,
Marzia Pellizzato,
Alejandra Hernández-Bueno,
Alma Martelli,
Valentina Citi,
Giancarlo Cravotto
Background: Creatine supplementation has long been established as a performance-enhancing strategy in power and strength-based sports. However, evidence in elite female athletes and in volleyball-specific contexts remains limited. Clonapure® is a novel creatine formulation containing creatine monohydrate, creatine phosphate, and phosphate, designed to optimize cellular uptake and metabolic synergy. Methods: In this randomized, double-blind, placebo-controlled pilot trial, 16 elite female volleyball players were randomized to receive either Clonapure® or placebo over 28 days. Performance was assessed at three timepoints: T0 (Day 1), T1 (Day 7), and T2 (Day 28). Primary outcomes included the Volleyball Intermittent Endurance Test (VIET), Intermittent Vertical Jump Test (IVJT), and Continuous Vertical Jump Test (CVJT). Quality indicators such as jump count and jump height were also recorded. Results: No adverse events or dropouts were reported. At T2, the Clonapure® group showed significantly improved aerobic endurance, with greater total distance covered in the VIET compared to placebo (p<0.001). In the IVJT, the Clonapure® group demonstrated early and sustained improvements in peak power (PP), mean power (MP), and fatigue index (FI), with statistical significance achieved for all variables by T2 (PP: p = 0.023; MP: p = 0.026; FI: p = 0.002). The CVJT revealed a similar trend, with significant enhancements in MP and FI at T2. Vertical jump quality indicators (NVJ60sec and VJ60sec) also showed significant improvements in the Clonapure® group across T1 and T2. NVJ15sec remained unchanged, while VJ15sec showed mild but consistent gains. Conclusion: Clonapure® supplementation over 28 days significantly enhanced both sport-specific endurance and neuromuscular performance in elite female volleyball players. These effects likely reflect improved phosphocreatine resynthesis, enhanced buffering capacity, and superior maintenance of explosive output during repeated high-intensity efforts. The findings support Clonapure® as a safe and effective ergogenic aid in elite-level, intermittent sport contexts such as volleyball.
| Published in | International Journal of Sports Science and Physical Education (Volume 10, Issue 3) |
| DOI | 10.11648/j.ijsspe.20251003.15 |
| Page(s) | 115-123 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2025. Published by Science Publishing Group |
Creatine, Clonapure®, Supplements, Performance, Training
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APA Style
Colletti, A., Pellizzato, M., Hernández-Bueno, A., Meo, A. D., Martelli, A., et al. (2025). Effects of Clonapure® Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players. International Journal of Sports Science and Physical Education, 10(3), 115-123. https://doi.org/10.11648/j.ijsspe.20251003.15
ACS Style
Colletti, A.; Pellizzato, M.; Hernández-Bueno, A.; Meo, A. D.; Martelli, A., et al. Effects of Clonapure® Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players. Int. J. Sports Sci. Phys. Educ. 2025, 10(3), 115-123. doi: 10.11648/j.ijsspe.20251003.15
AMA Style
Colletti A, Pellizzato M, Hernández-Bueno A, Meo AD, Martelli A, et al. Effects of Clonapure® Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players. Int J Sports Sci Phys Educ. 2025;10(3):115-123. doi: 10.11648/j.ijsspe.20251003.15
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Download@article{10.11648/j.ijsspe.20251003.15,
author = {Alessandro Colletti and Marzia Pellizzato and Alejandra Hernández-Bueno and Atanasio De Meo and Alma Martelli and Valentina Citi and Giancarlo Cravotto},
title = {Effects of Clonapure® Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players
},
journal = {International Journal of Sports Science and Physical Education},
volume = {10},
number = {3},
pages = {115-123},
doi = {10.11648/j.ijsspe.20251003.15},
url = {https://doi.org/10.11648/j.ijsspe.20251003.15},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijsspe.20251003.15},
abstract = {Background: Creatine supplementation has long been established as a performance-enhancing strategy in power and strength-based sports. However, evidence in elite female athletes and in volleyball-specific contexts remains limited. Clonapure® is a novel creatine formulation containing creatine monohydrate, creatine phosphate, and phosphate, designed to optimize cellular uptake and metabolic synergy. Methods: In this randomized, double-blind, placebo-controlled pilot trial, 16 elite female volleyball players were randomized to receive either Clonapure® or placebo over 28 days. Performance was assessed at three timepoints: T0 (Day 1), T1 (Day 7), and T2 (Day 28). Primary outcomes included the Volleyball Intermittent Endurance Test (VIET), Intermittent Vertical Jump Test (IVJT), and Continuous Vertical Jump Test (CVJT). Quality indicators such as jump count and jump height were also recorded. Results: No adverse events or dropouts were reported. At T2, the Clonapure® group showed significantly improved aerobic endurance, with greater total distance covered in the VIET compared to placebo (p® group demonstrated early and sustained improvements in peak power (PP), mean power (MP), and fatigue index (FI), with statistical significance achieved for all variables by T2 (PP: p = 0.023; MP: p = 0.026; FI: p = 0.002). The CVJT revealed a similar trend, with significant enhancements in MP and FI at T2. Vertical jump quality indicators (NVJ60sec and VJ60sec) also showed significant improvements in the Clonapure® group across T1 and T2. NVJ15sec remained unchanged, while VJ15sec showed mild but consistent gains. Conclusion: Clonapure® supplementation over 28 days significantly enhanced both sport-specific endurance and neuromuscular performance in elite female volleyball players. These effects likely reflect improved phosphocreatine resynthesis, enhanced buffering capacity, and superior maintenance of explosive output during repeated high-intensity efforts. The findings support Clonapure® as a safe and effective ergogenic aid in elite-level, intermittent sport contexts such as volleyball.},
year = {2025}
}
TY - JOUR T1 - Effects of Clonapure® Supplementation on Intermittent Aerobic Capacity and Explosive Power in Elite Female Volleyball Players AU - Alessandro Colletti AU - Marzia Pellizzato AU - Alejandra Hernández-Bueno AU - Atanasio De Meo AU - Alma Martelli AU - Valentina Citi AU - Giancarlo Cravotto Y1 - 2025/08/13 PY - 2025 N1 - https://doi.org/10.11648/j.ijsspe.20251003.15 DO - 10.11648/j.ijsspe.20251003.15 T2 - International Journal of Sports Science and Physical Education JF - International Journal of Sports Science and Physical Education JO - International Journal of Sports Science and Physical Education SP - 115 EP - 123 PB - Science Publishing Group SN - 2575-1611 UR - https://doi.org/10.11648/j.ijsspe.20251003.15 AB - Background: Creatine supplementation has long been established as a performance-enhancing strategy in power and strength-based sports. However, evidence in elite female athletes and in volleyball-specific contexts remains limited. Clonapure® is a novel creatine formulation containing creatine monohydrate, creatine phosphate, and phosphate, designed to optimize cellular uptake and metabolic synergy. Methods: In this randomized, double-blind, placebo-controlled pilot trial, 16 elite female volleyball players were randomized to receive either Clonapure® or placebo over 28 days. Performance was assessed at three timepoints: T0 (Day 1), T1 (Day 7), and T2 (Day 28). Primary outcomes included the Volleyball Intermittent Endurance Test (VIET), Intermittent Vertical Jump Test (IVJT), and Continuous Vertical Jump Test (CVJT). Quality indicators such as jump count and jump height were also recorded. Results: No adverse events or dropouts were reported. At T2, the Clonapure® group showed significantly improved aerobic endurance, with greater total distance covered in the VIET compared to placebo (p® group demonstrated early and sustained improvements in peak power (PP), mean power (MP), and fatigue index (FI), with statistical significance achieved for all variables by T2 (PP: p = 0.023; MP: p = 0.026; FI: p = 0.002). The CVJT revealed a similar trend, with significant enhancements in MP and FI at T2. Vertical jump quality indicators (NVJ60sec and VJ60sec) also showed significant improvements in the Clonapure® group across T1 and T2. NVJ15sec remained unchanged, while VJ15sec showed mild but consistent gains. Conclusion: Clonapure® supplementation over 28 days significantly enhanced both sport-specific endurance and neuromuscular performance in elite female volleyball players. These effects likely reflect improved phosphocreatine resynthesis, enhanced buffering capacity, and superior maintenance of explosive output during repeated high-intensity efforts. The findings support Clonapure® as a safe and effective ergogenic aid in elite-level, intermittent sport contexts such as volleyball. VL - 10 IS - 3 ER -
Department of Drug Science and Technology, University of Turin, Turin, Italy. Italian Society of Nutraceutical Formulators, Treviso, Italy
Italian Society of Nutraceutical Formulators, Treviso, Italy
Tradichem Group, Madrid, Spain
Italian Society of Nutraceutical Formulators, Treviso, Italy. Department of Pharmacy, University of Pisa, Pisa, Italy
Department of Pharmacy, University of Pisa, Pisa, Italy
Department of Drug Science and Technology, University of Turin, Turin, Italy. Italian Society of Nutraceutical Formulators, Treviso, Italy
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