8 weeks, were significantly reduced in serum. Administration of 1033.5 mg/kg BW A.cinnamomea daily would not only reduce the rats’ liver and spleen swelling, liver fibrosis, and level of hydroxyproline, but increase activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, and glutathione. In conclusion, the A.cinnamomea product via the novel process at 1033.5 mg/kg BW had hepatoprotective effects on carbon tetrachloride-induced hepatotoxicity in rats.
VL  - 7
IS  - 4
ER  -

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