Research Article
Phytotherapeutic Effects of Ashanti Pepper and Horn of Plenty in Sleep Disorder Management Resulting from Stress-Induced Neurobehavioral Alterations
Akingbesote Babajide Oluwaseun*
,
Sule Ola Salawu,
Bashorun Bukola Justina
Issue:
Volume 10, Issue 1, February 2024
Pages:
1-9
Received:
6 December 2023
Accepted:
6 January 2024
Published:
2 April 2024
Abstract: This investigation explores the potential antidepressant effects arising from the inherent bioactive compounds found in Cnestis ferruguinea and Piper guineense. Both botanical entities contain flavonoids, phenolics, saponins, and tannins, which are known for their anxiolytic, antidepressant, and antioxidant properties. It is worth noting that Cnestis ferruguinea also contains terpenoids, which are recognized for their anxiolytic effects. Given the growing interest in nutritional interventions for neuropsychiatric conditions, our study meticulously examines the antioxidant capacities and anxiolytic properties of these phytochemicals, positioning them as potential regulators of brain health, particularly in the realm of sleep disorders. In response to the increasing demand for therapeutic alternatives with reduced side effects, our inquiry thoroughly examines the antioxidant and anxiolytic profiles of these botanical extracts. Of particular importance, Cnestis ferruguinea exhibits superior antioxidant potential compared to Piper guineense, thus warranting further investigation into its pharmacological utility. Subsequent analysis of the effects of Cnestis ferruguinea on sleep architecture, especially in the context of chronic stress, reveals promising results. The botanical extract significantly prolongs sleep duration in rats exposed to stress, suggesting a potential dual role in mitigating stress-induced neurobehavioral changes and depressive symptoms. Additionally, a noticeable decrease in immobility duration in the forced swim test, along with improvements in acetylcholinesterase levels following Cnestis ferruguinea treatment, provides mechanistic insights into its antidepressant effects. Our findings provide substantial evidence to support the pharmacotherapeutic potential of Cnestis ferruguinea, highlighted by its antioxidant abilities and anxiolytic effects. Further investigations should delve into the intricate molecular pathways underlying these effects, potentially paving the way for innovative botanical-based interventions in neuropsychiatric disorders, particularly those associated with stress-induced neurobehavioral changes and sleep disorders.
Abstract: This investigation explores the potential antidepressant effects arising from the inherent bioactive compounds found in Cnestis ferruguinea and Piper guineense. Both botanical entities contain flavonoids, phenolics, saponins, and tannins, which are known for their anxiolytic, antidepressant, and antioxidant properties. It is worth noting that Cnest...
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