Introduction: Several risk factors influence the recurrence of thyroid cancer, including age, tumor size, lymph node involvement, and other prognostic indicators. The purpose of this study is to evaluate the impact of these risk factors on the recurrence rates of thyroid cancer, with the aim of improving diagnostic and treatment strategies for better patient outcomes. Aim of the study: The aim of the study was to evaluate risk factors for thyroid cancer recurrence and preventive strategies. Methods: This retrospective cohort study conducted at the Department of Otolaryngology-Head & Neck Surgery at Bangabandhu Sheikh Mujib Medical University (BSMMU) included 108 thyroid cancer patients treated between April 2023 and March 2024. Patients were categorized into low-risk and high-risk groups based on prognostic factors. Follow-up for three years assessed recurrence and survival through outpatient visits and telephone interviews. Statistical analyses using SPSS version 22.0 included descriptive statistics, chi-square tests for recurrence rates, and Kaplan-Meier survival analysis. Result: The study identified Differentiated Thyroid Carcinoma (DTC) as the most common type, with Papillary Thyroid Carcinoma being the predominant subtype. Recurrence rates were notably higher in patients aged ≥45 and in males. Significant predictors of recurrence included age, gender, tumor diameter, and lymph node metastasis. High-risk patients mostly received Total Thyroidectomy, Radioiodine ablation, and Thyroxin. Follow-up showed recurrence rates of 8.33% in low-risk and 7.55% in high-risk patients over three years. Conclusion: The study highlights the critical role of age, gender, tumor diameter, and lymph node metastasis in predicting thyroid cancer recurrence, emphasizing the need for personalized treatment and monitoring based on risk levels.
| Published in | International Journal of Otorhinolaryngology (Volume 10, Issue 2) |
| DOI | 10.11648/j.ijo.20241002.13 |
| Page(s) | 58-64 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Thyroid Cancer Recurrence, Differentiated Thyroid Carcinoma, Risk Factors, Surgical Treatment, Follow-Up Outcomes
| [1] | Ferlay J, Ervik M, Lam F, et al. Global Cancer Observatory: cancer today. Lyon: International Agency for Research on Cancer; 2020. |
| [2] | Miranda-Filho A, Lortet-Tieulent J, Bray F, Cao B, Franceschi S, Vaccarella S, et al. Thyroid cancer incidence trends by histology in 25 countries: a population-based study. Lancet Diabetes Endocrinol. 2021; 9(4): 225–34. |
| [3] | Li M, Dal Maso L, Vaccarella S. Global trends in thyroid cancer incidence and the impact of overdiagnosis. Lancet Diabetes Endocrinol. 2020; 8(6): 468–70. |
| [4] | Surveillance, Epidemiology, and End Results Program (SEER). Cancer statistics review, 1975–2018. Bethesda, MD: National Cancer Institute; 2021 Apr 15. |
| [5] | Lim H, Devesa SS, Sosa JA, Check D, Kitahara CM. Trends in thyroid cancer incidence and mortality in the United States, 1974-2013. JAMA. 2017; 317(13): 1338. |
| [6] | Asa SL. The current histologic classification of thyroid cancer. Endocrinol Metab Clin North Am. 2019; 48(1): 1–22. |
| [7] | Baek S-K, Jung K-Y, Kang S-M, Kwon S-Y, Woo J-S, Cho S-H, et al. Clinical risk factors associated with cervical lymph node recurrence in papillary thyroid carcinoma. Thyroid. 2010; 20(2): 147–52. |
| [8] | Feng J-W, Qin A-C, Ye J, Pan H, Jiang Y, Qu Z. Predictive factors for lateral lymph node metastasis and skip metastasis in papillary thyroid carcinoma. Endocr Pathol. 2020; 31(1): 67–76. |
| [9] | Ryu IS, Song CI, Choi S-H, Roh J-L, Nam SY, Kim SY. Lymph node ratio of the central compartment is a significant predictor for locoregional recurrence after prophylactic central neck dissection in patients with thyroid papillary carcinoma. Ann Surg Oncol. 2014; 21(1): 277–83. |
| [10] | Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med. 1994; 97(5): 418–28. |
| [11] | Minimally invasive video-assisted thyroidectomy for papillary carcinoma. Surgery. 2002; 132: 107–11. |
| [12] | Yang X, Liang J, Li T-J, Yang K, Liang D-Q, Yu Z, et al. Postoperative stimulated thyroglobulin level and recurrence risk stratification in differentiated thyroid cancer. Chin Med J (Engl). 2015; 128(8): 1058–64. |
| [13] | Takami H, Ito Y, Okamoto T, Onoda N, Noguchi H, Yoshida A. Revisiting the guidelines issued by the Japanese Society of Thyroid Surgeons and Japan Association of Endocrine Surgeons: a gradual move towards consensus between Japanese and western practice in the management of thyroid carcinoma. World J Surg. 2014; 38(8): 2002–10. |
| [14] | Dralle H, Musholt TJ, Schabram J, Steinmüller T, Frilling A, Simon D, et al. German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors. Langenbecks Arch Surg. 2013; 398(3): 347–75. |
| [15] | Alauddin M, Joarder AH. Management of thyroid carcinoma-an experience in Bangladesh. Indian J Otolaryngol Head Neck Surg. 2004; 56(3): 201–5. |
| [16] | Mazzaferri EL, Massoll N. Management of papillary and follicular (differentiated) thyroid cancer: new paradigms using recombinant human thyrotropin. Endocr Relat Cancer. 2002; 9(4): 227-247. |
| [17] | Luo X, Wu ACYZYJBZJ. Analysis of risk factors for postoperative recurrence of thyroid cancer. J BUON. 2019; 24(2): 813–8. |
| [18] | Lo TEN, Canto AU, Maningat PDD. Risk factors for recurrence in Filipinos with well-differentiated thyroid cancer. Endocrinol Metab (Seoul). 2015; 30(4): 543–50. |
| [19] | Kruijff S, Petersen JF, Chen P, Aniss AM, Clifton-Bligh RJ, Sidhu SB, et al. Patterns of structural recurrence in papillary thyroid cancer. World J Surg. 2014; 38(3): 653–9. |
| [20] | Yi JW, Kim SJ, Kim JK. Upregulation of the ESR1 Gene and ESR Ratio (ESR1/ESR2) is Associated with a Worse Prognosis in Papillary Thyroid Carcinoma: The Impact of the Estrogen Receptor alpha/beta Expression on Clinical Outcomes in Papillary Thyroid Carcinoma Patients. Ann Surg Oncol. 2017; 24: 3754–62. |
| [21] | Cho SY, Lee TH, Ku YH, Kim HI, Lee GH, Kim MJ. Central lymph node metastasis in papillary thyroid microcarcinoma can be stratified according to the number, the size of metastatic foci, and the presence of desmoplasia. Surgery. 2015; 157(1): 111–8. |
| [22] | Hay ID, Thompson GB, Grant CS, Bergstralh EJ, Dvorak CE, Gorman CA, Maurer MS, McIver B, Mullan BP, Oberg AL, Powell CC, van Heerden JA, Goellner JR. Papillary thyroid carcinoma managed at the Mayo Clinic during six decades (1940-1999): temporal trends in initial therapy and long-term outcome in 2444 consecutively treated patients. World J Surg. 2002; 26(8): 879-885. |
| [23] | Cady B, Rossi R. An expanded view of risk group definition in differentiated thyroid carcinoma. Surgery. 1988; 104(6): 947-953. |
APA Style
Rahman, M., Hossain, M. A., Rahman, T., Jewel, A. M. (2024). Thyroid Cancer Recurrence: Risk Factors and Preventive Strategies. International Journal of Otorhinolaryngology, 10(2), 58-64. https://doi.org/10.11648/j.ijo.20241002.13
ACS Style
Rahman, M.; Hossain, M. A.; Rahman, T.; Jewel, A. M. Thyroid Cancer Recurrence: Risk Factors and Preventive Strategies. Int. J. Otorhinolaryngol. 2024, 10(2), 58-64. doi: 10.11648/j.ijo.20241002.13
AMA Style
Rahman M, Hossain MA, Rahman T, Jewel AM. Thyroid Cancer Recurrence: Risk Factors and Preventive Strategies. Int J Otorhinolaryngol. 2024;10(2):58-64. doi: 10.11648/j.ijo.20241002.13
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Download@article{10.11648/j.ijo.20241002.13,
author = {Masroor Rahman and Mohammad Anwar Hossain and Tawfiqur Rahman and Arif Mahmud Jewel},
title = {Thyroid Cancer Recurrence: Risk Factors and Preventive Strategies
},
journal = {International Journal of Otorhinolaryngology},
volume = {10},
number = {2},
pages = {58-64},
doi = {10.11648/j.ijo.20241002.13},
url = {https://doi.org/10.11648/j.ijo.20241002.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijo.20241002.13},
abstract = {Introduction: Several risk factors influence the recurrence of thyroid cancer, including age, tumor size, lymph node involvement, and other prognostic indicators. The purpose of this study is to evaluate the impact of these risk factors on the recurrence rates of thyroid cancer, with the aim of improving diagnostic and treatment strategies for better patient outcomes. Aim of the study: The aim of the study was to evaluate risk factors for thyroid cancer recurrence and preventive strategies. Methods: This retrospective cohort study conducted at the Department of Otolaryngology-Head & Neck Surgery at Bangabandhu Sheikh Mujib Medical University (BSMMU) included 108 thyroid cancer patients treated between April 2023 and March 2024. Patients were categorized into low-risk and high-risk groups based on prognostic factors. Follow-up for three years assessed recurrence and survival through outpatient visits and telephone interviews. Statistical analyses using SPSS version 22.0 included descriptive statistics, chi-square tests for recurrence rates, and Kaplan-Meier survival analysis. Result: The study identified Differentiated Thyroid Carcinoma (DTC) as the most common type, with Papillary Thyroid Carcinoma being the predominant subtype. Recurrence rates were notably higher in patients aged ≥45 and in males. Significant predictors of recurrence included age, gender, tumor diameter, and lymph node metastasis. High-risk patients mostly received Total Thyroidectomy, Radioiodine ablation, and Thyroxin. Follow-up showed recurrence rates of 8.33% in low-risk and 7.55% in high-risk patients over three years. Conclusion: The study highlights the critical role of age, gender, tumor diameter, and lymph node metastasis in predicting thyroid cancer recurrence, emphasizing the need for personalized treatment and monitoring based on risk levels.
},
year = {2024}
}
TY - JOUR T1 - Thyroid Cancer Recurrence: Risk Factors and Preventive Strategies AU - Masroor Rahman AU - Mohammad Anwar Hossain AU - Tawfiqur Rahman AU - Arif Mahmud Jewel Y1 - 2024/09/23 PY - 2024 N1 - https://doi.org/10.11648/j.ijo.20241002.13 DO - 10.11648/j.ijo.20241002.13 T2 - International Journal of Otorhinolaryngology JF - International Journal of Otorhinolaryngology JO - International Journal of Otorhinolaryngology SP - 58 EP - 64 PB - Science Publishing Group SN - 2472-2413 UR - https://doi.org/10.11648/j.ijo.20241002.13 AB - Introduction: Several risk factors influence the recurrence of thyroid cancer, including age, tumor size, lymph node involvement, and other prognostic indicators. The purpose of this study is to evaluate the impact of these risk factors on the recurrence rates of thyroid cancer, with the aim of improving diagnostic and treatment strategies for better patient outcomes. Aim of the study: The aim of the study was to evaluate risk factors for thyroid cancer recurrence and preventive strategies. Methods: This retrospective cohort study conducted at the Department of Otolaryngology-Head & Neck Surgery at Bangabandhu Sheikh Mujib Medical University (BSMMU) included 108 thyroid cancer patients treated between April 2023 and March 2024. Patients were categorized into low-risk and high-risk groups based on prognostic factors. Follow-up for three years assessed recurrence and survival through outpatient visits and telephone interviews. Statistical analyses using SPSS version 22.0 included descriptive statistics, chi-square tests for recurrence rates, and Kaplan-Meier survival analysis. Result: The study identified Differentiated Thyroid Carcinoma (DTC) as the most common type, with Papillary Thyroid Carcinoma being the predominant subtype. Recurrence rates were notably higher in patients aged ≥45 and in males. Significant predictors of recurrence included age, gender, tumor diameter, and lymph node metastasis. High-risk patients mostly received Total Thyroidectomy, Radioiodine ablation, and Thyroxin. Follow-up showed recurrence rates of 8.33% in low-risk and 7.55% in high-risk patients over three years. Conclusion: The study highlights the critical role of age, gender, tumor diameter, and lymph node metastasis in predicting thyroid cancer recurrence, emphasizing the need for personalized treatment and monitoring based on risk levels. VL - 10 IS - 2 ER -
Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Department of Otolaryngology-Head & Neck Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
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