Parkinson’s Disease Treatment Using Cell Transplantation

Sana Khalid

doi:doi:10.11648/j.rs.20200503.12

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Parkinson’s Disease Treatment Using Cell Transplantation

Sana Khalid

Published in Rehabilitation Science (Volume 5, Issue 3)

Received: 22 April 2020 Accepted: 14 May 2020 Published: 27 October 2020

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Abstract

The testing of human fetus mesencephalic tissue with intrastriatal transplantation clinically that are rich in dopamine producing neurons. Parkinson’s disease patient showed cell transplantation works and in many cases produces impervious improvements. Due to the poor availability of tissues, this method could only be administered in fewer number of patients, and acclimatization was very difficult, leads to immense deflection in operative outcomes. For transplantation, undifferentiasted (stem) cells and special (reprogrammed) cells could be availed potentially to emolument dopamine producing neurons.From human embryonic stem cells dopamine producing neurons that will be of the appropriate substantia nigra phenotype can be emolumented in larger numbers and soon will be ready for application in patients. Dopamine producing neurons obtained from pluripotent stem cells of human are supposed to be used for clinical transplantation. In a controlled clinical studies, the present data justifies leading in away with these dopamine producing neurons, that should be tested by choosing desirable patients, anticipation of cells and methods of transplantation.

Published in	Rehabilitation Science (Volume 5, Issue 3)
DOI	10.11648/j.rs.20200503.12
Page(s)	24-30
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

Human Fetus Mesencephalic Tissue, Dopamine Producing Neurons, Human Pluripotent Stem Cells, Stem Cells Transplantation, Human Embryonic Stem Cells, Reinnervation, Denervated Striatum

References

[1]	Brkund A, Stenevi U. 1979 Reconstrucyon of the nigrostriatal dopamine pathway by intraceberal nigral transplants. Brain Res 177, 55-560.
[2]	Perlow MJ, Freed WJ, Hoffer BJ, Seiger A, Olson L, Wyatt RJ. 1979 Brain grafts reduce motor abnormalities produced by dstruction of nigrostriatal dopamine system. Science 204, 643-647.
[3]	Backlund EO, Granberg PO, Hamberger B, Knutsson E, Martensson A, Swdvall G, Geiger A, Olson L 1985 transplantation of adrenal medullary tissue to striatum in parkinsonism. First clinical trials. J. Neurosurg. 62, 169-173.
[4]	Lindvall O, Backlund EO, Frade L, Sedvall G, Freedman R, Hoffer B, Nobin a, seiger a, olson l.1987 Transplantation in parkinson’s disease: two major cases of adrenal medullary grafts to the putamen. Ann. neurol. 22, 457-468.
[5]	Lindvall o.2013 developing dopaminergic cell therapy for parkinson’s disease-give up or move forward? Mov. Disord. 28, 268-273.
[6]	(2015) Press Release International Stem Cell Corporation Receives Authorization to Initiate Phase I/IIa Clinical Trial of ISC-hpNSC for the Treatment of Parkinson’s Disease: http://www.internationalstemcell.com/proﬁles/investor/ResLibraryView.asp?ResLibraryID=80072&GoTopage=1&Category=958&BzID=1468&G=583
[7]	(2015) Press release, International Stem Cell Corporati- on. http://www.internationalstemcell.com/proﬁles/investor/NewsPrint.asp?b=1468&ID=80129&m=rl&pop=1&Nav=0&g=583&t=1983.
[8]	Brundin P, Strecker R. E., Clarke D. J., Widner H., Nilsson O. G., Astedt B, Lindvall O., & Bjorklund A (1988) Can human fetal dopamine neuron grafts provide a therapy for Parkin- son’s disease? Prog Brain Res, 78, 441-448.
[9]	Brundin P, Barker RA, & Parmar M (2010) Neural graft- ing in Parkinson’s disease Problems and possibilities. Prog Brain Res, 184, 265-294. [5] Thompson L, & Bjorklund A (2012) Survival, differentia- tion, and connectivity of ventral mesencephalic dopamine neurons following transplantation. Prog Brain Res, 200, 61-95.
[10]	Barker RA, Drouin-Ouellet J, & Parmar M (2015) Cell- based therapies for Parkinson disease-past insights and future potential. Nat Rev Neurol, 11, 492-503.
[11]	Freed CR, Greene PE, Breeze RE, Tsai WY, DuMouchel W, KaoR, Dillon S., Winﬁeld H., Culver S., Trojanowski J. Q., Eidelberg D., & FahnS (2001) Transplantation of embryonic dopamine neurons for severe Parkinson’s disease. N Engl J Med, 344, 710-719.
[12]	Olanow CW, Goetz CG, Kordower JH, Stoessl AJ, Sossi V, Brin MF, Shannon KM, Nauert GM, Perl DP, Godbold J, & Freeman TB (2003) A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson’s disease. Ann Neurol, 54, 403-414.

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APA Style

Sana Khalid. (2020). Parkinson’s Disease Treatment Using Cell Transplantation. Rehabilitation Science, 5(3), 24-30. https://doi.org/10.11648/j.rs.20200503.12

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ACS Style

Sana Khalid. Parkinson’s Disease Treatment Using Cell Transplantation. Rehabil. Sci. 2020, 5(3), 24-30. doi: 10.11648/j.rs.20200503.12

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AMA Style

Sana Khalid. Parkinson’s Disease Treatment Using Cell Transplantation. Rehabil Sci. 2020;5(3):24-30. doi: 10.11648/j.rs.20200503.12

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@article{10.11648/j.rs.20200503.12,
  author = {Sana Khalid},
  title = {Parkinson’s Disease Treatment Using Cell Transplantation},
  journal = {Rehabilitation Science},
  volume = {5},
  number = {3},
  pages = {24-30},
  doi = {10.11648/j.rs.20200503.12},
  url = {https://doi.org/10.11648/j.rs.20200503.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.rs.20200503.12},
  abstract = {The testing of human fetus mesencephalic tissue with intrastriatal transplantation clinically that are rich in dopamine producing neurons. Parkinson’s disease patient showed cell transplantation works and in many cases produces impervious improvements. Due to the poor availability of tissues, this method could only be administered in fewer number of patients, and acclimatization was very difficult, leads to immense deflection in operative outcomes. For transplantation, undifferentiasted (stem) cells and special (reprogrammed) cells could be availed potentially to emolument dopamine producing neurons.From human embryonic stem cells dopamine producing neurons that will be of the appropriate substantia nigra phenotype can be emolumented in larger numbers and soon will be ready for application in patients. Dopamine producing neurons obtained from pluripotent stem cells of human are supposed to be used for clinical transplantation. In a controlled clinical studies, the present data justifies leading in away with these dopamine producing neurons, that should be tested by choosing desirable patients, anticipation of cells and methods of transplantation.},
 year = {2020}
}

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TY  - JOUR
T1  - Parkinson’s Disease Treatment Using Cell Transplantation
AU  - Sana Khalid
Y1  - 2020/10/27
PY  - 2020
N1  - https://doi.org/10.11648/j.rs.20200503.12
DO  - 10.11648/j.rs.20200503.12
T2  - Rehabilitation Science
JF  - Rehabilitation Science
JO  - Rehabilitation Science
SP  - 24
EP  - 30
PB  - Science Publishing Group
SN  - 2637-594X
UR  - https://doi.org/10.11648/j.rs.20200503.12
AB  - The testing of human fetus mesencephalic tissue with intrastriatal transplantation clinically that are rich in dopamine producing neurons. Parkinson’s disease patient showed cell transplantation works and in many cases produces impervious improvements. Due to the poor availability of tissues, this method could only be administered in fewer number of patients, and acclimatization was very difficult, leads to immense deflection in operative outcomes. For transplantation, undifferentiasted (stem) cells and special (reprogrammed) cells could be availed potentially to emolument dopamine producing neurons.From human embryonic stem cells dopamine producing neurons that will be of the appropriate substantia nigra phenotype can be emolumented in larger numbers and soon will be ready for application in patients. Dopamine producing neurons obtained from pluripotent stem cells of human are supposed to be used for clinical transplantation. In a controlled clinical studies, the present data justifies leading in away with these dopamine producing neurons, that should be tested by choosing desirable patients, anticipation of cells and methods of transplantation.
VL  - 5
IS  - 3
ER  -

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Author Information

Sana Khalid

University of Sargodha, Sargodha, Pakistan

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APA Style

Sana Khalid. (2020). Parkinson’s Disease Treatment Using Cell Transplantation. Rehabilitation Science, 5(3), 24-30. https://doi.org/10.11648/j.rs.20200503.12

Copy | Download

ACS Style

Sana Khalid. Parkinson’s Disease Treatment Using Cell Transplantation. Rehabil. Sci. 2020, 5(3), 24-30. doi: 10.11648/j.rs.20200503.12

Copy | Download

AMA Style

Sana Khalid. Parkinson’s Disease Treatment Using Cell Transplantation. Rehabil Sci. 2020;5(3):24-30. doi: 10.11648/j.rs.20200503.12

Copy | Download

@article{10.11648/j.rs.20200503.12,
  author = {Sana Khalid},
  title = {Parkinson’s Disease Treatment Using Cell Transplantation},
  journal = {Rehabilitation Science},
  volume = {5},
  number = {3},
  pages = {24-30},
  doi = {10.11648/j.rs.20200503.12},
  url = {https://doi.org/10.11648/j.rs.20200503.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.rs.20200503.12},
  abstract = {The testing of human fetus mesencephalic tissue with intrastriatal transplantation clinically that are rich in dopamine producing neurons. Parkinson’s disease patient showed cell transplantation works and in many cases produces impervious improvements. Due to the poor availability of tissues, this method could only be administered in fewer number of patients, and acclimatization was very difficult, leads to immense deflection in operative outcomes. For transplantation, undifferentiasted (stem) cells and special (reprogrammed) cells could be availed potentially to emolument dopamine producing neurons.From human embryonic stem cells dopamine producing neurons that will be of the appropriate substantia nigra phenotype can be emolumented in larger numbers and soon will be ready for application in patients. Dopamine producing neurons obtained from pluripotent stem cells of human are supposed to be used for clinical transplantation. In a controlled clinical studies, the present data justifies leading in away with these dopamine producing neurons, that should be tested by choosing desirable patients, anticipation of cells and methods of transplantation.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Parkinson’s Disease Treatment Using Cell Transplantation
AU  - Sana Khalid
Y1  - 2020/10/27
PY  - 2020
N1  - https://doi.org/10.11648/j.rs.20200503.12
DO  - 10.11648/j.rs.20200503.12
T2  - Rehabilitation Science
JF  - Rehabilitation Science
JO  - Rehabilitation Science
SP  - 24
EP  - 30
PB  - Science Publishing Group
SN  - 2637-594X
UR  - https://doi.org/10.11648/j.rs.20200503.12
AB  - The testing of human fetus mesencephalic tissue with intrastriatal transplantation clinically that are rich in dopamine producing neurons. Parkinson’s disease patient showed cell transplantation works and in many cases produces impervious improvements. Due to the poor availability of tissues, this method could only be administered in fewer number of patients, and acclimatization was very difficult, leads to immense deflection in operative outcomes. For transplantation, undifferentiasted (stem) cells and special (reprogrammed) cells could be availed potentially to emolument dopamine producing neurons.From human embryonic stem cells dopamine producing neurons that will be of the appropriate substantia nigra phenotype can be emolumented in larger numbers and soon will be ready for application in patients. Dopamine producing neurons obtained from pluripotent stem cells of human are supposed to be used for clinical transplantation. In a controlled clinical studies, the present data justifies leading in away with these dopamine producing neurons, that should be tested by choosing desirable patients, anticipation of cells and methods of transplantation.
VL  - 5
IS  - 3
ER  -

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