Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerative diseases, such as, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. In the 1930’s Warburg described a link between mitochondrial function and tumorigenesis. Modern Medicine has fallen prey to the overusage and misuse of antibiotics. This minireview postulates that this misuse may attack the mitochondrion and alter host-antibiotic interactions that might cause serious pathophysiologic conditions. One such condition may be cancer which was proposed by Warburg and supported by our work on normal mitochondria organelle transplantation in cancer. Some groups of antibiotics attack targets that are shared by prokaryotes and mitochondria. This leads to mitochondrial dysfunction possibly promoting tumorigenesis and neurodegenerative conditions.
| Published in | Journal of Cancer Treatment and Research (Volume 5, Issue 4) |
| DOI | 10.11648/j.jctr.20170504.11 |
| Page(s) | 62-65 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2017. Published by Science Publishing Group |
Antibiotics, Mitochondria, Warburg Effect, Tumorigenesis
| [1] | Warburg O, Wind F, Negleis E (1930) “On the metabolism of tumors in the body”, In Warburg, Ed., The metabolism of tumors constable, Princeton, pp. 254-270. |
| [2] | Warburg O (1956) on the origin of cancer cells. Science 123: 309-314. |
| [3] | Elliott RL, Jiang XP, et al. (2012) Mitochondrial organelle transplantation: introduction of normal epithelial mitochondria into human cancer cells inhibits proliferation and increases drug sensitivity. Breast Cancer Res Treat. 136; 347-354. |
| [4] | Jiang XP, Elliott RL et al. (2015) Exogenous normal mammary epithelial mitochondria suppress glycolytic metabolism and glucose uptake of human breast cancer cells. Breast Cancer Res. Treat. 153: 519-529. |
| [5] | Margulis L. (1970) origin of eukaryotic cells. Yale University Press, New Haven CT. |
| [6] | Gray MW (2012) Mitochondrial evolution. Cold Spring Harb Perspect Biol 4: ao/1403. |
| [7] | Hiltunen T, Virta M, Laine AL. (2017) antibiotic resistance in the wild; on eco-evolutionary perspective. Phil. Trans. R, Soc. B 372: 20160039. |
| [8] | Woolhouse ME, Ward MJ. (2013) Sources of antimicrobial resistance. Acience 341: 1460-1461. |
| [9] | Johnson CH, Spilker ME, Goetz L, Peterson SN, Sluzdak G. (2016) Metabolite and microbiome interplay in cancer immunotherapy. Cancer Res; 76 (21): 6146-6152. |
| [10] | Arpaia N, Campbell C, Fara X, Didiy S, Vander Veeken J, deRoos P. (2013) Metabolites produced by commensal bacteria promote peripheral regulatory T-Cell generation. Nature 504: 451-455. |
| [11] | Park J, Kim M, Kang SG, Jannasch AH, et al. (2015) Short-chain fatty acids induce both effector and regulatory T-cells by suppression of histone deacetylases and regulation of the MTOR 56K pathway. Mucosal Immunol 8: 80-93. |
| [12] | O’Sullivan D, Pearce El. (2015) Targeting T-cell metabolism for therapy. Trends Immunol; 36: 71-80. |
| [13] | Sivan A, Corrales L, Huber N, Williams JB, et al. (2015) Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science: 350: 1084-1089. |
| [14] | Mockler MB, Conroy MJ, Lysaght J. (2014) Targeting T-cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. Front Oncol; 4: 107. |
| [15] | Viaud S, Saccheri F, Mignot G, Yamazaki T, et al. (2013) The intestinal microbiota modulates the anticancer immune effects of cyclophosphamide. Science; 342: 974-976. |
| [16] | Ida N, Dzutzen A, Stewart CA, Smith L, et al. (2013) Commensal bacteria control cancer response to therapy by modulating the tumor microenvironment. Science; 342: 967-970. |
| [17] | Vertizou M, Pitt JM, Daillere R, Lepage P, et al. (2015) Anticancer immunotherapy by CTLA-4 blockage relies on the gut microbiota. Science; 250: 1079-1084. |
| [18] | Nagiec EE, et al. (2005) orazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis. Antimicrob. Agents Chemother. 49: 3896-3902. |
| [19] | Barnhill AE, Brewer MT, Carlson SA. (2012) adverse effects of antimicrobials via predictable or idiosyncratic inhibition of host mitochondrial components. Antimicrob agents chemother. 56 (8); 4046-4051. |
| [20] | Garrabou G. et al. (2007) Rversible inhibition of mitochondrial protein synthesis during linegolid related hyperlactatemia. Antimicrob agents chemother. 51: 962-967. |
| [21] | Seyfried, TN and Shelton IM (2010) Cancer as a metabolic disease. Nutrition and Metabolis. 7: 1-22. |
| [22] | Leiter LM, Thatte HS, Okafor C, Marks PW, et al. (1999) chloramphenicol induced mitochondrial dysfunction is associated with decreased transferrin receptor expression and ferritin synthesis in K562 cells and is unrelated to IRE-IRP interactions. J. cell. Physiol. 180: 334-344. |
| [23] | Lamb R, Ozsvari B, Lisanti CL, Tanowitz HB et al. (2015) antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: Treating cancer like an infectious disease. Oncotarget; 6 (7): 4569-4584. |
| [24] | Son K, Fujioka S, Tida T, Furukawa K, Fujita T, et al. (2009) Doxycycline induces apoptosis in PANC-1 pancreatic cancer cells. Anticancer Res. 29 (10): 3995-4003. |
APA Style
Robert L. Elliott, Xian P. Jiang, Catherine C. Baucom. (2017). Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. Journal of Cancer Treatment and Research, 5(4), 62-65. https://doi.org/10.11648/j.jctr.20170504.11
ACS Style
Robert L. Elliott; Xian P. Jiang; Catherine C. Baucom. Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. J. Cancer Treat. Res. 2017, 5(4), 62-65. doi: 10.11648/j.jctr.20170504.11
AMA Style
Robert L. Elliott, Xian P. Jiang, Catherine C. Baucom. Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis. J Cancer Treat Res. 2017;5(4):62-65. doi: 10.11648/j.jctr.20170504.11
Share This Article
Twitter
Linked In
Facebook
Copy
Download@article{10.11648/j.jctr.20170504.11,
author = {Robert L. Elliott and Xian P. Jiang and Catherine C. Baucom},
title = {Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis},
journal = {Journal of Cancer Treatment and Research},
volume = {5},
number = {4},
pages = {62-65},
doi = {10.11648/j.jctr.20170504.11},
url = {https://doi.org/10.11648/j.jctr.20170504.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jctr.20170504.11},
abstract = {Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerative diseases, such as, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. In the 1930’s Warburg described a link between mitochondrial function and tumorigenesis. Modern Medicine has fallen prey to the overusage and misuse of antibiotics. This minireview postulates that this misuse may attack the mitochondrion and alter host-antibiotic interactions that might cause serious pathophysiologic conditions. One such condition may be cancer which was proposed by Warburg and supported by our work on normal mitochondria organelle transplantation in cancer. Some groups of antibiotics attack targets that are shared by prokaryotes and mitochondria. This leads to mitochondrial dysfunction possibly promoting tumorigenesis and neurodegenerative conditions.},
year = {2017}
}
TY - JOUR T1 - Antibiotic Overusage Causes Mitochondrial Dysfunction Which May Promote Tumorigenesis AU - Robert L. Elliott AU - Xian P. Jiang AU - Catherine C. Baucom Y1 - 2017/06/20 PY - 2017 N1 - https://doi.org/10.11648/j.jctr.20170504.11 DO - 10.11648/j.jctr.20170504.11 T2 - Journal of Cancer Treatment and Research JF - Journal of Cancer Treatment and Research JO - Journal of Cancer Treatment and Research SP - 62 EP - 65 PB - Science Publishing Group SN - 2376-7790 UR - https://doi.org/10.11648/j.jctr.20170504.11 AB - Mitochondria are dynamic intracellular organelles involved in many vital cellular functions. It is important to maintain good mitochondrial biogenesis and health. Mitochondrial dysfunction is known to be associated with many neurodegenerative diseases, such as, Parkinson’s, Alzheimer’s and amyotrophic lateral sclerosis. In the 1930’s Warburg described a link between mitochondrial function and tumorigenesis. Modern Medicine has fallen prey to the overusage and misuse of antibiotics. This minireview postulates that this misuse may attack the mitochondrion and alter host-antibiotic interactions that might cause serious pathophysiologic conditions. One such condition may be cancer which was proposed by Warburg and supported by our work on normal mitochondria organelle transplantation in cancer. Some groups of antibiotics attack targets that are shared by prokaryotes and mitochondria. This leads to mitochondrial dysfunction possibly promoting tumorigenesis and neurodegenerative conditions. VL - 5 IS - 4 ER -
Information
Email: