The Oligopeptides, Homologous of ACTH<sub>15-18</sub> Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats

Roman Danylovych Deiko; Serhiy Yuriyovych Shtrygolʹ; Tetyana Victorivna Gorbach; Alexandr Alexandrovich Kolobov; Andrey Semenovich Simbirtsev

doi:doi:10.11648/j.ijpbs.20160103.14

The Oligopeptides, Homologous of ACTH_15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats

Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev

Published in International Journal of Psychological and Brain Sciences (Volume 1, Issue 3)

Received: 19 October 2016 Accepted: 5 November 2016 Published: 16 December 2016

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Abstract

The series of tetrapeptides, homologues of ACTH_15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.

Published in	International Journal of Psychological and Brain Sciences (Volume 1, Issue 3)
DOI	10.11648/j.ijpbs.20160103.14
Page(s)	62-68
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2016. Published by Science Publishing Group

Keywords

Cerebral Ischemia, Cytokines, Nerve Growth Factor, Neuroprotection, Oligopeptides, Rats

References

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APA Style

Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev. (2016). The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. International Journal of Psychological and Brain Sciences, 1(3), 62-68. https://doi.org/10.11648/j.ijpbs.20160103.14

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ACS Style

Roman Danylovych Deiko; Serhiy Yuriyovych Shtrygolʹ; Tetyana Victorivna Gorbach; Alexandr Alexandrovich Kolobov; Andrey Semenovich Simbirtsev. The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. Int. J. Psychol. Brain Sci. 2016, 1(3), 62-68. doi: 10.11648/j.ijpbs.20160103.14

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AMA Style

Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev. The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. Int J Psychol Brain Sci. 2016;1(3):62-68. doi: 10.11648/j.ijpbs.20160103.14

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@article{10.11648/j.ijpbs.20160103.14,
  author = {Roman Danylovych Deiko and Serhiy Yuriyovych Shtrygolʹ and Tetyana Victorivna Gorbach and Alexandr Alexandrovich Kolobov and Andrey Semenovich Simbirtsev},
  title = {The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats},
  journal = {International Journal of Psychological and Brain Sciences},
  volume = {1},
  number = {3},
  pages = {62-68},
  doi = {10.11648/j.ijpbs.20160103.14},
  url = {https://doi.org/10.11648/j.ijpbs.20160103.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20160103.14},
  abstract = {The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.},
 year = {2016}
}

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TY  - JOUR
T1  - The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats
AU  - Roman Danylovych Deiko
AU  - Serhiy Yuriyovych Shtrygolʹ
AU  - Tetyana Victorivna Gorbach
AU  - Alexandr Alexandrovich Kolobov
AU  - Andrey Semenovich Simbirtsev
Y1  - 2016/12/16
PY  - 2016
N1  - https://doi.org/10.11648/j.ijpbs.20160103.14
DO  - 10.11648/j.ijpbs.20160103.14
T2  - International Journal of Psychological and Brain Sciences
JF  - International Journal of Psychological and Brain Sciences
JO  - International Journal of Psychological and Brain Sciences
SP  - 62
EP  - 68
PB  - Science Publishing Group
SN  - 2575-1573
UR  - https://doi.org/10.11648/j.ijpbs.20160103.14
AB  - The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.
VL  - 1
IS  - 3
ER  -

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Author Information

Roman Danylovych Deiko

Department of Pharmacology, National University of Pharmacy, Kharkiv, Ukraine
Serhiy Yuriyovych Shtrygolʹ
Tetyana Victorivna Gorbach

Department of Biochemistry, Kharkiv National Medical University, Kharkiv, Ukraine
Alexandr Alexandrovich Kolobov

Department of Chemistry of Peptides, State Research Institute of Highly Pure Biopreparations, St. Petersburg, Russia
Andrey Semenovich Simbirtsev

Department of Chemistry of Peptides, State Research Institute of Highly Pure Biopreparations, St. Petersburg, Russia

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Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev. (2016). The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. International Journal of Psychological and Brain Sciences, 1(3), 62-68. https://doi.org/10.11648/j.ijpbs.20160103.14

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ACS Style

Roman Danylovych Deiko; Serhiy Yuriyovych Shtrygolʹ; Tetyana Victorivna Gorbach; Alexandr Alexandrovich Kolobov; Andrey Semenovich Simbirtsev. The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. Int. J. Psychol. Brain Sci. 2016, 1(3), 62-68. doi: 10.11648/j.ijpbs.20160103.14

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AMA Style

Roman Danylovych Deiko, Serhiy Yuriyovych Shtrygolʹ, Tetyana Victorivna Gorbach, Alexandr Alexandrovich Kolobov, Andrey Semenovich Simbirtsev. The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats. Int J Psychol Brain Sci. 2016;1(3):62-68. doi: 10.11648/j.ijpbs.20160103.14

Copy | Download

@article{10.11648/j.ijpbs.20160103.14,
  author = {Roman Danylovych Deiko and Serhiy Yuriyovych Shtrygolʹ and Tetyana Victorivna Gorbach and Alexandr Alexandrovich Kolobov and Andrey Semenovich Simbirtsev},
  title = {The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats},
  journal = {International Journal of Psychological and Brain Sciences},
  volume = {1},
  number = {3},
  pages = {62-68},
  doi = {10.11648/j.ijpbs.20160103.14},
  url = {https://doi.org/10.11648/j.ijpbs.20160103.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpbs.20160103.14},
  abstract = {The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.},
 year = {2016}
}

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TY  - JOUR
T1  - The Oligopeptides, Homologous of ACTH15-18 Sequence: Neurotrophic and Anti-inflammatory Activity on the Model of Cerebral Ischemia in Rats
AU  - Roman Danylovych Deiko
AU  - Serhiy Yuriyovych Shtrygolʹ
AU  - Tetyana Victorivna Gorbach
AU  - Alexandr Alexandrovich Kolobov
AU  - Andrey Semenovich Simbirtsev
Y1  - 2016/12/16
PY  - 2016
N1  - https://doi.org/10.11648/j.ijpbs.20160103.14
DO  - 10.11648/j.ijpbs.20160103.14
T2  - International Journal of Psychological and Brain Sciences
JF  - International Journal of Psychological and Brain Sciences
JO  - International Journal of Psychological and Brain Sciences
SP  - 62
EP  - 68
PB  - Science Publishing Group
SN  - 2575-1573
UR  - https://doi.org/10.11648/j.ijpbs.20160103.14
AB  - The series of tetrapeptides, homologues of ACTH15-18 sequence that contain D-form of lysine and arginine have been synthesized at the State Research Institute of Highly Pure Biopreparations (Saint-Petersburg, Russian Federation). Previous research allowed to reveal their neuroprotectivе, anti-hypoxic and favorable psychotropic properties and capability to stimulate blood supply to the injured brain. The influence of neuropeptide on rats survival, neurological deficit (ND), nerve growth factor (NGF) expression, tumor necrosis factor α (TNF-α), interleukine-1 beta (IL-1β) and interleukine-4 (IL-4) levels in rats brain tissue was studied on the irreversible bilateral carotid occlusion model. Neuroprotectivе properties of the neuropeptides KK-1 and KK-5 namely increase in rats with acute ischemic stroke (AIS) survival rate up to 75% and 80%, respectively, were shown. Neuropeptides decreased ND 1.7 times compared with the untreated group (UG). Neuroprotectivе effect of the neuropeptides is manifested by their ability to decrease the level of NGF compensatory overexpression, pro-inflammatory and anti-inflammatory cytokines such as TNF-α, IL-1β, IL-4. It has been established that the mechanism of the tetrapeptides KK-1 and KK-5 neuroprotectivе activity is connected with their neurotrophic and anti-inflammatory action.
VL  - 1
IS  - 3
ER  -

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